非洛地平联合美托洛尔治疗73例高血压患者疗效研究

目的：观察复方降尿酸合剂对高尿酸血症合并高脂血症患者血清超敏C反应蛋白（hs-CRP）及胱抑素C（Cys-C）的影响。方法：将120例高尿酸血症合并高脂血症患者随机分为治疗组（60例）和对照组（60例）,治疗组给予服用复方降尿酸合剂（15mL/次,每日3次）,对照组则服用苯溴马隆（50mg/次,每日1次）,12周后观察两组患者血尿酸（UA）、总胆固醇（TC）、甘油三酯（TG）及hs-CRP、Cys-C的水平变化情况。结果：治疗后,两组患者的UA水平均较治疗前显著下降（P〈0.01）,但下降幅度无显著性差异（P〉0.05）;治疗组治疗后的TG、TC、hs-CRP、Cys-C水平、不良反应发生率均低于对照组（P〈0.05）。结论：复方降尿酸合剂与苯溴马隆均能显著降低血尿酸水平,而复方降尿酸合剂还能较好地降低甘油三酯和总胆固醇,控制炎症反应,减轻内皮损伤,从而起到血管保护作用。     

复方降尿酸合剂对高尿酸血症合并高脂血症患者血清hs-CRP及Cys-C的影响

目的：观察复方降尿酸合剂对高尿酸血症合并高脂血症患者血清超敏C反应蛋白（hs-CRP）及胱抑素C（Cys-C）的影响。方法：将120例高尿酸血症合并高脂血症患者随机分为治疗组（60例）和对照组（60例）,治疗组给予服用复方降尿酸合剂（15mL/次,每日3次）,对照组则服用苯溴马隆（50mg/次,每日1次）,12周后观察两组患者血尿酸（UA）、总胆固醇（TC）、甘油三酯（TG）及hs-CRP、Cys-C的水平变化情况。结果：治疗后,两组患者的UA水平均较治疗前显著下降（P〈0.01）,但下降幅度无显著性差异（P〉0.05）;治疗组治疗后的TG、TC、hs-CRP、Cys-C水平、不良反应发生率均低于对照组（P〈0.05）。结论：复方降尿酸合剂与苯溴马隆均能显著降低血尿酸水平,而复方降尿酸合剂还能较好地降低甘油三酯和总胆固醇,控制炎症反应,减轻内皮损伤,从而起到血管保护作用。     

黄芪四妙散治疗高尿酸血症50例

目的：观察黄芪四妙散治疗高尿酸血症的临床疗效。方法：将入选的100例高尿酸血症患者,随机分为观察组50例、对照组50例,患者均采用常规治疗,包括适当休息,避免劳累、受寒、饮酒或进食富含嘌呤类食物,保持低脂、低糖、低盐饮食,多饮水。观察组服用黄芪四妙散煎剂,对照组服用别嘌醇片。观察两组患者血尿酸、血尿素氮、血肌酐、尿β2微球蛋白、胱抑素C等指标变化。结果：观察组可以明显降低高尿酸血症患者血尿酸、尿β2微球蛋白及血胱抑素C水平。对照组可以降低血尿酸,但对尿β2微球蛋白及血胱抑素C无作用。结论：黄芪四妙散不但可以降尿酸,还可以防治高尿酸血症对肾脏的损害,并且无毒副作用。     

益肾通络泄毒方治疗早期糖尿病肾病临床观察

目的观察益肾通络泄毒方治疗早期糖尿病肾病(DN)的临床疗效。方法选取早期DN患者64例,按随机数字表法分为2组。治疗组32例予益肾通络泄毒方治疗,对照组32例予缬沙坦胶囊治疗,2组同时给予相应基础治疗,12周后统计疗效。比较2组治疗前后中医症状评分(包括神疲乏力、气短懒言、面色白、腰背痠软、五心烦热及口干咽燥)、24 h尿蛋白定量、血肌酐(Cr)、尿素氮(BUN)、总胆固醇(TC)、甘油三酯(TG)、胱抑素C(Cys-C)及尿β_22微球蛋白(β_22-MG)水平变化情况。结果治疗组总有效率81. 3%,对照组总有效率59. 4%,治疗组疗效优于对照组(P 0. 05); 2组治疗后中医症状神疲乏力、气短懒言、面色白、腰背痠软、五心烦热、口干咽燥评分及总分与本组治疗前比较均明显降低(P 0. 05),治疗组各中医症状评分及总分改善均优于对照组(P 0. 05); 2组治疗后24 h尿蛋白定量、Cr、TC、TG、Cys-C及尿β_22-MG水平与本组治疗前比较均明显下降(P 0. 05),治疗组治疗后24 h尿蛋白定量、TC、TG、Cys-C及尿β_22-MG水平低于对照组(P 0. 05)。结论益肾通络泄毒方治疗DN疗效确切,可明显改善患者中医症状,保护肾功能,降低尿蛋白排泄,改善脂质代谢紊乱,延缓DN病情发展。     

