江门市新会区脂肪肝的流行病学调查及危险因素分析

目的研究脂肪肝在江门市新会区成人中的流行趋势、现状与危险因素。方法对3483各类体检人员的健康咨询、体格检查、空腹血糖、肝功能、血脂等指标及肝脏B超检查结果进行回顾性分析。结果江门市新会区体检人员中检出脂肪肝769例（22．08％），经年龄和性别调整后，新会区成人脂肪肝患病率21．57％。酒精性脂肪肝、可疑酒精性脂肪肝、非酒精性脂肪肝患病率分别为0．86％、0．69％、20．02％。脂肪肝患病率均随年龄增长而增加，60岁之前男性脂肪肝患病率显著高于女性．而60岁以后男女脂肪肝患病率相当。单因素分析显示，脂肪肝组年龄、体重指数、腰围、舒张压、空腹血糖、甘油三酯、胆固醇、丙氨酸氨基转移酶均显著高于非脂肪肝组（P〈0．001）。多元回归分析显示：甘油三酯、腰围、空腹血糖、BMI、舒张压、丙氨酸氨基转移酶、年龄和性别（男性）等指标与脂肪肝密切相关。结论江门市新会区成人脂肪肝患病率高，主要为非酒精性脂肪肝。脂肪肝发病率男性明显高于女性。高脂血症、超重及肥胖、糖代谢紊乱、高血压、高丙氨酸氨基转移酶、年龄、男性等为脂肪肝危险因素。     

上海市社区60岁以上人群脂肪肝患病率及危险因素的横断面研究

目的了解上海市社区60岁以上人群脂肪肝的患病率及危险因素。方法对闵行区梅陇社区7534名60岁以上人群定期体检,填写统一设计的调查表,内容包括:一般情况、实验室检查、B型超声检查结果等。结果其中女性4198名,男性3336名,女男之比为1.26:1,平均年龄(68.8±7.0)岁。经B型超声检出脂肪肝3074例,占40.80%。60岁以上老年人脂肪肝患病率随着年龄增加而呈下降趋势,患病率最高的年龄段为60～64岁,达到45.20%。80岁以下,女性患病率显著高于男性。脂肪肝组的体质指数(BMI)、腰围、腰臀比(WHR)、三酰甘油、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、收缩压(SBP)、ALT、γ-谷氨酸转肽酶(GGT)等指标显著高于非脂肪肝组,而高密度脂蛋白胆固醇(HDL-C)则低于非脂肪肝组。相比正常对照组,肥胖、中心性肥胖和高脂血症分别增加脂肪肝患病风险15.2倍、10.8倍和8.6倍(P<0.01)。多元回归分析发现,女性、BMI、SBP、三酰甘油、HDL-C、LDL-C、TC、ALT、GGT等9项指标与脂肪肝密切相关。结论上海市社区60～64岁人群脂肪肝患病率较高,与肥胖及脂代谢紊乱密切相关。     

陕、甘两省酒精性与非酒精性脂肪肝流行病学分析

目的调查陕西省和甘肃省成人酒精性、非酒精性脂肪肝患病率并分析相关危险因素。方法采用横断面调查的方式，调查两省成人脂肪肝患病率，内容包括填写问卷，测量身高、体重、腰围，生化检查和B超检查。结果共调查1500人，其中男性1023名，女性477名。共检出脂肪肝247例，其中饮酒率、酒精性脂肪肝、非酒精性脂肪肝的检出率分别为56．53％、3．87％、12．60％。男性脂肪肝患病率无论是酒精性还是非酒精性均高于女性（P〈O．05）。脂肪肝的患病率随年龄的增加而上升。经Logistic多元回归分析，年龄、日酒精摄入量、饮酒年限、BMI与酒精性脂肪肝密切相关，其中以日酒精摄入量相对风险度最高（OR=9．941，95％CI4．803～20．577）；年龄、男性、高脂血症、BMI、腰围与非酒精性脂肪肝密切相关，其中以高脂血症相对风险度最高（OR=3．750，95％cI2．752～6．745）。结论两省成人脂肪肝患病率较高，以非酒精性脂肪肝为主。肥胖、饮酒是脂肪肝最重要的危险因素。     

