首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到10条相似文献,搜索用时 109 毫秒
1.
红花妊娠毒性选择性表达的实验研究   总被引:1,自引:0,他引:1  
赵云龙  冯蓓  周宜  张静 《辽宁中医杂志》2011,(11):2274-2276
目的:通过研究红花的毒性作用对不同机能状态下的妊娠大鼠的选择性,探讨中药的毒性作用在机体不同机能状态下具有特异的选择性。方法:用含生药2g/kg的红花煎剂分别给正常妊娠大鼠(红花组)和外伤血瘀妊娠大鼠(红花治疗组)灌胃,观察红花煎液分别对两组大鼠妊娠和胚胎发育的影响。结果:与空白组比较,红花组生产数明显减少(P<0.001),妊娠时间延长(P<0.05),完全流产率高达25%,胚胎未成形率为35%,母体体重增长缓慢(P<0.05),肝重指数及肾重指数均有所增高,胚胎宫内生长迟缓率(IUGR)高达100%;而红花治疗组在妊娠和胎儿的各项指标上均接近于空白组。结论:红花仅对正常孕鼠表现为毒性作用,说明红花的妊娠毒性在机体处于不同机能状态下具有选择性。  相似文献   

2.
The aqueous extract from the leaves of Ocimum suave was evaluated for acute and sub chronic toxicity and teratogenic effects. Swiss mice were administered single oral doses of 2000, 4000, 6000 and 8000 mg/kg and monitored for death and body weight gained for 7 days (acute toxicity). In sub-acute toxicity, experimental rats, received daily doses of 250, 500 and 1000 mg/kg for 42 consecutive days and the toxic effects were assessed using biochemical and haematological data and histology of vital organs. In a teratogenic study, 1-day pregnant rats were administered orally 500 and 1000 mg/kg of extract daily for 21 consecutive days and 14th day corpora lutea and foetal implants and litter size at birth were noted. Reproductive performance of F(1) generation rats was studied by crossing them at maturity and recording the number, birth weight and physical presentation of the young offspring. Acute intake of extract up to 8000 mg/kg did not produce mortality or significant changes in general behaviour. Sub chronic treatment did not show any change in body and organ weights, feeding habits or behaviour between the control and the treated groups of both sexes. Haematological analysis and blood biochemistry revealed no toxicity effects of the extract. No gross abnormalities or histological changes were observed. Teratogenic and fertility studies did not reveal any toxic manifestations or foetal abnormalities. The leaf aqueous extract of Ocimum suave is non toxic in acute and sub chronic intake.  相似文献   

3.
Podophyllum hexandrum has been shown to mitigate radiation injuries and especially the haemopoietic syndrome in adult mice. To monitor the radiation-induced changes in the nervous system, the neurons of postnatal young mice and their modification by P. hexandrum, were studied histologically for differences in the apical and basal dendritic branching and intersections in the CA1 neurons of the hippocampal region of rats which were delivered a 2 Gy gamma dose while in utero (day 17 of gestation). Irradiation significantly reduced the dendritic branching and intersections but pre-irradiation administration of the extract of P. hexandrum (i.p. 200 mg/kg/b.w., 2 h) reduced the damage in postnatal young mice. These studies indicate that P. hexandrum provides protection to neurons against radiation-induced damage and the mechanism of neuronal damage and its repair need to be investigated further.  相似文献   

4.
The effects of gossypol acetic on pregnancy, embryofoetal development and on some selected parameters of immunological response in mice were studied. Daily intragastric administration of gossypol (50 or 75 mg/kg/day) during day 1-15 of gestation in mice produced a dose-dependent embryocidal effect (37.8% and 94.5% respectively) of non-viable foetuses. There was a significant reduction in foetal bodyweight when pregnant mice were treated with gossypol, although no foetal abnormalities were observed. Lymphocyte transformation induced by mitogen concanavalin A, was not inhibited by pretreatment with gossypol (25, 50 or 75 mg/kg/day) for 10 weeks. However, both plaque-forming cells to sheep red blood cell immunisation and the total spleen cell population were significantly depressed by higher doses (50 or 75 mg/kg/day) of gossypol. The results of the present study indicate that gossypol is not teratogenic, but exerts embryocidal and a selective depression on humoral immune response at high dose levels (50 or 75 mg/kg/day). It is not clear, whether the dose-dependent embryocidal and/or immunodepressive effects of gossypol are mediated by the parent compound or its metabolites, or whether these findings have any clinical relevance.  相似文献   

5.
宋金春  刘红  刘薇芝 《中国药学杂志》2006,41(15):1136-1137
 目的以指纹图谱的方式,研究当归(A)、川芎(B)、红花(C)不同组合方式提取物中化学成分的差异。方法将方药组合成5组(ABC、AB+C、AC+B、BC+A、A+B+C)进行提取,并用RP-HPLC法进行分析,比较其色谱指纹图谱。结果5种组合提取液中化学成分组成存在差异,ABC合煎提取物中主要化学成分的提取率大于其他各组的提取物,且5种组合的化学成分组成比例的差异较大。结论当归、川芎、红花不同组合提取物中主要化学成分组成及其共有成分比例存在差异,3味药合煎成分煎出较完全。  相似文献   

