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1.
目的 观察重组人类表皮生长因子(rhEGF)滴眼液对白内障超声乳化术后眼表损伤的修复疗效.方法 白内障超声乳化术后89例60岁以上老年患者120只眼,随机分为:A组(40只眼)术后给予rhEGF滴眼液;B组(40只眼)术后给予人工泪液.C组(40只眼)为空白对照组.分别于术后第1、7、15、30天观察干眼症状,并进行角膜荧光素染色、泪膜破裂时间(BUT)及泪液分泌试验.结果 术后第7、15、30天,三组角膜荧光素染色有显著差异(P<0.05).术后第15、30天,三组泪膜破裂时间有显著差异(P<0.05).术后第7、15、30天三组泪液分泌试验有显著差异(P<0.05).结论 rhEGF滴眼液对白内障超声乳化吸除术后眼表损伤的修复有促进作用.  相似文献   

2.
目的分析干眼症与2型糖尿病及其有关因素的相关性。方法选取2016年2月—2017年12月在医院接收的30例2型糖尿病患者30例非糖尿病患者作为该次研究的观察对象。30例2型糖尿病患者作为此次研究的观察组,30例非糖尿病患者作为此次研究的对照组。对两组患者的性别、年龄、血糖、糖尿病病程、血清CRP。同时对患者的瞬目次数、视力角膜荧光素染色评分、基础泪液分泌、泪膜破裂时间进行记录评分。对生化指标和眼表指标之间的关系进行对比。同时利用回归分析方法对2型糖尿病患者患干眼的相关因素及危险因素进行分析。结果经过相关的检查,发现观察组患者的干眼症发病率要显著高于对照组,其发病率为30%。观察组患者的平均泪膜破裂时间(4~8秒)要明显低于对照组。观察组患者的泪液分泌试验滤纸条的平均浸润长度要低于对照组,为5~9 mm。观察组患者的角膜荧光素染色评分要高于对照。两组患者的差异有统计学意义(P0.05)。分析得出糖尿病患者的年龄、糖尿病病程、泪膜破裂时间、泪液基础分泌量是2型糖尿病患者出现干眼症的相关因素。结论 2型糖尿病患者的基础泪液分泌量减少,且泪膜破裂时间缩短,同时患者的角膜荧光素染色评分提高。2型糖尿病与干眼症有着一定的相关性。泪膜破裂时间、泪液基础分泌量、年龄、血糖控制水平、糖尿病病程是2型糖尿病患者主要的相关因素与危险因素。  相似文献   

3.
目的观察人工泪液治疗白内障超声乳化联合人工晶体植入术后发生干眼症的临床疗效。方法 205例(205眼)行白内障超声乳化联合人工晶状体植入术,将术后发生干眼症的患者随机分为对照组、玻璃酸钠组、聚丙烯酸组、聚乙二醇组,比较术后第1、2、3周及1个月术眼症状、角膜荧光素染色、泪膜破裂时间(BUT)、基础泪液分泌量(sehimer I)。结果对照组与三个用药组术后1个月患者的恢复情况差异显著,说明三种药对于白内障超声乳化术后起到加速泪膜恢复的作用。观察组间比较,玻璃酸钠组术后干眼症状消失时间早。结论白内障超声乳化联合人工晶体植入术后加用不同种类人工泪液可以有效改善干眼症状,其中含有玻璃酸钠成分的人工泪液效果较好。  相似文献   

4.
目的探讨长期滴用抗青光眼药物对老年患者睑板腺功能的影响。方法回顾性分析26例(48只眼)长期局部滴用抗青光眼药物的老年患者病史、问卷调查、眼部常规检查:Schirmer I试验、泪膜破裂时间、角膜荧光素染色、裂隙灯观察睑板腺情况。结果 48只眼中有32只眼患有睑板腺功能障碍,用药时间的增长会增加对睑板腺功能的损害。经过分组治疗,有效率达到96.87%。结论长期局部滴用抗青光眼药物可损害睑板腺功能,可能造成睑板腺功能障碍。  相似文献   