固本泄浊方治疗无症状高尿酸血症的疗效及其对hs-CRP及血脂的影响

目的:观察固本泄浊方治疗无症状高尿酸血症患者的疗效及其对hs-CRP及血脂的影响。方法:将90例无症状高尿酸血症患者随机分成中药组、西药组、对照组,每组30例,治疗8周为1个疗程。观察3组患者治疗前后血清UA、hs-CRP、甘油三酯(TG)、胆固醇(TC)水平,及治疗前后患者及停药8周后患者血尿酸变化。结果:治疗后,中药组、西药组血尿酸水平较治疗前降低,且均低于对照组,差异均有统计学意义(P0.05),中药组与西药组比较,差异无统计学意义(P0.05)。停药8周后,中药组血尿酸水平低于西药组,差异有统计学意义(P0.05)。中药组、西药组总有效率比较,差异无统计学意义(P0.05),两组总有效率与对照组比较,差异均有统计学意义(P0.05)。停药8周后,中药组总有效率优于西药组,差异有统计学意义(P0.05)。中药组患者治疗后hs-CRP、TG、TC水平较治疗前下降,差异均有统计学意义(P0.05);西药组患者治疗后hs-CRP水平较治疗前降低,差异有统计学意义(P0.05),TG、TC水平较治疗前比较,差异均无统计学意义(P0.05);对照组患者治疗前后hsCRP、TG、TC水平比较,差异均无统计学意义(P0.05)。结论:固本泄浊方可有效降低高尿酸血症患者血尿酸水平,还能降低患者hs-CRP、TC、TG水平,减轻炎症反应。     

中西医结合治疗2型糖尿病合并高尿酸血症40例

目的:观察中西医结合治疗2型糖尿病合并高尿酸血症的临床疗效。方法:将2型糖尿病合并高尿酸血症患者80例,按1∶1比例随机分成观察组和对照组,每组40例。两组均给予常规降糖治疗及生活方式干预,观察组另给予口服益气养阴活血方加大黄、泽泻,对照组另给予口服别嘌醇,共治疗4周。检测并观察两组治疗前后血清总胆固醇(TC)、三酰甘油(TG)及空腹血糖(FBG)、血尿酸(UA)等指标变化。结果:两组TG、FBG、UA及观察组TC治疗前后比较,差异有统计学意义(P0.05,P0.01),治疗后两组TG、TC、UA比较,差异同样有统计学意义(P0.050)。结论:内服中药与别嘌醇均有降低2型糖尿病合并高尿酸血症患者血尿酸的作用,但中药降尿酸作用更加明显,且能够显著改善患者血脂水平。     

丹参酮ⅡA磺酸钠注射液对冠心病合并高尿酸血症患者血尿酸、CRP及血液流变学的影响

目的观察丹参酮ⅡA磺酸钠注射液对冠心病合并高尿酸血症患者血尿酸、C反应蛋白(CRP)及血液流变学的影响。方法将100例冠心病合并高尿酸血症患者随机分为2组,对照组50例给予苯溴马隆、辛伐他汀治疗,观察组50例在此基础上加用丹参酮ⅡA磺酸钠注射液治疗,观察2组治疗前后血尿酸、CRP、血脂、全血高切黏度、全血低切黏度、血浆黏度、血细胞比容、血小板聚集率及纤维蛋白原水平,统计2组临床疗效和不良反应发生情况。结果 2组治疗后血尿酸、CRP、TC、TG、LDL-C、全血高切黏度、全血低切黏度、血浆黏度、血细胞比容、血小板聚集率及纤维蛋白原水平均显著降低(P均0.05),HDL-C水平显著提高(P均0.05),且观察组治疗后以上指标均显著优于对照组(P均0.05);观察组治疗总有效率显著高于对照组(P0.05);2组不良反应发生率比较差异无统计学意义(P0.05)。结论丹参酮ⅡA磺酸钠注射液治疗冠心病合并高尿酸血症可有效降低尿酸和CRP水平,调节血脂水平,改善血液流变学指标,且安全。     

