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1.
枸杞和枸杞多糖与抗衰延寿   总被引:17,自引:0,他引:17  
对喂饲和服用枸杞及其多糖的实验动物(小鼠和果蝇)和老年人测定了平均寿命、最高寿命和能反映免疫学、生理生化学和遗传学机能状态的指标19项。结果表明,枸杞和枸杞多糖能显著地延长果蝇平均寿命,提高或显著提高和改善老年人上述诸领域中的绝大部分指标(溶菌酶活力,IgG含量,T细胞转化率,IFN和IL-2含量,T3含量,cAMP和cGMP含量,SOD和LPO含量),使这些指标向年轻化方向逆转;对实验动物的最高  相似文献   

2.
枸杞胶囊对果蝇的延缓衰老作用   总被引:11,自引:1,他引:10  
目的 探讨枸杞胶囊对果蝇的延缓衰老作用及其机理。方法 将未交配的果蝇随机分成5组,给予含不同浓度枸杞胶囊的培养基喂养,用生存实验检测寿命,羟胺法测定SOD活性,TBA法测定MDA含量。结果 枸杞 胶囊能显著延长果蝇的平均最高寿命及雌蝇的平均帮助,雌蝇体内SOD活性明显升高(P<0.05),雌雄果蝇体内的MDA含量均降低(P<0.05)。结论 枸杞胶囊具有抗氧化、延缓果蝇衰老的作用。  相似文献   

3.
对河北引种的枸杞子进行了升高白细胞、增加免疫功能和抗衰老作用研究。结果表明:河北引种枸杞水提液连续ig可抑制环磷酰胺所致白细胞减少并促使其回升,能提高小鼠胸腺指数,显著延长小鼠死亡时间。证明河北引种的枸杞具有促进造血机能,增强机体免疫能力,延缓衰老的药理作用。  相似文献   

4.
枸杞山茱萸水煎液对小鼠抗疲劳和耐缺氧作用的研究   总被引:1,自引:0,他引:1  
目的枸杞山茱萸水煎液对小鼠的抗疲劳和耐缺氧作用的研究。方法本研究采用游泳法测定小鼠的游泳持续时间,常压耐缺氧法测定小鼠的存活时间,断头缺血缺氧法测定小鼠张口喘气时间和呼吸次数。结果枸杞山茱萸水煎液连续灌胃给药,能显著延长小鼠的游泳时间、常压缺氧下的存活时间和断头喘气时间,增加呼吸次数(P<0.05,P<0.01)。结论枸杞山茱萸水煎液能增强小鼠的抗疲劳和耐缺氧能力,提高动物机体的应激反应能力。  相似文献   

5.
枸杞油胶丸缓解体力疲劳作用的动物实验研究   总被引:1,自引:0,他引:1  
目的探讨枸杞油胶丸对疲劳小鼠各项疲劳指标的影响.方法将小鼠按体重随机分为对照组和低、中、高剂量实验组.低、中、高剂量组分别灌胃给予0.1、0.2、0.6g/(kg·bw)剂量的枸杞油胶丸,对照组灌胃给予等体积的植物油,连续30 d后,测定负重游泳时间、血清尿素、血乳酸和肝糖原.结果0.2g/(kg·bw)剂量能显著延长小鼠的负重游泳时间,减少疲劳小鼠血清尿素产生,减小血乳酸曲线下面积,对小鼠的肝糖原储备量无明显影响.结论枸杞油胶丸对动物具有缓解体力疲劳功能.  相似文献   

6.
何首乌多糖和枸杞多糖的协同抗衰老作用机制的实验研究   总被引:8,自引:0,他引:8  
目的研究何首乌多糖和枸杞多糖的协同抗衰老作用及其机制。方法用两因素两水平正交法设计实验,用D半乳糖制备衰老小鼠模型,试药组衰老小鼠分别灌胃50∶50,50∶200,200∶50,200∶200mg·(kg·d)-1何首乌多糖∶枸杞多糖,观察其对衰老模型小鼠免疫器官及抗氧化系统的影响。结果试药组衰老小鼠分别灌胃不同浓度比的何首乌多糖和枸杞多糖能使衰老模型小鼠胸腺指数和脾脏指数不同程度升高;肝、肾组织中MDA不同程度下降,SOD及GSHPX活力不同程度提高;脑组织中LF不同程度下降。统计学分析表明,何首乌多糖和枸杞多糖对各实验指标有显著或极显著的协同作用。结论何首乌多糖和枸杞多糖联用有显著的协同抗衰老作用,两药最佳组合为200mg∶50mg。其机制可能与提高免疫功能,清除氧自由基,活性氧及抗脂质过氧化有关。  相似文献   