5.
《内科》2017,(4)
目的观察杞菊地黄汤内服联合熏敷治疗肝肾阴虚型干眼症患者的疗效。方法将肝肾阴虚型干眼症患者70例随机分为两组,对照组患者35例(70只眼)给予玻璃酸钠滴眼液治疗,研究组患者35例(70只眼)在对照组的治疗基础上给予杞菊地黄汤内服联合熏敷治疗,两组患者疗程均为4周。比较两组患者治疗前后眼部主观症状积分、中医证候积分、泪液分泌试验(SIT)结果、泪膜破裂时间(BUT)、角膜荧光素染色(FL)情况以及临床治疗效果。结果疗程结束后,两组患者眼部主观症状积分、中医证候积分均显著下降(P0.05),研究组患者显著低于对照组(P0.01);两组患者SIT、BUT均显著增大,FL积分显著降低(P0.05),研究组患者SIT、BUT显著大于对照组,FL积分显著低于对照组(P0.05);研究组患者治疗总有效率(94.29%)显著高于对照组(71.43%),临床疗效优于对照组(P0.01)。结论在使用玻璃酸钠滴眼液治疗的基础上,杞菊地黄汤内服联合熏敷治疗肝肾阴虚型干眼症患者,能显著改善患者的眼部症状,促进泪液分泌,增强泪膜稳定性,提高临床治疗效果。  相似文献   

6.
目的探讨玻璃酸钠联合重组人表皮生长因子(rh EGF)滴眼液对老年白内障术后干眼症泪膜的疗效。方法白内障术后干眼症患者85例,依据随机数字表法分为观察组(45例)和对照组(40例)。对照组给予玻璃酸钠治疗,观察组同时给予玻璃酸钠联合rh EGF滴眼液联合治疗。对比两组临床疗效、泪膜破裂时间(BUT)、泪液分泌长度、角膜荧光素染色(FL)评分,并检测两组治疗前后白细胞介素(IL)-6和肿瘤坏死因子(TNF)-α水平。结果观察组治疗总有效率显著高于对照组(P<0.05)。治疗后两组BUT均升高,泪液分泌长度、FL评分、IL-6和TNF-α水平均降低,且观察组以上各指标改善更明显(P<0.05)。结论玻璃酸钠联合rh EGF滴眼液对老年白内障术后干眼症泪膜能够促进泪膜修复、减轻炎症反应,临床效果更好。  相似文献   

7.
自体血清治疗干眼症临床观察   总被引:1,自引:0,他引:1  
目的 寻找治疗干眼症的新方法。方法 对9例干眼症患者采用自体血清点眼.观察治疗前后泪膜破裂时间、Schirmer试验、荧光素染色、泪河高度等各项临床指标变化。结果 各项临床观察指标均有不同程度好转。结论 自体血清点眼治疗干眼症,方法简便,效果确切。  相似文献   

8.
目的观察杞菊地黄丸联合聚乙二醇滴眼液点眼与单纯应用聚乙二醇滴眼液治疗2型糖尿病患者的干眼症的治疗效果。方法将2017年3—12月已经确定患有2型糖尿病患者,同时符合干眼症诊断标准的50例患者,随机分为联合组和对照组,各25例50眼。联合组采用口服杞菊地黄丸和局部滴用聚乙二醇(思然)滴眼液;对照组采用单纯滴用聚乙二醇(思然)滴眼液。根据临床症状和基础泪液分泌试验、泪膜破裂时间、角膜荧光素钠染色等检查进行评分,治疗观察3个月。结果两组不同方法治疗后,BUT,SIt,FL 3项指标与治疗前比较,差异有统计学意义(P0.05),且治疗后联合组上述实验结果明显高于对照组(P0.01);联合药物治疗组有效率96%,单纯药物治疗组总有效率64%,联合组疗效明显优于对照组(P0.01)。结论杞菊地黄丸联合聚乙二醇滴眼液局部点眼治疗2型糖尿病的患者干眼症疗效较单纯使用聚乙二醇液滴眼疗效好。  相似文献   

