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1.
早期原发性开角型青光眼彩色图形视网膜电图的特征   总被引:2,自引:0,他引:2  
目的观察早期原发性开角型青光眼(primaryopenangleglaucoma,POAG)彩色图形视网膜电图(colorpatternelectroretinogram,CP-ERG)的改变特征。方法对29例(48只眼)POAG,10例(16只眼)高眼压症及33例(48只眼)年龄匹配的正常人做CP-ERG检测,并进行统计学比较及多因素分析。结果早期POAG的CP-ERG的P1、N2波幅下降,红黑N2与蓝黑P1峰时间延长;部分高眼压症已出现N2波幅下降。采用多因素逐步判别分析方法,筛选出对早期POAG诊断有判别能力的5项指标:蓝黑N2波幅、红黑P1波幅、红黑N2波幅、红黑N2峰时间及白黑P1波幅与N2波幅的比值,同时建立了判别函数。结论CP-ERG是检测早期POAG视网膜功能改变的有效方法,有助于早期POAG的诊断。  相似文献   

2.
视电生理对视网膜静脉阻塞分型的临床意义   总被引:1,自引:0,他引:1  
本文观察了32例视网膜静脉阻塞病人患眼(静脉郁滞性视网膜病变与缺血性视网膜病变)与对侧健眼的暗视ERG及振荡电位。发现(1)b波波幅及b/a值患眼较对侧眼显著下降,且b波峰时值明显延长。(2)OPS各波幅患眼较对侧眼显著下降,O1,O2,O4峰时值明显延长。(3)HR型较VSR型b波波幅及b/a波波幅比值显著下降。(4)HR型较VSR型O1,O2波幅值显著下降。这些对判断RVO分型有价值,对不能行  相似文献   

3.
结晶样视网膜变性的视觉电生理改变探讨   总被引:2,自引:1,他引:1  
目的探讨结晶样视网膜变性的视觉电生理改变。方法采用眼电图(EOG)和视网膜电图(ERG)检测14例28眼结晶样视网膜变性患者(病例组)和15例30眼正常人(对照组)、观察指标:(1)EOG的基值电位(BVP)、暗谷电位(DTP)、暗谷时间(DTT)、光峰电位(LPP)、光峰时间(LPT)、QAr-den、QGliem、(2)暗适应和明视ERGa、b波振幅、峰时值。采用t检验对上述各项指标做两组间比较分析。结果病例组EOG的BVP、DTP、LPP、QArdenQGliem均较对照组明显降低,峰两组间有极显著性差异(P<0.01);而EOG的DTT、LPT与对照组比无明显改变,两组间无显著性差异(P>0.05)。病例组暗适应和明视ERGa、b波振幅、峰时值较对照组均有明显改变,两组间有极显著性差异(P<0.01);但在2例早期患者中,其ERGa、b波振幅、峰时值均在正常范围。结论EOG、ERG作为客观定量的视功能检查方法,可为结晶样视网膜变性的视网膜功能损害程度提供客观指标。对结晶样视网膜变性早期患者EOG可能较ERG更具诊断价值。  相似文献   

4.
多焦视网膜电图在糖尿病视网膜病变不同病期诊断的应用   总被引:7,自引:0,他引:7  
目的:评价多焦视网膜电图(MERG)在糖尿病性视网膜病变(DR)不同期诊断的应用价值。方法:对24名(35眼)正常人及63名(96眼)糖尿病患者分别进行眼科常规检查、眼压测定、眼底荧光血管造影(FFA)、Octopus视野及MERG检测,并对MERG与视野进行相关性分析,对比MERG与其他视网膜功能检查方法的异常检出率。结果:MERG总反应波的P1波反应密度在临床未见DR(NDR)的糖尿病患者低于  相似文献   

5.
本文观察了32例视网膜静脉阻塞病人患眼(静脉郁滞性视网膜病变与缺血性视网膜病变)与对侧健眼的暗视ERG及振荡电位。发现①b波波幅及b/a值患眼较对侧眼显著下降,且b波峰时值明显延长。②OPS各波幅患眼较对侧眼显著下降,O1、O2、O4峰时值明显延长。③HR型较VSR型b波波幅及b/a波波幅比值显著下降。④HR型较VSR型O1、O2波幅值显著下降。这些对判断RVO分型有价值,对不能行荧光造影者,以及早期治疗、预后判断有重要临床意义。  相似文献   