邵阳市区成人胆石症患病率及其危险因素流行病学调查

目的明确邵阳市区成人胆石症的患病率及其主要危险因素。方法通过多阶段随机抽样,对邵阳市3个城区26个社区18岁以上居民进行调查,内容涉及问卷调查、体格检查、生化检测及肝胆B超检查。结果5267名成人完成调查,占邵阳市区总人口的1.24%。其中男性2704名,女性2563名,年龄46.1±14.4岁。B超共检出胆石症388例,占7.4%,年龄≥70岁组最高,女性患病率为男性的1.14倍。胆石症组的年龄、收缩压、体重指数(BMI)、空腹血糖和低密度脂蛋白胆固醇(LDL-ch)、糖尿病、血脂异常和脂肪肝患病率等显著高于对照组。多元回归分析显示:体重指数、年龄、脂肪肝等三项指标与胆石症密切相关。结论邵阳市区成人胆石症患病率高,体重指数、年龄、脂肪肝与胆石症密切相关。     

延安地区成人脂肪肝患病率及其危险因素的探讨

目的调查并探讨延安地区成人脂肪肝的患病率及其主要危险因素。方法收集延安大学附属医院2011年2月-2013年3月资料完整的健康体检者,均接受人体学测量(身高、体质量、血压)、生化及免疫学检查(肝功能、血糖、血脂、血尿酸、肾功能、病毒标志物)及超声检查。资料分析采用t检验、χ2检验及Logistic回归分析法。结果共6236例健康体检者参与调查研究,约占延安市人口的3.76‰。其中男3532例,女2704例,平均(49.27±12.93)岁。B超共检出脂肪肝1602例,占25.69%,其中酒精性、可疑酒精性、非酒精性脂肪肝分别占4.55%、7.08%及88.37%。脂肪肝组肥胖、高血压、高尿酸血症、空腹血糖过高、糖尿病、血脂异常患病率等均显著高于非脂肪肝组。多元回归分析显示:年龄、男性、饮酒、腰围、身体质量指数(BMI)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、尿酸(UA)、空腹血糖、糖尿病、高血压病是脂肪肝的危险因素,其中HDL-C是脂肪肝的保护因素。空腹血糖调节受损组及糖尿病组较血糖正常组相比脂肪肝患病风险分别增加了1.584、2.638倍(P值均0.001);超重、Ⅰ度肥胖、Ⅱ度肥胖组与正常体质量组相比脂肪肝患病风险分别增加了1.627、1.796、9.544倍(P值均0.001);适量饮酒、过量饮酒组与无饮酒组相比,脂肪肝患病风险分别增加1.638、3.648倍(P值均0.001);肥胖加饮酒组较无肥胖和饮酒组相比,脂肪肝患病风险增加了17.672倍(P0.001)。收缩压、舒张压、UA、TG、总胆固醇(TC)、LDL-C增高组及HDL-C降低组较正常组相比脂肪肝患病风险分别增加了1.835、1.768、1.821、4.524、1.569、1.824、2.724倍,差异具有统计学意义(P0.05)。其中以TG及HDL-C异常的危险性增加最为明显。结论延安地区成人脂肪肝患病率偏高,主要为非酒精性脂肪肝,性别、年龄、肥胖、饮酒、糖代谢紊乱、高尿酸血症、高血压及血脂异常为主要的危险因素。     