9.
目的 探讨原发性干燥综合征(pSS)患者干眼病的临床特点.方法 回顾性分析2009年8月至2011年8月在我院风湿免疫科住院并确诊为pSS的96例患者的干眼病诊断性检查数据.结果 在96例患者中:①干眼症状明显的患者达到89例,其中23例有2种以上的干眼症状;②泪膜破裂时间( BUT)检查<5 s的154只眼,5~10 s的18只眼,>10 s的20只眼,平均(3.7±1.9)s;③泪河高度:<0.3 mm的154只眼,平均(0.21±0.10) mm;④Van Bijsterveld角膜荧光素染色评分:平均得分为5.2±2.4;⑤Schirmer Ⅰ试验:192只眼滤纸湿长均<10mm/5min,平均为(4.6±1.8)mm;⑥睑板腺功能评分:平均1.5±0.9.结论 pSS患者的泪河宽度降低、Schirmer Ⅰ试验滤纸湿长减少,泪液分泌量减少;同时BUT缩短、伴有睑板腺功能障碍.pSS所致的干眼病是一种混合型的干眼病.  相似文献   

10.
吴娜  张蕊 《山东医药》2014,(2):75-77
目的 探讨青光眼合并白内障患者行超声乳化白内障吸除人工晶状体植入术联合小梁切除术后泪膜变化情况.方法 闭角型青光眼合并年龄相关性白内障患者36例(36眼),均行超声乳化白内障吸除人工晶状体植入术联合小梁切除术(术眼组),每例以对侧健康眼作对照(对照组),分别于术前3d及术后1d、1周、1个月、3个月以干眼调查问卷获得患者的自觉症状并进行评分,同时行泪膜破裂时间(BUT)、基础泪液分泌试验(SIt)、角膜荧光素染色(FL)检查,对两组上述指标进行比较.结果 术眼组术前有干眼症状者12例(30.5%),术后有干眼症状者28例(77.8%),术后多于术前(P均<0.05).术眼组术后1d、1周、1个月FL评分明显高于术前(P均<0.05),术后3个月与术前相比差异无统计学意义(P均>0.05).术眼组术后各时间点BUT短于术前(P均<0.05),SIt值明显下降,以术后1d和1周下降最为明显,术后1~3个月SIt值有所升高,但仍明显低于术前(P均<0.05).术后28例发生干眼症.结论 超声乳化白内障吸除人工晶状体植入术联合小梁切除术治疗青光眼合并白内障,患者术后干眼症状加重,泪膜稳定性下降,泪液分泌减少.  相似文献   

11.
目的胰岛素瘤是最常见的胰腺神经内分泌肿瘤,因其临床表现多样,导致诊断困难。影像学诊断尤其是超声内镜(EUS)在胰岛素瘤的诊断中起着重要作用,拥有较高的敏感性和特异性。本研究拟通过明确胰岛素瘤的解剖分布特点,以期有助于提高影像学的诊断准确率和降低漏诊率,尤其是在教育和培训实践中对于EUS的学习者更具有指导价值。 方法回顾性分析解放军总医院第一医学中心病案资料数据库1993年1月至2019年11月经外科手术、病理确诊为胰岛素瘤的患者的临床资料,检索方法采取搜索术后病理诊断为"胰岛素瘤"的病例,通过查阅病例的方法,提取出胰岛素瘤的大小和解剖分布等数据,进一步分析其特点。 结果共检索到确诊为胰岛素瘤的患者116例,其中,男45例、女71例,年龄13~76岁,平均年龄(44.4±14.85)岁。胰岛素瘤单发110例(94.8%)、多发6例(5.2%)。位置分布:头颈部46例(39.7%),单发45例、多发1例;体尾部68例(58.6%),单发65例、多发3例;全胰腺多发2例(1.7%)。病变大小特点:最大径0.4~3.4 cm,平均大小(1.53±0.58)cm。≤1 cm 29例、>1 cm而≤1.5 cm41例、>1.5 cm而≤2.0 cm28例,≤3 cm 15例,>3 cm 3例。年龄与肿瘤的大小相关,≤44岁患者肿瘤平均大小为(1.36±0.51)cm、>44岁患者肿瘤平均大小为(1.70±0.60)cm,P<0.05。头颈部的肿瘤大于体尾部的肿瘤,头颈部肿瘤平均大小(1.66±0.63)cm,体尾部(1.42±0.52)cm,P<0.05。 结论胰岛素瘤在胰腺体尾部较头颈部更好发;绝大多数单发,但可以全胰腺多发;多数小于1.5 cm,肿瘤的大小与患者年龄和肿瘤的解剖分布相关。  相似文献   

