ACUPUNCTURE TREATMENT ON 40 CASES OF IRRITABLE COLON SYNDROME ACCORDING TO DIFFERENTIATION OF SYMPTOMS AND SIGNS

Irritable intestinal tract syndrome was classified and treated with acupuncture according to differentiation of symptoms and signs.Of the 40 cases treated,28 were cured,11 improved,and 6 ineffective.The total effective rate was 85％.The syndrome was classified into fourtypes:weakness of the spleen and stomach,disharmony of the liver spleen,Yang deficiency ofthe spleen and kidney,and retention of dampness and heat.There was no statistically significant difference in therapeutic effects among the four types of syndromes.However,the curative effect in theacupuncture group was better than that in the medication group,and the difference was of statisticalsignificance.     

Curative Effect observation on tuina therapy for spleen-deficiency infantile diarrhea

Objective: To observe the clinical effect of tuina for spleen deficiency infantile diarrhea. Methods: A total of 60 cases were randomized into a treatment group and a control group (30 in each group). Tuina manipulations were employed in the treatment group, whereas medication was administered in the control group. The between-group clinical effects were compared after one course of treatment. Results: The recovery rate was 20.0% in the treatment group, versus 3.3% in the control group, showing a statistical significance (P<0.05). After treatment, there were between-group statistical differences (P<0.05) in infants’ main accompanying symptoms such as complexion, spirit, vomiting, and abdominal pain. Conclusion: Tuina is effective for infantile diarrhea due to spleen deficiency.     

温针灸夹脊穴治疗抑郁症疗效观察及对患者脑电α波的影响

Objective To discuss the therapeutic effect and mechanism of warming needling technique for the treatment of depression. Methods A total of 60 patients with depression were randomly divided into treatment group and control group with 30 cases each, The treatment group was treated with warming needle technique on the Jiaji points of the heart, lung, liver, spleen and kidney, control group with Amitriptyline, HAMD scale and the qualitative change of EEG-α wave were observed before and after the treatment. Results The total effective rate of treatment group was 100 %, much better than that of the control group with 80% （P〈0.05）; the HAMD scale of treatment group was better than that of control group （P〈0.05）; the comparison of the improvement of somatic symptoms between treatment group and control group was significant （P〈0. 05）; the comparison of frequency and amplitude of EEG-α wave was significant （P〈0. 05）, there was no toxic and side effect in the treatment group. Conclusion Warming needling technique for depression has better effect than Amitriptyline, and there was no toxic and side effect in the treatment group. Warming needle technique can effectively regulate the frequency and amplitude EEG-α wave, and acts to improve depressive condition.     

Curative effect of warming kidney and fortifying spleen recipe on di- arrhea-predominant irritable bowel syndrome

OBJECTIVE： To observe the curative effect of a recipe for warming the kidney and fortifying the spleen on diarrhea-predominant irritable bowel syndrome（IBS-D）.METHODS： This multi-center, double-blind, randomized, and controlled trial included 240 patients that met the inclusion criterion and were then divided into two groups of 120. Patients in the treatment group（group A） took modified Sishen Wan orally for warming the kidney and fortifying the spleen and patients in the control group（group B）took a placebo, Chao Maiya, for 4 weeks. 28 days after withdrawal, there was a 6-month follow-up to observe patient recurrence condition. The total effective rate, curative effect, and recurrence rate were evaluated after treatment.RESULTS： There was statistical difference（P0.01）between the two groups in total effective rate（92.24% in the treatment group and 49.07% in the control group）, in curative effect of TCM syndrome（90.52% and 47.22%, respectively）, and in the recurrence rate（15.79% and 56.86%, respectively） within6 months after treatment.CONCLUSION： Modified Sishen Wan, for warming the kidney and fortifying the spleen, can effectively treat IBS-D and better control its recurrence.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

Objective： To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. Methods： 92 cases were divided randomly into the treatment group （treated by acupuncture-moxibustion and Chinese Tuina） and the control group （treated,by acupuncture-moxibustion）. Results： The therapeutic effect of the treatment group was obviously Superior to that of the control group （the x^2 test showed P〈0.01）. Conclusions： The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for,treatment of insomnia due to deficiency of both the heart and spleen.     

Clinical observation on treatment of 63 cases of enuresis by scalp acupuncture, body acupuncture plus moxibustion with box

To observe the clinical therapeutic effect of scalp acupuncture,body acupuncture plus moxibustion with box in treating enuresis.MethodsNinety-three patients were divided into treatment group of 63 cases and control group of 30 cases.Scalp acupuncture,body acupuncture plus moxibustion with box were used in treatment group.Routine western medicine therapy was used in control group.Results and ConclusionThe cured rate was 69.8% and the total effective rate was 95.3% in the treatment group and 33.3% and 76.7% in the control group.The therapeutic effect in treatment group was superior to that in control group(P＜0.05).     

