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1.
The present study investigates the effect of oral administration of the aqueous extract of Rubus fructicosis L. (RF) and Globularia alypum L. (GA) leaves on blood glucose levels in normal and streptozotocin (STZ) diabetic rats. In normal rats, single and repeated oral administration of RF lowered significantly the blood glucose levels, while, GA treatment did not change blood glucose levels. In STZ rats, single and repeated oral administration of both RF and GA produced significant decrease of blood glucose levels. RF and GA treatments did not affect insulin secretion both in normal and STZ rats, indicating that mechanism(s) by which these plants decrease blood glucose levels is extra-pancreatic at least, for the doses used. In addition, the acute toxicity study revealed that the aqueous extracts may be considered relatively safe since that the LD(50) value was over 8.1 and 14.5 g/kg for RF and GA respectively. These findings indicate that RF and GA represent an effective blood glucose lowering and a potential source for discovery of new orally active component(s) for future therapy.  相似文献   

2.
The antihyperglycemic effect of the Antidiabetis herbal preparation ((Myrtilli folium (Vaccinium myrtillus L.), Taraxaci radix (Taraxacum officinale Web.), Cichorii radix (Cichorium intybus L.), Juniperi fructus (Juniperus communis L.), Centaurii herba (Centaurium umbellatum Gilib.), Phaseoli pericarpium (Phaseolus vulgaris), Millefollii herba (Achillea millefolium L.), Morii folium (Morus nigra L.), Valeriane radix (Valleriana officinalis L.), Urticae herba et radix (Urtica dioica L.)), patent No. P-9801091 Zagreb, Croatia was investigated. Two extracts were prepared: ethanol extract (extract 1), and ethanol extract from which ethanol was evaporated on a rotatory evaporator at a temperature of 45 degrees C (extract 2). Extract 1 and extract 2 were administered (in experiment 1) to alloxan-induced non-obese diabetic (NOD) mice in the same dose of 20 mg/kg. Blood glucose was determined before, and 10, 30, 60 and 120 min after the preparation administration. Extract 1 and extract 2 decreased the level of blood glucose by 10 and 20%, respectively, of the initial value (at 0 min, mean = 22.6 +/- 8.3 mmol/l). Serum levels of glucose and fructosamine were determined in NOD mice, NOD mice administered extract 2 in a dose of 20 mg/kg of extract 2, and NOD mice administered acarbose in a dose of 25 mg/100 g chow, in order to verify the hypoglycemic action of extract 2 (in experiment 2). Extract 2 and acarbose were admixed to the chow. The duration of treatment was 7 days. Significantly lower glucose (P < 0.05) and fructosamine (P < 0.001) levels were recorded in extract 2 treated NOD mice as compared with NOD mice. Study results showed extract 2 to significantly decrease the level of glucose and fructosamine in alloxan induced NOD mice. Our future studies will be focused on the search of active principles of the extracts.  相似文献   

3.
Ethanolic and aqueous extracts from five plant species used in Turkish traditional medicine were evaluated for in vivo hypercholesterolaemic and antioxidant activities: Agrostemma githago L., Potentilla reptans L., Thymbra spicata var. spicata L., Urtica dioica L. and Viscum album var. album L. We assayed the effects of the administration of plant extracts on serum total cholesterol, triglyceride, HDL-C, LDL-C, glucose, AST and ALT concentrations in mice fed with cholesterol-rich diet. In addition, plasma TAA, MDA and NO(x) levels in the same animals were assayed. All the aqueous plant extracts did not affect the serum cholesterol concentration. However, the ethanolic extracts of Agrostemma githago, Thymbra spicata and Viscum album decreased the serum cholesterol concentration in the mice fed with high-cholesterol diet without inducing any gastric damage. The ethanolic extracts of Thymbra spicata, Viscum album, Potentilla reptans and Urtica dioica and the aqueous extract of Agrostemma githago increased the serum HDL concentration, whereas the ethanolic extracts of Agrostemma githago, Thymbra spicata, Viscum album and Urtica dioica decreased the serum LDL-C concentration. Thymbra spicata and Viscum album were observed to decrease the serum triglyceride concentration. Among the plant extracts studied, the ethanolic extracts of Thymbra spicata significantly decreased the MDA level in mice. The ethanolic extract of Potentilla reptans increased in NO(x). None of these plants showed statistically prominent activity on plasma TAA. Results of the present study indicated that the ethanolic extracts of Agrostemma githago, Thymbra spicata and Viscum album showed potent hypocholesterolaemic activity in the mice fed with a diet containing high-cholesterol.  相似文献   

4.
The aqueous leaf extract of Vernonia amygdalina, Del, (Compositae) given i.p. produced a dose-related fall in blood sugar. A dose of 80 mg/kg body weight of adult rabbit produced a maximum lowering of blood sugar in both fasted normal and alloxanized rabbits. The fasting blood sugar in normoglycaemic rabbits was reduced from 96 mg% to 48 mg% in 4 h. In alloxanized rabbits, the blood sugar was reduced from the mean value of 520 mg% to 300 mg% in 8 h. The hypoglycaemic effects were compared with those of tolbutamide. Acute toxicity studies of the extract in mice gave LD50 value of 1122 mg/kg body weight when given i.p. The blood sugar lowering effect of Vernonia amygdalina extract may involve a mechanism not related to insulin secretion.  相似文献   

