首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献,搜索用时 62 毫秒
1.
目的:了解2013年江苏省恶性肿瘤死亡情况及其所致潜在寿命损失特征,为肿瘤的预防提供依据?方法:通过江苏省死因监测系统搜集2013年恶性肿瘤的死亡个案信息,利用从公安部门获取的人口学信息,计算死亡率?标化死亡率?潜在减寿年数(potential years of life lost,PYLL)和标化潜在减寿年数(standardized potential years of life lost,SPYLL)等指标,评价恶性肿瘤的死亡和早死负担及其人群分布特征?结果:2013年恶性肿瘤导致死亡135 236例,占2013年总死亡人数的29.38%,男?女分别为86 736?48 500例?恶性肿瘤死亡率和标化死亡率分别为196.80/10万和111.59/10万,死亡率男女比为1.77,城乡比为0.95?死亡率前5位依次为肺癌?胃癌?食管癌?肝癌和结直肠肛门癌,占全部恶性肿瘤的75.10%?恶性肿瘤所致PYLL和SPYLL分别为788 367和582 620.68人年,PYLLR男女比为1.78,城乡比为0.93,PYLL前5位依次为肝癌?肺癌?胃癌?食管癌和白血病,女性中乳腺癌取代食管癌处第4位?结论:导致全人群死亡和早死的主要恶性肿瘤为肺癌?胃癌?食管癌?肝癌?结直肠肛门癌和白血病,以及女性乳腺癌?对于恶性肿瘤死亡率和潜在减寿率,男性远高于女性?农村居民略高于城市居民?应针对重点癌种和人群,开展相关预防干预措施?  相似文献   

2.
本文运用减寿年数和减寿率指标分析了湖南省恶性肿瘤死亡所致的寿命损失情况,全省10个抽样县市1990-1992年三年合计减寿年数为170968,减寿率为8.73‰,其中男、女性减寿率分别为10.44‰和6.89‰。全省前四位恶性肿瘤依次为癌、白血病、胃癌、肺癌、肺癌、且在城市和农村中的排列位均在前四位。减寿率的分布显示男性同于女性,城市高于农村,30岁以上年龄组减寿率较高水平,并随年龄增长快速升高,  相似文献   

3.
背景 肝恶性肿瘤是全球常见的消化系统肿瘤之一,浦东新区居民肝恶性肿瘤死亡的流行病学资料依然缺乏。目的 了解2002-2019年浦东新区居民肝癌死亡特征与所导致的寿命损失,为制定针对性的干预措施提供依据。方法 以浦东新区户籍人口为对象,以户籍居民死因数据库为基础,从中筛选出死亡日期在2002-2019年的肝癌死亡资料进行分析。居民死因资料采用国际疾病分类第10版(ICD-10)进行编码与归类,肝癌的编码范围为C22。分别计算浦东新区居民肝癌粗死亡率、标化死亡率、潜在减寿年数(PYLL)、潜在减寿率(PYLLR)、平均减寿年数(AYLL)、标化潜在减寿年数(SPYLL)以及标化潜在减寿率(SPYLLR),对浦东新区居民肝癌死亡情况以及肝癌导致的寿命损失情况进行分析。肝恶性肿瘤死亡率与寿命损失的变化趋势采用年均变化百分比(APC)进行分析。结果 2002-2019年浦东新区居民肝癌死亡12 522例,年均粗死亡率为25.38/10万,标化死亡率为12.29/10万。2002-2019年浦东新区居民肝癌粗死亡率、标化死亡率均呈逐年下降趋势(粗死亡率:APC=-1.88%,Z=-12.468,P<0.001;标化死亡率:APC=-4.71%,Z=-10.601,P<0.001)。男性、女性居民肝癌粗死亡率与标化死亡率均呈下降趋势(P<0.001)。2002-2019年15~59岁、60~79岁浦东新区居民肝癌粗死亡率总体呈下降趋势(P<0.001),80岁以上浦东新区居民肝癌死亡率保持稳定(P=0.053)。2002-2019年浦东新区居民肝癌死亡PYLL为98 580年,PYLLR为2.00‰,AYLL为7.87年/人,SPYLL为61 767年,SPYLLR为1.25‰。2002-2019年浦东新区居民肝癌死亡PYLLR、SPYLLR、AYLL总体均呈逐年下降趋势(P<0.001),除2002-2010年浦东新区居民肝癌死亡AYLL保持稳定(P=0.853)。男性居民肝癌死亡PYLL为81 126年,PYLLR为3.29‰,AYLL为9.20年/人,SPYLL为50 225年,SPYLLR为2.04‰。女性居民肝癌死亡PYLL为17 454年,PYLLR为0.71‰,AYLL为4.72年/人,SPYLL为10 942年,SPYLLR为0.44‰。浦东新区男性居民肝癌死亡PYLL、PYLLR、AYLL、SPYLL及SPYLLR均大于女性。结论 2002-2019年浦东新区居民肝癌粗死亡率与标化死亡率均逐年下降,但仍引起了严重的寿命损失,肝癌对于男性及80岁高龄老年人群的危害需进一步关注,需采取差异化的防控措施,对于男性人群以改善行为危险因素为重点,降低肝癌对该人群的危害;对于高龄肝癌患者,应注重临终关怀与支持治疗工作,改善该人群的生存状态。  相似文献   