6.
早期原发性开角型青光眼彩色图形视觉电生理改变分析   总被引:2,自引:0,他引:2  
袁鹂  高燕  罗炎 《眼科新进展》2000,20(4):282-283
目的 探讨早期原发性开角型青光眼彩色图形视网膜电图(CP-ERG),彩色图形视觉诱发电位(CP-VEP)的改变特征。方法 采用电生理方法记录早期原发性开角型青光眼(POAG)患者在白/黑、红/黑、蓝/黑翻转图形刺激下的CP-ERG、CP-VEP,结果 (1)POAG组CP-ERG的b波幅值下降,潜伏期延长;CP-VEP的P100波幅值下降,潜伏期延长;(2)POAG组CP-ERG和CP-VEP的异  相似文献   

7.
目的研究8-Br-cAMP对人视网膜母细胞瘤HXO-Rb44细胞作用后产生一氧化氮(NO)的效应,以探讨HXO-Rb44细胞分化和凋亡的机制。方法应用原位杂交和 RNA斑点印迹技术检测 NOS mRNA及 Bcl-2 mRNA;应用硝酸还原酶法检测NO的含量;应用蛋白斑点印迹技术检测一氧化氮合成酶(NOS)的酶活性;应用免疫细胞化学及蛋白质斑点印迹技术检测 NSE的免疫反应性(IR)。结果 NOS mRNA,NOS酶活性,NO含量和 NSE-IR均为实验组(EG)强于对照组(CG)(P<0.01),而Bcl-2 mRNA为EG弱于CG(P<0.05),并在EG标本上可见HXO-Rb44细胞呈现神经样的突起。结论 8-Br-cAMP可使 HXO-Rb44细胞生成 NO增加,促进 NOS的酶活性和 NOS mRNA的表达,提高NSE-IR,并降低 Bcl-2 mRNA的表达。结果表明,8-Br-cAMP具有促使 HXO-Rb44细胞向神经细胞分化并诱导该细胞凋亡的效应,提示NO可能参与此效应。  相似文献   

8.
目的:分析Nd∶YAG激光后囊切开后视网膜脱离(retinaldetachment,RD)的发生情况。方法:回顾性分析1990年1月至1993年12月我院收治的Nd∶YAG激光后囊切开后RD11例11只眼。结果:11只眼中6只眼为人工晶体(intraocularlens,IOL)眼,5只眼为无晶体眼;后房型IOL眼激光后囊切开后RD发生率为1.7%,无晶体眼为4.0%;激光治疗至发生RD的平均间隔时间为12.1个月,8只眼在1年内发生;7只眼存在发生RD的危险因素(高度近视、格子样变性、对侧眼RD史)。结论:激光治疗增加了IOL眼和无晶体眼发生RD的危险,其RD特点和预后与IOL眼RD相同,发病机制尚不明  相似文献   

9.
糖尿病性视网膜病变的视网膜电图分析   总被引:4,自引:0,他引:4  
孙秀英  卢宁 《眼科》1995,4(2):85-87
ERG是DR较敏感的诊断方法。本文对59例100只眼DR的ERG及OPs改变进行了总结分析,结果PDR患者中34%b波幅值正常,60%降低,6%消失;BDR患者中62%b波幅值正常,36%下降,2%消失。在PDR患者中OPs的OZ值大于100μV者占62%,100μV者占26%,OPs消失者占68%;在BDR患者中OPs的OZ值大于100μV者占22%,小于100μV者占56%,OPs消失者占22  相似文献   

10.
切除黄斑部视网膜下新生血管膜治疗年龄相关性黄斑变性   总被引:1,自引:1,他引:0  
Wang Z  Ho PC 《中华眼科杂志》1999,35(6):436-439
目的 观察玻璃体切除术联合黄斑部视网膜的生血管膜(neovascular membrane,NVM)切除治疗年龄相关性黄斑变性(age-related macular degeneration,ARMD)的疗效。方法 选择病程在2年之内的ARMD患者,NVM≤3PD。完成闭合式玻璃体切除术后。结果 ARMD30例(30只眼)中,17只眼(56.7%)SY RG PYMQLT RJYM,JB WFF  相似文献   