761例成人脂肪肝患者的患病情况调查及相关危险因素分析

目的了解脂肪肝在本组成人中的患病情况及探讨脂肪肝发生的相关危险因素。方法对2009年在我院进行体检的3481名各类体检人员的体检资料进行统计,对比分析,内容包括健康咨询、空腹血糖、肝功能、血脂等指标及肝脏B超检查等。结果体检人员中检出脂肪肝患者761例(21.86%),经年龄和性别调整后,本组成人脂肪肝发生率21.6%。酒精性脂肪肝、可疑酒精性脂肪肝、非酒精性脂肪肝发生率分别为0.67%、0.83%和20.01%。脂肪肝发生率均随年龄增长而增加,50岁之前男性脂肪肝发生率显著高于女性。而50岁以后男女脂肪肝发生率相当。单因素分析显示,脂肪肝组的年龄、体重指数、腰围、腰臀比、舒张压、空腹血糖、甘油三酯、胆固醇、丙氨酸转氨酶均比非脂肪肝组显著为高。多元问归分析显示:甘油三酯、腰围、腰臀比、空腹血糖、体重指数、舒张压、丙氨酸转氨酶、年龄和男性等指标是脂肪肝的危险因素。结论成人脂肪肝发生率高,主要为非酒精性脂肪肝。高脂血症、超重及肥胖、糖尿病、高血压、高丙氨酸转氨酶、年龄、男性等为脂肪肝的危险因素。     

乌鲁木齐地区汉族成人脂肪肝及其相关危险因素的多元回归分析

目的了解乌鲁木齐地区机关汉族成人脂肪肝的临床特点及其相关危险因素。方法对机关工作的汉族健康体检者进行问卷调查、生化、肝脏超声检查等相关资料进行单因素和多因素logistic回归分析。结果脂肪肝患病率为26.8%,其中非酒精性脂肪肝患病率18.1%,酒精性脂肪肝患病率8.7%,男女脂肪肝患病率差异无显著性。单因素分析显示,非酒精性脂肪肝与年龄、胆固醇、甘油三酯、血糖、体重指数、腰围/臀围比值、吸烟、高脂饮食相关(P0.05);酒精性脂肪肝与年龄、胆固醇、饮酒相关(P0.05)。经多元回归分析,脂肪肝危险因素依次为TG、BMI、高脂饮食、TC。结论非酒精性脂肪肝的患病率与TG、BMI、TC、高脂饮食密切相关,饮酒是酒精性脂肪肝的独立危险因素,上述相关因素可作为预防和治疗脂肪肝的依据。     

海门市农村社区成人脂肪肝患病及相关因素分析

目的了解海门市农村社区成人脂肪肝的患病率及相关因素。方法选取海门镇振邦村20岁以上常住居民进行调查,获取一般情况、体格检查(身高、体重、腰围、臂围、血压等)、生化指标(空腹血糖、血酯、肝功能等)以及肝脏超声诊断结果。结果在670例调查对象中共发现脂肪肝87例,患病率为12.99%(男13.11%,女12.93%),标化患病率为12.52%(男23.54%,女9.53%)。男性以30岁以上组最高,女性以70岁以上组最高,但标化后也以30岁以上最高。男性各年龄组间患病率差异有统计学意义(x2=24.22,P<0.01),30岁以上组、40岁以上组同年龄组男女间差异有统计学意义。男性脂肪肝组BMI、腰围、腰臂化、甘油三脂、ALT水平均显著高于非脂肪肝组;女性脂肪肝组BMI、腰围、腰臂比、甘油三酯、总胆固醇、空腹血糖、ALT水平均显著高于非脂肪肝组。随着BMI的增高,男女脂肪肝的患病率均不断上升,以≥30kg-1·m2时的患病率最高,分别为50.00%、63.16%,男女同性别间比较差异有统计学意义。在腰围、血酯、高血压病、糖尿病方面,除男性高血压病者外,其余各项指标同性别间脂肪肝的患病率,差异均有统计学意义。结论海门市农村社区的成人脂肪肝患病率与城市机关职员患病率相近,并有低龄化趋势,以中青年为主。脂肪肝的发生与BMI、腰围、腰臂比和甘油三酯等的关系密切。     

