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1.
目的观察脱细胞异体真皮与自体薄皮片复合移植在功能部深Ⅱ度烧伤创面早期修复和烧伤后期功能部位瘢痕挛缩整复的治疗效果。方法在135例病员(烧伤61例,整形74例)共179个功能关节部位创面,用脱细胞异体真皮与自体整张薄皮片(0.15~0.20mm)组合成复合皮一次性移植覆盖。结果本组患者复合移植皮98。3%存活,随访6~9个月,移植部位皮肤外观光整,柔软有弹性,功能恢复良好,供皮区不留瘢痕。结论脱细胞异体真皮与自体薄皮片复合移植是早期修复功能部位深度烧伤创面和后期关节功能部位瘢痕挛缩整复的有效方法。  相似文献   

2.
目的:观察采用脱细胞异体真皮结合自体皮片复合移植在增生瘢痕导致功能部位畸形治疗中的疗效。方法:将功能部位的瘢痕松解或切除后,创面行脱细胞异体真皮结合自体皮片移植。结果:愈合后复合皮移植处组织柔软,富有弹性,功能良好,无明显排斥反应。结论:脱细胞异体真皮在修复深度烧伤创面愈合后瘢痕挛缩畸形中是较为理想的生物敷料之一。  相似文献   

3.
目的 为深度烧伤创面及功能部位瘢痕切除后的创面修复寻求良好的覆盖材料。方法 自 1998年以来 ,采用J- 1型脱细胞异体真皮 +自体薄皮片复合移植治疗Ⅲ°烧伤创面及对烧伤后功能部位瘢痕挛缩畸形进行整复。结果  8例烧伤创面及瘢痕切除后创面进行复合皮肤移植后 ,创面收缩轻、质软、功能良好、外观满意。结论 脱细胞异体真皮 +自体薄皮片复合移植是修复Ⅲ°烧伤创面及功能部位瘢痕挛缩畸形比较理想的覆盖材料  相似文献   

4.
李强华 《中外医疗》2011,30(5):40+42-40,42
目的探讨脱细胞异体真皮在深度烧伤后瘢痕整形中的临床疗效。方法在25例烧伤后不稳定性瘢痕及挛缩畸形患者共31个部位Ⅲ°烧伤创面,采用早期手术切痂,脱细胞异体真皮与自体刃厚皮移植修复。结果 25例均顺利完成手术,其中29个部位脱细胞异体真皮基质复合移植皮片完全成活,创面平整,皮片有光泽;2个部位皮片成活90%,换药后创面愈合,遗留散在瘢痕。随访6~18个月,移植皮片弹性及色泽好、瘢痕轻、耐磨,术区活动度尚好,与周围正常皮肤相似,色素沉着轻,未见明显瘢痕增生或挛缩;供皮区无瘢痕增生。结论应用脱细胞异体真皮基质与自体刃厚皮移植能有效修复瘢痕切除后创面,术后外观及功能恢复良好,组织结构与正常皮肤相似,具有良好的应用前景,作为一种新的治疗方法,还需进一步观察改进使其更好的在临床推广应用。  相似文献   

5.
目的:探讨脱细胞异体真皮与自体薄皮片(复合皮)移植修复深度烧伤创面,尤其是修复功能部位创面的临床疗效。方法:选择本院Ⅱ度和Ⅲ度烧伤创面,且创面集中在四肢关节功能部位的成年住院患者20例,随机分为治疗组和对照组各10例,治疗组创面切削痂后,采用脱细胞异体真皮+自体薄层皮(刃厚皮片)进行移植修复,对照组创面则单纯采用自体薄皮片移植修复。结果:两组皮片均成活良好,近期植皮区效果较接近;经随访观察6~12个月,治疗组脱细胞异体真皮无排异反应,植皮处光滑平整,色泽及弹性良好,瘢痕增生轻,关节运动角度基本正常;对照组表皮反复起水泡,瘢痕增生重,关节运动角度较正常小。结论:复合皮移植一次性完成对功能部位深度烧伤创面的修复是一种理想的方法,皮片成活率高,远期瘢痕增生轻,关节活动功能无明显受限。  相似文献   

6.
目的:探索脱细胞异体真皮在烧伤治疗中及烧伤后期瘢痕修复中的应用价值。方法:2008年1月至2009年11月入院治疗的28例烧伤患者,治疗烧伤后瘢痕采用削痂及切开充分松解萎缩的瘢痕组织,利用脱细胞异体真皮加自体刃厚皮移植于继发创面。结果:10例烧伤早期手术患者除1例踝关节因感染造成脱细胞异体真皮及刃厚皮溶解,二次手术植皮成活,其余9例均成活。烧伤后期瘢痕整形成活16例,成活率88.9%,关节部位瘢痕轻,关节活动良好,功能满意。结论:利用脱细胞异体真皮加自体刃厚皮移植于继发创面的方法治疗,可取得较好效果。  相似文献   