12.
Most adenomas and carcinomas of the small intestine and extrahepatic bile ducts arise in the region of the papilla of Vater. In familial adenomatous polyposis (FAP) it is the main location for carcinomas after proctocolectomy. In many cases symptoms due to stenosis lead to diagnosis at an early tumor stage. In about 80%, curative intended resection is possible. Operability is the most relevant prognostic factor. Most ampullary carcinomas resp. carcinomas of the papilla of Vater develop from adenomatous or flat dysplastic precursor lesions. They can be sited in the ampulloduodenal part of the papilla of Vater, which is lined by intestinal mucosa. They also can develop in deeper parts of the ampulla, which are lined by pancreaticobiliary duct mucosa. Intestinal-type adenocarcinoma and pancreaticobiliary-type adenocarcinoma represent the main histological types of ampullary carcinoma. Furthermore, there exist unusual types and undifferentiated carcinomas. Many carcinomas of intestinal type express the immunohistochemical marker profile of intestinal mucosa (keratin 7?, keratin 20+, MUC2+). Carcinomas of pancreaticobiliary type usually show the immunohistochemical profile of pancreaticobiliary duct mucosa (keratin 7+, keratin 20?, MUC2?). Even poorly differentiated carcinomas, as well as unusual histological types, may conserve the marker profile of the mucosa they developed from. These findings underline the concept of histogenetically different carcinomas of the papilla of Vater which develop either from intestinal- or from pancreaticobiliary-type mucosa of the papilla of Vater. Molecular alterations in ampullary carcinomas are similar to those of colorectal as well as pancreatic carcinomas, although they appear at different frequencies. In future studies, molecular alterations in ampullary carcinomas should be correlated closely with the different histologic tumor types. Consequently, the histologic classification should reflect the histogenesis of ampullary tumors from the two different types of papillary mucosa.  相似文献   

13.
Summary Palmitic acid oxidation in rat diaphragm homogenate is depressed by biguanide concentrations that are still incapable of inhibiting oxidative phosphorylation. Glucose oxidation is not directly effected by the same biguanide concentrations: however, the inhibitory effect of palmitic acid on glucose oxidation is partly removed by biguanides. Inhibition of fatty acid oxidation, which accounts for most of the metabolic effects caused by these drugs, can be regarded as the fundamental mechanism of action of biguanides. There is some evidence suggesting that these drugs might interact with carnitine, thus preventing long-chain fatty acids from being transported across the mitochondrial membrane to the site of oxidation. Traduzione a cura degli AA.  相似文献   

14.
BACKGROUND AND AIM: Both the clinical presentation and the degree of mucosal damage in coeliac disease vary greatly. In view of conflicting information as to whether the mode of presentation correlates with the degree of villous atrophy, we reviewed a large cohort of patients with coeliac disease. PATIENTS AND METHODS: We correlated mode of presentation (classical, diarrhoea predominant or atypical/silent) with histology of duodenal biopsies and examined their trends over time. RESULTS: The cohort consisted of 499 adults, mean age 44.1 years, 68% females. The majority had silent coeliac disease (56%) and total villous atrophy (65%). There was no correlation of mode of presentation with the degree of villous atrophy (p=0.25). Sixty-eight percent of females and 58% of males had a severe villous atrophy (p=0.052). There was a significant trend over time for a greater proportion of patients presenting as atypical/silent coeliac disease and having partial villous atrophy, though the majority still had total villous atrophy. CONCLUSIONS: Among our patients the degree of villous atrophy in duodenal biopsies did not correlate with the mode of presentation, indicating that factors other than the degree of villous atrophy must account for diarrhoea in coeliac disease.  相似文献   

15.
氯硝柳胺悬浮剂的毒性评价   总被引:4,自引:2,他引:2  
目的评价氯硝柳胺悬浮剂的毒性,为现场大规模应用灭螺提供依据。方法按照中华人民共和国国家标准GB 15670-1995《农药登记毒理学试验方法》和鱼类毒性试验方法进行。结果经口、经皮肤的LDso雌、雄性大鼠均>5 000 mg/kg,经呼吸道的LCso雌、雄性大鼠均>5 000mg/m3,该药经口、经皮肤、经呼吸道毒性均属微毒类药物;兔眼用药后,观察期内无不良反应,对眼无刺激性;皮肤用药后对皮肤无刺激性。与氯硝柳胺原药、氯硝柳胺乙醇胺盐原药和氯硝柳胺乙醇胺盐可湿性粉剂相比,氯硝柳胺悬浮剂对鱼急性毒性最低。结论氯硝柳胺悬浮剂属微毒类药物,对鱼的毒性低于其乙醇胺盐可湿性粉剂,适合于现场应用。  相似文献   