中医辨治痛风/高尿酸血症30例临床观察

目的:观察中西医结合治疗痛风/高尿酸血症的临床疗效。方法:将60例痛风/高尿酸血症患者随机分为2组各30例。2组均予基础治疗,对照组于急性发作期予塞来昔布治疗,缓解期予非布司他治疗,治疗组在对照组治疗的基础上急性期加用四妙丸加减治疗,缓冲期予益肾活血汤加减治疗,治疗12周后比较2组急性发作期的综合疗效及主要症状、体征及C反应蛋白(CRP)改善情况,缓解期的血尿酸(UA)、血肌酐(Scr)、血脂(TC、TG、LDL-C)、尿β2微球蛋白(β2-MG)变化情况。结果:(1)急性发作期:总有效率治疗组为86.7%,高于对照组的76.7%(P0.05);治疗组治疗前后主要症状体征积分及CRP水平均优于对照组(P0.05,P0.01);2组主要症状、体征及CRP治疗前后组内比较,差异均有统计学意义(P0.05,P0.01),但除外关节功能活动。(2)缓解期:2组治疗后UA、LDL-C、Scr均下降(P0.05,P0.01),组间比较,治疗组UA、LDL-C较对照组降低(P0.05,P0.01)。结论:中西医结合分期治疗痛风/高尿酸血症具有较好的临床疗效。     

百令胶囊联合前列地尔及银杏达莫治疗早期糖尿病肾病临床观察

目的:观察百令胶囊联合前列地尔及银杏达莫治疗早期糖尿病肾病(DN)的临床疗效。方法:选取早期DN患者80例,按随机数字表法分为观察组与对照组各40例,2组均给予血糖控制、营养支持等基础治疗,对照组在此基础上给予前列地尔加银杏达莫治疗,观察组在对照组基础上加用百令胶囊。检测2组治疗前后尿蛋白及肾功能相关指标,对比2组临床效果。结果:治疗后,2组β2微球蛋白(β2-MG)、尿蛋白排泄率(UAER)、24 h尿蛋白定量水平均较治疗前降低(P 0.05),观察组β2-MG、UAER、24 h尿蛋白定量水平均低于对照组(P 0.05)。治疗后,2组血肌酐(SCr)、尿素氮(BUN)、同型半胱氨酸(Hcy)、胱抑素C (CysC)水平均较治疗前降低(P 0.05),观察组4项指标水平均低于对照组(P 0.05)。观察组治疗总有效率92.50%,对照组治疗总有效率75.00%,2组比较,差异有统计学意义(P 0.05)。结论:百令胶囊联合前列地尔及银杏达莫治疗早期DN,可在显著减少患者尿蛋白排泄的同时改善其肾功能,临床疗效显著。     

降酸消脂方治疗无症状高尿酸血症合并高脂血症临床研究

目的：观察降酸消脂方治疗无症状高尿酸血症合并高脂血症的临床疗效。方法：将98例无症状高尿酸血症合并高脂血症患者随机分为治疗组与对照组各49例,2组均给予常规基础性治疗,治疗组口服医院协定方降酸消脂方,对照组口服别嘌醇片,4周为1个疗程。连续治疗2个疗程后,比较2组临床疗效,比较2组治疗前后中医证候积分及血尿酸、血脂、肝肾功能指标水平。结果：治疗后,治疗组总有效率89.58%,高于对照组72.92%(P<0.05)。治疗前,2组中医证候积分比较,差异无统计学意义（P>0.05）;治疗后,2组中医证候积分均降低（P<0.05）,且治疗组低于对照组（P<0.05）。治疗前,2组血尿酸、甘油三酯（TG）、总胆固醇（TC）水平比较,差异均无统计学意义（P>0.05）;治疗后,2组血尿酸水平均降低（P<0.05）,治疗组TC、TG水平降低（P<0.05）,且治疗组血尿酸、TC、TG水平均低于对照组（P<0.05）。2组治疗前后谷丙转氨酶（ALT）、尿素氮（BUN）、血肌酐（SCr）水平比较,差异均无统计学意义（P>0.05）。结论：降酸消脂方能...     