7.
目的研究枸杞山茱萸对东莨菪碱所致的小鼠记忆障碍的改善作用。方法以腹腔注射东莨菪碱的方法制作小鼠记忆获得障碍模型;以穿梭箱、跳台和水迷宫实验,观察枸杞山茱萸对小鼠记忆的改善作用。结果枸杞山茱萸(7.5~30 g/kg)能显著减少小鼠在穿梭箱实验中遭受电击的时间;减少小鼠在跳台实验中的错误次数,延长跳台潜伏期;30 g/kg枸杞山茱萸可缩短小鼠在水迷宫实验中的潜伏期,减少错误次数。结论枸杞山茱萸对东莨菪碱所致的小鼠记忆障碍有改善作用。  相似文献   

8.
吉林枸杞糖蛋白的初步药理研究   总被引:3,自引:0,他引:3  
吉林枸杞糖蛋白按200,400mg/kg给小鼠多次灌胃,能明显提高小鼠的耐缺氧和抗疲劳能力,呆促进正常小鼠的胸腺和脾脏重量增加,并对小鼠网状内皮系统的吞噬功能有明显的增强作用,提示从吉林枸杞制药废渣中仍能得到具有一定药理活性的多糖,可变废为宝。  相似文献   

9.
研究了枸杞蛇胆酒的抗炎,镇咳和对免疫功能的影响。结果表明,连续灌服能抑制角叉菜胶所致的小鼠足肿胀;延长氨水所致小鼠咳嗽的潜伏期,减少咳嗽次数;能增强小鼠单核-巨噬细胞的吞噬功能,提高小鼠胸腺指数,并能增强免疫功能低下小鼠的迟发性超敏反应,从而增强机体的免疫功能。证明枸杞蛇胆酒的抗炎和增强免疫功能作用都优于蛇胆酒。  相似文献   

10.
枸杞提取物对果蝇寿命的影响   总被引:12,自引:0,他引:12  
目的 研究枸杞对运动的抗衰老和。方法 采用枸杞提取液,经果蝇为试验材料进行实验研究。结果 枸杞提取物能有效的降低唾液腺细胞脂褐素及过氧化脂质(LPO)含量。结论 枸杞具有明显的抗衰延寿作用。  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

20.
ANTI-PROLIFERATION EFFECT OF ORIDONIN ON HL-60 CELLS AND ITS MECHANISM   总被引:4,自引:0,他引:4  
Objcetive To investigate the anti-proliferation effect of oridonin on leukemic HL-60 cells and its mechanism. Methods HL-60 cells in vitro in culture medium were given different concentrations of oridonin. The inhibitory rate of cells were measured by microculture tetrazolium (MTT) assay, cell apoptotic rate was detected by flow cytometry (FCM), morphology of cell apoptosis was observed by hoechst 33258 fluorescence staining, and the activity of telomerase was detected using telomere repeat amplification protocol (TRAP) PCR-ELISA before and after apoptosis occurred. Results Oridonin could decrease telomerase activity, inhibit growth of HL-60 cells, and cause apoptosis significantly. The suppression was both in time- and dose-dependent manner. Marked morphological changes of cell apoptosis including condensation of chromatin and nuclear fragmentation were observed clearly by hoechst 33258 fluorescence staining especially after cells were treated 48-60 hours by oridonin. Conclusions Oridonin has apparent anti-proliferation and apoptotic effects on HL-60 cells in vitro, decreasing telomerase activity of HL-60 cells may be one of its most important mechanisms. These results will provide strong laboratory evidence of oridonin for clinical treatment of acute leukemia.  相似文献   

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