中医药治疗糖尿病周围神经病变的研究进展

糖尿病周围神经病变(Diabetic peripheral neuropathy,DPN)是糖尿病(Diabetes mellitus,DM)最常见的并发症,是糖尿病晚期的主要并发症,死亡率高,预后差。文章检索近五年中医药诊疗DPN的文献,从DPN的中医病因病机、辨证论治、中医药治疗方面进行探讨,总结中医药治疗糖尿病周围神经病变的研究进展,以期为中医药治疗糖尿病周围神经病变的研究提供参考。     

彭万年教授糖尿病周围神经病变阳虚学说浅议

糖尿病周围神经病变（DPN）是临床常见的糖尿病并发症,彭万年教授根据中医理论,从自身的临床实践出发,结合现代医家对DPN病机的认识,探索研究提出了机体阳气是安身立命根本、机体阳虚对糖尿病转归产生重要影响、脾肾阳虚是DPN病机根本的糖尿病周围神经病变阳虚学说,丰富了DPN的中医病机理论,为中医药治疗DPN提供新的思路和途径,值得思考学习和推广。     

中医外治法治疗糖尿病周围神经病变研究近况

糖尿病周围神经病变（DPN）是常见的糖尿病慢性并发症,DPN以对称性、多发性周围神经病变较多见,其患病率可达7%~50%,若包括各种亚临床型神经病则可高达90%,是糖尿病病人致残致死的重要原因,严重威胁着糖尿病患者的健康。随着中医诊疗技术的不断应用,许多医家对中医外治法治疗糖尿病周围神经病变给予更多关注,并实施了大量的临床观察实验以验证其疗效,概况如下。     

略述中医治疗糖尿病合并周围神经病变

糖尿病合并周围神经病变(DPN)是临床上最为常见的糖尿病并发症,本病多由素体阴虚,脾失健运,肺胃燥热所引发,根据其临床症状可将其归为中医学的"消渴"、"痹症"范畴。本文通过对糖尿病合并周围神经病变病因病机、辨证分型、治疗方法进行梳理,总结多年来医家对本病的研究结果,提出提高中医辨证能力、统一规范中医治疗方法的必要性,使糖尿病合并周围神经病变的中医辨证论治脉络更为清晰,以期为提高临床疗效提供切实有效的理论依据。     

活血化瘀法在糖尿病周围神经病变治疗中的应用

糖尿病周围神经病变(DPN)是临床上常见的糖尿病慢性并发症之一,历来成为医学界研究的热点。本文通过分析DPN的病因病机,观察中医从"瘀"治疗DPN的临床疗效,说明"瘀"为DPN致病因素,活血化瘀法为DPN治疗关键所在。     

彭万年教授糖尿病周围神经病变阳虚学说浅议

糖尿病周围神经病变(DPN)是临床常见的糖尿病并发症,彭万年教授根据中医理论,从临床实践出发,结合现代医家对DPN病机的认识,提出了机体阳气是安身立命根本、阳虚对糖尿病转归产生重要影响、脾肾阳虚是DPN病机的根本,糖尿病周围神经病变阳虚学说,丰富了DPN的中医病机理论,为中医药治疗DPN提供新的思路和途径。     

糖尿病周围神经病变的中医药治疗研究进展

中医治疗糖尿病周围神经病变(DPN)在辨证论治、中成药制剂、针灸、熏洗等诸多方面取得了显著疗效,"多靶点、多途径整体治疗"的优势在临床应用中日益显现,中医药治疗DPN的前景为世界所瞩目。综述近年来糖尿病周围神经病变(DPN)中医药治疗方面的最近研究进展,以期为DPN的治疗研究提供基础。     

中医药治疗糖尿病周围神经病变的临床研究进展

糖尿病周围神经病变(DPN)是糖尿病常见的并发症,其病程变化及病因、发病机制尚未完全阐明,目前西医对本病的治疗手段有限,而众多研究结果和临床经验表明中医药在治疗DPN上取得较大进展。现将近几年的DPN中医药临床治疗作一概述。     

李小娟调营卫化痰瘀论治糖尿病周围神经病变经验撷菁

目的:总结李小娟教授调营卫化痰瘀辨证治疗糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)的经验。方法:通过跟师学习总结李小娟教授辨证论治经验,并通过具体的临床病案分析来验证以调营卫化痰瘀为治则治疗糖尿病周围神经病变的疗效及辨证依据。结论:以中医络病为基础,以调营卫化痰瘀为治则治疗糖尿病周围神经病变疗效显著。     