微波消解-电感耦合等离子体质谱法测定脉络宁注射液中25种矿物质元素

目的建立微波消解-电感耦合等离子体质谱(ICP-MS)直接稀释测定脉络宁注射液中25种矿物质元素(Mg、Ca、Fe、Cu、Zn、Mn、Al、B、Ba、Co、Cr、K、Li、Mo、Na、Ni、P、Pb、Sr、Th、Ti、V、As、Cd和Hg)的方法。方法分别对微波消解条件和测试条件进行考察;样品经微波消解后,采用电感耦合质谱仪测定25种矿物质元素,并对测定方法学进行考察。结果确定最佳消解条件为3步缓慢升温:400 W 80℃升温10 min,保留5 min;600 W 120℃升温10 min,保留5 min;900 W 200℃升温20 min,保留20 min;25种矿物质元素在各自的线性范围内线性关系良好,r≥0.999 6,精密度、稳定性和重复性试验的RSD均符合定量分析要求;加标回收率为94.7%~106.1%,RSD在0.34%~2.79%。脉络宁注射液中检测出Mg、Ca、Fe、Cu、Zn、Mn、Al、B、Ba、Co、Cr、K、Li、Mo、Na、Ni、P、Pb、Sr、Th、Ti、V,未检出As、Cd和Hg。结论该方法简便、迅速、准确,适用于脉络宁注射液中25种矿物质元素的同时测定。     

Die Lateralität und Lateralitätsinstabilität in der Diagnostik und Therapie

The disturbance and instability of laterality are obstacles to diagnostics and therapy. Correction prior to starting therapy is required. They also predispose toward defined health problems and unspecific diseases. Numerous research activities provide evidence of the relevance of undisturbed laterality in diagnostics and therapy. Techniques of testing and therapeutic corrections will allow for optimized therapy success.     

Yerba Mate or Paraguay Tea

正Beverages based on Ilex paraguariensis A.St.-Hil.are used in the south Brazil and other Latin American countries located at the so-called southern cone.It is known as chimarro or mate in south and southeast Brazil,tererêin     

Journal of Acupuncture and Tuina Science Instructions for Authors

The Journal of Acupuncture and Tuina Science, a journal with an international scope （IS SN 1672-3597, CN 31-1908/R, Bimonthly）, is embodied by ＇Springer Verlag＇ Database, Index Copernicus （IC） and Chinese Scientific and Technical Paper and Citations Data （CSTPCD）. You can search full text on http：//www, springerlink, com/content/1672 -3597.     

Ethnopharmacologic study of chinese rhubarb

This paper deals with an interdisciplinary study covering historic, botanical, phytochemical, pharmacological and clinical aspects of rhubarb and related species, to lay stress on the correlation between plant phylogeny, chemical constituents and purgative activity.

It was found that the official rhubarbs were exclusively restricted in the Sect. Palmata e.g. Rheum palmatum R. palmatum var. tanguticum R. officinale; the following criteria may serve as their standard, viz., the presence of sennoside derivatives and rhein, the occurrence of the reduced form of rhein and aloe-emodin, the leaves with any kind of palmate incision. Comprehensive multivariate analyses showed that there is a very close relationship between the leaf incision, existence of sennosides or rhein and purgative activity.     

基于ICP-MS法的加味左金丸中无机元素分析

目的 通过电感耦合等离子体质谱（inductively coupled plasma mass spectrometry,ICP-MS）法建立加味左金丸中Cd、Pb、As、Hg、Co、V、Ni、Cu、Li、Sb、Ba、Mo、Sn、Cr、Na、Mg、Al、Ca、Ti、Mn、Fe、Zn、Ga、Se、Sr、Tl共计26种无机元素的测定方法。方法 加味左金丸通过微波消解法处理后,根据相对分子质量的大小选择内标物,其中⁷Li、²³Na、²⁴Mg、²⁷Al、⁴⁰Ca、⁴⁸Ti、⁵¹V、⁵²Cr、⁵⁵Mn、⁵⁶Fe、⁵⁸Ni、⁵⁹Co、⁶³Cu、⁶⁶Zn、⁷⁰Ga、⁷⁵As、⁷⁷Se、⁸⁶Sr以⁷²Ge作为内标;⁹⁵Mo、¹¹⁴Cd、¹¹⁸Sn、¹²¹Sb、¹³⁷Ba以¹¹⁵In作为内标;²⁰²Hg、²⁰⁵Tl、²⁰⁸Pb以²⁰⁹Bi作为内标。对标准品溶液、空白溶液与供试品溶液进行分析,采用标准曲线法进行定量分析。通过ICP-MS法进行测定。结果 26种无机元素线性的相关系数r ≥ 0.999 6,检出限为0.001~1.500μg/L,定量限为0.01~5.00 μg/L,精密度与重复性试验的RSD均小于5%,平均回收率在82.64%~106.44%,RSD均小于5%。对3个厂家的12批样品进行了测定,26种元素的含量差异较大,其中Na、Mg、Ca、Fe 4种元素的含量比较高,均大于500 μg/g,Cd、Pb、As、Hg、Co、Li、Sb、Mo、Sn、Cr、Se、Tl的含量比较低,均小于1 μg/g。由结果可知,人体的常量元素,如Na、Mg、Ca的含量比较高,Cd、Pb、As、Hg等有害元素含量比较低。根据《中国药典》2020年版一部的要求,本品中Cd、Pb、As、Hg与Cu均符合规定。结论 该方法快速、准确,可以用于加味左金丸中无机元素的测定。     

