原因不明发热89例临床分析

目的 探讨原因不明发热(FUO)的病因和临床特点.方法 回顾性地总结分析2005年10月至2008年5月北京中日友好医院住院成人患者,符合FUO诊断标准者共89例.结果 最终明确诊断者共80例,确诊率89.9%.病因:感染性疾病41例,占46.1%;风湿性疾病15例,占16.9%;肿瘤性疾病18例,占20.2%,其中血液系统肿瘤17例;其他疾病6例,占6.7%;未明确诊断9例,占10.1%.结论 感染性疾病是FUO的主要病因,风湿性疾病和肿瘤性疾病是另两种主要病因.血液系统肿瘤是肿瘤性发热的主要病因.详尽的病史采集有助于诊断的确立.     

发热待查75例临床分析

目的探讨不明原因发热(FUO)的病因和临床特征。方法回顾性分析2005年1月～2012年1月在我科住院且符合FUO诊断标准的75例患者的临床资料,总结了病因、诊断方法和临床表现。结果 75例患者中,68例(90.7%)最终确诊,感染性疾病22例(32.4%),其中结核病9例(40.9%)、传染性单核细胞增多症5例(22.7%);结缔组织病29例(42.6%),其中成人Still病17例(58.6%)、系统性红斑狼疮6例(20.7%);恶性肿瘤10例(14.7%),其中淋巴瘤6例(60.0%);其他疾病7例(10.3%),其中组织细胞坏死性淋巴结炎4例(57.1%)。结论 FUO涉及的病因众多,发病机制复杂,感染性疾病、结缔组织病仍是发热待查的主要原因,肿瘤性疾病在发热待查中也占相当的比例,临床工作中要开阔思路,全面搜集资料,以利于明确诊断。     

其他

20031280 107例不明原因发热回顾分析/倪 武一刀解放军医学杂志一2002,27(10)一922~924 107例患者,发热持续2一3周以上,体温数次超过38.SC。仅1例最终未能明确诊断,明确诊断率为99.1%。人院后确诊时间为(10.6士12.3)天,为79天。其病因共49种,其中感染性疾病50例,风湿性疾病22例,恶性肿瘤巧例,三者共占总病例数的83.2%。感染性疾病中,各类化脓性细菌感染仍是最常见的病原体(72.0%),其次为结核菌感染(18.0%)。不明原因发热(FUO)的病程越长,感染性疾病所占比例越低,而风湿性疾病病程明显长于感染性疾病及其他杂病。淋巴造血组织肿瘤是FUO中…     

不明原因发热449例临床分析

目的探讨不明原因发热(FUO)的原因。方法回顾性分析2000年1月∽2003年12月间在我院住院诊治的符合不明原因发热诊断标准的患者449例。结果449例患者中经各种检查或诊断性治疗最终明确诊断者387例,确诊率为86．2％。病因包括：感染性疾病220例(56．8％),其中结核病96例,占43．6％(96／220);结缔组织病76例(19．6％),其中Still病占34．2％(26／76),系统性红斑狼疮占18．4％(14／76),血管炎占13．2％(10／76);肿瘤性疾病64例(16．5％),其中淋巴瘤占39．1％(25／64);其他疾病27例(7．0％),其中坏死性淋巴结炎占33．3％(9／27),伪热占22．2％(6／27),药物热占26％(7／27);出院时仍未确诊的62例(13．8％)。结论感染性疾病是本组FUO患者的主要病因,结核病是其中的主要病种,结缔组织病和肿瘤性疾病在本组FUO病因中也占重要地位;大多数FUO经仔细的临床检查和分析是可以得到确诊的。     

不明原因发热127例临床分析

目的探讨不明原因发热的常见病因及临床诊断思维。方法回顾性分析2005年1月～2009年6月因不明原因发热收入院的病人共127例。结果 127例病人中,感染性疾病78例,占61.4%,结缔组织病21例,占16.5%,恶性肿瘤共18例,占14.2%,为不明原因发热病人的主要病因。结论通过临床正确的诊疗,大部分FUO病因可以明确,其中仍以感染性疾病、结缔组织病及恶性肿瘤为主。     