Treatment with Hqi Bushen Koufuye Combined with Chemotherapy for Preventing Postoperative Metastasis of Stomach Cancer ——A Clinical Observation of 28 Cases

To study the effect of Yiqi Bushen Koufuye （益气补肾口服液 Oral Liquid for Invigorating Qi and Tonifying the Kidney） combined with chemotherapy on postoperative metastasis of stomach cancer. Methods： The 47 cases of postoperative stomach cancer with the syndrome of deficiency of both the spleen and kidney were divided randomly into the treatment group （28 cases）, and the control group （19 cases）. The control group was treated simply by chemotherapy; while the treatment group, was treated with Yiqi Bushen Koufuye in addition to chemotherapy. The effect was observed 12 months later on local relapse and distal metastasis, the life quality, peripheral hemogram, and immunologic function. Results： The rates of postoperative relapse and metastasis of the treatment group were obviously lower than those of the control group （P〈0.05）. The Karnofasky scores, peripheral hemogram and immunologic function of the treatment group were obviously improved in comparison with the control group （P〈0.01 or P〈0.05）. Conclusion： Yiqi Bushen Koufuye combined with chemotherapy is effective in preventing postoperative metastasis of stomach cancer, increasing sensitivity and decreasing toxins, and improving the life quality and immunologic function of the patient.     

Effects of Chinese herbs in children with Henoch-Schonlein purpura nephritis：a randomized controlled trial

OBJECTIVE： To research the curative effect of Chi- nese herbs for clearing away heat, promoting diure- sis, nourishing the kidney, and consolidating es- sence in children with Henoch-Schonlein purpura nephritis（HSPN） with internal accumulation of damp-toxin using randomized controlled observa- tions on large samples. To seek the mechanism of the therapy and its scope of indications. METHODS： Overall, 186 children with HSPN were randomly divided into two groups： treatment group（n=126） treated with Chinese herbs for clear- ing heat and promoting diuresis and a control group（n=60） treated with Western Medicine. The treatment was carried out for three courses of 4 weeks each. We recorded changes in patient urine routines, 24 h urinary protein, blood-coagulating series, immunoglobulin and T-cell subgroups, and improvements in main symptoms. We evaluated the alleviation of clinical symptoms and the im- provement of proteinuria, hematuria, and other lab-oratory test results. Finally, we analyzed the patient population suitable for this therapy according to the relationship between the grouping of patient body weight and curative effect. RESULTS： Damp-heat syndrome improved in the treatment group, with a significant difference in to- tal effective rate after a 4-week treatment（χ2= 13.5220, P=0.0002） and in curative rate after a 12-week treatment（χ2=6.3410, P=0.0118）, com- pared to those in the control group.The curative ef- fect in the treatment group was greater than that in the control group but there was no statistical dif- ference between the two groups. The curative ef- fect after a 4-week treatment of patients in the treatment group weighing 30 kg or less based on Traditional Chinese Medicine（TCM） signs and uri- nary protein was significantly greater than that in the control group. However, there was no statistical difference in the curative effect on urinary red cells and various indexes after a 12-week treatment be- tween the two groups. CONCLUSION： Therapy for clearing away heat, pro- moting diuresis, nourishing the kidney, and consoli- dating essence using TCM is effective in children with HSPN from internal accumulation of damp-toxin. The therapy is especially suitable for patients weighing 30 kg or less. The curative effect may be related to the improvement of immune function and blood-coagulation.     

Clinical Observation on Curative Effect of Dissolving Phlegm-Stasis on 50 Cases of Knee Osteoarthritis

Objective:To observe the curative effect of dissolving phlegm-stasis on knee osteoarthritis.Methods:The 100 patients with knee osteoarthritis were randomly divided into two groups.The 50 patients in the treatment group orally took Chinese medicine while the other 50 patients in the control groups orally took Votalin and Vitamin C for one week as a course of treatment.At the end of 2-week treatment,analytic comparison was carried in evaluate the curative effect and the changes in total score of symptoms before and after treatment between the two groups.Results:The total score of symptoms after treatment was significantly lower than that before treatment in both groups(P0.01,P0.05).The total score after treatment of patients with X-ray gradeⅠandⅡin the treatment group was more obviously reduced as compared to the control group(P0.05).The remarkably effective rate after treatment of patients with X-ray gradeⅠandⅡin the treatment group was also higher than that in the control group(P0.05).Conclusion:The treatment of knee osteoarthritis with dissolving phlegm-stasis can effectively improve the clinical symptoms.     

