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1.
Varinder Saini Bhaskar Lokhande Shivani Jaswal Deepak Aggarwal Kranti Garg Jasbinder Kaur 《The Indian journal of tuberculosis》2018,65(1):30-34
Background
Definitive laboratory diagnosis and confirmation of tuberculosis remains a major challenge because of lack of specificity and sensitivity of diagnostic methods especially in sputum smear negative tuberculosis. Many studies have proved the role of ADA in diagnosis of tuberculosis in effusion fluids and a decrease in ADA activity after treatment. This study was aimed to investigate the role of serum ADA level as an early diagnostic and prognostic marker for pulmonary tuberculosis (PTB).Material and methods
This was a cohort study done on patients visiting the OPD Clinics of the department of Pulmonary Medicine at GMCH, Chandigarh. 50 sputum positive and 50 sputum negative tuberculosis patients and 100 controls were recruited. Serum ADA levels were measured at the start of treatment and again after two months of treatment. Its correlation with severity of disease was seen.Results
Mean serum ADA (IU/L) was found to be 35.293 ± 30.941 in PTB patients and 11.819 ± 8.023 in control groups and the difference was found to be highly significant (P < 0.00). Mean ADA was 31.107 ± 29.32 in sputum positive patients, 39.478 ± 32.22 in sputum negative and 11.819 ± 8.0235 in control groups. No statistically significant difference was observed amongst sputum positive and sputum negative patients. The levels decreased significantly after intensive phase of treatment. At the cut off values of 14.6 IU/L, serum ADA had 78% sensitivity and 76% specificity (AUC = 0.801, P value < 0.00) to differentiate between PTB from healthy controls.Conclusion
Serum ADA levels may be used as a biomarker for diagnosis of PTB and to evaluate the response to treatment at follow up. 相似文献2.
Objective
To assess the efficacy of alternate day (thrice a week) Directly Observed Treatment Short-course (DOTS) regimen spanning six to nine months in providing sustained cure for skeletal tuberculosis (TB) under programmatic conditions.Design
Retrospective cohort study.Setting
An urban district tuberculosis centre in India under the Revised National Tuberculosis Programme.Participants
A cohort of 218 patients treated with alternate day DOTS regimen for skeletal TB between 2007 and 2012.Methods
All patients with the diagnosis of skeletal TB registered between 2007 and 2012 who successfully completed treatment were followed up for evidence of disease recurrence or relapse using structured interviews conducted between August 2013 and October 2015 after ensuring a minimum follow up of two years.Results
Of the 200 patients eligible for follow up in this study, 117 (58.5%) had a minimum follow up of two years. The remaining 83 cases could not be traced. 105 (89.7%) of these 117 patients were symptom free for two years or more after the completion of treatment. There were four cases who had a relapse of the disease within two years of completion of treatment. Eight cases were administered further ATT soon after the completion of treatment under DOTS.Conclusions
This study confirms the efficacy of the alternate day DOTS regimen in successfully treating all forms of skeletal TB, including spinal TB, with a success rate of 89.7%. 相似文献3.
Juan Carlos Sanz Belén Ramos Aurora Fernández Luis García-Comas Juan Emilio Echevarría Fernando de Ory 《Enfermedades infecciosas y microbiología clínica》2018,36(3):172-174
Introduction
The aim of this study was to evaluate a cut-off point of the titration of IgG by ELISA in the diagnosis of mumps.Methods
A study was made of serum samples from 85 mumps cases (confirmed by PCR in saliva) and 2,351 controls of the general population of the Region of Madrid.Results
The IgM detection was positive in 21 cases (sensitivity of 24.7%). The best cut-off point corresponded to IgG titres ≥ 4,900 (sensitivity of 64.7% and specificity of 86.1%). Among 42 patients immunised with at least one dose of measles mumps, rubella vaccine IgM was detected in 4 cases. However, the detection of IgG ≥ 4,900 was positive in 29 (sensitivity of 69.0%).Conclusions
An IgG result of ≥ 4.900 was almost 5 times more probable in a patient with mumps than in a non-infected patient. The detection of high titres of IgG against mumps could improve the IgM results in vaccinated people. 相似文献4.