发热待查184例临床分析

目的探讨近年来重庆地区长期不明原因发热待查(FUO)患者的病因。方法回顾性地总结分析1993—2003年重庆医科大学附属第一医院感染科符合FUO诊断标准的184例患者资料。结果184例患者经各种检查或诊断性治疗最后确诊者157例,确诊率85.3%。病因感染性疾病100例(54.3%),其中结核病30例,占感染性疾病的30.0%。肿瘤性疾病33例(17.9%),结缔组织疾病19例(10.3%),其他疾病5例(2.7%),原因仍未明确者27例(14.7%)。诊断方法学分析常规检查及诊断性治疗是确诊发热待查的主要方法。1999—2003年资料与1993—1998年资料相比,结核病、肿瘤性疾病、Still病比例增加。结论感染性疾病仍是发热待查的主要病因,结核病所占比例呈增高趋势。肿瘤性疾病和结缔组织疾病在发热待查中也占有相当比例,恶性组织细胞病和Still病是这两类疾病的主要病种。     

不明原因发热162例病因分析

选取2002～2008年我院急诊科收治的162例不明原因发热（FUO）患者的临床资料,分析其病因构成比及诊断方法。结果发现,149例（91．98％）FUO患者通过细菌学检查、病理学检查、影像学诊断以及诊断性治疗,得到明确诊断,其中,感染性疾病占47．53％,自身免疫疾病占19．75％,肿瘤占17．28％,其他疾病占7．41％;病因不明13例（8．02％）。认为感染性疾病是我院FUO患者的主要病因,其次为自身免疫疾病和肿瘤。制定合理的诊断策略,可减少或避免误诊或漏诊。     

95例发热待查病因分析

目的:总结分析最近2年住院发热待查患者的病因,为临床诊断治疗提供参考。方法:收集我院感染科2014年9月—2016年8月体温38.5℃以上、持续时间2周以上所有符合标准的患者95例,根据出院诊断和实验室检测结果,分析患者发热原因。结果:感染性疾病69例(72.63%),非感染性疾病21例(22.11%),不明原因者5例(5.26%)。感染性疾病中细菌感染最多(66.67%),病毒感染其次(21.74%),所有感染性疾病中,病原学明确者接近一半(47.83%)。非感染性疾病中,结缔组织病最多(52.63%)。所有病例中有明确实验室证据者占51.58%。结论:感染科发热待查主要病因仍然以感染性疾病为主,目前快速准确的诊断在一定程度上仍然依赖以临床综合分析为主,实验室病原学诊断方法有待提高。     

以不明原因发热为表现的感染性疾病50例临床分析

感染性疾病是不明原因发热 (FUO )的病因中最为常见的病种。其病原体多种多样 ,临床表现千变万化。较全面地总结此类疾病的临床特点及诊治经验 ,将为FUO的诊断提供有益的参考。本文回顾性分析了 1991年 11月～2 0 0 1年 6月间在我院感染科住院治疗的 10 7例FUO病例中 50例感染性疾病的临床特点。资料和方法一、FUO的诊断标准发热持续 2～ 3周以上 ,体温数次超过 3 8.5°C ,经完整的病史询问、体格检查以及常规的实验室检查不能明确诊断者[1 ] 。二、一般情况1991年 11月至 2 0 0 1年 6月我科共收治因“发热原因待查”而入院的患者 512…     

原因不明的长期发热369例病因诊断分析

统计FUO369例,其病因依次为感染性疾病占58%,肿瘤性疾病占18.7%,血管—结缔组织性疾病占10.6%,原因仍未明者占7%,其它疾病占5.7%.显示近5年感染性疾病减少,肿瘤和血管—结缔组织性疾病增加(P<0.05)。     

Fever of unknown origin: clinical overview of classic and current concepts

Fever of unknown origin (FUO) refers to disorders that present with prolonged and perplexing fevers that are difficult to diagnose. This article presents a clinical overview of classic and current causes of FUOs, which may be due to infectious, rheumatic/inflammatory, neoplastic, or miscellaneous disorders. Comprehensive but nonfocused diagnostic testing is ineffective and should be avoided. The FUO workup should be directed by the key history, physical, and laboratory findings in clinical presentation. The clinical syndromic approach in the differential diagnosis of FUOs is emphasized, and the diagnostic importance and significance of fever patterns are discussed.     