Effect of polypeptide 2B1 on condition of dampness pattern in rats in terms of Traditional Chinese Medicine

OBJECTIVE： This study investigated how polypeptide 2B1 is involved in regulating and governing dampness in rat models with dampness pattern defined in terms of Traditional Chinese Medicine. METHODS： We randomly divided 48 SPF 10-week-old male Sprague-Dawley （SD） rats into a normal group, normal ＋ Aristolochic acid I （AA-I） for 5 min group, normal ＋ AA-I for 60 min group, dampness pattern group （DS-Group）, dampness pattern ＋ AA-I for 5 rain tern ＋ AA-I for 60 min group, and dampness pat- group. Groups were then treated accordingly. We took out the lung, stom- ach, liver, spleen, kidney, large intestine, and small intestine tissues to detect gene and protein expres- sion of organic anion transporter polypeptide 2B1 （OATP2B1）. RESULTS= Gene expression of OATP2B1 in spleen, kidney, and small intestine of rats with dampness pattern was lower than that in normal rats （P〈0.05）. The gene expressions of OATP2B1 in liver, stomach, large intestine, and small intestine were lower than that in control rats at different time points after being stimulated by AA-I （P〈0.05）. CONCLUSION There is coordination among multiple viscera in handling the condition of dampness, and the mechanism underlying the action may rely on regulating the expression of OATP2B1.     

李振华辨治单纯性肥胖症验案1则

李振华教授出生于中医世家,其父为豫西名医,幼承庭训,后从事中医临床、教学及科研工作凡60载,其临床经验丰富,学术造诣精湛,为全国首批名老中医,擅长治疗急性热病、脾胃病及疑难杂病。笔者侍诊李老身侧,撷其治疗肥胖症验案介绍如下,以飨同道。1病案实录张某,男,45岁。初诊日期:2005年8月12日。患者患肥胖症3年,慢性胃炎病史7年余。3年前无明显诱因出现肥胖,以致行走困难,不能工作。3年来,经多方检查,仅发现三酰甘油轻度升高,余无异常,按内分泌紊乱治疗亦未取效。现症见:身体肥胖,头昏沉,倦怠乏力,动则易汗,多梦健忘;食后腹胀,大便溏薄,每日2~3次;舌质淡,舌体胖大,边有齿痕,苔白腻,脉濡缓。查体:面色白,身体呈对称性肥胖,体质量92.5kg,身高175cm,血压150/100mmHg;甲状腺无肿大,心肺无异常,皮肤无紫纹;腹壁脂肪厚,下肢轻度凹陷性浮肿。肝肾功能检查无异常。西医诊断:肥胖症,特发性水肿;中医诊断:肥胖,水肿;中医辨证:脾胃气虚,痰湿阻滞。治法:健脾益气,祛湿化痰;方以健脾豁痰汤加味(经验方)。处方:白术10g,茯苓20g,泽泻18g,玉米须30g,桂枝6g,半夏10g,厚朴10g,砂仁8g,广木...     

Regulative Effects of Auricular Acupuncture,Moxibustion and Chinese Herbs on Immunologic Function in the D-Galactose-induced Aging Mouse

Objective： To observe the regulative effect of auricular acupuncture, moxibustion and Chinese herbs on immunologic function in the D-galactose-induced aging mouse and to probe the feasibility and possible mechanisms for delaying aging, so as to provide experimental basis for acupuncture, moxibustion and Chinese herbs for delaying aging. Methods： Aging mouse model was established by subcutaneous injection of D-galactose, and treated by auricular acupuncture, auricular acupuncture plus moxibustion, and auricular acupuncture plus Chinese herbs respectively for 6 weeks and then serum interleukin-2 （IL-2） and IL-6 contents and splenic lymphocyte transformation rate were compared among the groups. Results： Compared with the young group, the serum IL-2 level and the splenic lymphocyte transformation rate significantly decreased and the IL-6 level significantly increased in the aging mouse. After treatment by auricular acupuncture, auricular acupuncture plus Chinese herbs, especially auricular acupuncture plus moxibustion, the serum IL-2 level and the splenic lymphocyte transformation rate significantly increased, and the IL-6 level significantly decreased as compared with the model group. Conclusions： Combined application of auricular acupuncture, moxibustion and Chinese herbs can improve the decline or dysfunction of immunological function in the aging organism to a certain extent.     

