治疗晚期非小细胞肺癌45例疗效观察

治疗晚期非小细胞肺癌４５例疗效观察江西省肿瘤医院（３３００２９）王晓关键词：辨证治疗，晚期非小细胞肺癌１９８７年５月～１９９１年１０月，我们根据中医辨证施治的原则，运用中药治疗晚期非小细胞肺癌４５例，取得了一定疗效，报告如下：一、临床资料１．病例选择...     

参麦注射液治疗晚期非小细胞肺癌32例

参麦注射液治疗晚期非小细胞肺癌３２例湖南省中医药研究院附属医院（４１０００６）蒋益兰，袁晓清，梁慧，杜小艳主题词肺肿瘤／中医药疗法，参麦注射液／治疗应用我科自１９９４年１１月～１９９５年１１月，运用参麦注射液治疗晚期非小细胞肺癌３２例，现小结如下。１...     

中西医结合治疗晚期非小细胞肺癌疗效观察

中西医结合治疗晚期非小细胞肺癌疗效观察王晓，傅坤生１９８９年９月～１９９４年９月，我们采用中酉医结合治疗晚期非小细胞肺癌５０例，并与单纯西药化疗的３０例对照，取得了一定疗效，现报告如下。临床资料８０例患者均经病理和／或细胞学诊断证实。临床分期参照１９...     

多西紫杉醇联合卡铂治疗晚期非小细胞肺癌的疗效观察

目的：探讨多西紫杉醇联合卡铂治疗晚期非小细胞肺癌的临床疗效。方法：回顾性分析我院近年来收治的84例晚期非小细胞肺癌患者的临床资料。结果：84例晚期非小细胞肺癌的患者，总有效率为53．57％；其中，Ⅲb期61例，RR为57．38％；Ⅳ期23例，RR为43．39％。疾病无进展时间76个月，中位生存期为12．2个月，1年生存率为36．90％（31／84）。发生的所有不良反应经对症治疗后症状均有所缓解，患者均可耐受，未影响继续治疗。结论：多西紫杉醇联合卡铂治疗晚期非小细胞肺癌的临床疗效确切，毒副反应轻，患者耐受良好，适合晚期患者推广使用。     

中药软坚散结汤治疗晚期非小细胞肺癌30例

目的 :观察中药软坚散结汤治疗非小细胞肺癌的疗效。方法 :治疗晚期非小细胞肺癌 30例 ,均为Ⅲ～Ⅳ期 ,男 18例 ,女 12例。结果 :部分缓解 (PR) 11例 ,稳定 (NC) 14例 ,进展 (PD) 5例。总有效率 36 7% ,最短生存期为 5个月 ,最长生存期为 3 5年 ,中位生存率为 10个月。未见任何毒副反应。结论 :软坚散结汤是一个治疗晚期非小细胞肺癌的无任何毒副反应且有效的方药     

氨甲喋呤与异环磷酰胺治疗恶性肿瘤的药物经济学分析

目的比较氨甲喋呤（A方案）与异环磷酰胺（B方案）治疗晚期非小细胞肺癌的疗效及药物经济学评价。方法：用A方案治疗晚期非小细胞肺癌20例与B方案治疗晚期非小细胞肺癌20倒，统计分析临床资料。结果：两组治疗有效率相比无显著性差异；B组的成本-效果好于A组，但是无显著性差异。结论：A组和B组方案均是治疗晚期非小细胞肺癌有效方案，两种方案均为治疗晚期非小细胞肺癌的有效治疗方案，适合不同经济条件或机能状态的患者选择。     

晚期肺癌患者NP方案化疗的不良反应观察和护理

85％肺癌为非小细胞癌，其中40％在诊断时已经为晚期或者转移。化疗是此类患者的主要治疗措施，去甲长春花碱(NVB)治疗非小细胞肺癌疗效显著。我院应用NVB DDP治疗晚期非小细胞肺癌患者21例，现将主要不良反应及护理措施报道如下。     

益气清毒化瘀法治疗晚期非小细胞肺癌的临床观察

正肺癌为临床常见的恶性肿瘤,近年来,其发病率与致死率呈逐年递增的趋势~([1])。临床肺癌患者中绝大多数均为非小细胞肺癌,晚期非小细胞肺癌一旦临床治疗不可控,将对患者生命安全造成严重威胁。笔者运用益气清毒化瘀法治疗晚期非小细胞肺癌,获得了较好的临床效果,现报道如下。一般资料选取2012年12月—2015年12月洛阳市第二中医院收治的80例晚期非小细胞肺癌患者进行回顾性分析。所有患者均经病理学诊断为晚期非小细胞肺癌,且     

扶正解毒中药内服、外敷治疗肺脾气虚型晚期非小细胞肺癌41例临床观察

目的:观察中药内服、外敷治疗晚期非小细胞肺癌的临床疗效。方法:41例肺脾气虚型晚期非小细胞肺癌患者,均给予扶正解毒中药内服并外敷治疗,观察治疗效果。结果:中药内外并治法治疗后,患者咳嗽、咯痰、胸痛、胸闷等不良症状消失或缓解显著。41例患者治疗前卡氏评分(63.13±13.32)分,治疗后(72.15±10.12)分,治疗前后比较差异有统计学意义(P0.01)。41例患者治疗后生存6个月以内1例,6个月~1年10例,1~2年11例,2~3年13例,3年以上6例,平均生存期29个月。结论:中药内外并治法治疗晚期非小细胞肺癌疗效显著。     