男女两性脂肪肝患病率随年龄变化的特征性分析

目的探讨石家庄市不同性别脂肪肝患病率随年龄的增长变化及其危险因素。方法选取2012年1月-2012年12月在某体检中心体检的健康体检者57 150名(男39 442名,女17 708名),通过年龄、性别分层后比较其患病率及其增长变化,通过单因素及二项Logistic回归分析探讨男女脂肪肝的危险因素。结果 B超检出脂肪肝共20 045例,总患病率35.1%,其中男性高于女性(41.7%vs 20.2%,χ2=2 491.00,P0.001),男性在26~34岁年龄段患病率增加最显著(2.1%/年),45~49岁年龄段达到高峰(49.9%);女性在45~59岁年龄段患病率显著增加,并于55~59年龄段达到高峰(1.75%/年,42.4%)。单因素分析显示年龄、体质量、体质量指数(BMI)、腰围、臀围、腰臀比、甘油三脂、总胆固醇、谷丙转氨酶、尿酸等在脂肪肝组明显高于非脂肪肝组(P0.01)。二项Logistic回归分析表明BMI、腰臀比、甘油三脂、谷丙转氨酶、尿酸均为男性女性脂肪肝患者的危险因素,但总胆固醇仅为男性脂肪肝患者的危险因素。结论男性人群在25~34岁年龄段脂肪肝患病率增长较快,女性人群在55~69岁年龄段脂肪肝患病率增长较快,在该年龄段实施预防能起到事半功倍的效果。     

乌鲁木齐地区脂肪肝发病率及非酒精性脂肪肝与代谢综合征的关系

目的了解乌鲁木齐地区机关汉族成人非酒精性脂肪肝及酒精性脂肪肝的流行状况,并分析非酒精性脂肪肝与代谢综合征的关系。方法对1037例体检者的问卷调查、体格检查、生化、肝脏超声检查等相关资料进行分析。结果乌鲁木齐地区成人脂肪肝检出278例,脂肪肝发生率为检出率为26.8%,非酒精性脂肪肝188例,占18.1%,其中男性161例,女性27例;酒精性脂肪肝90例,占8.7%,其中男性84例,女性6例,男性NAFLD高于女性。NAFLD患者合并MS共计115例,伴有率为61.2%。结论乌鲁木齐地区机关汉族成人脂肪肝（NAFLD及AFLD）患病率远高于国内以及世界范围平均患病率,体现了低龄化趋势及中年年龄段的患病高峰特点;年龄、BMI、WHR、TG以及FPG为NAFLD的相关危险因素,NAFLD可以作为MS组成成分之一。     

上海市成人胆石症患病率及危险因素的流行病学调查

目的明确上海市成人胆石症的患病率及其危险因素。方法通过随机多级分层整群抽样对杨浦区和浦东新区各4个居委会15岁以上居民进行调查,内容涉及问卷咨询、体格检查、75g葡萄糖耐量试验、血脂检测、以及肝脏及胆道系统实时超声检查。结果 3173名15岁以上人群成为此次调查的研究对象,约占上海市人口2.26/10000。男性1217名,女性1956名。年龄15～88岁,平均（52.4±15.1）岁,男女间年龄差异无统计学意义。B超共检出胆石症339例（10.7%）,经年龄和性别调整后,上海市成人胆石症患病率为7.5%。男性和女性的胆石症患病率均随年龄增长而增加。单因素分析显示,胆石症组年龄、体重指数、收缩压、舒张压、空腹及餐后2小时血糖、甘油三酯、低密度脂蛋白胆固醇（P〈0.01）、总胆固醇（P〈0.05）均显著高于非胆石症组,而高密度脂蛋白胆固醇则低于非胆石症组（P〈0.01）。男性胆石症危险因素包括肥胖、高血压病、糖耐量异常/糖尿病以及脂肪肝（P〈0.05）;女性胆石症危险因素包括肥胖、中心性肥胖、高血压病、糖耐量异常/糖尿病、高胆固醇血症、高甘油三酯血症以及脂肪肝（P〈0.05）。二项分类变量Logistic回归分析显示仅年龄、收缩压、脂肪肝共3项指标与胆石症相关。结论胆石症为上海市成人的常见病,年龄、肥胖、高血压病、糖耐量异常/糖尿病以及脂肪肝与其发病相关。     