Ranjeet Kumar Jaswant Rai N.C. Kajal Pushpa Devi 《The Indian journal of tuberculosis》2018,65(3):246-251
Background
Ashwagandha (Withania somnifera Linn.) a rejuvenative herb has long been used as an immunomodulator in Indian subcontinent. As immunity plays an important role in pathogenesis and treatment of tuberculosis (TB), so role of W. somnifera as an adjuvant has been studied on selected parameter.Method
A randomized, double-blind placebo-control study was conducted in two groups of 60 newly diagnosed sputum smear positive pulmonary TB patients on Directly Observed Treatment – short course (DOTS) regime. W. somnifera root extract or placebo capsules were given as add-on therapy for duration of 12 weeks. Effects on sputum conversion, Hemoglobin (Hb), body weight, Erythrocyte Sedimentation Rate (ESR), RBC counts, WBC counts, CD4 and CD8 counts, Serum Glutamic-Oxaloacetic Transaminase (SGOT), Serum Glutamic-Pyruvic Transaminase (SGPT), serum uric acid and HRQL (Health Related Quality of Life) Index scores were studied.Results
At the end of 8 weeks, sputum conversion was seen in 86.6% patients in study group and 76.6% in placebo group. At the end of 12 weeks a highly significant increase was seen in both CD4 and CD8 counts in study group. A raised SGOT and SGPT levels (>35 IU/L) were observed in 16.6% and 33.3% patients in study group; 43.33% and 53.33% in the placebo group of patients. Elevated serum uric acid levels (>6 mg/dl) were observed in 20% and 33.33% in study and placebo group respectively. Average gain in HRQL score was better in patients of study group.Conclusion
Use of W. somnifera as an adjuvant in conjunction with anti-TB drugs used as DOTS showed a favorable effect on symptoms and immunological parameters in patients with pulmonary TB. 相似文献5.
Ivan Sanz Muñoz Silvia Rojo Rello Raúl Ortiz de Lejarazu 《Enfermedades infecciosas y microbiología clínica》2018,36(9):572-575
Introduction
The aim of this study was to analyze the presence of antibodies against both Yamagata and Victoria influenza B lineages and to check the response after seasonal trivalent vaccination.Materials and methods
Haemagglutination inhibition assays were performed with pre-and post-vaccination serum samples from 174 individuals ≥65 years of age vaccinated with seasonal trivalent influenza vaccines during the 2006–2007, 2008–2009, 2009–2010 and 2010–2011 vaccine campaigns.Results
33.9% of individuals showed pre-vaccine protective antibodies (≥1/40) against B/Yamagata lineage and 41.4% against B/Victoria lineage. The annual trivalent vaccine induced significant homologous seroconversion in 14–35.6% of individuals in each vaccine campaign.Conclusions
The population ≥65 years has low-moderate seroprotection against B influenza lineages. Trivalent vaccination induced a slight increase of seroprotection. The trivalent vaccine should be administered to all individuals ≥65 years in all vaccine campaigns. 相似文献6.