11.
Bayer AU  Maag KP  Erb C 《Ophthalmology》2002,109(7):1350-1361
PURPOSE: To evaluate the clinical use of a test battery of short-wavelength automated perimetry (SWAP), frequency-doubling technology (FDT) perimetry, and pattern-electroretinography (PERG) in patients with definite primary open-angle glaucoma (POAG) but normal results on standard automated perimetry (SAP). STUDY DESIGN: Prospective, comparative, observational case series. PARTICIPANTS: Thirty-six patients with POAG with standard visual field defects in one eye and normal standard visual fields in the contralateral eye and 36 normal controls were enrolled. MAIN OUTCOME MEASURES: SWAP, PERG, FDT, and SAP were performed in all eyes, and global indices and amplitudes were used for statistical analysis. RESULTS: When contralateral POAG eyes with asymmetric glaucomatous damage was compared, a paired t test showed significant differences in SAP mean deviation (MD) (P < 0.0001), SWAP-MD (P = 0.0003), FDT-MD (P = 0.0008), and PERG amplitudes (P < 0.0001). When comparing between POAG eyes with normal results on SAP and normal controls, Student's t test showed significant differences for SWAP-MD (P < 0.0001), FDT-MD (P = 0.0006), PERG N1P1-amplitude (P = 0.0486) and P1N2-amplitude (P < 0.0001); receiver operating characteristic analysis revealed promising accuracy for SWAP-MD of 73.6% (P < 0.0001). SWAP-MD (P < 0.0001) and FDT-MD (P < 0.0001) correlated significantly with SAP-MD and with each other (range, P < 0.0001 to P = 0.0020). Regression analysis revealed that PERG P1N2-amplitude could improve the power of SWAP-MD from 73.6% to detect early POAG in eyes with normal results on SAP to an accuracy of 81.9%. CONCLUSIONS: A test battery of SWAP-MD and PERG P1N2-amplitude could detect glaucomatous optic neuropathy in POAG eyes with normal standard visual fields, whereas FDT-MD and SWAP-MD significantly correlated with each other and with SAP-MD. All tests were able to detect the eye with the more severe glaucomatous optic neuropathy in patients with asymmetric POAG.  相似文献   

12.
目的:评价几种视觉电生理检查在原发性开角型青光眼早期诊断中的价值,为临床青光眼早期诊断提供客观敏感的指标。方法:选择36例(70眼)原发性开角型青光眼患者、8例(12眼)可疑性青光眼患者和30例(60眼)正常对照者分别进行闪光视网膜电图(FERG)、视网膜振荡电位(OPs)、闪烁光视网膜电图(FLERG)、图形视网膜电图(PERG)、图形视诱发电位(PVEP)检查,并与视野指数、眼压、视力等进行多元相关分析。结果:原发性开角型青光眼PERG、PVEP、OPs表现异常,与正常对照组相比差异有显著性意义(p<0.05)。FLERG振幅降低,但和FERG同样与正常对照组相比差异无显著性意义(p>0.05)。在原发性开角型青光眼早期(特别是视野改变出现前),PERG的异常率较高。原发性开角型青光眼患者OPs与C/D负相关,与视野指数、眼压、视力不相关。PERG振幅与视野指数和眼压负相关,与C/D和视力不相关。PVEP潜伏期与视野指数和C/D正相关,而与眼压不相关。结论:统计学结果表明,对原发性开角型青光眼不同的表现形式,可选用不同的检查指标。在早期眼底改变出现前(C/D不大),如眼压升高,PERG应为比较敏感的指标;而一旦眼底发生改变,尽管眼压不高,可选用OPs或PVER作为观察指标。对早期和中晚期青光眼,PERG诊断和监测价值较好。联合多种视功能检查对原发性开角型青光眼的早期诊断具有较好的意义。  相似文献   

13.
蓝育青  葛坚 《眼科学报》1998,14(4):199-203,235
了解原发性开角型青光眼视觉电生理和计算机自动视野检查结果的变化特征并对其视功能状况进行综合分析以寻找比较敏感和特异的参数,为原发性开角型青光眼较早期和早期诊断提供依据。方法:对36例原发性开角型青光眼患者,8例可疑性青光眼患者,30例正常对照者分别进行视网膜振荡电位,视网膜电图,视诱发电位和Humphery计算机自动视野检查。  相似文献   