清肺固金汤对晚期非小细胞肺癌患者生存的影响

目的观察清肺固金汤维持治疗对晚期非小细胞肺癌患者无进展生存期及总生存期的影响。方法对52例在一线化疗后达到完全缓解或部分缓解的晚期非小细胞肺癌患者给予清肺固金汤加减口服。结果清肺固金汤维持治疗晚期非小细胞肺癌,其无进展生存期(PFS)为150天(5.0个月),总生存期(OS)为436天(14.5个月),无论在PFS还是OS方面均与目前国内外的临床研究相仿,体现了中药维持的优越性。结论清肺固经汤维持治疗晚期非小细胞肺癌可延长患者疾病无进展生存期及总生存期。     

基于ICP-MS法的加味左金丸中无机元素分析

目的 通过电感耦合等离子体质谱（inductively coupled plasma mass spectrometry,ICP-MS）法建立加味左金丸中Cd、Pb、As、Hg、Co、V、Ni、Cu、Li、Sb、Ba、Mo、Sn、Cr、Na、Mg、Al、Ca、Ti、Mn、Fe、Zn、Ga、Se、Sr、Tl共计26种无机元素的测定方法。方法 加味左金丸通过微波消解法处理后,根据相对分子质量的大小选择内标物,其中⁷Li、²³Na、²⁴Mg、²⁷Al、⁴⁰Ca、⁴⁸Ti、⁵¹V、⁵²Cr、⁵⁵Mn、⁵⁶Fe、⁵⁸Ni、⁵⁹Co、⁶³Cu、⁶⁶Zn、⁷⁰Ga、⁷⁵As、⁷⁷Se、⁸⁶Sr以⁷²Ge作为内标;⁹⁵Mo、¹¹⁴Cd、¹¹⁸Sn、¹²¹Sb、¹³⁷Ba以¹¹⁵In作为内标;²⁰²Hg、²⁰⁵Tl、²⁰⁸Pb以²⁰⁹Bi作为内标。对标准品溶液、空白溶液与供试品溶液进行分析,采用标准曲线法进行定量分析。通过ICP-MS法进行测定。结果 26种无机元素线性的相关系数r ≥ 0.999 6,检出限为0.001~1.500μg/L,定量限为0.01~5.00 μg/L,精密度与重复性试验的RSD均小于5%,平均回收率在82.64%~106.44%,RSD均小于5%。对3个厂家的12批样品进行了测定,26种元素的含量差异较大,其中Na、Mg、Ca、Fe 4种元素的含量比较高,均大于500 μg/g,Cd、Pb、As、Hg、Co、Li、Sb、Mo、Sn、Cr、Se、Tl的含量比较低,均小于1 μg/g。由结果可知,人体的常量元素,如Na、Mg、Ca的含量比较高,Cd、Pb、As、Hg等有害元素含量比较低。根据《中国药典》2020年版一部的要求,本品中Cd、Pb、As、Hg与Cu均符合规定。结论 该方法快速、准确,可以用于加味左金丸中无机元素的测定。     

Erstaunliches Ergebnis einer Schädelakupunktur nach Yamamoto bei Hemihypsarrhythmie rechts

A girl, three and a half years old at the respective date, premature in 25th week of gestation, had been presented. On day three after birth, she had had a IVH III° right and left with severe involvement of parenchyma and other multiple complications, e. a. infant respiratory distress syndrome up to the 42nd day postpartum, and epileptic attacks with apnoeic events.     

七味红花殊胜散对缺血再灌注肝损伤的保护作用

目的::研究七味红花殊胜敬对缺血再灌注肝损伤的保护作用.方法:在大鼠肝缺血再灌注模型上,观察七味红花殊胜散对缺血再灌注肝损伤引起的血清丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、一氧化氮(NO)含量的变化.结果:七味红花殊胜散对大鼠血清MDA、SOD、GSH与再灌组比较有明显差异(P<0.05),NO含量与再灌组比较有明显差异(P<0.05).结论:七味红花殊胜散对大鼠急性缺血再灌注肝损伤具有保护作用.     

Methodology of Canine/Feline YNSA and Tail Acupuncture

BackgroundYamamoto New Scalp Acupuncture (YNSA) is a well-known acupuncture system for human patients which was developed by Dr. Yamamoto.ObjectiveMy aim was to transpose the human YNSA map onto canines and felines.MethodI started researching a canine/feline YNSA map in 2002. I investigated approximately 3,000 canines and felines for YNSA and 2,500 for Tail Acupuncture. The ratio of canines and felines was 6 to 4. I researched and found all the equivalent points by palpating animal patients on the basis of an exact Neck Diagnosis.ResultsI nearly completed the map in 2006. The points in the occipital region are incomplete and my research is still in progress. In the process of researching canine/feline YNSA points, I accidentally found the other microsystems around the tail and named it “Tail Acupuncture”.ConclusionsYNSA and Tail Acupuncture are acupuncture systems utilizing microsystems and support each other in canines and felines. The merits of YNSA and Tail Acupuncture are 1) immediate effects, such as in cases of lameness, 2) simplicity in finding the exact points to treat and 3) the scalp and the tail can be utilized separately or together as treatment zones, according to the situation.     