Arupkumar Chakrabartty Pampa Basu Kazi Monjur Ali Aditi Kishore Sarkar Debidas Ghosh 《The Indian journal of tuberculosis》2018,65(2):145-151
Background
One major barrier to achieve goal of tuberculosis (TB) control program globally, is the stigma attached to the disease. Perceived stigma can delay sputum test in time. Delay will lead to spread of infection in the community. There is no scientific information available in India exactly looking into the association between delay in sputum examination and stigma.Aim
We conducted a study in rural West Bengal among persons with cough for 2 weeks or more to assess their level of stigma, its influence on delay for sputum test and identify factors those shape the level of stigma.Methods
A community based cross sectional survey was conducted from February to June 2015 in West Bengal, India. We interviewed 135 persons of 15–60 years. Data were collected using a pretested structured questionnaire. Chi-square and logistic regression analysis were done using SPSS 23.0 statistical software.Results
Among the ‘lower stigma’ group (score 4–24), ‘delay’ (14–25 days) is found among 46.2% respondents and ‘much delay’ (26–120 days) among 53.8%. Among the ‘higher stigma’ (score 25–36) group, ‘delay’ is found among 20.5% respondents and ‘much delay’ among 79.5%. Persons with lower stigma are 0.17 times likely to delay than persons with higher stigma [adjusted odds ratio (AOR): 0.17 (0.044–0.668), p = 0.011)]. Important influencers of stigma are caste [AOR: 5.90 (1.66–20.90), p = 0.006], number of family members [AOR: 3.46 (1.08–11.06), p = 0.009] and residence in urban or rural [AOR: 3.97 (1.03–15.27), p = 0.045].Conclusion
Revised National Tuberculosis Control Program in India should de-stigmatize the community giving priorities to lower castes, big families and rural areas. 相似文献7.
Hosien Shahdadi Morteza Salarzaee Abbas Balouchi 《The Indian journal of tuberculosis》2018,65(2):159-163
Background
The quality of life is an important indicator of quality of care in chronic diseases such as diabetes and TB. The present research is conducted with an aim to assess the Quality of Life of Diabetic Patients with Smear Positive PTB.Methods
This cross-sectional study was conducted on 62 diabetic patients with smear positive PTB from January to May 2016 in a diabetes clinic in Zahedan city (southeast of Iran). A simple random sampling method was used in this study. Instrument for data collection was quality of life (SF-36) questioner.Results
Total quality of life score was 48 that showed an average level of quality of life. Sixty-five patients with diabetes and affected by smear positive pulmonary tuberculosis (PTB) with the average age of 51.30 ± 10.84 years participated in this research. Four patients (0.06%) suffered from type 1 diabetes and 58 (94%) from type 2 diabetes, and all of them were smear positive PTB patients. Study of their quality of life revealed that, in general, the average scores for quality of life in the two main subgroups of physical health and mental health were lower than the average and, among the eight studied dimensions, the highest scores were those for physical activity (60 ± 14.23) and the lowest (31.42 ± 12.14) for general health in the subgroup of physical health.Conclusion
Results indicated that the patients had a low quality of life although they received the care and treatments that are effective in patients with diabetes and suffering from smear-positive PTB. 相似文献8.
Glória Abreu Pedro Azevedo Carlos Galvão Braga Catarina Vieira Miguel Álvares Pereira Juliana Martins Carina Arantes Catarina Rodrigues Alberto Salgado Jorge Marques 《Revista portuguesa de cardiologia》2018,37(6):481-488
Introduction
Prompt identification of higher-risk patients presenting with ST-segment elevation myocardial infarction (STEMI) is crucial to pursue a more aggressive approach.Objective
We aimed to assess whether the modified shock index (MSI), the ratio of heart rate to mean arterial pressure, could predict six-month mortality among patients admitted with STEMI.Methods
A retrospective observational cohort study was performed in a single center including 1158 patients diagnosed with STEMI, without cardiogenic shock on admission, between July 2009 and December 2014. They were divided into two groups: group 1 – patients with MSI <0.93 (72%); group 2 – patients with MSI≥0.93 (28%). The primary endpoint was six-month all-cause mortality.Results
MSI≥0.93 identified patients who were more likely to have signs of heart failure (p=0.002), anemia (p<0.001), renal insufficiency (p=0.014) and left ventricular systolic dysfunction (p=0.045). They more often required inotropic support (p<0.001), intra-aortic balloon pump (p<0.001) and mechanical ventilation (p<0.001). Regarding in-hospital adverse events, they had a higher prevalence of malignant arrhythmias (p=0.01) and mechanical complications (p=0.027). MSI≥0.93 was an independent predictor of overall six-month mortality (adjusted HR 2.00, 95% CI 1.20-3.34, p=0.008).Conclusion
MSI was shown to be a valuable bedside tool which can rapidly identify high-risk STEMI patients at presentation. 相似文献9.