王德光辨治脓毒血症验案1则

王德光系全国首批继承老中医药专家学术经验指导老师,从事中医临床至今已60余载,临床常用中医药治疗危重症候,每获奇效。现介绍王老早年治疗脓毒血症热闭心包医案1则,以飨读者。1病案实录季某,女,34岁。1962年6月3日初诊。患者发热10d,昏迷、抽搐、肢体瘫痪4d。10d前正值患者产后1个月,因左乳肿痛,发热恶寒,其母嘱以揉按患部,1日之内肿块消,寒热也随之而止。但3d后,又突然恶寒战、高热,体温高达40℃,伴喘息咳嗽、头痛,前往某市级医院治疗。当时查血常规示:白细胞30×109/L;X线透视、摄片提示大叶性肺炎。抗生素治疗3d后,热势转为弛张型。但神识逐渐不清,手足阵发性抽搐。西医会诊,根据其病史、症状、体征及各项检查,诊断为脓毒血症,认为细菌经血行播散通过血脑屏障已形成多发性脑脓肿。经3d急救治疗,热势虽稍退(每日下午39℃左右),但喘息、咳嗽未减,神识昏迷,四肢时发抽搐,并有右上肢及左下肢瘫痪,不能进食,饮水则呛。病至第10d症状仍无改善,故邀王老会诊。王老诊之,望其面赤而晦暗,两目上窜,昏不识人,左上肢循衣摸床,其余肢体时有抽动;汗出,大便已5d未行;舌干而瘦,舌质红绛,苔黄黑,脉弦细而数。心率120次...     

内伤发热的中医辨证分型

内伤发热属临床常见病之一，缘于脏腑虚损，阴阳气血失调，以定时或不定时的频发低热为特点，多数患者神疲虚惫兼见，其病程冗长，缠绵难愈，甚为痛苦。近年来，我们根据临床表现，辨证施治，取得较好的治疗效果，现将体会浅谈如下。     

Oplopanax elatus（Nakai） Nakai： chemistry,traditional use and pharmacology

Oplopanax elatus（Nakai） Nakai, a member of the ancient angiosperm plant family Araliaceae, is used for the treatment of different disorders in the medicine systems of China, Russia, and Korea, and was designated in Russia as a classical adaptogen. Despite extensive studies of classical adaptogens, there are comparatively few reports concerning the chemical composition and pharmacological effects of O. elatus in English. The plant is a potential source of saponins, flavonoids, anthraquinones, terpenes, and other active compounds. Experimental studies and clinical applications have indicated that O. elatus possesses a number of pharmacological activities, including adaptogenic, anti-convulsant, anti-diabetic, anti-fungal, anti-inflammatory, anti-oxidant, blood pressure modulating, and reproductive function effects. In this review, the chemistry, safety, and therapeutic potential of O. elatus are summarized and highlighted to encourage the further development of this plant.     

中药膏方治疗疑难杂症验案4则

所谓膏方又称膏滋方，具有治病纠偏，滋补强身等多种作用。时下在江南一带时兴冬令以膏方进补，实际上是中药传统剂型的丸、散、膏、丹、汤、酒、露、锭八种剂型之一。由于服用方便、疗效显著，在一年四季均可服用，尤其是针对一些需长期服药的慢性病或疑难顽症，更适合以膏方来调治。现代家庭多具备冰箱冷藏的条件，这为膏剂的收藏提供了方便。因此，更可以提倡以膏方剂型来治疗诸多慢性疾病。笔者常不拘季节以膏方为主，根据辨证施治原则来治疗某些疑难病症，现撷取4则医案，以飨读者，不当之处，请多赐教为盼。     

Polysaccharides from Tricholoma matsutake and Lentinus edodes enhance 5-fluorouracil-mediated H22 cell growth inhibition

