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1.
目的:对随访期2年或以上的随机对照试验进行Meta分析,探讨骨髓干细胞(BMC)移植对急性心肌梗死后患者远期左室收缩功能的影响?方法:系统检索数据库Medline?Embase?Cochrane图书馆和Cochrane对照试验注册中心?中国生物医学磁盘数据库;时间为从建库到2012年7月?用统一表格提取资料,应用RevMan 5.0软件进行定量分析?结果:6篇临床试验合计551名患者纳入本Meta分析?与对照组相比,BMC移植使左室射血分数(LVEF)显著增加(5.09%,95%CI:2.67%~7.52%,P < 0.001)?亚组分析显示,基线LVEF低于42%的患者从BMC治疗中获益明显,LVEF显著改善,而基线LVEF高于42%的患者未能从中获益?结论:BMC移植能够在标准治疗的基础上进一步增加急性心肌梗死后的LVEF,改善左室收缩功能,该效应至少能保持2年以上?该效应还需要未来大规模随机对照试验来证实?  相似文献   

2.
《海南医学院学报》2016,(24):3016-3019
目的:分析腹腔镜手术中经食道超声心动图对冠脉血流、心功能的评估及其与手术创伤的相关性。方法:80例在本院接受腹腔镜手术的患者随机分为标准气腹压组(12~15 mmHg)、高气腹压组(>15mmHg)各40例,对比两组经食道超声心动图(TEE)下冠脉血流、心功能参数水平、血清应激激素、急性时相蛋白含量差异。结果:标准气腹压组冠脉血流参数冠脉左前降支起始处直径(D)、冠脉分钟血流量(Q)、舒张期最大流速(PDV)、舒张期平均流速(MDV)、舒张期加速度(DAR)水平均显著高于高气腹压组;心功能参数左室流出道心脏排血量(COLVOT)、左室射血分数(LVEF)、左室面积变化分数(LVFAC)水平均显著高于高气腹压组;血清应激激素皮质醇(Cor)、血管紧张素Ⅰ(Ang-Ⅰ)、血管紧张素Ⅱ(Ang-Ⅱ)、去甲肾上腺素(NE)、胰高血糖素(Glucagon)、C-肽(C-peptide)及急性时相蛋白C反应蛋白(CRP)、甲壳质酶蛋白-40(YKL-40)、高迁移率族蛋白(HMGB1)含量均显著低于高气腹压组,急性时相蛋白前白蛋白(PA)含量显著高于高气腹压组。结论:经食道超声心动图可以及时发现腹腔镜手术中过高腹压对患者冠脉血流及心功能带来的损伤,同时也避免过度手术创伤的发生。  相似文献   

3.
目的观察实时三维心脏超声(RT-3DE)与磁共振成像(MRI)在评估法洛四联症(TOF)患者心功能中的应用价值。方法选取我院收治的25例行一期根治术TOF患者,采取RT-3DE与MRI方式了解患者心功能指标情况[左室与右室舒张末期容量(LVEDV与RVEDV)、左室与右室收缩末期容量(LVESV与RVESV)、左室与右室射血分数(LVEF与RVEF)],并分析这两种检查方式所得心功能指标相关性。结果RT-3DE与MRI检查出的LVEDV、RVEDV、LVESV、RVESV、LVEF及RVEF比较无显著差异(P>0.05);RT-3DE与MRI检查出的LVEDV、RVEDV、LVESV、RVESV、LVEF以及RVEF具有良好一致性(P<0.05)。结论RT-3DE评估TOF患者心功能与MRI评估结果一致性好,在TOF心室功能检测中具有较高应用价值。  相似文献   

4.
本文采用多门电路平衡法心血池显像(MGERNA)测定了13例正常人、32例慢性阻塞性肺疾病(COPD)患者右室及左室射血分数(RVEF 及LVEF)。结果表明,RVEF 能反映 COPD 患者右室功能的规律性变化,可作为诊断早期肺心病的敏感指标;LVEF 降低仅见于部分有右心衰且 RVEF 严重降低的肺心病患者。  相似文献   

5.
目的比较经动脉压力波形分析法(FloTrac系统)与传统经肺动脉导管间断热稀释法(Swan-Ganz导管技术)监测心排血量(CO)之间的相关性和一致性。方法选择10例行择期非停跳冠状动脉旁路移植术(OPCAB)的患者,美国麻醉医师学会(ASA)分级为Ⅱ~Ⅲ级,年龄62~76岁。所有患者均连接FloTrac传感器(Vigileo监测仪)监测外周动脉血CO(APCO);同时放置肺动脉漂浮导管,接Ewards VigilanceTM监护仪监测间断CO(ICO)。结果一元线性回归分析结果显示,患者术中在放置肺动脉导管后、第1次容量负荷后开胸前、开胸后、搭前降支固定器放置稳定后5min、搭回旋支固定器放置稳定后5min、搭后降支固定器放置稳定后5min、近端吻合时、关胸后第2次容量负荷之前及第2次容量负荷之后9个时间点的APCO与ICO之间均高度相关(相关系数分别为0.81、0.73、0.86、0.78、0.79、0.90、0.80、0.77、0.76,P值分别<0.01、0.05)。Bland-Altman散点图分析结果显示,各时间点APCO与ICO之间的偏差和一致性差异分别为-0.35(±1.08)、-0.21(±1.06)、-0.25(±0.88)、-0.43(±0.98)、-0.47(±0.72)、-0.27(±0.62)、-0.35(±0.94)、-0.26(±0.90)、-0.39(±1.04)L/min,两种监测方法有较好的一致性。结论 FloTrac系统测量的APCO与Swan-Ganz导管技术测量的ICO之间存在良好的相关性和一致性。  相似文献   

