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1.
刘文枝  刘惠娜 《中外医疗》2011,30(25):18+20-18,20
目的分析早发型重度子痫前期的患病率、临床特征、治疗、终止妊娠的时机及妊娠结局。方法选择2006年1月至2010年12月早发型重度子痫前期孕妇35例,对其治疗和妊娠结局进行分析。结果早发型重度子痫前期的患病率0.32%,合并症及并发症发病率为86.9%,以肝脏、肾脏、心脏损害为主,平均治疗时限为(8±3)d,围产儿死亡率为18.42%,无孕产妇死亡。结论早发型重度子痫前期患者在严密母胎监护下采取适宜的期待治疗,母亲的安全是有保障的,对母胎进行动态监护评估是期待治疗的关键,终止妊娠的时机更为重要。  相似文献   

2.
[目的]探讨早发型重度子痫前期终止妊娠时机与母儿结局关系.[方法]对80例早发型重度子痫前期患者的临床资料进行回顾性分析,按终止妊娠时间分为两组,A组<32周、B组≥32周≤34周.比较两组间母儿预后情况.[结果]A组新生儿窒息发生率、新生儿死亡率明显高于B组,两组间孕产妇并发症无明显差异.[结论]早发型重度子痫前期有较高的母婴并发症发生率.应根据母胎情况、严格选择病例进行期待治疗,同时密切监测母胎病情.适时终止妊娠,以获得较理想的母胎结局.  相似文献   

3.
金今月 《中外医疗》2011,30(10):100-100
目的探讨早发型重度子痫前期的诊断、治疗及发病对妊娠结局的影响。方法回顾性分析我院2004年1月至2009年12月收治的52例早发型重度子痫前期患者的治疗经过及妊娠结局。结果早发型重度子痫前期患者合并症及并发症发生率高达82.7%,平均保守保守治疗时间为3~12d,围产儿死亡率23.6%,无产妇死亡。结论早发型重度子痫前期患者终止妊娠前期待治疗是安全有效的,但密切监测母胎病情变化,掌握终止妊娠时机极为重要。  相似文献   

4.
罗润环  索冬梅  曾萌 《中外医疗》2013,(18):111-112
目的探析早发型与晚发型重度子痫前期在临床治疗中的各项情况,如母体并发症、妊娠终止时机、围产儿结局等。方法对该院2009年3月—2012年5月收治的238例重度子痫前期患者的临床资料进行回顾性对比分析。结果早发型重度子痫前期患者的舒张压和收缩压显著高于晚发型重度子痫前期患者;早发型重度子痫前期患者的HELLP综合征、胎盘早剥、低蛋白血症、产后出血、眼底病变、肝损害的发生率均显著高于晚发型重度子痫前期患者;早发型重度子痫前期患者的胎死宫内、胎儿窘迫、新生儿轻、新生儿畸形、重度窒息的发生率显著高于晚发型重度子痫前期患者。结论早发型重度子痫前期和晚发型重度子痫前期在并发症、妊娠终止时机、围产儿结局等方面是存在差异的,在临床治疗中应当对症治疗。  相似文献   

5.
目的:分析早发型重度子痫前期的患病率、临床特征、治疗原则、终止妊娠的时机方式及妊娠结局。方法:选择2005年11月~2007年6月孕周为24~34周重度子痫前期孕妇44例,对其治疗经过和妊娠结局进行分析总结。结果:早发型重度子痫前期的患病率1.2%,平均治疗时限为(8.6±5.2)d,合并症并发症的发生率高达95%,当发生危及母儿的严重的并发症时应及时终止妊娠,方式以剖宫产为宜。结论:早发型重度子痫前期可以在终止妊娠前有短期的期待治疗,给予积极治疗能明显改善妊娠结局。  相似文献   

6.
目的探讨重度子痫前期严重并发症发生情况及妊娠结局。方法回顾分析2010年1月~2011年5月我院产科收治的156例符合重度子痫前期诊断标准的患者,按重度子痫前期发病时间(以34周为界)不同分为:早发型76例、晚发型80例,观察早发型与晚发型重度子痫前期孕妇发生严重并发症发生率及构成比,观察早发型与晚发型重度子痫前期分娩方式及围生儿情况。结果早发型重度子痫前期76例出现严重并发症的发生率73.68%;晚发型重度子痫前期80例出现严重并发症的发生率61.25%;早发型剖宫产67例,阴道分娩9例,剖宫产率88.16%;晚发型剖宫产75例,阴道分娩5例,剖宫产率93.75%;早发型围生儿发生异常63例,发生率82.89%;晚发型围生儿发生异常34例,发生率42.5%。结论重度子痫前期进行严密临床监测,积极期待治疗,适当延长孕周,严格掌握终止妊娠指征,选择适当时机终止妊娠,以达到减少严重并发症发生及改善围生儿结局目的 。  相似文献   

