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1.
目的研究重组人脑利钠肽(rh BNP)和硝酸甘油治疗急性失代偿性心力衰竭(ADHF)的疗效和安全性。方法选择2013年1月~2014年12月于我院就诊的ADHF患者50例作为研究对象,根据治疗应用药物区别分为重组人脑利钠肽组和硝酸甘油组,各25例,针对两组患者疗效和安全性指标进行对比分析。结果治疗前血BNP、PCWP和PAP水平均较正常显著升高,两组患者治疗后三项治疗均有显著降低,差异有统计学意义(P0.05);但rh BNP组三项指标下降幅度明显大于硝酸甘油组,差异有统计学意义(P0.05)。两组患者均未发生于药物应用相关的严重不良反应。结论 rh BNP能够有效改善ADHF患者全身临床症状和血流动力学,疗效性高于硝酸甘油,且其安全性无明显改变。  相似文献   

2.
目的本文研究重组人脑利钠肽应用于急性心梗后失代偿性心力衰竭的疗效。方法选取我院2013年03月~2015年03月收治的急性心梗后失代偿性心力衰竭患者120例作为研究对象,将其平均划分为观察组(n=60例)与对照组(n=60例),分别予以重组人脑利钠肽、多巴酚丁胺治疗。对比2组患者治疗后的血脑钠肽水平(BNP)、左室射血分数(EF)。结果观察组经重组人脑利钠肽治疗后的血脑钠肽水平明显低于对照组(P0.05);观察组的左室射血分数则高于对照组(P0.05)。结论将重组人脑利钠肽药物应用于急性心梗后失代偿性心力衰竭患者中可降低血脑钠肽水平,改善患者的心功能。  相似文献   

3.
目的: 比较静脉注射重组人脑钠尿肽(recombinant human brain natriuretic peptide,rhBNP)对伴有不同水钠潴留程度的急性失代偿心力衰竭(ADHF)患者的血流动力学作用及临床疗效。方法: 我院40例ADHF住院患者按水钠潴留程度分为试验组(中重度者,20例)和对照组(轻度者,20例),各组再随机抽取10例应用Swan-Ganz导管进行血流动力学监测,记录给药前及给药后0.5、1、3、6及24 h肺毛细血管楔压(PCWP)、肺动脉压(PAP)和右房压(RAP)并通过热敏稀释法测定心排出量(CO),计算心脏指数(CI)。所有患者均给抗心力衰竭治疗并给予rhBNP,首先以2 μg/kg静脉冲击,随后以0.01 μg/(kg·min)连续静脉滴注24 h,记录两组患者给药前及给药后0.5、1、3、6及24 h的呼吸困难及整体临床状况改善程度,以及用药后24 h液体出入量。结果: 与对照组比较,试验组患者呼吸困难及整体临床状况改善更明显,并伴随更佳的利尿作用[(2.7±0.8) L vs. (1.7±0.4) L,P=0.01]。试验组PCWP及RAP下降较迅速、明显且稳定持久,两组间PAP比较无统计学差异。两组CI比较组内及组间均无明显统计学差异。结论: 伴有中重度水钠潴留的ADHF患者较伴有轻度水钠潴留的患者应用rhBNP治疗有更好的急性血流动力学效应和临床效果,可能是rhBNP临床使用的最佳人群。  相似文献   

4.
目的分析重组人脑利钠肽联合硝普钠对治疗急性失代偿性心力衰竭患者血流动力学指标及左心室射血分数(LVEF)的影响。方法选取本院108例急性失代偿性心力衰竭患者,随机分为对照组(n=54)与观察组(n=54),对照组给予硝普钠治疗,观察组在对照组治疗的基础上给予重组人脑利钠肽,对比两组血流动力学指标、尿量及LVEF的变化情况。结果观察组用药后1h平均肺动脉压与平均肺毛细血管楔压均低于治疗前(P0.05),且均低于对照组(P0.05),而心输出量则高于治疗前(P0.05),且高于对照组(P0.05)。观察组24h总尿量多于对照组(P0.05)。观察组用药后1h的LVEF高于对照组(P0.05)。结论重组人脑利钠肽联合硝普钠可以有效改善急性失代偿性心力衰竭患者的血流动力学指标,促进排尿,提高LVEF水平,增强临床疗效。  相似文献   

