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阿尔茨海默病的神经免疫炎症发病机制及其治疗研究进展 总被引:1,自引:1,他引:0
阿尔茨海默病(AD)是一种中枢神经系统 (CNS)退行性疾病[1],其病因多样、 复杂,但组织病理学特点几乎完全一致:以β-淀粉样蛋白(Aβ)沉淀为特征的老年斑(SP),神经元内tau蛋白异常聚集形成纤维缠结 (NFT),脑皮质、海马胆碱能神经元及其突触数量减少,累及的皮层动脉和小动脉出现血管淀粉样变性[2]. 相似文献
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神经系统变性疾病(degenerative diseases of the nervous sys-tem)是一组以原发性神经元变性为基础的慢性进行性神经系统疾病,可能是神经组织在衍化、发育、成熟、衰老等过程中出现一系列复杂的分子生物学障碍,从而表现出结构和功能等方面的变化,包括阿尔茨海默病(Alzheimer’s disease,AD)、帕金森病(Parkinson’s disease,PD)、肌萎缩侧索硬化(Amyotrophiclateral sclerosis,ALS)、亨廷顿舞蹈病(Huntington disease,HD)等,其中前3种在临床上最为常见。 相似文献
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阿尔茨海默病(AD)亦名老年性痴呆(senile dementia),是以进行性痴呆为特征的大脑退行性变性疾病。AD发病率从以往每年低于3%增至目前的4%以上,85岁以上的老年人发病率达40%。AD的特征性病理改变是神经元细胞外有大量神经炎性空斑(extra cellular neurotic plaque)即老年斑(senileplaques,SPs)及神经元细胞内有神经纤维缠结(neuro fibrillary tangles,NFTs)的释放。 相似文献
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研究表明阿尔茨海默病 (AD)中枢神经系统病理改变与早老素 (presenilin ,PS)、β 淀粉样蛋白 (Aβ)及神经元突触改变等因素密切相关。本文就PS、Aβ和神经元突触改变在AD发生过程中的相互关系进行阐述。1 PS自从 1992年发现PS 1基因后〔1〕,1995年又确定了PS 2基因〔2〕。PS的mRNA分析显示 ,PS 1和PS 2在神经系统有广泛的表达 ;同样也存在于其他许多器官中〔3〕。PS在人类一般常局限于粒细胞及新皮层等相同的神经组织中。正常人神经细胞与AD患者受损的神经细胞相比 ,PS表达可能相反 ,AD病人神经元纤维缠结 (NFT)中对PS免疫… 相似文献
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高血压降压治疗目标的再认识 总被引:1,自引:0,他引:1
华琦 《中华老年心脑血管病杂志》2007,9(12):793-795
根据传统的高血压水平的定义,1993年WHO高血压治疗指南提出血压控制目标为<140/90mm Hg(1mm Hg=0.133kPa),但是并非所有患者都必须将血压降至同一水平,而应根据患者情况进行个体化治疗。Framingham进行的一项长达10~12年的心血管事件研究发现,第5年后,正常上限血压[收缩压(SBP 相似文献
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H Z Ma 《中华结核和呼吸杂志》1987,10(6):344-5, 364, 24
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《Kardiologiia》2012,52(7):22-29
Cytokines as regulators of activity of inflammation play significant role in mechanisms of formation of atherosclerotic plaques and in processes of their destabilization. One of leading genetic factors determining level of their production appears to be polymorphism of cytokine genes structure at their promoter loci. We have conducted an analysis of distribution in groups of healthy male and female survivors of myocardial infarction (MI) of combined genetic signs represented as a complex of genotypes of a number of studied cytokine genes : TNF-A863C; TNF-A308G; TNF-A238G; IL1B-C511T; IL1B-C-31T; IL4-C590T; IL6-C174G; IL10A-1082G IL10-A592C. Among these homozygous combinations of cytokine genotypes characterizing a group of men who have lived up to middle and old age without development of MI there are widely represented genotypes associated with high levels of production of both cytokines with pronounced proinflammatory (IL-1) and antiinflammatory (IL-4, IL-10) activity. Absence of such multidirectional combinations in genome of patients with myocardial infarction can be considered one of genetic factors of risk of development of acute distirbances of coronary circulation. 相似文献
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Results of repair of tetralogy of Fallot 总被引:5,自引:0,他引:5
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A total 89 fish and lamprey species has been recorded from Polish freshwater habitats. Twenty-seven of them (30.3%) have not been surveyed for parasitic helminthes. Some of the latter fishes are either rare or not easily accessible. Other live only in specific habitats in scattered localities. An important obstacle for studying parasite faunas of some fishes may be their status on an endangered species. Among the non-surveyed fishes, are those which have been relatively recently introduced to Poland or migrated there on their own. The present paper attempts to review all hitherto not studied helminthologically fish species, their habitats, localities and current protection status. 相似文献