脂可平软胶囊治疗高脂血症临床研究

目的评价脂可平软胶囊治疗高脂血症(气滞血瘀证)的临床疗效和安全性.方法采用随机、双盲、双模拟、与阳性对照药脂必妥片平行对照的观察方法,疗程为6周.试验组101例用脂可平软胶囊;对照组1 00例用脂必妥片.两组均同时服用模拟药安慰剂.主要观察指标为:实验室客观血脂指标TC、TG、HDL等及中医证候表现.结果两组患者血脂水平比较表明,治疗后患者的总胆固醇、三酰甘油、低密度脂蛋白、极低密度脂蛋白有明显降低(P＜0.01),高密度脂蛋白升高,试验组降低三酰甘油和升高高密度脂蛋白的疗效优于对照组(P＜0.05).试验组治疗后载脂蛋白Apo-Al/Apo-B100、Apo-A1均有增高,且Apo-B100降低(P＜0.01),试验组升高Apo-Al、Apo-A1/Apo-B1 00和对照组组间比较,P＜0.05.脂可平软胶囊对高脂血癌患者中医证候总有效率为91.1%,与对照组比较差异有统计学意义(P＜0.05),对患者单一中医症状胸闷气短、胸痛、胸胁胀满、舌象等有明显改善.结论脂可平软胶囊对改善总胆固醇和三酰甘油等血症有确切的疗效,未见明显不良反应,使用较为安全.     

降脂抗凝冲剂治疗高脂血症(气滞血瘀证)临床研究

目的:对降脂抗凝冲剂治疗高脂血症(气滞血瘀证)的临床疗效及安全性进行初步分析.方法:将符合诊断标准的原发性高胆固醇血症、高甘油三酯症或混合性高脂血症的患者共80例随机分为降脂抗凝冲剂治疗组(A组)及辛伐他汀滴丸对照组(B组),采用随机、双盲、双模拟阳性对照研究,疗程4周.结果:完成试验患者80例,无剔除和脱落病例.中医症状疗效方面治疗组总有效率97.5％,对照组总有效率90.0％,2组之间有统计学意义(P＜0.05);2组在中医证候总积分的减少值和减少率方面均有统计学意义(P＜0.05),治疗组优于对照组.血脂疗效方面治疗组总有效率为97.5％,对照组为92.5％,2组比较没有统计学意义(P＞0.05).2组在胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、动脉硬化指数(TC-HDL-c/HDL-c)下降值、下降率方面没有统计学意义(P＞0.05).治疗前后2组均未出现不良反应.结论:降脂抗凝冲剂对高脂血症(气滞血瘀证)患者具有良好的作用,可显著改善其血脂水平和临床症状.     

降脂通络软胶囊治疗酒精性脂肪肝(气滞血瘀证)的临床研究

目的 研究降脂通络软胶囊对酒精性脂肪肝(气滞血瘀证)的临床疗效.方法 143例酒精性脂肪肝(气滞血瘀证)患者随机分组,试验组72例,用降脂通络软胶囊治疗;对照组71例,用东宝肝泰片治疗,疗程均为8周,比较两组患者治疗前后肝脾B超、中医证候、体征、血清生化指标、体重的变化.结果 试验组与对照组中医证候总有效率分别为89.7%、72.9%,组间比较差异有统计学意义(P<0.05);试验组和对照组B超显示脂肪肝严重程度改变的总有效率分别为57.4%、50.0%;试验组治疗后ALT、GGT有明显改善(P<0.05);试验组治疗后TC、TG及LDL-C降低,HDL-C升高(P<0.05),对照组治疗后TC、HDL-C降低(P<0.05); B超显示,试验组治疗后可显著减小患者左肝厚径和右肝斜径(P<0.05);两组治疗后体重减轻(P<0.05).结论 降脂通络软胶囊对脂肪肝气滞血瘀证有较好的临床疗效,明显改善酒精性脂肪肝(气滞血瘀证)患者的临床症状,降低酒精性脂肪肝严重程度,减轻肝内脂肪含量,改善脂质代谢,保护肝功能,减轻患者的体重.     