Chinesische Orthopädie: Teil 1: Die Zukunft der Akupunktur in der Postmoderne

The locomotor system is one of the major fields of application for acupuncture. The results of the large acupuncture studies funded by German Health Insurances from 2000 until 2006 are impressive and repressive: they restrict acupuncture application by allocation of reimbursement and create the necessity of reorientation, since acupuncture can neither be adequately described nor prescribed solely on the basis of disease entities. Regarding these disease entities, it seems rather necessary to analyse the layers of problems and formulate a hierarchy of therapeutic goals instead. Only in this way the effects of acupuncture, related techniques and further therapeutic modalities can be matched with the set of objectives. The article presents general principles and follows their application from biological aspects to implications for the locomotor system and consequences for the application of physical therapy. The manual of acupuncture focuses on therapeutic effects and objectives first, and then goes on to sketch simple therapeutic strategies and finally complex approaches within acupuncture. These may encompass acupuncture, microsystem acupuncture and complex therapeutic modes.     

Patientin mit chronisch rezidivierenden Gelenks- und Wirbelsäulenschmerzen

Background

Acupuncture as a regulative therapy is well-suited for the treatment of functional, reversible disorders. Additionally, the WHO recommends its application for pain therapy in cases of arthritis and back pain due to various causes. This case study should clarify which paths to take in the case of a multi-morbid patient suffering from chronic pains due to polyarthrosis.

Objective

Pain reduction and improvement of quality of life as well as improvement of sleep quality.

Methods

Annual treatment series consisting of 10 sessions each, one session per week.

Results

short-term pain reduction before undergoing endoprosthetic surgery; considerable improvement of general status and sleep.

Conclusions

Acupuncture may bring temporal relief in cases of chronic pain due to osteoarthritis and should therefore be applied in combination with western medicine. Acupuncture is particularly well-suited to treat the co-emergent vegetative symptoms.     

Fallbericht: Patientin mit Schlafstörung

Background

Since the onset of her menopause about ten years ago, a sixty-year old patient has been suffering from hot flashes and sleep disorders causing her to become increasingly anxious and nervous. As the patient's mother had died of breast cancer, substitution of hormones was not advisable. Relaxation methods such as Yoga and Autogenic Training could only mildly alleviate the symptoms.

Objective

To effectively treat the sleep disorder, improve quality of life, lessen frequency and severity of hot flashes

Methods

Weekly sessions with ear- and body acupuncture for ten weeks

Results

After the third acupuncture session the patient reported a decrease of nightly waking episodes but suffered from acute pain in the neck as well as shoulder region. After nine therapy sessions, the patient reported a 50% decrease of nightly waking episodes. The hot flashes, however, remained unchanged.

Discussion

In this case, acupuncture significantly improved the patient's sleeping disorder. It also reduced the symptoms of anxiety and nervousness. Other menopausal symptoms such as hot flashes and dryness of mucous tissues, could not be influenced.     

常见证候荷瘤小鼠神经内分泌免疫组织基因转录的总体特征

目的揭示常见证候荷瘤小鼠神经-内分泌-免疫组织基因转录的总体特征。方法采用小鼠标准化四诊及辨证方法，及Gene Chip Mouse Exon1．0ST Array等技术，检测H22荷瘤小鼠早期邪毒壅盛（邪毒）和气虚、中期阳气虚、中晚期气阴阳虚等4个常见证候下丘脑、垂体、肾上腺、睾丸、脾脏、胸腺、肿瘤RNA的转录与剪接。结果正常昆明种雄性小鼠下丘脑、垂体、肾上腺RNA电泳的28S峰低于18S，而睾丸、脾脏、胸腺、肿瘤相反。肿瘤发生的早期，下丘脑、垂体、肾上腺基因表达模式发生显著改变，邪毒尤甚，出现了失代偿。下丘脑28SRNA迅速抬升并持续，气虚强于邪毒。垂体RNA总量降低，28S陡降，邪毒尤甚。肾上腺RNA电泳特征类似垂体，气虚与邪毒相近，中晚期气阴阳虚尤甚。睾丸变化不明显。随着病情发展，脾脏重量持续增加，而胸腺相反，重量持续下降，蛋白合成和糖代谢下降。肿瘤组织蛋白合成与糖代谢，邪毒大于气虚。以上7个组织与正常对照组相比，有9127个基因表达发生差异、51126个外显子剪接发生差异。结论神经-内分泌-免疫网络组织基因转录的差异是荷瘤小鼠不同证候内在重要的物质基础。