共查询到20条相似文献,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
7.
8.
W F Doolittle J R Brown 《Proceedings of the National Academy of Sciences of the United States of America》1994,91(15):6721-6728
Early cellular evolution differed in both mode and tempo from the contemporary process. If modern lineages first began to diverge when the phenotype-genotype coupling was still poorly articulated, then we might be able to learn something about the evolution of that coupling through comparing the molecular biologies of living organisms. The issue is whether the last common ancestor of all life, the cenancestor, was a primitive entity, a progenote, with a more rudimentary genetic information-transfer system. Thinking on this issue is still unsettled. Much depends on the placement of the root of the universal tree and on whether or not lateral transfer renders such rooting meaningless. 相似文献
9.
Paul J. Hauptman 《Journal of cardiac failure》2017,23(10):717-718
10.
Gender, age, society, culture, and the patient's perspective in the functional gastrointestinal disorders 总被引:10,自引:0,他引:10
Chang L Toner BB Fukudo S Guthrie E Locke GR Norton NJ Sperber AD 《Gastroenterology》2006,130(5):1435-1446
Patients with functional gastrointestinal disorders (FGID) often experience emotional distress, a perceived lack of validation, and an unsatisfactory experience with health care providers. A health care provider can provide the patient with a framework in which to understand and legitimize their symptoms, remove self-doubt or blame, and identify factors that contribute to symptoms that the patient can influence or control. This framework can be strengthened with the consideration of various important factors that impact FGID but are often overlooked. These include gender, age, society, culture, and the patient's perspective. There is evidence for sex- and gender-related differences in FGID, particularly irritable bowel syndrome (IBS). Whereas the majority of FGID, including IBS, bloating, constipation, chronic functional abdominal pain, and pelvic floor dysfunction, are more prevalent in women than men, functional esophageal and gastroduodenal disorders do not appear to vary by gender. Limited studies suggest that sex differences in visceral perception, cardioautonomic responses, gastrointestinal motility, and brain activation patterns to visceral stimuli exist in IBS. Gender differences in social factors, psychological symptoms, and response to psychological treatments have not been adequately studied. However, there appears to be a greater clinical response to serotonergic agents developed for IBS in women compared to men. The impact of social and cultural factors on the meaning, expression, and course of FGID are important. The prevalence of IBS appears to be lower in non-Western than Western countries. Although further studies are needed, the existing literature suggests that they are important to consider from both research and clinical perspectives. 相似文献
11.
Reiber I Mezo I Mark L Paragh G 《Journal of the American College of Cardiology》2012,59(14):1333-4; author reply 1334
12.
Geoengineering: the good, the MAD, and the sensible 总被引:1,自引:0,他引:1
Schellnhuber HJ 《Proceedings of the National Academy of Sciences of the United States of America》2011,108(51):20277-20278
13.
14.
15.
16.
Estrogen--the good, the bad, and the unexpected 总被引:3,自引:0,他引:3
Simpson ER Misso M Hewitt KN Hill RA Boon WC Jones ME Kovacic A Zhou J Clyne CD 《Endocrine reviews》2005,26(3):322-330
17.
Selenium, the thyroid, and the endocrine system 总被引:14,自引:0,他引:14
18.
19.