崇明地区脂肪肝患病率及其危险因素的流行病学调查

目的:明确崇明地区脂肪肝的患病率及其相关危险因素.方法:采用随机整群抽样方法,调查崇明县城桥镇40～70岁3017名常住居民的脂肪肝患病情况,内容涉及问卷调查、体格检查、口服葡萄糖耐量试验、血脂等生化检测和肝脏实时B型超声(B超)检查.分析脂肪肝相关的危险因素.结果:3017名居民完成调查,占崇明地区人口的80.15/万,其中男882名,女2135名,平均年龄(55.6±8.0)岁.B超明确脂肪肝诊断共1262例,占41.83％,经年龄和性别标化后,崇明地区脂肪肝的患病率为21.25％.标化后男、女患病率无统计学差异(24.53％比20.40％,P＞0.05).其中非酒精性脂肪性肝病患者1120例,占脂肪肝总数的88.75％.单因素分析显示脂肪肝组的空腹血糖(FPG)、餐后2h血糖(2hPG)、总胆同醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、收缩压(SBP)、舒张压(DBP)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、γ-谷氨酰转肽酶(GGT)均显著高于非脂肪肝组,高密度脂蛋白胆固醇(HDL-C)低于非脂肪肝组,差异均有统计学意义(P＜0.0001).多元回归分析显示,年龄、2hPG、TG、LDL-C、SBP、ALT、GGT等指标与脂肪肝密切相关.结论:崇明地区脂肪肝患病率高,主要为非酒精性脂肪性肝病.年龄增长、血脂紊乱、高血压和糖尿病是脂肪肝患病的危险因素.     

Prevalence of nonalcoholic fatty liver among administrative officers in Shanghai： an epidemiological survey

AIM: To determine the prevalence of nonalcoholic fatty liver in a specific population in Shanghai by an epidemiological survey, and to analyze risk factors of fatty liver.METHODS: Total 4009 administrative officers who denied regular alcohol drinking participated in the survey, and underwent physical examination and laboratory tests. The important parameters were body mass index (BMI), waist hip circumferences ratio (WHR) and levels of serum lipids.Diagnosis of fatty liver was based on established real-time ultrasonographic criteria, the presence of an ultrasonographic pattern consistent with “bright liver”, with evident ultrasonographic contrast between hepatic and renal parenchyma, vessel blurring, and narrowing of the lumen of the hepatic veins. Analysis of data was performed through SPSS for Windows statistical package.RESULTS: The overall prevalence of fatty liver was 12.9%,15.8% in males and 7.5% in females, and the prevalence of fatty liver in males younger than 50 years old, was significantly higher (13.3%) than that of in females (2.7%).But the difference between the sexes became less significant in people older than 50 years (19.1% vs 18.1%). Theprevalence of fatty liver was increased with age; this was markedly presented in females younger than 50 years.Multiple variant regression analysis demonstrated that the prevalence of fatty liver was positively correlated to several risk factors, including male, aging (&gt;50yr), hyperlipidemia,impaired glucose tolerance/diabetes mellitus, hypertension and overweight/obesity.CONCLUSION: There is a high prevalence of nonalcoholic fatty liver among certain population in Shanghai, to which overweight and hyperlipidemia are closely relevant.     

Correlation between fatty liver and coronary risk factors: a population study of elderly men and women in Nagasaki, Japan.