5.
目的分析急性失代偿性心力衰竭治疗中使用重组人脑利钠肽和硝酸异山梨酯的重组人脑利钠肽和硝酸异山梨酯的效果。方法 2013年5月—2016年12月,于青海省西宁市第一人民医院收治的急性失代偿性心力衰竭患者中选取100例,随机分为两组,各50例。两组均采用常规疗法进行治疗,在此基础上,给予对照组患者硝酸异山梨酯治疗,给予观察组患者重组人脑利钠肽治疗,比较两组临床疗效。结果观察组临床治疗总有效率为98%,相较于对照组的64%更低(P0.05);相较于治疗前,两组患者治疗后的生活质量评分均有所降低,24h尿量均有所增加,且观察组改善幅度优于对照组(P0.05)。结论急性失代偿性心力衰竭治疗中使用重组人脑利钠肽的效果较硝酸异山梨酯更加显著,值得推广。  相似文献   

6.
李焕明 《山东医药》2010,50(5):53-54
目的探讨重组人脑利钠肽(rhBNP)治疗失代偿性心力衰竭(心衰)的疗效,以及其对肾素—血管紧张素—醛固酮系统(RAS)的影响。方法将60例失代偿性心衰患者随机分为两组,在常规治疗基础上,治疗组加用rhBNP,对照组加用硝酸甘油或硝普钠,治疗72 h观察两组疗效;记录其治疗前、治疗后心率、心功能NYHA分级,心脏超声检测左心室舒张末期内径、左心室射血分数(LVEF),以及血浆肾素(PRA)、血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)变化。结果与对照组比较,治疗组总有效率、LVEF明显升高,心率、血浆PRA、AngⅡ、ALD明显降低(P均〈0.05)。结论rhBNP治疗失代偿性心衰疗效明显,其作用机制可能与拮抗RAS过度激活有关。  相似文献   

7.
张青  葛海龙  周玉杰 《心脏杂志》2009,21(3):387-389
目的 评价重组人脑钠尿肽(rhBNP)治疗慢性心力衰竭(CHF)的疗效。方法 CHF患者53例,分为rhBNP组23例和对照组30例。观察两组用药前后右房压(RAP)、肺毛细血管楔嵌压(PCWP)、肺动脉压(PAP)、心脏指数(CI)、血浆去甲肾上腺素(NE)、血管紧张素Ⅱ(AngⅡ)及醛固酮(Ald)的变化。结果 rhBNP在降低RAP,PCWP,PAP,NE,AngⅡ及Ald等指标方面与对照组和本组治疗前比较均有统计学差异。对CI、血钠、血钾无明显影响。无明显不良反应。结论 rhBNP可改善CHF患者血流动力学状况,拮抗NE,AngⅡ,Ald的过度激活,较为安全。  相似文献   

8.
目的探讨重组人脑利钠肽治疗急性心梗后失代偿性心力衰竭的临床疗效。方法选择2013年6月~2014年5月我院收治的88例急性心梗后失代偿性心力衰竭患者作为研究对象,将其随机分为对照组与观察组,每组患者各44例,分别予以重组人脑利钠肽及多巴酚丁胺治疗,对两组患者用药前及用药72小时后血脑钠肽、左室射血分数值予以测定,重新评定患者心功能Killip分级,统计30天内患者病死率。结果治疗后,两组患者血脑钠肽水平较之于治疗前明显下降,且左室射血分数值显著上升;与对照组比较,观察组心功能Killip分级显著改善,组间比较差异显著(P0.05),无严重不良反应发生。结论重组人脑利钠肽与多巴酚丁胺相较可以更进一步改善急性心梗后失代偿性心力衰竭患者的临床症状,可作为有效的药物选择。  相似文献   