16.
17.
血吸虫童虫是宿主免疫系统攻击的重要靶标,包括皮肤型、肺型和肝门型童虫。宿主分子对童虫生长发育具有重要作用。童虫生长发育机制包括免疫调节、信号转导、性别发育及凋亡等。肌动蛋白、组织蛋白酶、烯醇化酶和葡萄糖基转移酶等分子为血吸虫童虫生长发育的重要分子。本文对血吸虫童虫生长发育及其机制的研究进展做一综述。  相似文献   

18.
The aim of the study was to assess the quality of life (QOL) and the psychological status of parents of children with juvenile chronic arthritis (JCA). The QOL, anxiety and depression of the parents of 28 children with JCA were evaluated and compared to those of the parents of 28 healthy children. Mothers of JCA children and mothers of healthy children reported similar QOL. The reported anxiety and depression levels were similar for mothers and fathers in both groups. The parents of children with pauciarticular-type JCA reported lower QOL and higher levels of anxiety and depression than the parents of children with other types, namely polyarticular and systemic JCA. These findings may be explained by the fact that the pauciarticular patients had shorter disease duration and were less frequently seen in the outpatient clinic. The QOL of mothers of children with JCA was found to be slightly impaired in the group of children with pauciarticular JCA. Future larger studies are needed to confirm these results, as the number of subjects in the three groups was rather low. Received: 26 September 2001 / Accepted: 8 February 2002  相似文献   

19.
G. Rock 《Vox sanguinis》2011,100(2):169-178
Introduction Current methods for pathogen inactivation of plasma involve four major processes using solvent–detergent (SD), methylene blue (MB), amotosalen and riboflavin as additives. Three of these methods involve the use of visible or ultraviolet light. Methods A comparison of the four methods was made using publications in Medline, Pubmed, Embase and Biosis to obtain data on the logistics of use, the quality of the plasma proteins and the effectiveness of pathogen inactivation. Results Three of the methods, MB, amotosalen and riboflavin, are designed for use in a blood bank; the SD method is generally applied at a centralized manufacturing centre and involves large plasma pools. All methods result in a reduction in protein values with the per cent retention of FVIII activity in the range of 67–78% and fibrinogen of 65–84%. Protein S and alpha2‐antiplasmin are lower following solvent–detergent treatment. Alterations in fibrinogen structure have been reported with methylene blue. Discussion Three of the methods are designed for small volume use in a blood bank. All four methods have some effect on the coagulant proteins; however, the final concentrations are within regulated limits. While there is variability in the effectiveness against pathogens, direct comparison is difficult because of the methodologies used. Nonetheless, all are effective in inactivating HIV and other lipid‐enveloped pathogens. Clinical studies on the effectiveness of these products are surprisingly sparse, and no randomized clinical trials have yet been performed with amotosalen or riboflavin plasmas.  相似文献   

20.
目的对临床分离的耐多药结核分枝杆菌相关基因的突变特征进行分析。方法对124例耐多药结核分枝杆菌以及50株敏感株的耐药相关基因(包括异烟肼inh A、kat G、oxyR-ahp C间隔区以及利福平rpo B)进行序列测定,分析其基因突变情况。结果异烟肼耐药inh A基因突变率为14.5%;kat G基因突变率为70.2%(87/124),主要位于315位;oxyR-ahp C间隔区突变率为15.3%;inh A、kat G两种基因同时突变率75.0%,三种基因同时突变率为89.5%。利福平rpo B基因突变的检出率高达95.2%,突变主要发生在531、526、516位点。结论我省耐多药菌异烟肼耐药相关基因最常见突变为kat G 315、inh A C-T(-15)、axyR-ahp C间隔区(-10)C-T,利福平为rpo B531、526、516。结合MDR-TB耐药相关基因的特征分析,可以建立一种快速、准确、特异的适合于我省的检测结核菌耐多药性的新方法。  相似文献   

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