The relation between fatty liver, detected by ultrasonography as a marker of visceral fat accumulation, and coronary risk factors was studied in 810 elderly men and 1,273 elderly women in Nagasaki, Japan from 1990 to 1992. The prevalence of fatty liver was 3.3% in the male and 3.8% in the female non-obese participants (BMI, body mass index < 26.0 kg/m2) and 21.6% in the male and 18.8% in the female obese participants (26.0 kg/m2 < or = BMI). Fatty liver was significantly (p < 0.01) related to hypercholesterolemia and hypertriglyceridemia in the men and to hypertension, hypercholesterolemia, low-HDL cholesterol, hypertriglyceridemia and diabetes mellitus or impaired glucose tolerance (DM+IGT) in the women independent of age, obesity, smoking and drinking. Non-obesity with fatty liver, rather than obesity with or without fatty liver, had the highest odds ratio for hypertension and low-HDL cholesterol in the men and for hypercholesterolemia, low-HDL cholesterol, hypertriglyceridemia and DM+IGT in the women. The prevalence of fatty liver is the same in elderly men and women, and fatty liver is an independent correlate of coronary risk factors in the elderly.     

Fatty liver and the metabolic syndrome among Shanghai adults

BACKGROUND AND AIM: To explore the relationship between fatty liver and the metabolic syndrome in the adults of Shanghai and evaluate the value of fatty liver as a marker for risk factor clustering. METHODS: Questionnaires, physical examinations, laboratory tests (blood lipid and glucose) and real-time liver ultrasonographies were performed in Shanghai adults and analyzed using randomized, multistage, stratified cluster sampling. Prevalence of the metabolic syndrome was defined by the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII) criteria with the exception of abdominal obesity (waist circumference > 90 cm in men and > 80 cm in women); fatty liver was diagnosed in accordance with the presence of an ultrasonographic pattern consistent with 'bright' liver (brightness and posterior attenuation of liver). RESULTS: The study population consisted of 3175 subjects (1218 men) with a mean (+/- SD) age of 52.4 +/- 15.1 years. Metabolic syndrome and fatty liver were found in 726 (22.87%) and 661 (20.82%) of sampled cases, respectively. After adjustment by age and sex, the prevalence of the metabolic syndrome and fatty liver in the general population of Shanghai were 15.30 and 17.29%, respectively. The risk for fatty liver in subjects with abdominal obesity, diabetes, dyslipidemia and hypertension increased 32.78-fold (95% confidence interval (CI) 14.85-72.35), 31.58-fold (95% CI 14.18-70.35), 22.64-fold (95% CI 10.26-49.99) and 23.25-fold (95% CI 10.54-51.30), respectively, compared with controls, whereas the risk for fatty liver in subjects with metabolic syndrome was increased by 39.33-fold (95% CI 17.77-87.05). After the 661 patients with fatty liver had been stratified by body mass index (BMI), the prevalence of abdominal obesity, hypertension and the metabolic syndrome were increased from 25.0, 47.2 and 36.1%, respectively, in people with normal BMI to 81.0, 73.8 and 55.4%, respectively, in obese persons. However, the prevalence of hypertriglyceridemia, high fasting glucose and low high-density lipoprotein-cholesterol showed no significant changes with increased BMI. Moreover, among fatty liver patients with normal BMI, the detection rate for one or more features of metabolic disorders was as high as 83.3% and that for five features was 2.8%. Compared with obesity (BMI > or = 25 kg/m2) and abdominal obesity, fatty liver had the highest clustering rate, specificity, positive predictive value and attributable risk percentage in detecting risk factor clustering in both sexes. CONCLUSIONS: There is a high prevalence of metabolic syndrome and fatty liver among Shanghai adults. Metabolic disorders are closely related to fatty liver; moreover, fatty liver appears to be a good predictor for the clustering of risk factors for metabolic syndrome.     