9.
目的比较重组人脑钠肽(rh BNP)与硝酸甘油治疗急性前壁心肌梗死(AAMI)合并失代偿性心力衰竭的疗效及安全性。方法选取2012年3月至2013年10月在驻马店市中心医院心内科CCU的AAMI合并失代偿性心力衰竭患者42例,男性29例,女性13例,年龄范围18~75岁。随机分为两组:脑钠肽组(20例)和硝酸甘油组(22例)。脑钠肽组在常规治疗基础上静脉泵入rh BNP;硝酸甘油组在常规治疗基础上静脉泵入硝酸甘油,均连续治疗72 h。两组患者治疗前后评定心功能分级,监测心率、血氧饱和度、72 h尿量等,检测左心室射血分数(LVEF)、左心室短轴缩短率(FS)、心脏指数(CI)、心输出量(CO)、二尖瓣血流舒张早期最大流速E峰与心房收缩期最大流速A峰的比值(E/A),并记录药物的不良反应,随访30 d内心血管不良事件情况。结果脑钠肽组总有效率高于硝酸甘油组(95.0%vs.63.6%),差异有统计学意义(P0.05)。脑钠肽组治疗开始后各时间点肺毛细血管楔压(PCWP)和肺动脉压(PAP)均低于硝酸甘油组,差异具有显著统计学意义(P均0.01)。治疗72 h后,与硝酸甘油组比较,脑钠肽组患者的心率、呼吸频率减少,血氧饱和度、72 h尿量增加,差异具有显著统计学意义(P均0.01);收缩压和呋塞米用量降低(P均0.05)。治疗72 h后,与硝酸甘油组比较,脑钠肽组患者的LVEF[(33.52±10.47)%vs.(46.86±11.32)%]、FS[(18.86±6.39)%vs.(22.40±6.55)%]、CI[(2.24±0.48)L/(min?m2)vs.(2.87±0.33)L/(min?m2)]、CO[(4.87±0.37)L/min vs.(5.16±0.42)L/min]、E/A[(0.85±0.17)vs.(0.93±0.19)]均升高,差异具有统计学意义(P均0.05)。脑钠肽组发生症状性低血压1例,硝酸甘油组发生头部胀痛7例,低血压1例。随访30 d内心血管不良事件,脑钠肽组心血管不良事件发生率明显低于硝酸甘油组(5%vs.45.5%,P0.05)。结论rh BNP能够降低PCWP、PAP,排钠利尿,改善血流动力学和心功能,减少心血管不良事件,不良反应较少,疗效与安全性优于硝酸甘油。  相似文献   

10.
目的:应用Swan-Ganz导管进行血流动力学监测,评价重组人脑钠肽注射液(商品名:奈西立肽)药物治疗急性失代偿性心力衰竭(急性心衰)患者的疗效和安全性. 方法:本研究有中国5家心血管临床研究中心参加,人选40例急性心衰患者.患者用药前应用Swan-Ganz导管进行血流动力学监测,使用奈西立肽先静脉注射2μg/kg,之后,持续静脉泵入0.01μg/(kg·min)24小时.分别在用药前、用药后15 min、1 h、3 h、24 h测量并记录肺毛细血管楔压(PCWP)、肺动脉压(PAP)和心脏排血指数(CI).同时记录治疗前、后的呼吸困难程度、其他临床症状以及全身临床情况的评估.用药过程中及用药后定期测量血压、心率、呼吸频率以及相关的血液生化指标,并对用药过程中出现所有不良事件进行记录,进行安全性评估. 结果:本试验40名受试者都完成了24小时治疗.用药后肺毛细血管楔压、肺动脉收缩压显著性下降、心脏排血指数显著性增高.用药后各观察时间点与用药前比较,差异均有统计学意义(P相似文献   

