危重机械通气患者强化胰岛素治疗

目的观察危重机械通气患者强化胰岛素治疗后的的疗效。方法将92例危重患者随机分为传统治疗组(CT)和强化胰岛素治疗组(IT)。CT组:当血糖>11.9mmol/L,皮下注射胰岛素,控制血糖10～11.1mmol/L,IT组:当血糖>6.1mmol/L,用微量输液泵静脉泵注胰岛素,控制血糖4.4～6.1mmol/L。结果CT组病死率达43.47%,远远高于IT组的13.04%_患者住重症监护时间、使用呼吸机日数、抗生素使用、死亡率、并发症发生明显高于IT组(P<0.05)。结论强化胰岛素治疗控制危重患者血糖4.4～6.1mmol/L。,能降低患者的病死率。     

胰岛素强化治疗对急诊重症监护病房危重病患者预后的影响

目的 探讨急诊重症监护病房(ICU)危重病患者胰岛素强化治疗与预后的关系.方法 选择入急诊ICU监护前无糖尿病病史且存在高血糖的危重病患者126例,收住ICU时血糖为(15.3±6.7)mmol/L.将患者随机分为3组,每组42例,均给予胰岛素强化治疗.A组血糖控制在4.4～6.1 mmol/L;B组血糖控制在6.1～8.3 mmol/L;C组血糖控制在8.3～11.1 mmol/L.观察3组患者治疗后的抗生素使用时间、入住ICU时间、入住ICU最后1 d的APACHE II评分、院内感染发生率、多脏器功能衰竭(MOF)发生率及病死率等参数.结果 A组患者治疗后抗生素使用时间、入住ICU时间、院内感染发生率、MOF发生率及病死率均显著低于C组,差异有统计学意义(P＜0.05).B组患者入住ICU时间及院内感染发生率显著高于A组,差异有统计学意义(P＜0.01).B组患者MOF发生率及病死率均显著低于C组,差异有统计学意义(P＜0.05).结论 对于急诊ICU危重病患者给予胰岛素强化治疗,将血糖控制在4.4～6.1 mmol/L可改善预后,降低并发症发生率及病死率.     

强化胰岛素治疗在内科综合性ICU中的疗效分析研究

目的研究强化胰岛素治疗在内科综合性ICU的临床疗效.方法选择至少在内科综合性ICU病房监护5 d以上,且既往无糖尿病史的危重病患者168例,收住ICU时血糖水平（13.8±5.5）mmol/L,随机分为3组（n=56）,第1、2组给予强化胰岛素治疗,使血糖控制在4.4～6.1 mmol/L、4.4～8.3 mmol/L;第3组当血糖大于11.1 mmol/L时予常规胰岛素治疗,分别使血糖控制在8.3～11.1 mmol/L;观察3组患者使用抗生素天数、机械通气天数、急性肾功能衰竭发生率、院内感染发生率、应激性溃疡发生率、低血糖发生率、多器官功能衰竭发生率、在ICU最后1 d急性生理学与慢性健康状况评分（APEACHⅡ）、住ICU天数及病死率（28 d）等参数.结果第1、2组在使用抗生素天数,机械通气天数,急性肾功能衰竭发生率,院内感染发生率,应激性溃疡发生率,多器官功能衰竭发生率,在ICU最后1 d急性生理学与慢性健康状况评分（APACHE I）I,住ICU天数及病死率（28 d）等参数均明显低于第3组（P〈0.05）.且第2组低血糖发生率低于第1组（P〈0.05）.结论对于内科综合性ICU的危重患者强化胰岛素治疗将血糖水平控制在4.4～8.3 mmol/L,可改善危重病患者的病情,降低病死率,且减少低血糖的发生.     

强化胰岛素治疗综合ICU患者应激性高血糖的临床效果

目的:研究强化胰岛素在治疗综合ICU患者应激性高血糖中的应用效果.方法:选择ICU于2013年7月-2014年7月收治的危重症患者110例.随机分为2组,强化治疗组55例,对照组55例,强化组目标血糖控制在4.4 ～ 6.1 mmol/L,对照组目标血糖控制在6.1 ～10.0 mmol/L,观察两组患者住ICU时间、机械通气时间、多器官功能衰竭综合征(MODS)发生率、低血糖发生率、病死率等.结果:胰岛素强化治疗组与对照组比较,前者在住ICU时间和机械通气时间方面比对照组短,差异有统计学意义(P＜0.05),MODS发生率和死亡率比对照组低,差异有统计学意义(P＜0.05).强化组低血糖发生率较对照组比例高,但差异无统计学意义(P＞0.05).结论:对于综合性ICU的危重病患者出现应激性血糖升高时,强化胰岛素治疗可以更好的改善危重病患者的病情,降低病死率,但需动态监测血糖值,防止低血糖发生.     