东北地区城市脂肪肝的患病率及其危险因素的流行病学调查

目的探讨东北地区成人脂肪肝的流行病学特征及其危险因素。方法选取2009年1月~2009年12月具有完整资料的某体检中心的健康体检者15 635例,其中男9 037例,女6 598例,男女之比为1.37：1,年龄16~95岁,平均年龄（47.85±13.21）岁。通过性别、年龄分层后比较脂肪肝的患病率,并将脂肪肝患者的体质量指数、血压、血脂、血糖、尿酸、血常规、肝功能等检测结果与非脂肪肝组进行对比分析。结果 B超共检出脂肪肝患者5 955例,总患病率为38.1%,男性患病率显著高于女性（48.8%vs23.4%,χ2=1039.853,P〈0.001）;30~69岁的男性脂肪肝的患病率超过50%,尤以40~49岁最高（55.2%）,女性在39岁之前脂肪肝的发生率不足10%,50岁后骤然上升至35%以上,60~69岁达到高峰并超过男性（43.4%vs40.5%）,70岁以后女性脂肪肝患病率仍显著高于同龄男性（35.5%vs28.3%,χ2=7.670,P〈0.006）。非脂肪肝人群超重者占35.6%,肥胖占7.5%,而脂肪肝人群两者分别为51.0%,36.8%。脂肪肝组的血压、血糖、甘油三酯（TG）等增高的检出率明显高于非脂肪肝组,高密度脂蛋白胆固醇（HDL-C）降低的检出率明显低于非脂肪肝组（P均〈0.001）。单因素分析显示,体质量指数（BMI）、收缩压、TG、空腹血糖（FBG）和血尿酸（UA）,以及γ谷氨酰基转移酶和丙氨酸氨基转移酶在脂肪肝组明显高于非脂肪肝组（P均〈0.001）;相反,HDL-C则显著低于非脂肪肝组（t=47.174,P〈0.001）。多因素Logistic回归分析提示,脂肪肝危险因素包括BMI、TG、UA、FBG、舒张压、胆固醇等,OR值分别为3.590、1.936、1.567、1.508、1.346和1.177。结论东北地区城市男女脂肪肝的发生率在各年龄段有明显差异,脂肪肝的发生与代谢综合征的组分明显相关,尿酸的增高也与脂肪肝的发生明显相关。     

Alcohol consumption and metabolic syndrome among Shanghai adults： A randomized multistage stratified cluster sampling investigation

AIM： To examine the relations of alcohol consumption to the prevalence of metabolic syndrome in Shanghai adults. METHODS： We performed a cross-sectional analysis of data from the randomized multistage stratified cluster sampling of Shanghai adults, who were evaluated for alcohol consumption and each component of metabolic syndrome, using the adapted U.S. National Cholesterol Education Program criteria. Current alcohol consumption was defined as more than once of alcohol drinking per month. RESULTS： The study population consisted of 3953 participants （1524 men） with a mean age of 54.3 ± 12.1 years. Among them, 448 subjects （11.3%） were current alcohol drinkers, including 405 males and 43 females. After adjustment for age and sex, the prevalence of current alcohol drinking and metabolic syndrome in the general population of Shanghai was 13.0% and 15.3%, respectively. Compared with nondrinkers, the prevalence of hypertriglyceridemia and hypertension was higher while the prevalence of abdominal obesity, low serum high-density-lipoprotein cholesterol （HDL-C） and diabetes mellitus was lower in subjects who consumed alcohol twice or more per month, with a trend toward reducing the prevalence of metabolic syndrome. Among the current alcohol drinkers, systolic blood pressure, HDL-C, fastingplasma glucose, and prevalence of hypertriglyceridemia tended to increase with increased alcohol consumption. However, low-density-lipoprotein cholesterol concentration, prevalence of abdominal obesity, low serum HDL-C and metabolic syndrome showed the tendency to decrease. Moreover, these statistically significant differences were independent of gender and age.CONCLUSION： Current alcohol consumption is associated with a lower prevalence of metabolic syndrome irrespe- ctive of alcohol intake （g/d）, and has a favorable influence on HDL-C, waist circumference, and possible diabetes mellitus. However, alcohol intake increases the likelihood of hypertension, hypertriglyceridemia and hyperglycemia. The clinical signi     

Non Alcoholic Fatty Liver Disease in Southern Iran: A Population Based Study

Background

Population based studies on prevalence and risk factors of NAFLD in Iranian population are few. The prevalence of NAFLD and non alcoholic steatohepatitis (NASH) in Iranians varies from 2.9% to 7.1% in general population and 55.8% in patients with type 2 diabetes mellitus.