Anil Kumar Jain Manmohan Puri Devika Tayal Ritu Singhal Rohit Sarin 《The Indian journal of tuberculosis》2018,65(4):285-289
Background
Allergic bronchopulmonary aspergillosis (ABPA) is characterized by an allergic inflammatory response to colonization by Aspergillus species, most commonly Aspergillus fumigatus.Aim
To study the prevalence of ABPA in asthmatic patients presenting to our institute.Materials and methods
All consecutive asthma patients attending our allergy clinic Out Patient Department (OPD) over a period of 20 months were tested with skin prick test (SPT) for Aspergillus antigens and those who were found positive were further evaluated for ABPA using Greenberger's criteria.Results
Seventy consecutive asthmatic patients were screened by SPT using Aspergillus antigens. Thirteen patients (18.57%) were found to be SPT positive, out of which nine patients (12.9%) were diagnosed as having ABPA using Greenberger's criteria. ABPA was common among 25–35 age group with no gender predilection. ABPA patients had longer duration of illness, predominantly mixed pattern in PFT, higher mean absolute eosinophil count (AEC) and serum total IgE compared to non-ABPA asthmatic patients. Specific IgE for A. fumigatus was positive in all ABPA patients and serum precipitins were positive in seven patients (77.58%). Chest X-ray abnormalities were seen in five patients (55.6%) and HRCT showed central bronchiectasis in eight patients (88.9%) with varying other radiological features. None were sputum fungal culture positive and five patients (55.6%) have been misdiagnosed as pulmonary tuberculosis in the past.Conclusion
The prevalence of ABPA is significantly higher in bronchial asthma patients presenting to tertiary care centers and hence awareness is required among physicians for early diagnosis and management of ABPA to achieve better asthma control and to avoid permanent lung damage. 相似文献10.
Background
A high level of knowledge about Tuberculosis amongst the Multi-Purpose Workers (MPWs) is the cornerstone for the successful implementation of Directly Observed Treatment Short-course (DOTS) strategy under the Revised National Tuberculosis control Programme of India. In this regard, the evaluation of MPWs, the major workforce of the Health Department of Solan district, has never been done in the past. Hence the present study was undertaken.Methods
Objective: To evaluate the knowledge about Tuberculosis among the MPW DOT and non DOT Providers.Design
A cross sectional study amongst 174 MPWs of the five Tubercular Units was conducted.Informed written consent was obtained. A pretested self-administered questionnaire was used.Data was analyzed in Microsoft Excel 2010 and IBM SPSS statistics version 21 software.Results
85.6 per cent of the study participants were or had been DOT Providers. Only 9.2 per cent of the workers had received RNTCP Modular training whereas, 87.4 per cent had received just the ‘On the Spot training’ about DOTS. The difference in knowledge by Gender distribution across the five TUs was found significant.Conclusion
There is inadequate knowledge of tuberculosis amongst the MPW DOT and Non DOT Providers. Hence regular Modular and refresher trainings are recommended. 相似文献11.
