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麻杏石甘汤出自《伤寒论》,是辛凉重剂的经典方,方由麻黄、杏仁、炙甘草、石膏、细茶组成。功能宣肺定喘。以发热、咳喘为辨证要点。笔者应用麻杏石甘汤加入臭灵丹、鱼腥草、黄芩、浙贝母组成灵丹麻石汤,治疗小儿肺热咳嗽,疗效满意,现总结如下。 相似文献
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常见胃溃疡模型小鼠胃组织病理变化及差异 总被引:1,自引:0,他引:1
目的观察常见胃溃疡模型小鼠胃的组织病理变化,评价和比较各模型.方法以昆明小鼠为实验对象,选取水浸拘束、乙酸、磷酸组胺、消炎痛、利血平、乙醇等6种方法,同步制作胃溃疡模型,并设置正常、禁食、假手术等对照组.在造模当天(第1天)及第8天取胃组织作病理组织学观察.结果禁食、水浸拘束、假手术等造模当日,小鼠胃出现明显的病理变化,第8天基本消失,持续时间短;消炎痛、利血平、乙醇造模当日,小鼠胃出现明显的病理变化,至第8天其病理改变仍未完全消失;磷酸组胺病变程度轻且易于恢复;乙酸造模对动物损伤重,易致死亡.以上病理变化,大多为黏膜局部或弥漫性炎症、水肿、出血,或黏膜萎缩、坏死和脱落,属急性胃炎或部分急性胃溃疡性质.结论水浸拘束、消炎痛、利血平、乙醇等造模成模率高,假手术、禁食次之,而磷酸组胺和乙酸造模似不宜作为小鼠常规胃溃疡模型. 相似文献
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Dong-li Qi Xiao-lin Yang Jing Chen Fei Li Pei-pei Zhou Ping Chene Li Yang Ru-feng Wangb 《中草药(英文版)》2021,13(1):43-48
Objective: The chemical finger printing-based methods for evaluating TCMs quality can report partial of TCMs quality without linking to effective constituents. In this study, a mathematical model was established for the quality evaluation of total saponins of Panax japonicus(TSPJ), a folk medicine in China and Japan for treating diseases, through coupling the dynamic changes of chemical constitutions with corresponding activities.Methods: High-performance liquid chromatography(HPLC) fingerprints were applied to establish the chromatographic database of TSPJ. The associated hypolipidemic activity database was determined by TG assay using Hep G2 cell model. Correlation analyses of two databases were performed by partial least squares(PLS) for calculating regression coefficients, and the interval value of YZL value(the ratio of positive and negative peak-to-peak area coefficient) closely related to hypolipidemic activity was refined by the formula of Norminv function to value the quality of TSPJ.Results: In this study, the chromatographic data of 16 common peaks were obtained from 20 batches of TSPJ. After the estimate by this mathematical evaluation model, seven peaks were positively correlated with hypolipidemic activity, and nine peaks were negatively correlated with hypolipidemic activity.When the YZL value was less than 0.7861, the quality of sample was inferior, while YZL value was more than 6.6992, and the quality of samples was superior. The quality of another ten batches of TSPJ was further assessed to verify this method.Conclusion: These results indicated that the established model could be usefully applied to evaluate the quality of TSPJ in the hypolipidemic activity. 相似文献
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血府逐瘀汤出自清代医家王清任的<医林改错>一书.全方由当归、生地、桃仁、红花、枳壳、赤芍、柴胡、桔梗、川芎、牛膝、甘草共11味药组成.主治胸中血瘀,胸痛、头痛日久不愈,痛如针刺而有定处,或呃逆日久不止,或内热烦闷,心悸失眠等症.笔者临床应用血府逐瘀汤加减治疗由血瘀引起各种病症,均获良效,现介绍如下. 相似文献