复方降脂茶治疗原发性高脂血症(痰浊内阻证)的临床研究

目的 探讨复方降脂茶治疗高脂血症(痰浊内阻证)的临床疗效.方法 将96例高脂血症(痰浊内阻证)患者随机分为试验组(复方降脂茶组48例)与对照组(血脂康胶囊组48例),观察治疗前后血脂、中医证候改善情况.结果 试验组调脂总有效率为79.2%,对照组总有效率为77.1%;试验组可显著降低血清TC、LDL-C、TG水平,升高HDL-C,其调脂效果与对照组比较,差异无统计学意义(P＞0.05).而复方降脂茶能显著改善中医证候程度并可有效改善头晕头重、胸闷、呕恶痰涎、口淡、食少等症状以及舌苔脉象,疗效明显高于对照组,差异具有显著性意义(P＜0.01或P＜0.05). 结论 复方降脂茶治疗高脂血症(痰浊内阻证)疗效确切.     

调脂通络方联合辛伐他汀胶囊治疗高脂血症的临床研究

目的探讨调脂通络方联合辛伐他汀胶囊治疗高脂血症的临床疗效。方法将60例高脂血症患者随机分为两组,各30例。其中对照组给予口服辛伐他汀胶囊治疗,治疗组则以自拟调脂通络方为主,配合应用辛伐他汀胶囊。一个月为1个疗程,共治疗2个疗程。比较治疗前后两组患者血脂及中医证候的变化。结果两组患者治疗前后血脂、中医证候改善情况比较,治疗组均明显优于对照组(P0.05)。结论调脂通络方联合辛伐他汀胶囊可以明显改善患者中医证候,降低血脂。     

银丹心脑通软胶囊治疗高脂血症120例中医证候疗效分析

目的 观察银丹心脑通软胶囊对高脂血症患者中医证候的效果.方法 选取高脂血症患者240例,随机分为治疗组与对照组,各120例.治疗组采用银丹心脑通软胶囊治疗4周,对照组采用脉平片治疗4周.观察两组治疗中医证候疗效.结果 两组在治疗高脂血症中证候总疗效差异无统计学意义,但银丹心脑通软胶囊治疗痰浊阻遏型及脾肾阳虚型患者比脉平片治疗疗效好,而脉平片在治疗肝肾阴虚型及阴虚火旺型比银丹心脑通软胶囊疗效好,两者治疗气滞血瘀型患者则疗效基本相同.结论 银丹心脑通软胶囊对高脂血症患者中痰浊阻遏型、脾肾阳虚型、气滞血瘀型疗效显著.     

降脂通络软胶囊治疗非酒精性脂肪性肝病患者60例临床观察

目的 观察降脂通络软胶囊治疗菲酒精性脂肪性肝病(NAFLD)的临床疗效. 方法 将120例NAFLD患者随机分为治疗组和对照组各60例.对照组在一般治疗基础上给予辛伐他汀片,每次10mg,每晚1次;硫普罗宁肠溶片,每次200mg,每日3次.治疗组在一般治疗基础上给予降脂通络软胶囊,每次2粒,每日3次.两组均连续治疗12周.观察两组患者治疗前后临床症状体征、体重指数(BMI)、腰围、血压、血脂、肝功能及CT影像学指标.结果 治疗组总有效率91.67,％,对照组85.00％,两组比较差异无统计学意义(P＞0.05),治疗组显效率51.67％优于对照组33.33％(P＜0.05);两组治疗后BMI、腰围、血压均较治疗前有改善(P＜0.05),但治疗组BMI、腰围改善更明显(P＜0.05);两组治疗后肝功能、血脂、肝/脾CT值均较治疗前明显改善(P＜0.05或P＜0.01),并且治疗组肝功能、血脂、肝/脾CT值改善更明显(P＜0.05或P＜0.01).结论 降脂通络软胶囊具有调脂保肝、改善代谢指标的疗效,可以多靶点起效治疗NAFLD.     