7.
目的探讨脱细胞异体真皮和自体刃厚皮复合移植在人体重要功能部位深度烧伤创面早期治疗中的临床效果。方法 2008年1月—2011年12月对37例53处关键功能部位深Ⅱ度度烧伤创面于24Ⅲ度烧伤创面于24120 h内局部进行早期切削痂扩创后,用脱细胞异体真皮和自体刃厚皮行复合移植,观察复合植皮的成活率、关节功能恢复及后期瘢痕形成等情况。结果除2例3个部位复合皮片边缘有散在点状坏死延迟愈合外,其余35例手术均成功,50处关键功能部位复合皮片均成活愈合好。复合皮片光滑柔软,弹性好,关节功能恢复好;随访6120 h内局部进行早期切削痂扩创后,用脱细胞异体真皮和自体刃厚皮行复合移植,观察复合植皮的成活率、关节功能恢复及后期瘢痕形成等情况。结果除2例3个部位复合皮片边缘有散在点状坏死延迟愈合外,其余35例手术均成功,50处关键功能部位复合皮片均成活愈合好。复合皮片光滑柔软,弹性好,关节功能恢复好;随访618(12·2±1.4)个月,供皮区无明显瘢痕,色泽接近正常皮肤,植皮区无明显增生挛缩的瘢痕,关节功能恢复接近正常水平。结论脱细胞异体真皮和自体刃厚皮应用于人体重要功能部位深度烧伤创面早期治疗是比较理想的方法,愈后植皮区关节功能恢复好,柔软度及弹性好,无明显增生及挛缩瘢痕。  相似文献   

8.
目的 为减少深度烧伤所形成瘢痕增生,特别是功能部位的障碍。方法 应用J - 1型脱细胞异体真皮与自体薄皮片复合移植于切痂创面10例16处创面上。结果 10例14处部位完全成活;2处部位大部分成活。6例随访0 5~1年,未发现排异现象,外观平整,皮肤弹性好,功能灵活,供皮区均无瘢痕形成。结论 脱细胞异体真皮与自体薄皮片复合移植于深度烧伤切痂术后创面上,是防止瘢痕增生、预防畸形,提高生活质量的一种较理想的材料。  相似文献   

9.
目的:观察脱细胞异体真皮在烧伤后瘢痕整形手术中的临床应用效果。方法:在22例烧伤后瘢痕整形手术中,创面应用脱细胞异体真皮 自体刃厚皮片复合移植。结果:20例皮片完全成活,创面平整,皮片有光泽;2例成活90%,换药后创面愈合,遗留散在瘢痕。随访4~6个月,术区活动度好,皮片色泽与周围皮肤相似,色素沉着轻,未见明显瘢痕增生或挛缩。结论:脱细胞异体真皮是烧伤后瘢痕整形良好的覆盖与填充材料。  相似文献   

10.
目的寻找功能部位深度烧伤创面与瘢痕畸形修复的理想覆盖材料。方法将功能部位的深度烧伤创面和瘢痕切除后,创面行脱细胞异体真皮+自体刃厚皮复合移植。结果25例患者复合皮全部成活,复合皮光滑柔软,局部弹性好,关节功能恢复良好。结论脱细胞异体真皮+自体刃厚皮是功能部位创面修复的理想覆盖材料。  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

20.
ANTI-PROLIFERATION EFFECT OF ORIDONIN ON HL-60 CELLS AND ITS MECHANISM   总被引:4,自引:0,他引:4  
Objcetive To investigate the anti-proliferation effect of oridonin on leukemic HL-60 cells and its mechanism. Methods HL-60 cells in vitro in culture medium were given different concentrations of oridonin. The inhibitory rate of cells were measured by microculture tetrazolium (MTT) assay, cell apoptotic rate was detected by flow cytometry (FCM), morphology of cell apoptosis was observed by hoechst 33258 fluorescence staining, and the activity of telomerase was detected using telomere repeat amplification protocol (TRAP) PCR-ELISA before and after apoptosis occurred. Results Oridonin could decrease telomerase activity, inhibit growth of HL-60 cells, and cause apoptosis significantly. The suppression was both in time- and dose-dependent manner. Marked morphological changes of cell apoptosis including condensation of chromatin and nuclear fragmentation were observed clearly by hoechst 33258 fluorescence staining especially after cells were treated 48-60 hours by oridonin. Conclusions Oridonin has apparent anti-proliferation and apoptotic effects on HL-60 cells in vitro, decreasing telomerase activity of HL-60 cells may be one of its most important mechanisms. These results will provide strong laboratory evidence of oridonin for clinical treatment of acute leukemia.  相似文献   

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