不同疗程胰岛素强化治疗危重病患者应激性高血糖的临床观察

目的探讨胰岛素强化治疗不同疗程对危重病患者应激性高血糖的调控及临床转归的影响。方法 选择入住ICU既往无糖尿病史的危重病患者156例,随机分为3组,每组52例,对照组始终给予常规血糖控制,控制血糖在4.4～11.1 mmol/L;7 d组、14 d组分别给予7 d、14 d的强化胰岛素治疗,随后给予常规的血糖控制,控制血糖在4.4～8.3 mmol/L。结果在强化胰岛素治疗期间,7 d组、14 d组胰岛素用量高于对照组,血糖水平低于对照组(P<0.01),强化治疗停止后第15～21天,7 d组、14 d组的平均血糖水平及胰岛素用量均明显低于对照组(P<0.01);7 d组、14 d组的ICU住院时间、机械通气天数、院内感染发生率、MODS发生率及病死率均明显低于对照组(P<0.05或P<0.01),而7 d组和14 d组比较,上述观察指标差异无统计学意义(P>0.05);低血糖的发生率随着胰岛素强化治疗时间的增长而增高,但差异无统计学意义(P>0.05)。结论在危重病患者中,采用7d短期胰岛素强化治疗,能达到同强化胰岛素治疗方案相同或相似的控制目的 ,既改善预后,又减少低血糖的发生率。     

胰岛素在治疗急性缺血性脑血管病中的疗效观察

目的:探讨强化胰岛素治疗对急性缺血性脑血管病的治疗作用及对预后的影响。方法:选取非糖尿病的急性缺血性脑血管病后高血糖病例100例,随机分为治疗组和对照组,治疗组51例,采取胰岛素强化治疗控制血糖。对照组采用瑞格列奈控制血糖。治疗组和对照组的血糖控制范围均是:重症病例空腹血糖≤6.1mmol/L,餐后血糖≤10mmol/L;非重症患者空腹血糖控制于5.0-7.2mmol/L。餐后血糖控制在≤10mmol/L。[1]两组患者于住院当日和住院治疗后14天用美国国立卫生所卒中评分量表对患者进行神经功能评分,根据评分比较两组的疗效。结果:强化胰岛素治疗组的显效率明显高于对照组,神经功能评分显著降低。     

胰岛素强化治疗急性脑卒中应激性高血糖疗效观察

目的:探讨胰岛素强化治疗急性脑卒中应激性高血糖的效果。方法:将160例无糖尿病伴有应激性高血糖的急性脑卒中患者随机分成2组,观察组80例,给予胰岛素强化治疗,使血糖控制在4.4～6.1 mmol/L;对照组80例,当血糖≥11.1mmol/L时,给予常规胰岛素治疗,控制血糖在8.0～11.1 mmol/L。观察2组病死率和感染并发症的发生率及神经功能恢复情况。结果:观察组肺部感染发生率8.75%,尿路感染发生率6.25%,病死率2.50%,均明显低于对照组(P0.01);观察组住院第15、30天的神经功能评分均明显优于对照组(P0.01)。结论:胰岛素强化治疗伴应激性血糖升高的急性脑卒中患者可降低感染发生率和病死率,有利于促进神经功能的恢复。     

重症急性胰腺炎并发ARDS强化胰岛素治疗的临床干预效果观察

目的观察重症急性胰腺炎并发ARDS强化胰岛素治疗的临床干预效果。方法将66例重症急性胰腺炎合并ARDS患者随机分为两组,传统组（TT组）与强化组（IT组）,两组均采用微量注射泵输入胰岛素,TT组将血糖控制在10.0～11.1mmol/L,IT组将血糖控制在4.4～6.1mmol/L。观察两组使用呼吸机时间、ICU住院时间及低血糖例数等情况。结果两组存活患者比较,IT组使用呼吸机时间、ICU住院时间均明显缩短（P〈0.05）。结论强化胰岛素治疗对重症急性胰腺炎并发ARDS的治疗过程起着一定的干预因素,加快了脱机时间,缩短ICU住院时间。     

改良强化胰岛素治疗在危重病应激性高血糖患者救治中的作用探讨

目的探讨改良强化胰岛素治疗在危重病应激性高血糖患者救治中的作用。方法将120例入住ICU的非糖尿病患者随机分为改良血糖控制组(改良组)和强化血糖控制组(强化组),每组60例,强化组血糖控制(ⅡT)在4.4～6.1 mmol/L,改良组则将目标血糖控制在8～10 mmol/L。统计2组患者日平均血糖值、呼吸机使用时间、气管插管留置时间、ICU住院时间、低血糖发生率、MODS发生率、28d病死率等。结果 2组患者呼吸机使用时间、气管插管留置时间、ICU住院时间比较差异无统计学意义(P>0.05),改良组日平均血糖值高于强化组(8.9mmol/L±2.1 mmol/L vs 5.3 mmol/L±2.6 mmol/L,P<0.05),低血糖发生率强化组明显高于改良组(13.33%vs3.33%,P<0.05)。改良组MODS发生率40.0%(24/60),28d病死率为16.7%(10/60),强化组相对应为46.7%(28/60)、20.0%(12/60),差异无统计学意义(P>0.05)。结论对于入住ICU的应激性高血糖患者,与ⅡT靶目标控制于4.4～6.1 mmol/L相比,将血糖靶目标水平控制于8～10 mmol/L更为合理。     

胰岛素泵治疗糖尿病37例疗效观察

目的观察胰岛素泵在糖尿病患者中的短期疗效.方法选择围手术期或并发急、重并发症或血糖较高的糖尿病患者共72例为观察对象,将72例糖尿病患者分为两组进行胰岛素强化治疗.治疗组:37例接受胰岛素泵持续皮下胰岛素注射治疗;对照组:35例给予分次皮下胰岛素注射治疗.观察时间为7～15d.结果治疗组患者血糖达到控制标准(空腹血糖3.9～6.1mmol/L,餐后2h血糖3.9～8.0mmol/L)或接近控制标准所需的治疗时间明显少于对照组(P＜0.01),胰岛素用量也明显少于对照组(P＜0.05).结论治疗组比对照组能更快、更有效地使血糖达到控制标准,这对于危重病人的抢救以及缩短手术前的准备时间是非常有利的.同时也减少了胰岛素的日用量.     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.