11.
This article continues a series of reports updating recent research developments of particular interest to personnel involved in the treatment and management of patients with heart failure. This is a summary of selected presentations made at the American College of Cardiology 51st Annual Scientific Session held in Atlanta on 17-20 March 2002. Reports of the following clinical studies are included: LIFE, DANAMI 2, MADIT-2, MIRACLE-ICD, OVERTURE, OCTAVE, ENABLE 1 & 2, CHRISTMAS, AFFIRM, RACE, WIZARD, AZACS, REMATCH, BNP trial and HARDBALL.  相似文献   

12.
The electrochemical behaviors of rare earth (RE) ions have extensively been studied because of their high potential applications to the reprocessing of used nuclear fuels and RE-containing materials. In the present study, we fully investigated the electrochemical behaviors of RE(III) (La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, and Yb) ions over a Ni sheet electrode in 0.1 M NaClO4 electrolyte solution by cyclic voltammetry between +0.5 and −1.5 V (vs. Ag/AgCl). Amperometry electrodeposition experiments were performed between −1.2 and −0.9 V to recover RE elements over the Ni sheet. The successfully RE-recovered Ni sheets were fully characterized by scanning electron microscopy, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and photoluminescence spectroscopy. The newly reported recovery data for RE(III) ions over a metal electrode provide valuable information on the development of the treatment methods of RE elements.  相似文献   

13.
14.
To investigate the prevalence, self-awareness, and treatment of hypertension in Lhasa, Tibet, a total of 1370 native Tibetan aged ≥18 years were selected, using stratified proportional sampling. The study showed that the prevalence of hypertension was 51.2%, significantly higher in men (56.0%) than in women (48.0%) (P = .004). The hypertension prevalence increased with increasing age (77.8% in 60–74 y and 82.5% in ≥75 y groups) and was higher in urban, suburban, or agricultural area than in pastoral area (P < .001). The self-awareness, treatment, and control rate of hypertension were 63.5%, 24.3% and 7.7%, respectively. In multivariable regression analysis, age, urban residence, amount of daily intake of fat and oil, and body mass index <18.5 kg/m2 were independently associated with hypertension. In conclusion, hypertension was highly prevalent among native Tibetan people in Lhasa, and the rates of self-awareness, treatment, and control of hypertension were low.  相似文献   

15.
16.

Aims

Drug interactions with bile acid sequestrants are primarily due to the potential of these agents to bind to concomitant drugs. Six clinical studies were performed to determine the effects of colesevelam on the pharmacokinetics of aspirin, atenolol, enalapril, phenytoin, rosiglitazone, and sitagliptin.

Methods

All six studies enrolled healthy subjects aged 18–45 years. The phenytoin study used a single-dose, three-period crossover design (phenytoin alone, phenytoin simultaneously with colesevelam, and phenytoin 4 h before colesevelam). The other studies used a two-period crossover design (test drug alone and test drug simultaneously with colesevelam). Colesevelam (3750 mg once daily) was dosed throughout the pharmacokinetic sampling period. After each single dose of the test drug, serial blood samples were collected for determination of plasma drug concentrations and calculation of pharmacokinetic parameters.

Results

For all six test drugs, 90% CIs for geometric least-squares mean ratios of AUC and Cmax for the measured analytes were within specified limits, indicating no interaction between the test drug and colesevelam.