4.
徐州市城区居民肺癌死亡情况及潜在寿命损失分析   总被引:2,自引:1,他引:1  
目的 探讨徐州城区居民肺癌死亡特征、死亡趋势及造成的潜在寿命损失。方法 按ICD - 9分类方法对 1990~ 1999年城区居民肺癌死亡情况进行回顾性调查。结果 徐州市肺癌年平均死亡率为 2 6 13 / 10万 ,标化死亡率为 2 9 4 6/ 10万 ,居民肺癌死亡减寿年数 (PYLL)合计 16882人年 ,减寿率为 1 86‰ ,标化减寿率为 2 0 2‰ ,每例肺癌死亡造成潜在寿命损失 6 5 7岁 ;男、女肺癌死亡率间差别有显著性意义 ,男、女肺癌死亡率比值为 2 0 1,2 0岁以后男、女年龄别死亡专率与年龄之间的线性趋势有显著性意义 (P <0 0 1)。结论 肺癌是威胁徐州市居民生命健康最严重的恶性肿瘤之一 ,应积极启动对其预防和控制工作。  相似文献   

5.
目的了解甘肃省疾病监测点胃癌死亡特征,为制定胃癌的防制策略提供科学依据。方法对甘肃省各监测点依据死亡医学证明书收集的胃癌死因数据进行核对,按照ICD标准进行死因编码,然后由甘肃省CDC进行分类汇总和统计分析。结果1993-2007年甘肃省疾病监测点胃癌死亡均处于肿瘤死亡的第一位。2007年胃癌的死亡率为36.73/10万,占所有肿瘤死亡的35.91%,胃癌死亡的潜在减寿年数(PYLL)为5 420人年,潜在减寿年数顺位处第一位,胃癌死亡的减寿率为3.38‰,胃癌平均死亡年龄为64.08岁,去胃癌死因预期寿命为72.83岁,延长寿命0.75岁。胃癌死亡男性显著高于女性。结论胃癌死亡率和减寿率均处甘肃省肿瘤死亡的第一位,并且男性死亡大于女性死亡,中老年男性是胃癌防治的重点人群。  相似文献   

6.
目的:调查贫困县农村居民主要的死亡原因及潜在减寿年数(potential years of life lost,PYLL)。方法:采用整群抽样的方法抽取河南省睢县后台乡、尚屯乡和城隍乡,对其3a来死亡居民的情况进行回顾性调查。运用全死因和PYLL分析方法对死亡资料进行分析。结果:引起当地居民寿命损失的主要疾病为恶性肿瘤、脑血管病、呼吸系病、心脏病及损伤和中毒。其中损伤和中毒占死因构成的9.99%,占总PYLL的22.77%,恶性肿瘤、脑血管病、心脏病和呼吸系病这几种主要的慢性病的死亡率累积构成为65.07%,PYLL累计构成为36.95%。结论:以恶性肿瘤为主的慢性非传染性疾病成为当前贫困地区疾病控制工作的重点,损伤与中毒成为重要的公共卫生问题。  相似文献   

