乳腺增生患者膻中穴体表红外辐射光谱探讨

目的：比较乳腺增生病患者膻中穴与非穴对照点体表红外辐射光谱的差异。方法：采用高灵敏度PHE201体表红外光谱仪，检测68例乳腺增生病患者膻中穴与非穴对照点体表1．5～16．0μm波段的红外辐射光谱。结果：乳腺增生病患者膻中穴与非穴对照点红外辐射光谱形态相似，但辐射强度减低，在检测的59个波长点中有13个波长检测点（6．75～8．25μm、9．00μm、9．25μm、9．75μm、13．25～13．75μm），膻中穴与非穴对照点的红外辐射强度比较差异有显著性意义（P〈0．05）。结论：膻中穴红外辐射强度降低。结合期门穴红外辐射强度等研究，提示乳腺增生病在病理状态下，不同的经脉系统处于不同的虚实状态。     

乳腺增生肿块与期门穴体表红外辐射光谱比较

目的：比较乳腺增生病患者增生肿块与期门穴体表红外辐射光谱的差异。方法：采用高灵敏度PHE201体表红外光谱仪，检测68名乳腺增生病患者乳腺增生肿块1．5～16}xm波段的体表红外辐射光谱并与自身左右期门穴对照。结果：乳腺增生病患者乳腺增生肿块与左右期门穴的体表红外辐射光谱形态基本一致，但左右期门穴红外辐射强度均高于增生肿块，在检测的59个波长中，分别有48个和49个波长有显著性差异（P=0．000～0．037）。结论：乳腺增生患者期门穴红外辐射强度高于增生肿块，可能与形成乳腺增生的病理相关。     

乳腺增生患者不同月经状态下肿块体表红外辐射光谱比较

目的:比较乳腺增生患者不同月经状态下肿块体表红外辐射光谱特性。方法:采用高灵敏度PHE201体表红外光谱仪,观察了52例乳腺增生病患者在月经前和月经后,及月经规则和月经不规则患者乳腺增生肿块体表1.5~16μm波段的红外辐射光谱的差异。结果:月经前及月经后患者肿块体表红外辐射光谱,在检测的59个波长中,除3个(5.08%)波长点(2.75、5.75、16.0μm),56个(94.92%)波长检测点红外辐射强度比较无显著差异(P>0.05);月经规则与月经不规则患者乳腺增生肿块体表红外辐射光谱,在检测的59个波长检测点中,除1个(1.69%)波长点(3.75μm),58个(98.31%)波长检测点红外辐射强度比较无显著差异(P>0.05)。结论:体表红外辐射光谱诊断乳腺增生病具有良好的稳定性。     

乳腺增生病与乳腺癌术后患者关元穴体表红外光谱比较

目的:比较乳腺癌术后患者与乳腺增生病患者任脉经穴关元穴体表红外辐射光谱特性。方法:采用高灵敏度PHE201体表红外光谱仪,观察了29例乳腺癌术后患者与30例乳腺增生病患者关元穴1.5～16μm波段体表红外辐射光谱的差异。结果:乳腺癌术后组与乳腺增生病组关元穴红外辐射强度不同,乳腺癌术后组关元穴红外辐射强度低于乳腺增生病组;在59个波长检测点中,21个波长检测点(3.0μm,10.25～14.25μm,14.75μm,15.75μm,16.0μm),差异具有统计学意义(P0.05)。结论:关元穴红外辐射强度的差异可能与乳腺癌的发生仅仅是全身进行性疾病的局部表现,虽然病理组织切除了,但体质并未改善有关。     