7.
①目的 探讨早发型重度子痫前期的治疗和母儿结局.②方法 对46例早发型重度子痫前期的患者,根据病情需要进行期待治疗和终止妊娠.分析不同治疗方法的母儿结局.③结果 孕周>32周的围生儿病死率明显低于32周前终止妊娠者(P<0.05).④结论 选择合适的早发型重度子痫前期孕妇进行期待治疗,可以明显改善围生儿结局,对孕产妇也是安全和可行的;终止妊娠时机的把握尤为重要.  相似文献   

8.
梅吉  于红 《现代医学》2012,40(6):663-666
目的:探讨早发型及晚发型重度子痫前期的临床特点及围产结局。方法:回顾性分析东南大学附属江阴医院产科2010年1月至2012年2月收治的重度子痫前期80例患者的临床资料,将其分为早发型重度子痫前期组(早发型组,妊娠<34周,20例)和晚发型重度子痫前期组(晚发型组,妊娠≥34周,60例)。结果:孕产妇并发症早发型组高于晚发型组,终止妊娠的孕周早于晚发型组,终止妊娠的方式剖宫产率高于晚发型组,差异均具有统计学意义(P<0.05);胎儿窘迫、死胎、胎儿生长受限、新生儿窒息、新生儿死亡等发生率早发型组显著高于晚发型组(P<0.01)。结论:早发型重度子痫前期严重影响母婴预后,适当期限的期待治疗有助于改善母婴结局,剖宫产是终止重度子痫前期的主要方法。  相似文献   

9.
86例早发型重度子痫前期诊断和治疗   总被引:1,自引:0,他引:1  
目的 探讨早发型重度子痫前期期待治疗和终止妊娠时机选择对母儿结局的影响.方法 对86例早发型重度子痫前期病例进行回顾性分析.按终止妊娠的孕周分3组,比较母儿结局和终止妊娠的方式.结果 随期待治疗时间的延长,新生儿窒息率和死亡率明显下降(P<0.01),而孕妇并发症未见明显增加.结论 对早发型重度子痫前期,期待治疗和终止妊娠是最大限度地降低孕产妇和围产儿病死率的重要方法.  相似文献   

10.
目的分析早发型重度子痫前期结束妊娠时机的选择及对妊娠结局的影响。方法选择辽宁省朝阳市中心医院2005年1月~2010年12月收治的妊娠≤34周的早发型重度子痫前期患者75例,按发病时孕周分为A组28~31+6周(23例)和B组32~34周(52例)。分析其发病的孕周、终止妊娠的时间及对母婴的影响等情况。结果两组病例保守治疗的时间对围生儿的预后有明显影响。结论早发型重度子痫前期严重影响母婴的预后,在期待治疗过程中要密切监护母胎的情况,选择好终止妊娠的适当时间,以提高母婴的安全。  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

20.
ANTI-PROLIFERATION EFFECT OF ORIDONIN ON HL-60 CELLS AND ITS MECHANISM   总被引:4,自引:0,他引:4  
Objcetive To investigate the anti-proliferation effect of oridonin on leukemic HL-60 cells and its mechanism. Methods HL-60 cells in vitro in culture medium were given different concentrations of oridonin. The inhibitory rate of cells were measured by microculture tetrazolium (MTT) assay, cell apoptotic rate was detected by flow cytometry (FCM), morphology of cell apoptosis was observed by hoechst 33258 fluorescence staining, and the activity of telomerase was detected using telomere repeat amplification protocol (TRAP) PCR-ELISA before and after apoptosis occurred. Results Oridonin could decrease telomerase activity, inhibit growth of HL-60 cells, and cause apoptosis significantly. The suppression was both in time- and dose-dependent manner. Marked morphological changes of cell apoptosis including condensation of chromatin and nuclear fragmentation were observed clearly by hoechst 33258 fluorescence staining especially after cells were treated 48-60 hours by oridonin. Conclusions Oridonin has apparent anti-proliferation and apoptotic effects on HL-60 cells in vitro, decreasing telomerase activity of HL-60 cells may be one of its most important mechanisms. These results will provide strong laboratory evidence of oridonin for clinical treatment of acute leukemia.  相似文献   

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