Standardised work-up programme for fever of unknown origin and contribution of magnetic resonance imaging for the diagnosis of hidden systemic vasculitis

BACKGROUND: Fever of unknown origin (FUO) is a diagnostic challenge. Rheumatologists are often in charge of patients with FUO because the vasculitides, especially, are potential and common causes of FUO. OBJECTIVE: To evaluate the value of a standardised investigation to identify the cause of FUO. METHODS: A standardised work-up programme for patients with FUO was started at the beginning of September 1999. The rate of identified causes of FUO was compared between all patients with FUO admitted to a tertiary care centre of rheumatology between January 1996 and August 1999 (control group) and September 1999 and January 2003 (work-up group). In January 2002 magnetic resonance imaging (MRI) was added to the investigation. RESULTS: 67 patients with FUO were identified--32 before and 35 after institution of the work-up programme. Before implementation 25% of all patients with FUO remained undiagnosed, after implementation 37%. After institution of the investigation the percentage of patients with vasculitides increased significantly from 6% (n = 2) to 26% (n = 9, p = 0.047, Fisher's exact test). This increase could be attributed to the addition of MRI in 2002. When all patients with FUO before 2002 (n = 55) and thereafter (n = 12) were compared the prevalence of systemic vasculitis increased from 11% (n = 6) to 42% (n = 5, p = 0.021). CONCLUSION: Implementation of a standardised work-up programme for FUO did not improve the overall rate of diagnosis. Addition of MRI significantly increased the diagnosis of systemic vasculitis as the underlying cause of FUO. MRI should be included in the investigation of patients with FUO when vasculitis is suspected.     

Fever of unknown origin (FUO) caused by multiple myeloma: the diagnostic value of the Naprosyn test

Fever of unknown origin (FUO) remains a difficult diagnostic problem. The causes of FUO have changed over the years. Neoplastic disorders have now displaced infectious diseases as the most common cause of FUOs. Most neoplasms are associated with no or low-grade temperatures, with some important exceptions. Hypernephromas and lymphomas are neoplasms typically associated with high spiking fevers or may present as FUOs. Hematologic malignancies, that is, the acute and chronic leukemias, myeloproliferative disorders, and multiple myeloma, do not usually present with acute fevers or as FUOs. We present an elderly male patient who presented with an FUO, whose history is significant for multiple myeloma in remission. Differential diagnostic possibilities in this patient included plasma cell leukemia, relapse of multiple myeloma, secondary/superimposed malignancy, or opportunistic infection. The main differential diagnosis for his FUO was between neoplastic and infectious disorders. As part of the diagnostic workup, a Naprosyn test (naproxen 375 mg [by mouth] every 12 hours for 3 days) was used to differentiate neoplastic from infectious causes of FUO in this patient. The Naprosyn test was positive, which indicated a neoplastic explanation for the patient's FUO and eliminated, along with the infectious disease workup, an infectious explanation for his FUO. The patient's FUO was finally determined to be the result of a relapse of multiple myeloma and not of a secondary malignancy or malignant transformation of myeloma into plasma cell leukemia. We conclude the Naprosyn test remains a valuable diagnostic test to use to narrow differential diagnostic possibilities in patients with FUOs when a malignancy is a diagnostic consideration.     

Fever of unknown origin (FUO) due to babesiosis in a immunocompetent host

Fevers of unknown origin (FUOs) are defined as prolonged fevers of 101 degrees F or greater lasting 3 or more weeks that remain undiagnosed after comprehensive inpatient/outpatient laboratory testing. Tick-borne infections are uncommon causes of FUOs. Any infectious disease accompanied by prolonged fevers can present as an FUO if the diagnosis is not suspected or if specific laboratory testing is not done to confirm the diagnosis. Babesiosis is transmitted by the Ixodes scapularis ticks endemic to areas in the northeastern United States. We present the case of a 73-year-old, non-human immunodeficiency virus, male from Long Island who presented with FUO for 6 weeks. As with malaria, there are usually few or no localizing signs in babesiosis. During the patient's hospitalization, babesiosis was suspected on the basis of nonspecific laboratory findings, that is, relative lymphopenia, thrombocytopenia, thrombocytopenia, and an elevated lactate dehydrogenase. When babesiosis was considered in the differential diagnosis, stained blood smears demonstrated the red blood cell inclusions of babesiosis. In the hospital, the patient developed noncardiac pulmonary edema, which rapidly resolved which has been described as a rare complication of babesiosis. He also had an elevated immunoglobulin-M Lyme titer indicating coinfection with Lyme disease. Although his hemolytic anemia persisted for weeks, he only had 3% parasitemia and intact splenic function. We believe this to be the first case of babesiosis presenting as an FUO in a normal host.     