降脂通络饮治疗高脂血症60例临床观察

目的:观察降脂通络饮治疗高脂血症的临床疗效.方法:将符合纳入标准的90例患者,随机分为治疗组60例和对照组30例,治疗组采用降脂通络饮,对照组采用脂必妥片,两个疗程后,对比临床疗效.结果:中医临床疗效总有效率治疗组为95.0%,对照组为66.0%,治疗组优于对照组(P<0.01),且治疗组治疗后血脂指标降低、临床症状改...     

清脂六通丸治疗高脂血症(气滞血瘀痰浊内阻证)临床研究

目的探讨清脂六通丸治疗高脂血症(气滞血瘀痰浊内阻证)的临床疗效.方法将选自5家三甲医院的230例高脂血症(气滞血瘀痰浊内阻证)患者随机分为试验组(清脂六通丸组115例)与对照组(脂必妥胶囊组115例),观察治疗前后血脂、中医证候改善情况.结果两组患者血脂、中医证候改善情况比较无统计学差异.结论清脂六通丸能有效地改善患者血脂情况,适用于治疗高脂血症(气滞血瘀痰浊内阻证).     

四物降脂颗粒治疗脾虚湿盛型高脂血症的临床观察

目的观察四物降脂颗粒治疗脾虚湿盛型高脂血症的疗效。方法将中医辨证为脾虚湿盛型的92例高脂血症患者随机分为治疗组47例,对照组45例,治疗组采用四物降脂颗粒治疗,对照组采用血脂平治疗,共治疗8周,观察治疗前后各组中医证候积分、血脂指标、血液流变学指标,并进行统计学分析。结果在改善症状积分方面,治疗组和对照组均能改善患者症状学积分,但治疗组优于对照组治疗组(P0.05);在改善血脂水平方面,治疗组和对照组均能有效改善患者TG、TC、LDL水平(P0.05),两组治疗后TG、TC、LDL无统计学差异(P0.05),但治疗组在HDL改善方面优于对照组(P0.05);在改善患者血流动力学方面,治疗组和对照组均能改善血流动力学指标(P0.05),两组之间无统计学差异(P0.05)。结论四物降脂颗粒可改善脾虚湿盛型高脂血症患者中医证候积分、血脂指标、血液流变学指标。     

基于ICP-MS法的加味左金丸中无机元素分析

目的 通过电感耦合等离子体质谱（inductively coupled plasma mass spectrometry,ICP-MS）法建立加味左金丸中Cd、Pb、As、Hg、Co、V、Ni、Cu、Li、Sb、Ba、Mo、Sn、Cr、Na、Mg、Al、Ca、Ti、Mn、Fe、Zn、Ga、Se、Sr、Tl共计26种无机元素的测定方法。方法 加味左金丸通过微波消解法处理后,根据相对分子质量的大小选择内标物,其中⁷Li、²³Na、²⁴Mg、²⁷Al、⁴⁰Ca、⁴⁸Ti、⁵¹V、⁵²Cr、⁵⁵Mn、⁵⁶Fe、⁵⁸Ni、⁵⁹Co、⁶³Cu、⁶⁶Zn、⁷⁰Ga、⁷⁵As、⁷⁷Se、⁸⁶Sr以⁷²Ge作为内标;⁹⁵Mo、¹¹⁴Cd、¹¹⁸Sn、¹²¹Sb、¹³⁷Ba以¹¹⁵In作为内标;²⁰²Hg、²⁰⁵Tl、²⁰⁸Pb以²⁰⁹Bi作为内标。对标准品溶液、空白溶液与供试品溶液进行分析,采用标准曲线法进行定量分析。通过ICP-MS法进行测定。结果 26种无机元素线性的相关系数r ≥ 0.999 6,检出限为0.001~1.500μg/L,定量限为0.01~5.00 μg/L,精密度与重复性试验的RSD均小于5%,平均回收率在82.64%~106.44%,RSD均小于5%。对3个厂家的12批样品进行了测定,26种元素的含量差异较大,其中Na、Mg、Ca、Fe 4种元素的含量比较高,均大于500 μg/g,Cd、Pb、As、Hg、Co、Li、Sb、Mo、Sn、Cr、Se、Tl的含量比较低,均小于1 μg/g。由结果可知,人体的常量元素,如Na、Mg、Ca的含量比较高,Cd、Pb、As、Hg等有害元素含量比较低。根据《中国药典》2020年版一部的要求,本品中Cd、Pb、As、Hg与Cu均符合规定。结论 该方法快速、准确,可以用于加味左金丸中无机元素的测定。     