寸口脉太渊穴红外辐射光谱病理信息探测

目的 探测寸口脉太渊穴红外辐射光谱中的病理信息。方法 采用高灵敏度PHE201体表红外光谱仪检测50例冠心病患者和47例健康成年人太渊穴1．5～16μm红外辐射光谱，并对两者比较分析。结果患者与正常人太渊穴红外辐射光谱形态基本相似；在某些波长，患者与正常人太渊穴的红外辐射强度比较有显著差异（P〈0．05）；正常人左太渊穴红外辐射强度与非穴对照点比较有显著差异的波长数明显多于患者左太渊穴红外辐射强度与非穴对照点比较有显著差异的波长数（P〈0．05）。结论 寸口脉太渊穴红外辐射光谱中的某些波长的红外辐射强度变化承载特异性病理信息。     

乳腺增生病不同证型关元穴红外辐射光谱探讨

目的:比较乳腺增生病患者不同证型任脉经穴关元穴体表红外辐射光谱特性。方法:采用高灵敏度PHE201体表红外光谱仪,观察了60例乳腺增生病患者不同证型关元穴1.5～16μm波段体表红外辐射光谱的差异。结果:乳腺增生病肝郁痰凝型患者与冲任失调型患者比较,两组关元穴体表红外辐射强度存在显著性差异。具有统计学意义差异的波段为:1.5～2.25μm,2.75μm,3μm,3.5μm,3.75～5μm,6～6.5μm,7μm,7.75μm,10.5～14μm,(P<0.05)。结论:关元穴红外辐射强度的差异可能与乳腺增生病不同证型有关。     

Infrared radiation temperature comparison on body surface of points between healthy people and patients with hyperplasia of mammary glands

目的：比较乳腺增生病患者与正常人穴位体表红外辐射温度的差异。方法：采用ThermaCAMTMP30红外热像仪，检测74名乳腺增生病患者和63名身体健康，无乳腺增生病的正常人四条经脉八个穴位的体表红外辐射温度。结果：乳腺增生病患者右幽门穴的体表红外辐射温度显著高于正常人的右幽门穴的体表红外辐射温度（P=0．009）.左幽门穴及所测其余各穴的红外辐射温度患者与正常人无明显差异（P〉0.05）.结论：乳腺增生病患者与正常人右幽门穴的红外辐射温度有显著差异，这种差异可能与乳腺增生病的病才暇幽门穴的特异性有关。     

大陵穴宽谱红外辐射光谱特性研究

目的:研究大陵穴在宽谱范围内微弱红外辐射光谱特性。方法:采用高灵敏度体表红外光谱检测装置对47例正常人双侧大陵穴在1.5~16μm光谱范围内的红外辐射进行检测,通过光谱形态分析和点值比较的方法对大陵穴红外辐射光谱进行研究。结果:不同个体大陵穴的光谱形态基本一致,但不同个体红外辐射强度有较大的差异,归一化处理后的光谱个体差异非常小;在7~14.7μm辐射集中的光谱范围内,两侧大陵穴红外辐射强度比较均无显著性差异(P>0.05)。结论:本方法能够较为全面地研究人体穴位宽谱红外辐射信息,严格控制实验室温度等条件对获取准确的穴位红外辐射数据有重要意义;正常人两侧大陵穴红外辐射基本处于平衡状态。     

太渊穴自发红外辐射与肺功能的相关性分析

目的探讨太渊穴自发红外辐射与肺功能的相关性。方法用PHE201型体表红外光谱仪对104名志愿者的太渊、大陵及非穴位对照点的自发红外辐射进行检测,分析其与肺功能的相关性。结果在穴位和非穴位对照点共6个检测部位中,有4个检测部位在某些波长的自发红外辐射强度与第1秒呼气容积(FEV1)和最大通气量(MVV)有相关关系(r=0.197~0.334,P<0.05或P<0.01),其中左太渊穴自发红外辐射与肺功能有相关关系的波长数明显多于其他检测部位(P<0.01)。结论太渊穴自发红外辐射与肺通气功能有明显的相关性,能灵敏地反映肺通气功能的变化。     

太渊穴自发红外辐射的相对特异性

目的探讨太渊穴自发红外辐射在反映肺通气功能方面的相对特异性.方法用PHE201型体表红外光谱仪,对104名志愿者的太渊、内关、大陵及非穴位对照点的自发红外辐射进行检测,分析其与肺功能的相关性.结果在穴位和非穴对照点共10个检测部位中,有6个检测部位在某些波长的自发红外辐射强度与FEVI和MVV有相关关系,但左太渊穴自发红外辐射与肺功能有相关关系的波长数明显多于其它检测部位(P＜0.001或P＜0.01).结论左太渊穴自发红外辐射比邻近的其它检测部位更能灵敏地反映肺通气功能的变化.     