5.
魔芋低聚糖对小鼠血糖含量和抗氧化能力的影响   总被引:34,自引:0,他引:34  
杨艳燕  李小明  李顺意  高尚  倪红 《中草药》2001,32(2):142-143
目的:研究魔芋低聚糖对小鼠血糖含量及抗氧化能力的影响。方法分别用5%、15%的葡萄糖溶液和同样匠魔芋低聚糖溶液为小鼠ig,取血样测定多项生化指标。结果高浓度葡萄糖可使小鼠血糖含量增高,而同样浓度的魔芋低聚糖未使血糖含量发生明显变化,即使小鼠体内超氧化物歧化酶(SOD)活性明显升高,同时降低了过氧化脂质(LPO)水平。结论魔芋低聚糖不升高血糖,且能提高机体抗氧化能力。  相似文献   

6.
A study was undertaken to evaluate the antihyperglycemic activity of aqueous extract of bark of Garuga pinnata Roxb. (Burseraceae). The various parameters studied included fasting blood sugar levels, serum lipid levels, liver glycogen content, serum insulin level and glycated hemoglobin in diabetic and normal rats. Streptozotocin-nicotinamide was used to induce type-II diabetes mellitus. Treatment with the extract at two dose levels showed a significant increase in the liver glycogen and serum insulin level and a significant decrease in fasting blood glucose and glycated hemoglobin levels. The total cholesterol and serum triglycerides levels were also significantly reduced and the HDL cholesterol levels were significantly increased upon treatment with the extract thus proving the potent antidiabetic property of the plant.  相似文献   

7.
This study was performed on anaesthetized male Wistar rats that received a continuous intravenous perfusion during 1.25 h of an aqueous extract of aerial parts of Urtica dioica L. (Urticaceae) at a low dose of 4 mg/kg/h or at a high dose of 24 mg/kg/h, or furosemide (control diuretic) at a dose of 2 mg/kg/h. As compared with a control period in each rat, the arterial blood pressure was reduced proportionally to the dose of the perfusion of the plant extract (15 and 38%, P<0.001, respectively). These effects were accompanied by a correlative increase of diuresis (11 and 84%, P<0. 001, respectively) and natriuresis (28 and 143%, P<0.001, respectively). In the rats perfused by furosemide, the arterial blood pressure was reduced by 28% (P<0.001). The diuresis and natriuresis were also increased proportionally in this case (85 and 155%, P<0.001, respectively). Nevertheless, the hypotensive action of U. dioica was reversible during the recovery periods in about 1 h with the lower dose of the plant extract and furosemide, while the effect of the higher dose was persistent, indicating a possible toxic effect. In conclusion, the results demonstrate an acute hypotensive action of U. dioica that indicates a direct effect on the cardiovascular system. Moreover, diuretic and natriuretic effects were also observed, suggesting an action on the renal function. Finally, the plant extract seems to have a toxic effect at the higher dose.  相似文献   

8.
The purpose of this study was to evaluate the pancreatic beta cell protective and glucose uptake enhancing effect of the water extract of Tinospora cordifolia stem (TCSE) by using rat insulinoma (RIN)‐m5F cells and 3 T3‐L1 adipocytes. RIN‐m5F cells were stimulated with interleukin‐1β and interferon‐γ, and the effect of TCSE on insulin secretion and cytokine‐induced toxicity was measured by ELISA and MTT assay, respectively. The glucose uptake and protein expression were measured by fluorometry and western blotting. Antidiabetic effect of TCSE was measured using streptozotocin‐induced diabetic rats. TCSE dose dependently increased cell viability and insulin secretion in RIN‐m5F cells. In addition, TCSE increased both the glucose uptake and glucose transporter 4 translocation in 3 T3‐L1 adipocytes via PI3K pathway. Finally, TCSE significantly lowered blood glucose and diet intake and increased body weight in streptozotocin‐induced diabetic rats. The level of serum insulin and hepatic glycogen was increased, whereas the level of serum triglyceride, total cholesterol, dipeptidyl peptidase‐4, and thiobarbituric acid reactive substances was decreased in TCSE‐administered rats. TCSE also increased glucose transporter 4 protein expression in the adipose tissue and liver of TCSE‐fed diabetic rats. Our results suggested that TCSE preserved RIN‐m5F cells from cytokine‐induced toxicity and enhanced glucose uptake in 3 T3‐L1 adipocytes, which may regulate glucose metabolism in diabetic rats.  相似文献   

9.
The immunomodulatory and antiinflammatory activities of aqueous Urtica dioica extract were investigated for their effect on the mitogenic response of murine splenocytes and nitric oxide production by murine peritoneal macrophages in vitro. It was found that this extract stimulated the proliferation of T-lymphocytes and suppressed NO production in lipopolysaccharide-stimulated macrophages without affecting cell viability.  相似文献   

10.
羊栖菜提取物的降血糖作用研究   总被引:1,自引:0,他引:1  
目的研究羊栖菜提取物对正常及四氧嘧啶所致糖尿病小鼠血糖的影响。方法用四氧嘧啶糖尿病小鼠为模型,以血糖、糖耐量为指标研究羊栖菜提取物的降血糖作用。结果羊栖菜提取物对正常小鼠无降血糖作用;预防性给予羊栖菜粗多糖(350,700 mg.kg-1)后,四氧嘧啶糖尿病小鼠血糖显著降低;羊栖菜粗多糖和醇提物(700 mg.kg-1)有治疗作用,能明显降低糖尿病小鼠血糖水平;对正常小鼠和糖尿病小鼠糖耐量无明显改善。结论羊栖菜提取物对四氧嘧啶糖尿病小鼠具有防治作用。  相似文献   

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