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1.
目的比较皮下注射与静脉注射重组人类促红细胞生成素对慢性肾衰竭患者贫血的疗效。方法30例慢性肾衰竭患者分为皮下注射组15例,静脉注射组15例。皮下注射组每周给予重组人类促红细胞生成素75u/kg,每周2次,静脉注射组每周给予重组人类促红细胞生成素100u/kg,分2次使用,透析患者于透析后静脉注射。治疗共8周。结果2组病例在治疗前贫血状况无统计学差异(P〉0.05);在应用促红细胞生成素治疗8周后,皮下注射组与静脉注射组贫血状况也无统计学差异(P〉0.05),皮下注射组高血压发生率低于静脉注射组。结论皮下注射较静脉注射重组人类促红细胞生成素用量小,节省费用,高血压发生率低,是较经济、有效的给药途径。  相似文献   

2.
目的:观察重组人红细胞生成素治疗肾性贫血的疗效。方法:应用重组人红细胞生成素治疗90例肾性贫血患者,测定治疗前及治疗后4、8、12周的红细胞,血红蛋白,红细胞压积水平。结果:治疗后与治疗前相比,患者的红细胞,血红蛋白及红细胞压积水平明显提高,两者有显著性差异(P<0.01),结论:重组人红细胞生成素对肾性贫血具有较好的治疗作用。  相似文献   

3.
目的通过对慢性肾功能衰竭性贫血患者行重组人红细胞生成素(γ-HuEPO)联合还原型谷光甘肽(GSH)治疗,监测红细胞寿命,深入研究GSH对慢性肾功能衰竭性贫血患者红细胞寿命的实际影响。方法将30例慢性肾功能衰竭性贫血患者随机分为两组,均皮下给予1-HuEPO50U/kg,每周2次,连续给药16周.治疗组同时静脉给予GSH20mg/kg,每周2次。连续给药16周。治疗前和治疗后6、12周对患者进行应用51Cr标记红细胞的红细胞寿命测定法测定患者红细胞寿命。治疗前和治疗后4、8、12周分别抽取全血2ml送临床检验中心测定两组病人血红蛋白(Hb)、红细胞(RBC)和HCT的水平。结果治疗组红细胞寿命值高于对照组(P〈0.05),两组患者Hb、(RBC)、红细胞比积(HCT)水平显著上升(P〈0.01)治疗组Hb,RBC和HCT水平与对照组比较差异有统计学意义(P〈0.05)。结论还原型谷光甘肽能明显延长慢性肾功能衰竭性贫血患者红细胞寿命,能显著提高γ-HuEPO治疗肾性贫血的疗效。  相似文献   

4.
谢辉 《中原医刊》2003,30(8):13-13
目的 :观察基因重组人红细胞生成素 (rHuEPO )治疗肾性贫血的疗效。方法 :对 2 6例肾性贫血病人予国产rHuEPO注射治疗 ,剂量 5 0U /kg/次 ,每周 2 3次。结果 :治疗 8周后患者血红蛋白和红细胞压积较治疗前均有明显增加 (P <0 0 1)。结论 :rHuEPO能有效治疗肾性贫血  相似文献   

5.
目的:探讨人工基因重组红细胞生成素治疗肾性贫血的疗效、失败原因、补救措施及不良反应。方法:分析16例肾性贫血患者的临床资料及应用人工基因重组红细胞生成素的疗效及不良反应。结果:16例肾性贫血患者病因为慢性肾小球肾炎者9例,糖尿病肾病者3例,高血压者3例,多囊肾者1例;贫血程度:轻度贫血者4例,中度贫血者10例,重度贫血2例;有低蛋白血症者10例,无低蛋白血症者6例;透析频度:每周2至3次者9例,每2周3次者5例,每周1次者2例;在应用人工基因重组红细胞生成素治疗期间均补充铁剂。16例应用人工基因重组红细胞生成素的患者,治疗后血红蛋白浓度稳定在100g/L左右者8例,血红蛋白浓度在60~90g/L者5例,血红蛋白浓度在30~60g/L者3例;应用人工基因重组红细胞生成素后引起高血压加重者5例,透析器复用次数较应用前减少者6例,应用人工基因重组红细胞生成素后血钾升高者4例。结论:人工基因重组红细胞生成素治疗肾性贫血疗效肯定,但其疗效受多种因素影响,且应注意其不良反应。  相似文献   

6.
左卡尼汀与促红细胞生成素对肾性贫血患者的疗效观察   总被引:2,自引:0,他引:2  
苏彩芳  郭井娟 《中外医疗》2011,30(29):90-90,92
目的观察左卡尼汀与促红细胞生成素对维持性血液透析患者肾性贫血的疗效。方法将60例维持性血液透析患者随机均分成2组,A组血液透析后皮下注射促虹细胞生成素,每周100~150U/kgI待血细胞比容(Hct)上升至30%后战量。B组在A组治疗基础上加甩左卡尼汀1.0g,静脉注射,每周2次,观察12周。结果B组的血红蛋白(Hb).血细胞比客水平显著高于A组(P〈0.05)。B组于治疗后促红细胞生成素用量较治疗前明显减少,而A组促虹细胞生成素用量无明显改变。结论左卡尼汀与促红细胞生成素联合治疗维持性血液透析患者贫血可提高促虹细胞生成素疗效,减少其用量。  相似文献   