María Isabel Pacheco-Tenza José Antonio Ruiz-Maciá María Navarro-Cots Joan Gregori-Colomé José María Cepeda-Rodrigo Jara Llenas-García 《Enfermedades infecciosas y microbiología clínica》2018,36(1):24-28
Introduction
Strongyloides stercoralis infection is more prevalent in tropical regions but autochthonous cases have been reported in Spain, mainly in La Safor (Valencia). The objective is to describe the strongyloidiasis cases registered in a regional hospital of Alicante province (Spain) and to determine if they were autochthonous cases.Methods
Retrospective study of all diagnosed cases of strongyloidiasis in Vega Baja Hospital (Orihuela, Alicante) between January 1999 and March 2016.Results
A total of 10 cases were found, four of which were autochthonous cases. Two of them presented with a hyper-infection syndrome, with a fatal outcome. All autochthonous cases were in patients ≥ 69 years old with gastrointestinal, cutaneous, and/or respiratory symptoms. Serology was positive in the 8 cases studied. Larvae were found in histopathological samples of the gastrointestinal tract of three patients.Conclusions
We communicate the first autochthonous cases of strongyloidiasis in the region of Vega Baja. Screening programs should be implemented, especially in immunosuppressed patients or patients under chronic corticosteroid treatment. 相似文献12.
V.K. Chadha S.M. Anjinappa Kiran Rade D. Baskaran P. Narang C. Kolappan J. Ahmed P. Praseeja 《The Indian journal of tuberculosis》2019,66(1):99-104
Setting
Community based five pulmonary tuberculosis (PTB) surveys among adults.Objectives
Estimate sensitivity and specificity of screening tools for PTB and sputum microscopy.Methods
For each survey site, we estimated sensitivity and specificity of different screening criteria and microscopy against culture; pooled estimates were obtained using Random Effects Model.Results
Sensitivity of cough alone, screening for any symptom (persistent cough ≥2 weeks, fever or chest pain ≥1 month, hemoptysis), any symptom or history of anti-TB treatment (h/o ATT) were 56.2%, 66% and 71.2% respectively; specificities were 95.3%, 93.8% and 92.7% respectively.X-ray when used alone for primary screening had sensitivity and specificity of 76.6% and 97.3% respectively. When used along with screening for cough, these figures were 94.3% and 93.1%, and 100% and 97.3% when used with any symptom and h/o ATT. When used for secondary screening, sensitivity and specificity of X-ray was 66.8% and 87.8% respectively after primary screening for cough, 65.0% and 89.8% after screening for any symptom, and 67.1% and 86.7% when used after screening for any symptom or h/o ATT.Pooled sensitivity and specificity of smear was 46.2% and 99.3% respectively.Conclusion
Program managers may use these estimates while evaluating algorithms for active case finding. 相似文献13.
Tarek Mohamed Ali Ahmad El Askary 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):1045-1050
Background
Inconsistent results have been described regarding the part of fetuin-A and testosterone in arterial stiffness in type 2 diabetes mellitus (T2DM).Aim
To look into the links of serum fetuin-A and testosterone levels with brachial-Ankle pulse wave velocity (baPWV), a marker of arteriosclerosis and common carotid intima media thickness (ccIMT), a marker of early atherosclerosis, in diabetic Saudi men patients.Subjects and methods
One hundred and fifty adult male patients with T2DM and 60 non-diabetic control subjects were enrolled from different Saudi Arabia Taif hospitals. Biochemical analysis, anthropometric measurements, blood pressure, baPWV and ccIMT were investigated.Results
Stepwise regression in diabetic patients revealed that the most important predictor of ba-PWV was serum fetuin-A followed by serum glucose and the most important predictor of ccIMT was serum fetuin-A followed by serum HDL then serum triglycerides.Conclusions
Only fetuin-A levels not testosterone are negatively associated with early markers of atherosclerosis. 相似文献14.
A.O. Grøn E.-M. Dalsgaard A.R. Ribe S. Seidu G. Mora A.M. Cebrián-Cuenca M. Charles 《Primary Care Diabetes》2018,12(4):289-304
Background and aim
Individuals with severe mental illness (SMI) who suffer from type 2 diabetes (T2DM) are likely to be sub-optimally treated for their physical condition. This study aimed to review the effect of interventions in this population.Methods
A systematic search in five databases was conducted in July 2017.Results
Seven studies on multi-faced interventions were included. These comprised nutrition and exercise counselling, behavioural modelling and increased disease awareness aiming to reduce HbA1c, fasting plasma glucose, body mass index and weight.Conclusion
Non-pharmacologic interventions in individuals with SMI and T2DM could possibly improve measures of diabetes care, although with limited clinical impact. 相似文献15.