7.
本文应用减寿年数(PYLL)和减寿率等减寿指标分析了迁安县常见恶性肿瘤在性别、年龄上的分布特征,并按照标化减寿率排列了死因顺位,揭示了各种恶性肿瘤对迁安县居民寿命损失影响的相对重要性。  相似文献   

8.
目的通过对南通市某县居民恶性肿瘤状况及死亡原因的研究探讨,为制定预防措施提供依据。方法按国际疾病分类法(ICD-10)对2010年南通市某县居民的恶性肿瘤死亡状况资料进行编码以及统计分析,计算死亡率、构成比等。结果 2010年南通市某县居民恶性肿瘤死亡率为240.25/10万,占全部死亡原因的30.48%,仅次于循环系统疾病居全死因的第2位。除宫颈癌和乳腺癌外,其他恶性肿瘤的死亡率均为男性高于女性。占死因前3位恶性肿瘤为肺癌、肝癌、胃癌。其中肝癌主要危害青壮年男性,造成的男性潜在寿命损失远远大于其他恶性肿瘤。南通市某县2010年居民恶性肿瘤潜在减寿年数(PYLL)为68536.5人年,平均减寿年数(AYLL)为13.31人年。结论恶性肿瘤已对该县居民生命健康构成了严重威胁,重点应加强肺癌和肝癌防治力度。  相似文献   

9.
目的 探讨恶性肿瘤对宁夏居民寿命的危害。方法应 用潜在寿命损失年数(YPLL)对1994—2000年宁夏死亡监测资料进行分析。结果 1994—2000年宁夏居民恶性肿瘤全死因YPLL率为8.93年/1000人口。男性YPLL率为10.78年/1000人口。女性YPLL率为7.01年/1000人口。男性高于女性。胃癌、肝癌、白血病和肺癌居YPLL的前四位。是危害宁夏居民长寿水平的主要恶性肿瘤;造成男性居民寿命损失的主要恶性肿瘤为:肝癌、胃癌、白血病和肺癌。女性为:胃癌、白血病、肝癌及子宫颈癌。恶性肿瘤潜在寿命损失的高峰年龄为45—60岁。结论 胃癌、肝癌、白血病和肺癌是危害宁夏居民健康的主要恶性肿瘤。导致男性与女性居民寿命损失的主要恶性肿瘤及其顺位不完全相同。肝癌、胃癌、白血病、肺癌及子宫颈癌是我区需要重点防治的恶性肿瘤。  相似文献   

10.
目的:了解湖北省监测点居民伤害死因及潜在寿命损失状况,为预防控制提供科学依据。方法:采用死亡率与潜在减寿年数(PYLL)等指标对湖北省2006-2007年监测点居民伤害死亡资料进行分析。结果:监测点居民伤害死亡5994例,粗死亡率为61.45/10万(标化死亡率为58.26/10万),其中男性3 725例、女性2 26...  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

20.
ANTI-PROLIFERATION EFFECT OF ORIDONIN ON HL-60 CELLS AND ITS MECHANISM   总被引:4,自引:0,他引:4  
Objcetive To investigate the anti-proliferation effect of oridonin on leukemic HL-60 cells and its mechanism. Methods HL-60 cells in vitro in culture medium were given different concentrations of oridonin. The inhibitory rate of cells were measured by microculture tetrazolium (MTT) assay, cell apoptotic rate was detected by flow cytometry (FCM), morphology of cell apoptosis was observed by hoechst 33258 fluorescence staining, and the activity of telomerase was detected using telomere repeat amplification protocol (TRAP) PCR-ELISA before and after apoptosis occurred. Results Oridonin could decrease telomerase activity, inhibit growth of HL-60 cells, and cause apoptosis significantly. The suppression was both in time- and dose-dependent manner. Marked morphological changes of cell apoptosis including condensation of chromatin and nuclear fragmentation were observed clearly by hoechst 33258 fluorescence staining especially after cells were treated 48-60 hours by oridonin. Conclusions Oridonin has apparent anti-proliferation and apoptotic effects on HL-60 cells in vitro, decreasing telomerase activity of HL-60 cells may be one of its most important mechanisms. These results will provide strong laboratory evidence of oridonin for clinical treatment of acute leukemia.  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号