7.
目的:观察服用铁剂治疗的婴幼儿缺铁性贫血加用重组人红细胞生成素(rh—EPO)的疗效。方法:26例患儿接受了益比奥治疗,500U/(kg·次),2次/周。同期18例患儿做对照治疗。两组患儿同时服用铁剂,连续观察5周。结果:两组患儿在治疗后贫血均得到了改善,但益比奥组贫血改善明显,两组对比差异有显著性。结论:应用铁剂治疗时加用重组人红细胞生成素能更有效治疗缺铁性贫血,快速提高血红蛋白等各项指标。  相似文献   

8.
目的:探讨肾性贫血患者应用左卡尼汀联合红细胞生成素的临床治疗效果。方法选取我院2011年4月—2013年6月收治的42例肾性贫血患者,随机分为观察组与对照组各21例。2组患者完成血液透析后,每周均给予100~150 U/kg重组人红细胞生成素(r-HuEPO)进行皮下注射,观察组在每次血液透析后另外给予左卡尼汀静脉注射。结果观察组21例患者中,1例出现血压升高症状,占4.8%;对照组21例患者中,7例出现血压升高症状,占33.3%,不良反应发生率明显高于观察组,差异有统计学意义(P<0.05)。结论肾性贫血患者的临床治疗过程中,给予红细胞生成素的同时,加用左卡尼汀可有效提高治疗效果,减少红细胞生成素的用量,降低不良反应发生率,值得临床推广应用。  相似文献   

9.
目的:观察大剂量红细胞生成素治疗尿毒症贫血的临床疗效。方法:收集36例行维持性血透治疗的慢性肾功能不全,尿毒症期病人随机分成两组,试验组18例,使用重组人红细胞生成素(rHu-EPO)10000U皮下注射每周1次,对照组18例,使用rHu-EPO3000U,皮下注射每周2次。治疗期间每次血透前检查血压,每周检查1次血常规,每2周检查1次肾功能,血电解质,肝功能,血糖,血胆固醇和甘油三酯。结果:试验组和对照组总有效率分别为94.45%,94.44%,疗效相似,除少数病人血压升高外,其他无明显副作用。结论:每周1次皮下注射10000U重组人红细胞生成素治疗尿毒症贫血疗效确切且安全可靠,其疗效与使用3000UrHu-EPO每周二次相同,同时减少了病人的注射次数,提高了患者的依从性及生活质量。  相似文献   

10.
宁红欣与利血宝治疗肾性贫血的疗效   总被引:1,自引:0,他引:1  
目的:比较宁红欣(国产红细胞生成素)和利血宝治疗肾性贫血的临床疗效。方法选择肾性贫血120例,随机分为宁红欣(2000U,皮下注射,每周3次)治疗组60例和利血宝(3000U,皮下注射,每周2次)对照组60例,均治疗12周。结果与治疗前比较,它红欣总有效率86.75,显效率55.0%。利血宝总有效率85.0%,显效率50.0%。两组间上述参数在治疗前、治疗后4、8、12周均无统计学差异(P>0.05)。结论宁红欣治疗肾性贫血与利血宝疗效基本相当。  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

20.
ANTI-PROLIFERATION EFFECT OF ORIDONIN ON HL-60 CELLS AND ITS MECHANISM   总被引:4,自引:0,他引:4  
Objcetive To investigate the anti-proliferation effect of oridonin on leukemic HL-60 cells and its mechanism. Methods HL-60 cells in vitro in culture medium were given different concentrations of oridonin. The inhibitory rate of cells were measured by microculture tetrazolium (MTT) assay, cell apoptotic rate was detected by flow cytometry (FCM), morphology of cell apoptosis was observed by hoechst 33258 fluorescence staining, and the activity of telomerase was detected using telomere repeat amplification protocol (TRAP) PCR-ELISA before and after apoptosis occurred. Results Oridonin could decrease telomerase activity, inhibit growth of HL-60 cells, and cause apoptosis significantly. The suppression was both in time- and dose-dependent manner. Marked morphological changes of cell apoptosis including condensation of chromatin and nuclear fragmentation were observed clearly by hoechst 33258 fluorescence staining especially after cells were treated 48-60 hours by oridonin. Conclusions Oridonin has apparent anti-proliferation and apoptotic effects on HL-60 cells in vitro, decreasing telomerase activity of HL-60 cells may be one of its most important mechanisms. These results will provide strong laboratory evidence of oridonin for clinical treatment of acute leukemia.  相似文献   

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