6.
中西医结合治疗冠心病不稳定型心绞痛疗效观察   总被引:2,自引:0,他引:2  
目的:观察在常规西医治疗的基础上联合运用黄芪、红花注射液治疗冠心病不稳定型心绞痛的临床疗效,并探讨其作用机理。方法:将76例冠心病不稳定型心绞痛患者随机分为两组。对照纽36例,采用西医常规治疗;治疗组40例,在西医常规治疗的基础上给予黄芪注射液、红花注射液治疗2个疗程。结果:治疗组显效13例,有效24例,无效3例,总有效率为92.5%(95%CI=79.3%~98.4%);对照组显效3例,有效23例,无效10例,总有效率为72.2%(95%CI=54.8%-85.8%);两组心绞痛综合疗效比较(u=2.7187,P=0.0082),差异有统计学意义;心电图变化综合疗效比较(u=2.1110,P=0.0351),差异亦有统计学意义。结论:黄芪、红花注射液联合西医常规治疗冠心病不稳定型心绞痛疗效优于单纯西医治疗,其心绞痛疗效收益为OR=0.21(95%CI:0.05—0.84),NNT:5(95%CI=2.69~30.12);其心电图疗效收益为OR=0.43(95%CI=0.17—1.09),NNT=5(95%CI=2.35—56.21)。  相似文献   

7.
红花等10种中药的植物雌激素活性研究   总被引:26,自引:2,他引:26  
目的:评价红花、川牛膝、丹参、女贞子、枸杞、甘草、肉苁蓉、淫羊藿、补骨脂、菟丝子等10味中药的植物雌激素活性。方法:选用昆明种雌性乳鼠,随机分为A,B二组:A组又分为12组(溶剂对照组、己烯雌酚组和10个中药组);B组也分为12组(溶剂对照组、己烯雌酚组和10个中药拮抗组),其中中药拮抗组每天同时灌胃中药和己烯雌酚;各组给药4 d后分离血清。利用雌激素受体(ER)阳性MCF-7细胞,以MTT法检测中药含药血清对细胞增殖的影响。结果:A组中,红花、川牛膝、丹参、枸杞、肉苁蓉、淫羊藿、补骨脂和菟丝子等中药含药血清可显著促进MCF-7细胞增殖;而女贞子组可见细胞增殖受到明显抑制。B组中,红花、川牛膝、丹参、甘草、淫羊藿、补骨脂和菟丝子组可见己烯雌酚促细胞增殖的作用受到了显著抑制;而肉苁蓉可协同并显著增强己烯雌酚促细胞增殖的作用。结论:红花、川牛膝、丹参、淫羊藿、补骨脂、菟丝子等6种中药在单独用药时具有拟雌激素作用,在与雌激素同时用药时具有抗雌激素作用,其双向调节效应依赖于体内雌激素水平的高低。  相似文献   

8.
The purpose of this study was to characterize the putative anxiolytic-like effects of the aqueous extract of hooks with stem of Uncaria rhynchophylla using the elevated plus maze (EPM) and the hole-board apparatus in rats and mice. Control rats were treated with an equal volume of saline, and positive control rats with buspirone (1 mg/kg). Single or repeated treatments of the aqueous extract of Uncaria rhynchophylla (200 mg/kg/day, p.o.) for 7 days significantly increased the time-spent and entries into open arms of the EPM, and reduced the time-spent and entries into the closed arms versus saline controls (P<0.05). However, no changes in spontaneous locomotor activity or myorelaxant effects were observed versus saline controls. In the hole-board test, repeated treatment with the aqueous extract of Uncaria rhynchophylla (100 or 200 mg/kg/day, p.o.) significantly increased the number of head-dips (P<0.05). In addition, the anxiolytic-like effects of Uncaria rhynchophylla extract as assessed using the EPM test were abolished by WAY 100635 (0.3 mg/kg, i.p.), a 5-HT(1A) receptor antagonist. These results suggest that Uncaria rhynchophylla is an effective anxiolytic agent, and acts via the serotonergic nervous system.  相似文献   

9.
The aim of the present investigation was determine whether a standardized Hibiscus sabdariffa calyces aqueous extract has an effect on body weight in an obese animal model induced by the administration of monosodium glutamate. Hibiscus sabdariffa aqueous extract, containing 33.64 mg of total anthocyanins per each 120 mg of extract, was orally administered (120 mg/kg/day) for 60 days to healthy and obese mice, and body weight gain, food and liquid intake, aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholesterol, and triglycerides levels were measured. Hibiscus sabdariffa administration significantly reduced body weight gain in obese mice and increased liquid intake in healthy and obese mice. ALT levels were significantly increased on the 15th and 45th days in obese mice, but AST levels did not show significant changes. Mortality was not observed in the Hibiscus sabdariffa treated groups. Triglycerides and cholesterol levels showed non-significant reductions in animals treated with Hibiscus sabdariffa. Our data confirm the anti-obesity effect of Hibiscus sabdariffa reported by the Mexican population.  相似文献   

10.
The anti-amoebic effects of crude methanol extracts of Piper longum fruit, Piper sarmentosum root and Quercus infectoria nut gall against Entamoeba histolytica infecting the caecum of mice were studied. Caecal amoebiasis in mice was induced by injection of Entamoeba histolytica trophozoites directly into the caecum. The mice were then treated orally with the extract, a standard drug (metronidazole), or vehicle p.o. for five consecutive days, beginning 24 h after the infection and were examined on the sixth day. At a dose of 1000 mg/kg per day, the extracts of Piper longum fruit, Piper sarmentosum root and Quercus infectoria nut gall had a curative rate of 100, 40 and 26%, respectively. At a concentration of 500 and 250 mg/kg/day, extract from Piper longum fruit was still effective in 93 and 46% of the cases, respectively, while extract from Piper sarmentosum root at a dose of less than 1000 mg/kg per day did not cure any mice from amoebiasis. Extract of Quercus infectoria nut gall at a concentration of 500 and of 250 mg/kg per day cured 26 and 13% of mice, respectively. Metronidazole at a concentration of 125 and of 62.5 mg/kg per day had a curative rate of 100 and 60%, respectively. The severity of caecal wall ulceration was reduced in mice which received the extract and metronidazole as compared to the control animals.  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号