Conclusions

Aspirin, atenolol, enalapril, rosiglitazone, and sitagliptin may be taken with colesevelam. Although the phenytoin study indicated no pharmacokinetic interaction, phenytoin should continue to be taken ≥4 h before colesevelam in accordance with current prescribing information.  相似文献   

17.
18.
This article provides information and a commentary on trials relevant to the pathophysiology, prevention and treatment of heart failure, presented at the American College of Cardiology. Unpublished reports should be considered as preliminary data, as analyses may change in the final publication. CARISMA investigated the use of implantable loop recorders for detecting life-threatening arrhythmias in patients with LVSD after MI and found that brady- and ventricular tachy-arrhythmias predicted an adverse prognosis. The TRENDS study showed that the burden of atrial fibrillation detected by pacemakers or defibrillators predicted the risk of embolic events but not with sufficient precision to justify changes in anti-thrombotic management. A meta-analysis of six trials reported an increased cardiovascular risk associated with celecoxib, particularly for heart failure, which was related to dose and baseline cardiovascular risk. The HAT study failed to show a benefit of providing post-MI patients with a home defibrillator. MOMENTUM, a study of a device designed to augment aortic blood flow, was stopped early due to increased bleeding risk. Results from PROTECT support the use of rolofylline 30 mg/day in acute heart failure, a definitive study is now underway. Istaroxime, an agent that appears to have both inotropic and lusitropic effects, improved haemodynamics when added to standard therapy in patients stabilised after admission with heart failure in HORIZON-HF. The REVERSE study suggested that CRT improves ventricular function and reduces morbidity even in patients with few or no symptoms of heart failure and may delay or prevent worsening heart failure.  相似文献   

19.
During the last few years, the number of patients receiving anticoagulant and antiplatelet therapy has increased worldwide. Since this is a chronic treatment, patients receiving it can be expected to need some kind of surgery or intervention during their lifetime that may require treatment discontinuation. The decision to withdraw antithrombotic therapy depends on the patient's thrombotic risk versus hemorrhagic risk. Assessment of both factors will show the precise management of anticoagulant and antiplatelet therapy in these scenarios. The aim of this consensus document, coordinated by the Cardiovascular Thrombosis Working Group of the Spanish Society of Cardiology, and endorsed by most of the Spanish scientific societies of clinical specialities that may play a role in the patient-health care process during the perioperative or periprocedural period, is to recommend some simple and practical guidelines with a view to homogenizing daily clinical practice.Full English text available from: www.revespcardiol.org/en  相似文献   

20.
BACKGROUND:The process of microcrystallization,its sequel and the assessment of nucleation time is ignored.This systematic review aimed to highlight the importance of biliary microlithiasis,sludge,and crystals,and their association with gallstones,unexplained biliary pain,idiopathic pancreatitis, and sphincter of Oddi dysfunction.DATA SOURCES:Three reviewers performed a literature search of the PubMed database.Key words used were"biliary microlithiasis","biliary sludge","bile crystals","cholesterol crystallisation","bile microscopy","microcrystal formation of bile","cholesterol monohydrate crystals","nucleation time of cholesterol","gallstone formation","sphincter of Oddi dysfunction"and"idiopathic pancreatitis".Additional articles were sourced from references within the studies from the PubMed search.RESULTS:We found that biliary microcrystals account for almost all patients with gallstone disease,7%to 79%with idiopathic pancreatitis,83%with unexplained biliary pain, and 25%to 60%with altered biliary and pancreatic sphincter function.Overall,the detection of biliary microcrystals in gallstone disease has a sensitivity ranging from 55%to 87%and a specificity of 100%.In idiopathic pancreatitis,the presence of microcrystals ranges from 47%to 90%.A nucleation time less than 10 days in hepatic bile or ultra-filtered gallbladder bile has a specificity of 100%for cholesterol gallstone disease.CONCLUSIONS:Biliary crystals are associated with gallstone disease,idiopathic pancreatitis,sphincter of Oddi dysfunction, unexplained biliary pain,and post-cholecystectomy biliary pain.Pathways of cholesterol super-saturation,crystallisation, and gallstone formation have been described with scientificsupport.Bile microscopy is a useful method to detect microcrystals and the assessment of nucleation time is a good method of predicting the risk of cholesterol crystallisation.  相似文献   

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