Objectives

To determine the prevalence and determinants of non alcoholic fatty liver disease (NAFLD) in a sample of adult Iranian general population.

Patients and Methods

This was a cross-sectional study being performed in Shiraz, southern Iran during a 10-month period from November 2010 to September 2011 through cluster random sampling of Iranian general population in Shiraz region. All individuals undergone anthropometric, blood pressure measurements, thorough medical history and physical examinations. Laboratory measurements included fasting blood glucose (FBS), lipid profile, complete blood count (CBC) and liver function tests. NAFLD was diagnosed by transabdominal ultrasonography.

Results

819 subjects were included in this study among which were 340 males (41.5%) and 479 females (58.5%) with the mean age of 43.1 ± 14.1 years. NAFLD was diagnosed in 176 (21.5%) subjects. Patients with NAFLD were significantly older (P < 0.001), had higher proportion of male gender (P = 0.004) and had higher BMI (P < 0.001). They also had higher prevalence of hypertension (P < 0.001), high FBS (P < 0.001), high cholesterol (P = 0.026), high triglyceride (P < 0.001) and high waist circumference (P < 0.001). Taking all these together, patients with NAFLD had significantly higher prevalence of metabolic syndrome when compared to healthy subjects (P < 0.001).

Conclusion

The prevalence of NAFLD in this group of Iranian adult general population is 21.5%. NAFLD in Iranian population is associated with male gender, old age, obesity, and features of metabolic syndrome.     

人体质量指数及其变化与非酒精性脂肪性肝病发病的关系

目的 探讨健康成人基线体质量及其变化与非酒精性脂肪性肝病(NAFLD)发病的关系.方法 回顾性分析1999年和2001年上海宝山钢铁责任有限公司的普通员工健康体检资料,主要包括个人嗜好、既往病史、人体学指标、动脉血压,空腹血清甘油三酯(TG)、总胆固醇、葡萄糖、ALT以及肝脏实时超声的检查结果.选择研究期间无习惯性饮酒史[每月饮酒小于2次和(或)每周饮用乙醇量小于140 g]以及基线时血清ALT正常(小于40 U/L)和实时超声检查未发现脂肪肝者为研究对象.血清生物化学指标用Bayer 1650全自动生物化学分析仪测定,由同一名资深影像学医师利用同一台1400型Aloka实时超声显像仪(探头频率3.5MHz)作肝脏检查.应用SPSS12.0统计软件进行数据分析,计量资料用均数±标准差表示,采用t检验、方差分析、非参数检验.计数资料用率表示,采用x2检验.结果 有5402例研究对象2年后再次体检时影像学诊断脂肪肝327例(6.05%),每1000人每年发生NAFLD 30例.年龄＜50岁发生脂肪肝者占5.7%(281/4624),≥50岁发生脂肪肝者占9.3%(46/451),x2=9.87,P＜0.01.人体质量指数(BMI)差值在无脂肪肝组为0.50±1.29,脂肪肝组为0.95±1.25,t-6.11,P＜0.01.TG差值在无脂肪肝组为(0.11±1.06)mmol/L,脂肪肝组为(0.35±1.71)mmol/L,t=2.48,P＜0.05.TC差值无脂肪肝组为(0.52±0.63)mmol/L,脂肪肝组为(0.62±0.70)mmol/L,t=2.40,P＜0.05.NAFLD的发病率随基线BMI增加而显著增高,趋势分析显示x2=389.01,P=0.000.体质量正常、超重、肥胖症和重度肥胖症患者NAFLD发病率分别为1.4%、6.4%、16.8%和24.5%.多元回归分析显示基线年龄、BMI和血清TG水平以及随访期间BMI和TG增加幅度与NAFLD的发病密切相关.结论 普通职工NAFLD发病率高,基线时肥胖和代谢紊乱以及随访中体质量和TG增加是发生NAFLD的重要预测因素.