Erstaunliches Ergebnis einer Schädelakupunktur nach Yamamoto bei Hemihypsarrhythmie rechts

A girl, three and a half years old at the respective date, premature in 25th week of gestation, had been presented. On day three after birth, she had had a IVH III° right and left with severe involvement of parenchyma and other multiple complications, e. a. infant respiratory distress syndrome up to the 42nd day postpartum, and epileptic attacks with apnoeic events.     

七味红花殊胜散对缺血再灌注肝损伤的保护作用

目的::研究七味红花殊胜敬对缺血再灌注肝损伤的保护作用.方法:在大鼠肝缺血再灌注模型上,观察七味红花殊胜散对缺血再灌注肝损伤引起的血清丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、一氧化氮(NO)含量的变化.结果:七味红花殊胜散对大鼠血清MDA、SOD、GSH与再灌组比较有明显差异(P<0.05),NO含量与再灌组比较有明显差异(P<0.05).结论:七味红花殊胜散对大鼠急性缺血再灌注肝损伤具有保护作用.     

Methodology of Canine/Feline YNSA and Tail Acupuncture

BackgroundYamamoto New Scalp Acupuncture (YNSA) is a well-known acupuncture system for human patients which was developed by Dr. Yamamoto.ObjectiveMy aim was to transpose the human YNSA map onto canines and felines.MethodI started researching a canine/feline YNSA map in 2002. I investigated approximately 3,000 canines and felines for YNSA and 2,500 for Tail Acupuncture. The ratio of canines and felines was 6 to 4. I researched and found all the equivalent points by palpating animal patients on the basis of an exact Neck Diagnosis.ResultsI nearly completed the map in 2006. The points in the occipital region are incomplete and my research is still in progress. In the process of researching canine/feline YNSA points, I accidentally found the other microsystems around the tail and named it “Tail Acupuncture”.ConclusionsYNSA and Tail Acupuncture are acupuncture systems utilizing microsystems and support each other in canines and felines. The merits of YNSA and Tail Acupuncture are 1) immediate effects, such as in cases of lameness, 2) simplicity in finding the exact points to treat and 3) the scalp and the tail can be utilized separately or together as treatment zones, according to the situation.     