乳腺增生患者膻中穴体表红外辐射光谱探讨

OBJECTIVE: To compare differences of surface infrared radiation spectrums between Danzhong (CV 17) A high-sensitive PHE and non-acupoint control point in the patient of hyperplasia of mammary glands. METHODS: 201 surface infrared spectrograph was used to detect infrared radiation spectrums of Danzhong (CV 17) and non-acupoint control point at 1.5-16.0 microm wave band in the patient of hyperplasia of mammary glands. RESULTS: The shape of the infrared spectrums of Danzhong (CV 17) was similar to that of the non-acupoint control point, but with lower radiation intensity. Of the 59 wavelength spots detected, 13 (6.75-8.25 microm, 9.00 microm, 9.25 microm, 9.75 microm, 13.25-13.75 microm) had significant differences in infrared radiation intensity between Danzhong (CV 17) and non-acupoint control point (P<0.05). CONCLUSION: The intensity of infrared radition of Danzhong (CV 17) is lower and Qimen (LR 14) is higher than that of the non-acupoint control point in the patient with hyperplasia of mammary glands, showing that different channels are at different states of deficiency and excess under pathological condition of hyperplasia of mammary glands.     

冠心病患者神门穴红外辐射光谱检测

采用自制高灵敏度PHE201体表红外光谱仪检测47名健康成年人和50名冠心病患者神门穴红外辐射光谱。结果示．神门穴红外辐射强度个体差异较大，但光谱形态相似；冠心病患者的神门穴在多个波长上的红外辐射强度与正常人的相比有显著差异，虽然冠心病患者神门穴在某一波长上的辐射强度左减右差值与止常人的无显著性差异，但似乎在更多的波长上左右神门辐射强度有显著性差异。     

溃疡性结肠炎患者大肠经原穴与下合穴红外光谱的比较研究

目的：探讨穴位红外光谱对溃疡性结肠炎的诊断价值。方法：使用PHE201型高灵敏度红外光谱分析仪检测34名溃疡性结肠炎患者大肠经原穴合谷与大肠经下合穴上巨虚的红外光谱。结果：在59个检查波长中，溃疡性结肠炎患者右侧合谷穴共有28个波长的红外辐射强度与正常人有显著差异（P〈0．05或P〈0．01），左侧有13个波长的红外辐射强度与正常人有显著差异（P〈0．05）。右侧上巨虚穴共有16个波长的红外辐射强度与正常人有显著差异（P〈0．05或P〈0．01），左侧有17个波长的红外辐射强度与正常人有显著差异（P〈0．05或P〈0．01）。患者左右合谷有18个波长的辐射强度有显著差异（P〈0．05或P〈0．01），正常人左右合谷7个波长上有显著差异（P〈0．05）。患者左右上巨虚共有4个波长的辐射强度有显著差异（P〈0．05或P〈O．01），而正常人左右上巨虚有1个波长的辐射强度有显著差异（P〈0．01）。结论：上巨虚与合谷穴均能在红外辐射光谱上反映出肠道病变，而合谷穴似乎更明显一些。     