Wirksamkeit der Akupunktur bei der Therapie von idiopathischen Schmeckstörungen: Eine randomisierte Placebo-kontrollierte Studie

Background

At present, the state-of-the-art medication in treating idiopathic taste disorder (gustatory dysfunction) is zinc. If zinc medication was unsuccessful, not tolerated or if it is contraindicated the persons affected can hardly be helped.

Objectives

In a randomized placebo-controlled clinical trial an attempt was made to determine the efficacy of acupuncture.

Methods

The treatment group was treated with acupuncture needles, the placebo group with an inactive acupuncture-laser. Endpoints of the study were changes in the taste test, the quality of life and the severity of symptoms of depression (BDI) as well as mood changes (ZMS). Satisfaction with the success of the respective therapy was also evaluated. Data were collected before and after therapy and again for the treatment group 10 weeks after completion of the treatment period.

Findings

Treatment with real acupuncture showed a significant improvement in gustatory function as well as a significant improvement in psychological symptoms. Greater satisfaction with the treatment results was evident in the treatment group. The treatment results of acupuncture remained stable over a period of ten weeks after completion of the treatment.

Conclusion

Acupuncture was effective in the therapy of idiopathic taste disorders and therefore it is an effective alternative when zinc medication is not tolerated or unsuccessful. But it is also suitable as a therapy of first choice. Acupuncture can be considered as an extension of the therapeutic spectrum in the difficult treatment of taste disorders.     

Erstaunliches Ergebnis einer Schädelakupunktur nach Yamamoto bei Hemihypsarrhythmie rechts

A girl, three and a half years old at the respective date, premature in 25th week of gestation, had been presented. On day three after birth, she had had a IVH III° right and left with severe involvement of parenchyma and other multiple complications, e. a. infant respiratory distress syndrome up to the 42nd day postpartum, and epileptic attacks with apnoeic events.     

Veränderungen der Herzratenvariabilität (HRV) während Low Level Lasernadelakupunktur: Placebokontrollierte Studie an 19 herzgesunden Probanden

Background

Experimental and clinical studies postulate a neurobiological mechanism of acupuncture by modulating central pain systems, neurohormones and -transmitters. It seems to be quite likely that the autonomic nervous system (ANS) plays an important mediating role in this neuromodulation.

Aim

In measuring heart rate variability (HRV), as a non-invasive approach to the ANS-function, the object of this study was to monitor probable acupuncture-induced changes of autonomic balance. The innovative technology of laser-needle acupuncture offers for the first time a stimulation method which fulfils the demands on a placebo-controlled acupuncture trial not requiring controversial sham acupuncture.

Method

19 healthy voluntary subjects underwent 3 treatments in randomized sequence, consisting of placebo-, 1-point- (PC 6) and simultaneous 3-point- (PC 6, LR 3, SI 3) laser-needle-stimulation over 20 minutes. Before, during and after placebo-/verum laser-needle acupuncture, HRV-data for normalized HF(high frequency)- and LF(low frequency)-Power (nHF, nLF) and their quotient nLF/nHF obtained by power spectrum analysis (FFT), were measured and analyzed statistically at 5 different time points (ANOVA repeated measures, p < 0,05).

Results

During both verum applications, the 1-point- (PC 6) as well as the simultaneous 3-point- (PC 6, LR 3, SI 3) laser-needle stimulation, significant changes of the ANS-activity were found in comparison to the placebo application. The most significant modification of HRV was an increase of nHF (p < 0,05 (PC 6), p < 0,0001 (PC 6, LR 3, SI 3)) as an expression of growing vagal activity during acupuncture.

Conclusion

Laser-needle acupuncture causes in 1-point-stimulation (PC 6) as well as in simultaneous 3-point-stimulation (PC 6, LR 3, SI 3) significant changes in HRV in comparison to placebo application. HRV-monitoring seems to be a suitable approach in exploration of acupuncture-induced changes of ANS and could possibly be established in combination with laser needle acupuncture as a standard for further scientific and clinical acupuncture investigations which are greatly needed.