源于多孔菌的抗肿瘤活性成分研究进展

多孔菌是一类重要的药用真菌，具有显著的抗肿瘤活性。近年来国内外学者对多孔菌的抗肿瘤活性成分进行了大量的研究。现查阅国内外相关文献，对源于多孔菌的抗肿瘤活性大分子成分，如多糖、糖肽、糖蛋白、凝集素，及脂溶性的小分子成分，如萜类、甾类、酚类和苯并吡喃酮类进行了综述，并探讨了多孔菌的应用在抗肿瘤新药开发上的重要意义。     

Biologically active compounds from plants with reputed medicinal and sweetening properties

Examples are presented of plants with folkloric reputations that have recently afforded constituents with great potential for use as drugs or pharmaceutical excipients. Described are the results of laboratory investigations at this institution on the biologically active compounds of four plants with reputed medicinal properties and of six sweet plants used by local populations in various regions of the world. It is concluded that folklore information should be considered seriously in programs designed to yield prototype, biologically active molecules from plant sources.     

Biologically active indole alkaloids from Kopsia arborea

Nine new indole alkaloids, rhazinoline (1), 19(S)-methoxytubotaiwine (2), 19(R)-methoxytubotaiwine (3), kopsamidine A (4), kopsamidine B (5), kopsinidine A (6), kopsinidine B (7), paucidactine C (8), and pericine N-oxide (9), in addition to several recently reported novel indoles and 34 other known ones, were obtained from the stem-bark extract of the Malayan Kopsia arborea. The structures were determined using NMR and MS analysis. Valparicine (12) showed pronounced cytotoxic effects against KB and Jurkat cells (IC(50) 13.0 and 0.91 microM, respectively).     

Biologically active aspidofractinine alkaloids from Kopsia singapurensis

Ten new indole alkaloids of the aspidofractinine type, in addition to several recently reported indole alkaloids and 20 other known alkaloids, were obtained from the leaf and stem-bark extract of the Malayan Kopsia singapurensis, viz., kopsimalines A-E (1-5), kopsinicine (6), kopsofinone (7), and kopsiloscines H-J (8-10). The structures of these alkaloids were determined using NMR and MS analysis. Kopsimalines A (1), B (2), C (3), D (4), and E (5) and kopsiloscine J (10) were found to reverse multidrug-resistance in vincristine-resistant KB cells, with 1 showing the highest potency.     

Biologically active triterpenoid saponins from Acanthopanax senticosus

Three new triterpenoid saponins, acanthopanaxosides A (1), B (7), and C (13), were isolated from the leaves of Acanthopanax senticosus, together with 12 known saponins. The structures of these new saponins were established as 3-O-beta-D-glucopyranosyl-(1-->2)-alpha-L-arabinopyranosyl-30-nor-olean-12,20(29)-dien-28-oic acid 28-O-alpha-L-rhamnopyranosyl-(1-->4)-6-O-acetyl-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl ester (1), 3-O-beta-D-glucopyranosyl-(1-->2)-alpha-L-arabinopyranosyl oleanolic acid 28-O-alpha-L-rhamnopyranosyl-(1-->4)-6-O-acetyl-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl ester (7), and 3-O-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranosyl-3beta-hydroxyolean-12-ene-28,29-dioic acid (13), on the basis of spectroscopic analysis and chemical degradation. Among the known compounds, sessiloside and tauroside H1 are reported for the first time from A. senticosus. The biological activity of compounds 1-15 was examined against pancreatic lipase. Ciwujianoside C1 (6), tauroside H1 (11), 3-O-alpha-rhamnopyranosyl-(1-->2)-alpha-arabinopyranosyl mesembryanthemoidigenic acid (12), acanthopanaxoside C (13), sessiloside (14), and chiisanoside (15) inhibited pancreatic lipase activity in vitro. In turn, ciwujianosides C2 (3), D2 (5), C4 (8), and C3 (10) and hederasaponin B (9) enhanced this enzyme.     

Biologically active sesquiterpene coumarins from Ferula species

Extracts from different species of the genus Ferula (Apiaceae) have had various biomedical applications for many centuries. Many biological features of this genus such as cytotoxicity, antibacterial, antiviral, P-glycoprotein (P-gp) inhibitory and antiinflammatory activity have been attributed to sesquiterpene coumarins; structures containing a common coumarin group and a sesquiterpene moiety. This both highlights the importance of sesquiterpene coumarins as biologically active natural products and necessitates further studies on these compounds. Taking into account the versatile biological properties of compounds isolated from Ferula and the unprecedented interest in the application of natural products as a new generation of therapeutics, the present review will discuss reports on biological activities of sesquiterpene coumarins of the genus Ferula, from 1990 onwards.     

Biologically active triterpenoid saponins from Ardisia japonica

Eleven new triterpenoid saponins, ardisianosides A (1), B (2), C (4), D (5), E (6), F (7), G (15), H (16), I (17), J (18), and K (19), together with 10 known saponins, were isolated from the whole plants of Ardisia japonica. The structures of the new saponins were established on the basis of extensive 1D and 2D NMR and MS studies coupled with chemical degradations. The cytotoxic activities of saponins 1-21 are reported against three human cancer cell lines, namely, HL-60 myeloid leukemia, KATO-III stomach adenocarcinoma, and A549 lung adenocarcinoma cells.     

Biologically active preparations from Lactuca virosa L.

The crude preparations from Lactuca virosa L. (P-1, P-2, P-3), lactucin (1) and jacquinelin (2) were investigated pharmacologically in Albino-Swiss mice. The results indicate that P-1, P-2, P-3 and 1, but not 2 show sedative and analgesic properties. The most active of them was preparation P-2 which at a dose of 2 mg/kg reduced the spontaneous locomotor activity and at a dose of 15 mg/kg produced an analgesic effect. Jacquinelin (2), 8-desoxylactucine (4), 11β,13-dihydrolactucin (5) and lactuside A (6) were isolated from this preparation.