Maria Pipa-Muñiz Lluis Castells Sonia Pascual Javier Fernández-Castroagudín Iratxe Díez-Miranda Javier Irurzun Roberto Díaz-Beveridge María Senosiaín Juan Arenas Manuel de la Mata Juan Turnes María Isabel Monge-Romero Daniel Pérez-Enguix Javier Bustamante-Schneider Nora Otegui Esther Molina-Pérez José Eduardo Rodríguez-Menéndez Maria Varela 《Gastroenterologia y hepatologia》2017,40(8):515-524
Introduction
The appropriate selection of hepatocellular carcinoma (HCC) patients who are eligible for transarterial chemoembolization (TACE) remains a challenge. The ART score has recently been proposed as a method of identifying patients who are eligible or not for a second TACE procedure.Objective
To assess the validity of the Assessment for Retreatment with TACE (ART) score in a cohort of patients treated with drug-eluting bead TACE (DEB-TACE). Secondary objective: to identify clinical determinants associated with overall survival (OS).Method
A retrospective, multicentre study conducted in Spain in patients with HCC having undergone two or more DEB-TACE procedures between January 2009 and December 2014. The clinical characteristics and OS from the day before the second DEB-TACE of patients with a high ART score (ART ≥ 2.5) and a low ART score (ART 0–1) were compared. Risk factors for mortality were identified using Cox's proportional hazards model.Results
Of the 102 patients included, 51 scored 0–1.5 and 51 scored ≥2.5. Hepatitis C was more frequent in patients scoring ≥2.5. Median OS from the day before the second DEB-TACE was 21 months (95% CI, 15–28) in the group scoring 0–1.5, and 17 months (95% CI, 10–25) in the group scoring ≥2.5 (P = 0.3562). Platelet count and tumour size, but not the ART score, were independent baseline predictors of OS.Conclusions
The ART score is not suitable for guiding DEB-TACE retreatment according to Spanish clinical practice standards. 相似文献16.
Maryam Abbasian Mehri Delvarianzadeh Hossein Ebrahimi Farideh Khosravi Pirasteh Nourozi 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(4):497-500
Aims
This study aimed to investigate the relationship between the total antioxidant capacity (TAC) and Malondialdehyde (MDA) with number of metabolic syndrome (Mets) components on the personnel working in Shahroud University of Medical Sciences.Methods
This cross-sectional study was conducted on 167 personnel aged 30–60 years old. ATP III criteria were used to diagnose patients with MetS. Oxidative stress indicators were measured. The data was analyzed via one-way ANOVA, and Pearson and Spearman correlation coefficients.Results
The result showed that TAC had a significant positive correlation with HDL and a significant negative correlation with abdominal obesity. In addition, there was a significant positive association between the level of MDA and age, BMI, abdominal obesity, diastolic blood pressure, triglycerides, and LDL; however, it had a negative significant correlation with HDL.Conclusions
The measurement of TAC and MDA biomarkers can increase the early diagnosis of patients at risk of developing Mets. 相似文献17.