蜂蜜炼制前后黄酮类成分种类和含量变化分析

目的研究中药辅料蜂蜜炼制前后黄酮类成分变化。方法参考《中药药剂学》,对不同来源的6种蜂蜜进行炼制。供试品经固相萃取法富集黄酮类成分。采用高效液相色谱-三重四级杆串联质谱(HPLC-TQ-MS)法测定,Thermo Accucore RP-MS色谱柱(100 mm×2.1 mm,2.6μm),以0.1%甲酸水溶液-甲醇为流动相进行梯度洗脱,体积流量0.3 m L/min,柱温30℃。质谱条件:采用电喷雾离子源(ESI),正离子检测模式,多反应监测模式(MRM)扫描分析。结果蜂蜜中共检测到12种黄酮类成分,包括黄酮苷元、二氢黄酮苷元和异黄酮苷元。黄酮苷元有8种:槲皮素、桑黄素、木犀草素、山柰酚、芹菜素、汉黄芩素、高良姜素和白杨素;二氢黄酮苷元有3种:短叶松素、柚皮素和乔松素;异黄酮苷元染料木素。不同蜜源蜂蜜所含黄酮类成分种类和含量存在明显差异。6个蜂蜜样品炼制后,都发现了蜂蜜中没有报道过的芦丁和芸香柚皮苷,12种检测到的蜂蜜黄酮类成分在炼制后其量都有不同程度的变化,椴树蜜的槲皮素、桑黄素、木犀草素、山柰酚、芹菜素、汉黄芩素、乔松素和白杨素量均有增加,短叶松素、柚皮素和高良姜素量没增加反而还有下降的;洋槐蜜中除芹菜素量增加不明显外,其余均有所增加,尤其是槲皮素和桑黄素增加的较为明显;百花蜜和枣花蜜12种黄酮类成分量均显著增加。结论炼制可造成蜂蜜中黄酮类成分的种类和含量发生改变。     

Chinesische Orthopädie: Teil 1: Die Zukunft der Akupunktur in der Postmoderne

The locomotor system is one of the major fields of application for acupuncture. The results of the large acupuncture studies funded by German Health Insurances from 2000 until 2006 are impressive and repressive: they restrict acupuncture application by allocation of reimbursement and create the necessity of reorientation, since acupuncture can neither be adequately described nor prescribed solely on the basis of disease entities. Regarding these disease entities, it seems rather necessary to analyse the layers of problems and formulate a hierarchy of therapeutic goals instead. Only in this way the effects of acupuncture, related techniques and further therapeutic modalities can be matched with the set of objectives. The article presents general principles and follows their application from biological aspects to implications for the locomotor system and consequences for the application of physical therapy. The manual of acupuncture focuses on therapeutic effects and objectives first, and then goes on to sketch simple therapeutic strategies and finally complex approaches within acupuncture. These may encompass acupuncture, microsystem acupuncture and complex therapeutic modes.     

Patientin mit chronisch rezidivierenden Gelenks- und Wirbelsäulenschmerzen

Background

Acupuncture as a regulative therapy is well-suited for the treatment of functional, reversible disorders. Additionally, the WHO recommends its application for pain therapy in cases of arthritis and back pain due to various causes. This case study should clarify which paths to take in the case of a multi-morbid patient suffering from chronic pains due to polyarthrosis.

Objective

Pain reduction and improvement of quality of life as well as improvement of sleep quality.

Methods

Annual treatment series consisting of 10 sessions each, one session per week.

Results

short-term pain reduction before undergoing endoprosthetic surgery; considerable improvement of general status and sleep.

Conclusions

Acupuncture may bring temporal relief in cases of chronic pain due to osteoarthritis and should therefore be applied in combination with western medicine. Acupuncture is particularly well-suited to treat the co-emergent vegetative symptoms.     

Fallbericht: Patientin mit Schlafstörung

Background

Since the onset of her menopause about ten years ago, a sixty-year old patient has been suffering from hot flashes and sleep disorders causing her to become increasingly anxious and nervous. As the patient's mother had died of breast cancer, substitution of hormones was not advisable. Relaxation methods such as Yoga and Autogenic Training could only mildly alleviate the symptoms.

Objective

To effectively treat the sleep disorder, improve quality of life, lessen frequency and severity of hot flashes

Methods

Weekly sessions with ear- and body acupuncture for ten weeks

Results

After the third acupuncture session the patient reported a decrease of nightly waking episodes but suffered from acute pain in the neck as well as shoulder region. After nine therapy sessions, the patient reported a 50% decrease of nightly waking episodes. The hot flashes, however, remained unchanged.

Discussion

In this case, acupuncture significantly improved the patient's sleeping disorder. It also reduced the symptoms of anxiety and nervousness. Other menopausal symptoms such as hot flashes and dryness of mucous tissues, could not be influenced.