糖尿病周围神经病变的中医临床治疗近况

本文概述了中医治疗糖尿病周围神经病变（DPN）的近况。DPN是糖尿病的主要并发症之一，近年来，中医对DPN治疗进行了不断的探索，取得了比较丰富的经验，中医药对治疗DPN具有较好的临床疗效，现归纳如下以供借鉴和探讨。     

基于ICP-MS法的加味左金丸中无机元素分析

目的 通过电感耦合等离子体质谱（inductively coupled plasma mass spectrometry,ICP-MS）法建立加味左金丸中Cd、Pb、As、Hg、Co、V、Ni、Cu、Li、Sb、Ba、Mo、Sn、Cr、Na、Mg、Al、Ca、Ti、Mn、Fe、Zn、Ga、Se、Sr、Tl共计26种无机元素的测定方法。方法 加味左金丸通过微波消解法处理后,根据相对分子质量的大小选择内标物,其中⁷Li、²³Na、²⁴Mg、²⁷Al、⁴⁰Ca、⁴⁸Ti、⁵¹V、⁵²Cr、⁵⁵Mn、⁵⁶Fe、⁵⁸Ni、⁵⁹Co、⁶³Cu、⁶⁶Zn、⁷⁰Ga、⁷⁵As、⁷⁷Se、⁸⁶Sr以⁷²Ge作为内标;⁹⁵Mo、¹¹⁴Cd、¹¹⁸Sn、¹²¹Sb、¹³⁷Ba以¹¹⁵In作为内标;²⁰²Hg、²⁰⁵Tl、²⁰⁸Pb以²⁰⁹Bi作为内标。对标准品溶液、空白溶液与供试品溶液进行分析,采用标准曲线法进行定量分析。通过ICP-MS法进行测定。结果 26种无机元素线性的相关系数r ≥ 0.999 6,检出限为0.001~1.500μg/L,定量限为0.01~5.00 μg/L,精密度与重复性试验的RSD均小于5%,平均回收率在82.64%~106.44%,RSD均小于5%。对3个厂家的12批样品进行了测定,26种元素的含量差异较大,其中Na、Mg、Ca、Fe 4种元素的含量比较高,均大于500 μg/g,Cd、Pb、As、Hg、Co、Li、Sb、Mo、Sn、Cr、Se、Tl的含量比较低,均小于1 μg/g。由结果可知,人体的常量元素,如Na、Mg、Ca的含量比较高,Cd、Pb、As、Hg等有害元素含量比较低。根据《中国药典》2020年版一部的要求,本品中Cd、Pb、As、Hg与Cu均符合规定。结论 该方法快速、准确,可以用于加味左金丸中无机元素的测定。     

Erstaunliches Ergebnis einer Schädelakupunktur nach Yamamoto bei Hemihypsarrhythmie rechts

A girl, three and a half years old at the respective date, premature in 25th week of gestation, had been presented. On day three after birth, she had had a IVH III° right and left with severe involvement of parenchyma and other multiple complications, e. a. infant respiratory distress syndrome up to the 42nd day postpartum, and epileptic attacks with apnoeic events.     

七味红花殊胜散对缺血再灌注肝损伤的保护作用

目的::研究七味红花殊胜敬对缺血再灌注肝损伤的保护作用.方法:在大鼠肝缺血再灌注模型上,观察七味红花殊胜散对缺血再灌注肝损伤引起的血清丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、一氧化氮(NO)含量的变化.结果:七味红花殊胜散对大鼠血清MDA、SOD、GSH与再灌组比较有明显差异(P<0.05),NO含量与再灌组比较有明显差异(P<0.05).结论:七味红花殊胜散对大鼠急性缺血再灌注肝损伤具有保护作用.     

Methodology of Canine/Feline YNSA and Tail Acupuncture

BackgroundYamamoto New Scalp Acupuncture (YNSA) is a well-known acupuncture system for human patients which was developed by Dr. Yamamoto.ObjectiveMy aim was to transpose the human YNSA map onto canines and felines.MethodI started researching a canine/feline YNSA map in 2002. I investigated approximately 3,000 canines and felines for YNSA and 2,500 for Tail Acupuncture. The ratio of canines and felines was 6 to 4. I researched and found all the equivalent points by palpating animal patients on the basis of an exact Neck Diagnosis.ResultsI nearly completed the map in 2006. The points in the occipital region are incomplete and my research is still in progress. In the process of researching canine/feline YNSA points, I accidentally found the other microsystems around the tail and named it “Tail Acupuncture”.ConclusionsYNSA and Tail Acupuncture are acupuncture systems utilizing microsystems and support each other in canines and felines. The merits of YNSA and Tail Acupuncture are 1) immediate effects, such as in cases of lameness, 2) simplicity in finding the exact points to treat and 3) the scalp and the tail can be utilized separately or together as treatment zones, according to the situation.     