OBJECTIVE： Few studies have investigated the ef- fects produced by combinations of polysaccharides and chemotherapeutic drugs in cancer treatment. We hypothesized that a combination of polysaccha- rides （COP） from Lentinus edodes and Tricholoma matsutake would improve the efficacy of 5-fluoro- uracil （5-FU）-mediated inhibition of H22 cell growth. METHODS： Mice were injected H22 cells and then treated with either 5-FU, polysaccharides from Tri- choloma matsutake （PTM）, polysaccharides from Lentinus edodes （PL）, PTM ＋ PL, 5-FU ＋ PTM, 5-FU ＋ PL, or 5-FU ＋ COR The tumor weight and volume, and splenic CD4 ＋ and CD8 ＋ T cell frequencies, were determined. Additionally, splenic natural killer （NK） cell and cytotoxic T lymphocyte （CTL） activities were assessed and the serum levels of tumor necro- sis factor-a （TNF-a）, Interleukin-2 （IL-2）, and Interfer- on-y （IFN-y） were measured. RESULTS： Compared with mice from the control,5-FU, PL, PTM, PTM ＋ PL, 5-FU ＋ PL, and 5-FU ＋ PTM groups, mice treated with 5-FU ＋ COP showed： （a） significantly reduced tumor weight and volume （P〈 0.05）, （b） significantly higher serum levels of TNF-α, IL-2, and IFN-y （P〈0.05）, （c） significantly increased CD4＋ and CD8＋ 1 cell frequencies in the spleen （P〈 0.05）, and （d） significantly increased splenic NK cell and CTL activities （P〈0.05）. The tumor weight and volume in mice treated with 5-FU＋PL or 5-FU＋PTM were significantly reduced compared with mice treated with 5-FU alone （P〈0.05）. Serum levels of TNF-α, 11.-2, and IFN-y, frequencies of CD4 ＋ and CD8＋ T cells in the spleen, and splenic NK and CTL activities were also significantly increased in mice treated with 5-FU＋PL or 5-FU＋PTM compared with mice treated with 5-FU alone （P〈0.05）. CONCLUSION： Polysaccharides from Lentinus edodes and Tricholoma matsutake could enhance the efficacy of 5-FU-mediated H22 cell growth inhi- bition.     

刘公望运用经方治疗放化疗不良反应验案2则

恶性肿瘤的致死率甚高，源自上皮组织者称为癌，源自间叶非上皮组织者称为肉瘤，二者均病情凶险，预后恶劣。目前肿瘤的治疗有外科手术治疗、放射治疗及化学治疗。在放化疗过程中往往发生毒副作用，导致患者的抵抗力下降，严重时可影响治疗的继续进行。刘公望教授巧用经方治疗放化疗后引起的毒副反应，收效良好。现举医案2则，以飨读者。     

Clinical Application of Yongquan （KI 1）Acupointd

Yongquan （KI 1） is the Jing-Well point of Kidney Meridian of Foot Shaoyin. It can be used to treat many kinds of diseases, such as parietal headache, vertigo and blurred vision, hypopharynx swelling and pain, dry tongue, voice loss, epistaxis, apoplexy and apoplectic sequela, dysufia, ungratifying defecation, epilepsy, syncope, planter fever, palpitations, lower limbs spasm, hypertension, vomiting, infantile convulsion. The author applied Yongquan （KI 1） in clinical practice and obtained satisfactory therapeutic effects. Now five cases were introduced as follows.     

Antidepressant-like effect of essential oil of Perilla frutescens in a chronic,unpredictable, mild stress-induced depression model mice

Perilla frutescens（Perilla leaf）, a garnishing vegetable in East Asian countries, as well as a plant-based medicine, has been used for centuries to treat various conditions, including depression. Several studies have demonstrated that the essential oil of P. frutescens（EOPF） attenuated the depressive-like behavior in mice. The present study was designed to test the anti-depressant effects of EOPF and the possible mechanisms in an chronic, unpredictable, mild stress（CUMS）-induced mouse model. With the exposure to stressor once daily for five consecutive weeks, EOPF（3, 6, and 9 mg·kg-1） and a positive control drug fluoxetine（20 mg·kg-1） were administered through gastric intubation to mice once daily for three consecutive weeks from the 3rd week. Open-field test, sucrose consumption test, tail suspension test（TST）, and forced swimming test（FST） were used to evaluate the behavioral activity. The contents of 5-hydroxytryptamine（5-HT） and its metabolite, 5-hydroxyindoleacetic acid（5-HIAA）, in mouse hippocampus were determined by HPLC–ECD. Serum interleukin（IL）-1, IL-6, and tumor necrosis factor（TNF）-α levels were evaluated by enzyme-linked immunosorbent assay（ELISA）. The results showed that CUMS significantly decreased the levels of 5-HT and 5-HIAA in the hippocampus, with an increase in plasma IL-6, IL-1β, and TNF-α levels. CUMS also reduced open-field activity, sucrose consumption, as well as increased immobility duration in FST and TST. EOPF administration could effectively reverse the alterations in the concentrations of 5-HT and 5-HIAA; reduce the IL-6, IL-1β, and TNF-α levels. Moreover, EOPF could effectively reverse alterations in immobility duration, sucrose consumption, and open-field activity. However, the effect was not dose-dependent. In conclusion, EOPF administration exhibited significant antidepressant-like effects in mice with CUMS-induced depression. The antidepressant activity of EOPF might be related to the relation between alteration of seroto