共查询到20条相似文献,搜索用时 171 毫秒
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Zakaria Jalal Pierre-Emmanuel Seguela Xavier Iriart François Roubertie Astrid Quessard Bernard Kreitmann Jean-Benoit Thambo 《The Canadian journal of cardiology》2018,34(6):812.e5-812.e7
We present the case of a 4-month-old child with atrioventricular canal associated with severe left atrioventricular valve dysfunction who previously underwent 3 surgical valve reconstructions without significant improvement. A Hybrid Melody valve (Medtronic, Minneapolis, MN) insertion was planned. Because of the low weight, the risk of left ventricular outflow tract obstruction was significant and therefore evaluated preprocedurally using a cardiac computed tomography-derived 3-dimensional printed model. In vitro tests showed good anchorage of the valve without subaortic obstruction and the procedure was then achieved with an excellent clinical result. 相似文献
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Jonathan Yap Fang Yi Lim Shaw Yang Chia John Carson Allen Fazlur Rehman Jaufeerally Michael Ross Macdonald Ping Chai Seet Yoong Loh Patrick Lim Ma Wai Wai Zaw Louis Teo David Sim Carolyn S.P. Lam 《Journal of cardiac failure》2019,25(7):571-575
BackgroundRisk scores predicting in-patient mortality in heart failure patients have not been designed specifically for Asian patients. We aimed to validate and recalibrate the OPTIMIZE-HF risk model for in-hospital mortality in a multiethnic Asian population hospitalized for heart failure.Methods and ResultsData from the Singapore Cardiac Databank Heart Failure on patients admitted for heart failure from January 1, 2008, to December 31, 2013, were included. The primary outcome studied was in-hospital mortality. Two models were compared: the original OPTIMIZE-HF risk model and a modified OPTIMIZE-HF risk model (similar variables but with coefficients derived from our cohort). A total of 15,219 patients were included. The overall in-hospital mortality was 1.88% (n = 286). The original model had a C-statistic of 0.739 (95% CI 0.708–0.770) with a good match between predicted and observed mortality rates (Hosmer-Lemeshow statistic 13.8; P = .086). The modified model had a C-statistic of 0.741 (95% CI 0.709–0.773) but a significant difference between predicted and observed mortality rates (Hosmer-Lemeshow statistic 17.2; P = .029). The modified model tended to underestimate risk at the extremes (lowest and highest ends) of risk.ConclusionsWe provide the first independent validation of the OPTIMIZE-HF risk score in an Asian population. This risk model has been shown to perform reliably in our Asian cohort and will potentially provide clinicians with a useful tool to identify high-risk heart failure patients for more intensive management. 相似文献
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Estibaliz Valdeomillos Zakaria Jalal Alexandre Metras François Roubertie David Benoist Olivier Bernus Michel Haïssaguerre Pierre Bordachar Xavier Iriart Jean-Benoit Thambo 《The Canadian journal of cardiology》2019,35(12):1762-1771
Tetralogy of Fallot is the most common cyanotic congenital heart disease. Despite ongoing improvements in the initial surgical repair, there are lingering concerns regarding the long-term outcomes that may be complicated by right ventricular dysfunction, right ventricular dyssynchrony, and sudden cardiac death. The mechanisms leading to these late complications remain incompletely understood. Experimental animal models have been developed as preclinical steps to gain better insight into the pathophysiology of diseases and to develop new therapeutic strategies. This article summarizes the various types of experimental animal models of repaired tetralogy of Fallot published to date in the literature, with the aim of achieving a greater understanding of the deleterious mechanisms that may lead to these known late and sometimes lethal complications. In addition to analysing the type of animals that can be used according to a given study’s objectives, needs, and constraints, the present review also evaluates the type of dysfunction that can be reproduced in our model according to the research objectives, as well as the different types of studies in which these models can be used. In view of all that, we propose a decision algorithm to create an animal model of repaired tetralogy of Fallot. This synthesis should furthermore help in the development of future studies and in the design of new experimental models, thus allowing greater insight into this disease, while not forgetting the ultimate goal of broadening future therapeutic measures to reduce the morbidity and mortality of this prevalent congenital heart disease. 相似文献
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Meng Zhang Shuo-Lin Liu Hui-Hui Liu Geng Liu Qian Dong Jian-Jun Li 《The American journal of cardiology》2019,123(4):544-548
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Golnaz Sadjadieh Thomas Engstrøm Steffen Helqvist Dan Eik Høfsten Lars Køber Frants Pedersen Peter Nørkjær Laursen Lars Nepper-Christensen Peter Clemmensen Ole Kristian Møller-Helgestad Rikke Sørensen Jan Ravkilde Christian Juhl Terkelsen Erik Jørgensen Kari Saunamäki Hans-Henrik Tilsted Henning Kelbæk Lene Holmvang 《The American journal of cardiology》2018,121(7):781-788
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Lorenzo Azzalini Luciano Candilio Soledad Ojeda Joseph Dens Alessio La Manna Susanna Benincasa Barbara Bellini Francisco Hidalgo Jorge Chavarría Joren Maeremans Giacomo Gravina Eligio Miccichè Guido DAgosta Giuseppe Venuti Corrado Tamburino Manuel Pan Mauro Carlino Antonio Colombo 《The American journal of cardiology》2018,121(10):1138-1148
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Diego López Otero Alejandro Ávila-Carrillo Rocío González Ferreiro Adrián Cid Menéndez Diego Iglesias Álvarez Leyre Álvarez Rodríguez Pablo Antúnez Muiños Belén Cid Álvarez Xoan Carlos Sanmartín Pena Fernando Gómez Pérez Alfredo Redondo Diéguez Ignacio Cruz-González Ramiro Trillo Nouche José Ramón González-Juanatey 《The American journal of cardiology》2019,123(6):948-955
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