Inês Rodrigues Ana Abreu Mário Oliveira Pedro S. Cunha Helena Santa Clara Paulo Osório Ana Lousinha Bruno Valente Guilherme Portugal Pedro Rio Luís A. Morais Vanessa Santos Miguel M. Carmo Rui C. Ferreira 《Revista portuguesa de cardiologia》2018,37(12):961-969
Introduction
There is a lack of consensus on the definition of response to cardiac resynchronization therapy (CRT), and it is not clear which response criteria have most influence on cardiac event-free survival.Objectives
To assess the predictive value of various response criteria in patients undergoing CRT and the agreement between them.Methods
We performed a secondary analysis of the BETTER-HF trial. Patient response was classified at six months after CRT according to eleven criteria used in previous trials. The predictive value of response criteria for survival free from mortality, cardiac transplantation and heart failure hospitalization was assessed by Cox regression analysis. Agreement between the different response criteria was assessed using Cohen's kappa (κ).Results
A total of 115 patients were followed for a mean of 25 months. During follow-up, 15 deaths occurred (13%) and 29 patients had at least one adverse cardiac event (25%). Only five of the eleven response criteria were predictors of event-free survival. The most powerful isolated clinical and echocardiographic predictors were a reduction of ≥1 NYHA functional class (HR 0.39 for responders; 95% CI 0.18-0.83, p=0.014) and an increase of at least 15% in left ventricular ejection fraction (HR 0.43, 95% CI 0.20-0.90, p=0.024), respectively. Agreement between the different response criteria was poor.Conclusions
Most currently used response criteria do not predict clinical outcomes and have poor agreement. It is essential to establish a consensus on the definition of CRT response in order to standardize studies. 相似文献18.
Gabriel Sebastián Díaz-Ramírez Juan Ignacio Marín-Zuluaga Jorge Hernando Donado-Gómez Octavio Muñoz-Maya Óscar Santos-Sánchez Juan Carlos Restrepo-Gutiérrez 《Gastroenterologia y hepatologia》2018,41(2):87-96
Introduction
Autoimmune hepatitis is a chronic liver disease that impacts on morbidity and mortality of patients. Few epidemiological data exist of this in Latin America and Colombia.Objectives
The aim of this study is to describe the demographic, clinical and laboratory characteristics of the patients; the treatment and the response to it, the evolution and course of the disease, requirement of liver transplantation and mortality.Methods
Historical cohort study that include patients attended at an University Hospital in Medellin, Colombia between January 2010 and December 2016 with ≥16 years age at the time of diagnosis of autoimmune hepatitis. Data collection was done from the review of medical records. Statistical analysis was performed using SPSS version 20.Results
The study included 278 patients, 90% of the patients were women, the median age at diagnosis was 50 years. 37.8% were cirrhotic at the time of diagnosis. The biochemical remission was 85%. In patients who developed cirrhosis it was found a higher proportion of men (21.2 vs. 7.8%, p=.027), a greater frequency of overlap autoimmune-primary sclerosant cholangitis (6.0 vs. 0% p=.006) and a greater frequency of non-response to treatment (12.1 vs. 1.6%, p=.004).Conclusion
Autoimmune hepatitis is not a rare disease in Colombian population; it predominates in women but has a less favourable course in men. An important number of patients are cirrhotic at the time of diagnosis, the response to treatment and complications in our population are similar to those described worldwide. 相似文献19.
M.ª Fátima López-Fabal Alfredo Pérez-Rivilla José Luis Gómez-Garcés 《Enfermedades infecciosas y microbiología clínica》2018,36(4):222-224
Objective
All commercial assays used to measure the presence of Hepatitis C virus (HCV) antibodies set cut-off points to categorise the results, but the problem of false positive results in screening hepatitis C sera is well known.The aim of this study was to evaluate the results obtained by two chemiluminescent assays in selected sera, and compare these results with the detection of viral RNA in the specimens studied.Material and methods
Two hundred reactive sera (positive) were selected, although with a low signal to cut-off ratio (S/CO), were selected, using two chemiluminescent assays and were then subjected to genome amplification.Results and discussion
Viral RNA could be only be detected in 8 (4%) of the selected specimens. Taking these results into account, we believe that the design of the current chemiluminescent assays do not provide sufficient specificity when they are used as the only tests for the diagnosis of hepatitis C. 相似文献20.
Iker Falces-Romero Paloma Troyano-Hernáez Silvia García-Bujalance Fernando Baquero-Artigao María José Mellado-Peña Julio García-Rodríguez 《Enfermedades infecciosas y microbiología clínica》2018,36(6):357-361