The infrared radiation spectrum of acupoint taiyuan (LU 9) in asthma patients

[OBJECTIVE]:To analyze the distinctive pathological characteristics in the spectrums of spontaneous infrared radiation at the Taiyuan (LU 9) acupoint in patients with asthma.[METHODS]:A highly sensitive infrared spectrum detecting device was used to detect the spectrums of spontaneous infrared radiation at Taiyuan (LU 9) in 37 asthma patients and 34 healthy volunteers.[RESULTS]:Asthma patients had significantly lower infrared intensity than that of the healthy volunteers (P＞0.01).Asthma patients had significantly lower overall infrared radiation intensity at the left Taiyuan (LU 9) than that of healthy volunteers (P＞0.05),but there was no significant difference between healthy volunteers and asthma patients at the right Taiyuan (LU 9) (P＞0.05).The infrared radiation intensity of 17 wavelength spots at the left Taiyuan (LU 9) and 4 wavelength spots at the right Taiyuan (LU 9) in asthma patients were significantly lower than those of healthy volunteers (P＞0.05).At 2 μm,the infrared radiation intensity of asthma patients was significantly stronger than that of healthy volunteers (P＞0.05).At 19 wavelength spots in the healthy volunteers and at 4 wavelength spots in the asthma patients,the left Taiyuan (LU 9) showed a significantly stronger intensity than that of the right Taiyuan (LU 9) (P＞0.05).By Pearson's X2 test,healthy volunteers had more wavelength spots that were significantly different between the left and right Taiyuan (LU 9) than the asthma patients (P＞0.01).[CONCLUSION]:Changes in the infrared spectrum at the Taiyuan (LU 9) acupoint in asthma patients may reflect distinct pathological changes.Certain acupuncture points may be related to specific organs.     

Pathologic analysis on hyperplasia of mammary gland with different syndromes based on infrared radiation temperature of acupoints

Objective

To explore the pathologic characteristics of hyperplasia of the mammary gland (HMG) by observing differences in infrared radiation temperature of points of HMG in patients with different syndromes compared with healthy controls.

Methods

A FLIR Systems Therma CAM™ P30 infrared thermal camera was used to detect the infrared temperature of Shanzhong (CV 17), Qimen (LR 14), Zhongwan (CV 12), Qihai (CV 6), Guanyuan (CV 4), Taixi (KI 3), and Taichong (LR 3) in 113 patients with HMG. Of these patients, 71 were placed in the Liver Qi stagnation group, 34 were placed in the Dysfunction of conception and thoroughfare vessels group, and 8 were placed in the Phlegm and blood stasis in combination group. The infrared radiation temperature of each point in the patients was compared with that of healthy controls, and the differences in the infrared radiation temperatures of the points in the patients were analyzed.

Results

Overall, the bilateral corresponding point in both the controls and patients exhibited no significant difference in infrared radiation temperature. In all cases, the infrared radiation temperature of the points from proximal to distal tended to decrease. In a comparison of the patients and controls, the infrared radiation temperature of the trunk points Shanzhong (CV 17), Qimen (LR 14), Zhongwan (CV 12), Qihai (CV 6), and Guanyuan (CV 4) of the patients was higher than that of the controls, while the infrared radiation temperature of the lower extremity points Taixi (KI 3) and Taichong (LR 3) was lower than that of the controls. Of these points, Shanzhong (CV 17) (P=0.0368), Zhongwan (CV 12) (P=0.0028), Qihai (CV 6) (P=0.0085), and Guanyuan (CV 4) (P=0.0018) showed significant differences. In a comparison of the corresponding point on the same side in the Liver Qi stagnation group and controls, the infrared radiation temperature of Shanzhong (CV 17) (P=0.0089), right-side Qimen (LR 14) (P=0.0382), Zhongwan (CV 12) (P= 0.0000), Qihai (CV 6) (P=0.0011), and Guanyuan (CV 4) (P=0.0000) of the patients was significantly higher than that of the controls, while the differences in the infrared radiation temperature of the other points were not statistically significant (P= 0.0833–0.8397). In a comparison of the corresponding point on the same side in the Dysfunction of conception and thoroughfare vessels group and controls, the infrared radiation temperature of left-side Taichong (LR 3) (P=0.0048), right-side Taichong (LR 3) (P=0.0329), left-side Taixi (KI 3) (P= 0.0171), and right-side Taixi (KI 3) (t=0.544, P= 0.0165) of the patients was significantly lower than that of the controls, while the differences in the infrared radiation temperature of the other points were not statistically significant (P=0.3793–0.9197). In a comparison of the corresponding point on the same side in the Phlegm and blood stasis in combination group and controls, the infrared radiation temperature of Shanzhong (CV 17), Qimen (LR 14), Qihai (CV 6), Guanyuan (CV 4), Taixi (KI 3), Taichong (LR 3), and Zhongwan (CV 12) tended to increase, but without statistical significance (P=0.175-.759).