6.
1988年2月至1989年2月,对43例慢性阻塞性肺疾病(COPD)患者,用放射性~(113m)铟输铁蛋白或~(99m)TC-RBC体内标记,测定右室射血分数(RVEF)及左室射血分数(LVEF),现将结果报道如下。  相似文献   

7.
目的: 评价重症冠脉搭桥术患者应用主动脉内球囊反搏(IABP)治疗的效果?方法:31例重症冠脉搭桥术患者(左室射血分数LVEF≤40%)分别于术前放置球囊反搏导管,心脏复跳后行IABP辅助,对使用IABP前和停IABP前患者舒张压(DBP)?心输出量(CO)?尿量?血管活性药的剂量进行比较?结果:1例患者术后死于右心功能不全,病死率3.2%,其余患者于2~8天转出ICU;停用IABP前心输出量?舒张压和尿量均值明显高于使用IABP前均值;停用IABP前肾上腺素和多巴胺均值明显低于使用IABP前均值?结论:对重症冠脉搭桥术患者进行IABP辅助具有明显的循环支持效果,提高了重症冠脉搭桥术患者的手术成功率?  相似文献   

8.
目的 探讨急性呼吸困难患者血浆B 型钠尿肽 (B typenatriureticpeptide,BNP)浓度与左、右心室功能的相关性。方法 对 87例发生急性呼吸困难的患者进行快速床旁血浆BNP浓度检测 ,通过心脏超声测定左室射血分数 (LVEF)、左室舒张功能及肺动脉收缩压 ,并对结果进行相关性分析。结果 血浆BNP浓度与LVEF、左室舒张功能障碍程度及肺动脉收缩压均有显著相关性 ,相关系数分别为- 0 .6 0 4、0 .4 82、0 .36 3。结论 血浆BNP浓度受左室收缩功能、左室舒张功能和右室功能的综合影响。  相似文献   

9.
发生心肌梗死后,患者心脏功能均不同程度受到影响。左室射血分数(LVEF)是反映左室排血功能较为敏感的指标。我们在临床工作中,应用依那普利治疗急性心肌梗塞死(AM I)患者,比较观察了其LVEF的变化,旨在探索依那普利对此类患者LVEF的影响。1资料与方法1.1一般资料2004~2006年我院  相似文献   

10.
目的 比较经动脉压力波形分析法(FloTrac系统)与传统经肺动脉导管间断热稀释法(SwanGanz导管技术)监测心排血量(CO)之间的相关性和一致性.方法 选择10例行择期非停跳冠状动脉旁路移植术(OPCAB)的患者,美国麻醉医师学会(ASA)分级为Ⅱ~Ⅲ级,年龄62~76岁.所有患者均连接FloTrac 传感器(Vigileo监测仪)监测外周动脉血CO(APCO);同时放置肺动脉漂浮导管,接Ewards VigilanceTM监护仪监测间断CO(ICO).结果 一元线性回归分析结果显示,患者术中在放置肺动脉导管后、第1次容量负荷后开胸前、开胸后、搭前降支固定器放置稳定后5 min、搭回旋支固定器放置稳定后5 min、搭后降支固定器放置稳定后5 min、近端吻合时、关胸后第2次容量负荷之前及第2次容量负荷之后9个时间点的APCO与ICO之间均高度相关(相关系数分别为0.81、0.73、0.86、0.78、0.79、0.90、0.80、0.77、0.76,P值分别<0.01、0.05).Bland-Altman散点图分析结果显示,各时间点APCO与ICO之间的偏差和一致性差异分别为-0.35(±1.08)、-0.21(±1.06)、-0.25(±0.88)、-0.43(±0.98)、-0.47(±0.72)、-0.27(±0.62)、-0.35(±0.94)、-0.26(±0.90)、-0.39(±1.04) L/min,两种监测方法有较好的一致性.结论 FloTrac系统测量的APCO与Swan-Ganz导管技术测量的ICO之间存在良好的相关性和一致性.  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

20.
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P<0.01);the MAP decreased(P<0.01)and the HR increased drastically(P<0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.  相似文献   

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