共查询到20条相似文献，搜索用时 296 毫秒
1.
《Clinical gastroenterology and hepatology》2023,21(2):370-379
- Download : Download high-res image (312KB)
- Download : Download full-size image
2.
3.
4.
《Clinical gastroenterology and hepatology》2023,21(2):456-466.e7
- Download : Download high-res image (431KB)
- Download : Download full-size image
5.
6.
7.
8.
9.
10.
Salvatore Petta Giada Sebastiani Mauro Viganò Javier Ampuero Vincent Wai-Sun Wong Jerome Boursier Annalisa Berzigotti Elisabetta Bugianesi Anna Ludovica Fracanzani Calogero Cammà Marco Enea Marraud des Grottes Vito Di Marco Ramy Younes Aline Keyrouz Sergio Mazzola Yuly Mendoza Grazia Pennisi Victor de Ledinghen 《Clinical gastroenterology and hepatology》2021,19(4):806-815.e5
Background & AimsPatients with advanced fibrosis related to nonalcoholic fatty liver disease (NAFLD) are at risk of developing hepatic and extrahepatic complications. We investigated whether, in a large cohort of patients with NAFLD and compensated advanced chronic liver disease, baseline liver stiffness measurements (LSMs) and their changes can be used to identify patients at risk for liver-related and extrahepatic events.MethodsWe performed a retrospective analysis of consecutive patients with NAFLD (n = 1039) with a histologic diagnosis of F3–F4 fibrosis and/or LSMs>10 kPa, followed for at least 6 months, from medical centers in 6 countries. LSMs were made by FibroScan using the M or XL probe and recorded at baseline and within 1 year from the last follow-up examination. Differences between follow up and baseline LSMs were categorized as: improvement (reduction of more than 20%), stable (reduction of 20% to an increase of 20%), impairment (an increase of 20% or more). We recorded hepatic events (such as liver decompensation, ascites, encephalopathy, variceal bleeding, jaundice, or hepatocellular carcinoma [HCC]) and overall and liver-related mortality during a median follow-up time of 35 months (interquartile range, 19–63 months).ResultsBased on Cox regression analysis, baseline LSM was independently associated with occurrence of hepatic decompensation (hazard ratio [HR], 1.03; 95% CI, 1.02–1.04; P < .001), HCC (HR, 1.03; 95% CI, 1.00–1.04; P = .003), and liver-related death (HR, 1.02; 95% CI, 1.02–1.03; P = .005). In 533 patients with available LSMs during the follow-up period, change in LSM was independently associated with hepatic decompensation (HR, 1.56; 95% CI, 1.05–2.51; P = .04), HCC (HR, 1.72; 95% CI, 1.01–3.02; P = .04), overall mortality (HR, 1.73; 95% CI, 1.11–2.69; P = .01), and liver-related mortality (HR, 1.96; 95% CI, 1.10–3.38; P = .02).ConclusionsIn patients with NAFLD and compensated advanced chronic liver disease, baseline LSM and change in LSM are associated with risk of liver-related events and mortality. 相似文献
11.
12.
13.
Donghee Kim Nia Adeniji Nyann Latt Sonal Kumar Patricia P. Bloom Elizabeth S. Aby Ponni Perumalswami Marina Roytman Michael Li Alexander S. Vogel Andreea M. Catana Kara Wegermann Rotonya M. Carr Costica Aloman Vincent L. Chen Atoosa Rabiee Brett Sadowski Veronica Nguyen Renumathy Dhanasekaran 《Clinical gastroenterology and hepatology》2021,19(7):1469-1479.e19
14.
15.
Karin Feldmann Carlo Maurer Katja Peschke Steffen Teller Kathleen Schuck Katja Steiger Thomas Engleitner Rupert Öllinger Alice Nomura Nils Wirges Aristeidis Papargyriou Rim Sabrina Jahan Sarker Raphela Aranie Ranjan Zahra Dantes Wilko Weichert Anil K. Rustgi Roland M. Schmid Roland Rad Maximilian Reichert 《Gastroenterology》2021,160(1):346-361.e24
- Download : Download high-res image (146KB)
- Download : Download full-size image
16.
17.
18.
19.
《Clinical gastroenterology and hepatology》2023,21(5):1303-1313.e11
- Download : Download high-res image (269KB)
- Download : Download full-size image