Conclusion

The corresponding points of HMG patients with different syndromes are in different deficiency/excess states. Changes in the infrared radiation temperature of the trunk points Shanzhong (CV 17), Qimen (LR 14), Zhongwan (CV 12), Qihai (CV 6), and Guanyuan (CV 4) are closely related to the pathological characteristics of the Liver Qi stagnation syndrome of HMG patients, while changes in the infrared radiation temperature of the lower extremity points Taixi (KI 3) and Taichong (LR 3) are closely related to the pathological characteristics of the Dysfunction of conception and thoroughfare vessels syndrome of HMG patients. On the whole, HMG patients with Liver Qi stagnation syndrome are characterized by “upper excess,” and those with Dysfunction of conception and thoroughfare vessels syndrome are characterized by “lower deficiency.”     

基于复杂网络技术对电针治疗乳腺增生病处方分析

目的基于复杂网络技术分析电针治疗乳腺增生病的核心穴位及配伍穴相关性,并对电针波型进行探讨。方法检索中国期刊全文数据库(CNKI)、万方数据库、维普网数据库(VIP)中从1954年1月1日到2018年12月31日公开发表的电针治疗乳腺增生病的临床中文文献,利用Excel表格工具建立电针治疗乳腺增生病数据库,利用Matlab2014a软件进行节点中心性分析和聚类分析,利用Gephi0.9.1软件制作复杂网络示意图对分析结果进行描述和展示,利用Excel表格工具制作电针治疗乳腺增生病不同波形比例饼状图并分析其规律。结果选定43条电针处方:电针治疗乳腺增生病主穴核心度前三位依次为膻中穴、足三里、肩井穴;配伍穴位核心度前三位依次为太冲穴、太溪穴、脾俞穴;经络核心度前三位依次为足阳明胃经、任脉、足少阳胆经。配伍穴位相关性分析中,相关性频度前三位组合依次为太冲穴-太溪穴、太冲穴-肾俞穴、太冲穴-三阴交。电针波形中以连续波与疏密波常见,均具有较高的临床应用价值。结论电针治疗乳腺增生病处方以足阳明胃经为最多,其次为任脉;电针波型以连续波为主。     

针刺穴位和非穴位对脑功能连接影响的MR研究

目的:观察穴区与非穴区对脑功能连接的影响,以探讨腧穴作用特异性的基础.方法:选择21名健康志愿者,随机分为穴位组(12例)和非穴位组(9例),分别针刺受试者双侧足三里和足三里外侧3～4 mm处,采用捻针手法,分别于针刺前、出针后25 min进行功能磁共振扫描,以双侧扣带回作为种子点,分析穴位组和非穴位组脑功能连接情况.结果:穴位组和非穴位组均能产生广泛的脑功能连接,穴位组与非穴位组相比,穴位组在双侧小脑扁桃体、右侧小脑齿状核、双侧小脑悬雍垂、左侧小脑山坡、右侧小脑结节、左侧额下回、双侧颞中回、双侧旁中央小叶、左侧扣带回、右侧颞上回、右侧前扣带回等区域与后扣带回存在功能连接增强,而穴位组双侧额内侧回、右侧额下回与后扣带回的脑功能连接强度较非穴位组减弱.结论:穴位和非穴位所引发脑功能连接的脑区大部分相同,但穴位组在脑内的脑功能连接强度总体上高于非穴位组.