Fever of unknown origin in Turkey: evaluation of 87 cases during a nine-year-period of study

OBJECTIVES: To investigate fever of unknown origin (FUO) in 87 patients. METHODS: We investigated 87 (61 male) patients with FUO using the criteria of Petersdorf and Beeson [Medicine 40 (1961) 1] hospitalized between January 1994 and August 2002 at Cukurova University Hospital. RESULTS: The median age of the patients was 38.5 years (range: 14-80 years). Eleven patients (12.6%) were over 65. The mean duration of hospitalization was 22.5+/-13 days. Infectious diseases were the most common causes of FUO. Tuberculosis (n=15, 17.2%), infective endocarditis (n=6), abdominal abscess (n=6), brucellosis (n=5), urinary tract infection (n=5), visceral leishmaniasis (n=4), salmonellosis (n=3), rhinocerebral mucormycosis (n=4), atypical pneumonia, cerebral toxoplasmosis, Cytomegalovirus infection or encephalitis were diagnosed in 51 (58.6%) patients. The second most common causes of FUO were collagen vascular diseases (n=16, 18.3%) determined as vasculitis syndrome, adult Still's disease (n=4), systemic lupus erythematosus, Beh?et's disease, juvenile ankylosing spondylitis. Neoplasm was found in 12 (13.7%) patients; (non-Hodgkin lymphoma, Hodgkin lymphoma, chronic myeloid leukemia, gastrointestinal tract carcinoma, glioma). Miscellaneous diseases thyroiditis, granulomatous hepatitis were diagnosed in two (2.2%) patients. On admission, six patients (6.8%) were neutropenic. CONCLUSIONS: Infectious diseases, especially tuberculosis, were the leading diagnostic category of FUO in this study. Adult Still's disease was more common than expected. An aetiological diagnosis could not be reached in six (7%) patients who were followed for 1 year. Five of these patients completely recovered, and one patient died.     

Fever of unknown origin: focused diagnostic approach based on clinical clues from the history, physical examination, and laboratory tests

The causes of fevers of unknown origin (FUOs) are diverse and may be the result of infectious rheumatic or inflammatory, neoplastic, or miscellaneous disorders. This article reviews the focused diagnostic approach to FUOs, emphasizing relevant history, physical examination, and selected laboratory tests using a clinical syndrome approach. Laboratory tests should be guided by the most likely diagnoses based on the presenting clinical syndrome. Considered in concert, nonspecific laboratory tests may provide important diagnostic clues. Using a sequential diagnostic approach, a focused evaluation diagnoses all but the rarest or most obscure causes of FUO.     

Fever of unknown origin: temporal arteritis presenting with persistent cough and elevated serum ferritin levels

BACKGROUND: Fever of unknown origin (FUO) at the present time is most frequently caused by neoplasm and less commonly by infection. Currently, collagen vascular diseases (CVDs) are an uncommon cause of FUO because most are readily diagnosable by serologic methods and do not remain undiagnosed for sufficient time to present as FUOs. CVDs presenting as FUOs not readily diagnosable with specific tests include late-onset rheumatoid arthritis, adult juvenile rheumatoid arthritis, and polymyalgia rheumatica/temporal arteritis (TA). TA, or giant cell arteritis, is an uncommon arteritis of the mid- and large-sized extracranial arteries of the head and neck and is a rare cause of FUO. TA is characterized by headache, scalp tenderness, jaw pain on chewing, and sudden loss of vision. Fever, anorexia, weight loss, and night sweats may also be present. With TA, respiratory symptoms occur in 9% and are the presenting feature in 4%. Laboratory abnormalities associated with TA include a highly elevated erythrocyte sedimentation rate, anemia, and thrombocytosis, and mildly increased alkaline phosphatase/serum transaminases. PATIENT: We present a patient with FUO caused by TA whose predominant presenting symptom was persistent cough that overshadowed head and neck symptoms of TA. To the best of our knowledge, this is the first case of TA presenting as an FUO, with a highly elevated serum ferritin level. RESULTS: We conclude that highly elevated serum ferritin levels in patients with FUO should alert the clinician to consider TA in the differential diagnosis.     

Fever of unknown origin in North Jordan

This is a retrospective study of all patients admitted to Basma Teaching Hospital with a diagnosis of fever of unknown origin (FUO). The study took place from January 1995 to December 2001. Fifty-two patients fulfilled the criteria of FUO. Infections were responsible for 26 cases (50%), malignancy for eight cases (15%), connective tissue disorder for six cases (12%) and others for 12 cases (23%). Infections remain the most common causes of FUO in Jordan, mainly tuberculosis, brucellosis and typhoid fever.