Chinesische Orthopädie: Teil 1: Die Zukunft der Akupunktur in der Postmoderne

The locomotor system is one of the major fields of application for acupuncture. The results of the large acupuncture studies funded by German Health Insurances from 2000 until 2006 are impressive and repressive: they restrict acupuncture application by allocation of reimbursement and create the necessity of reorientation, since acupuncture can neither be adequately described nor prescribed solely on the basis of disease entities. Regarding these disease entities, it seems rather necessary to analyse the layers of problems and formulate a hierarchy of therapeutic goals instead. Only in this way the effects of acupuncture, related techniques and further therapeutic modalities can be matched with the set of objectives. The article presents general principles and follows their application from biological aspects to implications for the locomotor system and consequences for the application of physical therapy. The manual of acupuncture focuses on therapeutic effects and objectives first, and then goes on to sketch simple therapeutic strategies and finally complex approaches within acupuncture. These may encompass acupuncture, microsystem acupuncture and complex therapeutic modes.     

Patientin mit chronisch rezidivierenden Gelenks- und Wirbelsäulenschmerzen

Background

Acupuncture as a regulative therapy is well-suited for the treatment of functional, reversible disorders. Additionally, the WHO recommends its application for pain therapy in cases of arthritis and back pain due to various causes. This case study should clarify which paths to take in the case of a multi-morbid patient suffering from chronic pains due to polyarthrosis.

Objective

Pain reduction and improvement of quality of life as well as improvement of sleep quality.

Methods

Annual treatment series consisting of 10 sessions each, one session per week.

Results

short-term pain reduction before undergoing endoprosthetic surgery; considerable improvement of general status and sleep.

Conclusions

Acupuncture may bring temporal relief in cases of chronic pain due to osteoarthritis and should therefore be applied in combination with western medicine. Acupuncture is particularly well-suited to treat the co-emergent vegetative symptoms.     

Fallbericht: Patientin mit Schlafstörung

Background

Since the onset of her menopause about ten years ago, a sixty-year old patient has been suffering from hot flashes and sleep disorders causing her to become increasingly anxious and nervous. As the patient's mother had died of breast cancer, substitution of hormones was not advisable. Relaxation methods such as Yoga and Autogenic Training could only mildly alleviate the symptoms.

Objective

To effectively treat the sleep disorder, improve quality of life, lessen frequency and severity of hot flashes

Methods

Weekly sessions with ear- and body acupuncture for ten weeks

Results

After the third acupuncture session the patient reported a decrease of nightly waking episodes but suffered from acute pain in the neck as well as shoulder region. After nine therapy sessions, the patient reported a 50% decrease of nightly waking episodes. The hot flashes, however, remained unchanged.

Discussion

In this case, acupuncture significantly improved the patient's sleeping disorder. It also reduced the symptoms of anxiety and nervousness. Other menopausal symptoms such as hot flashes and dryness of mucous tissues, could not be influenced.     

常见证候荷瘤小鼠神经内分泌免疫组织基因转录的总体特征

目的揭示常见证候荷瘤小鼠神经-内分泌-免疫组织基因转录的总体特征。方法采用小鼠标准化四诊及辨证方法，及Gene Chip Mouse Exon1．0ST Array等技术，检测H22荷瘤小鼠早期邪毒壅盛（邪毒）和气虚、中期阳气虚、中晚期气阴阳虚等4个常见证候下丘脑、垂体、肾上腺、睾丸、脾脏、胸腺、肿瘤RNA的转录与剪接。结果正常昆明种雄性小鼠下丘脑、垂体、肾上腺RNA电泳的28S峰低于18S，而睾丸、脾脏、胸腺、肿瘤相反。肿瘤发生的早期，下丘脑、垂体、肾上腺基因表达模式发生显著改变，邪毒尤甚，出现了失代偿。下丘脑28SRNA迅速抬升并持续，气虚强于邪毒。垂体RNA总量降低，28S陡降，邪毒尤甚。肾上腺RNA电泳特征类似垂体，气虚与邪毒相近，中晚期气阴阳虚尤甚。睾丸变化不明显。随着病情发展，脾脏重量持续增加，而胸腺相反，重量持续下降，蛋白合成和糖代谢下降。肿瘤组织蛋白合成与糖代谢，邪毒大于气虚。以上7个组织与正常对照组相比，有9127个基因表达发生差异、51126个外显子剪接发生差异。结论神经-内分泌-免疫网络组织基因转录的差异是荷瘤小鼠不同证候内在重要的物质基础。