14.
The aim of the study was to asses the neurosensory retinal function in 12 patients (24 eyes) with different stages of Best's disease, by determining how pattern and full field flash ERG responses were related to visual acuity, stage of disease and extent of visual field loss. All patients had typically abnormal EOG responses and normal full field-flash ERG responses. Patients were stratified in two groups according to visual acuity. In the first group 12 eyes with visual acuity better than 0.5, all amplitudes and latencies of PERG P50 and N95 responses were in the normal range. Small central scotoma was detected by static perimetry in four of these eyes. In the second group of 12 eyes with visual acuity 0.5 or less, PERG showed reduced both P50 and N95 amplitudes in five eyes, and N95 solely, in two eyes. All patients had central scotomas detected by static perimetry. Progression of the disease, seen in deterioration of visual acuity and progression of central visual field defects, corresponded well with reduction of both PERG P50 and N95 amplitudes. There was no correlation found between visual acuity and EOG responses. Our results show that in Best's distrophy, pattern ERG is getting abnormal with progression of the disease, indicating relative preservation of neurosensory retina in initial stages of the disease. In contrast to EOG - being abnormal in all the patients regardless of the stage of disease - and full field-flash ERG - being normal in most of the patients - PERG gives opportunity for electrophysiological determination of the progression of the disease.  相似文献   

15.
兰长骏  宋广瑶 《眼科》1997,6(4):223-225
对30例50只青光眼、14例28只高眼压症进行PERG和PVEP同时记录。首次发现青光眼和高眼压症的RCT延长,同时青光眼组AP50、AP100下降、LP100延长,异常率分别为46%、52% ̄54%,高眼压症组AP50和LP100的异常率均为28.57%。青光眼组LP100、RCT与视野缺损、C/D在小呈正相关,AP100与视野缺损、C/D大小呈负相关,AP50与视野缺损呈负相关。本研究从电生理  相似文献   

16.
Bayer AU  Erb C 《Ophthalmology》2002,109(5):1009-1017
PURPOSE: To evaluate the clinical use of a test battery of short wavelength automated perimetry (SWAP), frequency doubling technology perimetry (FDT), and pattern electroretinography (PERG) in predicting progressive glaucomatous visual field defects on standard automated perimetry (SAP). STUDY DESIGN: A prospective, longitudinal, observational case series. PARTICIPANTS: One hundred and fifty-two patients with primary open-angle glaucoma (POAG) with bilateral glaucomatous visual field defects on SAP were followed at 6-month intervals over a period of 30 months. MAIN OUTCOME MEASURES: Short wavelength automated perimetry, FDT, and PERG results were compared between POAG eyes with and without progressive field loss on SAP. These two groups were used to evaluate whether PERG, SWAP, and/or FDT is predictive of future progression of field loss on SAP. RESULTS: Using the criteria of progressive field loss on SAP defined by the Collaborative Normal Tension Glaucoma Study, 54 eyes (study group) of 54 POAG patients showed progressive defects, whereas 84 eyes (control group) of 84 POAG patients showed no progression. Only 11.1% (6 of 54) of the eyes with a progression of field loss on SAP showed no increase of deficits on the three functional tests before progression. Short wavelength automated perimetry detected early progressive defects on SAP in 43 of the 54 eyes (79.6%). Of these 54 POAG eyes, FDT showed progressive deficits in 40 eyes (74.1%), whereas PERG amplitude P1N2 showed progressive deficits in 35 eyes (64.8%) before progression of field loss on SAP. A test battery consisting of SWAP and PERG P1N2-amplitude was able to detect 88.9% of eyes before a prediction of field loss on SAP. When comparing the results of the two functional tests, SWAP and FDT in the 84 eyes without progression of field loss on SAP between baseline and at 30 months, SWAP and FDT showed progressive deficits in 34.5% and 35.7%, respectively. CONCLUSIONS: All three tests (SWAP, FDT, and PERG) have been successful in detecting glaucoma eyes with a future progression of standard visual field defects. A test battery of SWAP and PERG P1N2-amplitude improved the power to predict these progressive defects on SAP. It remains to be seen whether the long-term follow-up in POAG eyes will improve the false-positive rate of SWAP and FDT.  相似文献   

17.
BACKGROUND/AIMS: The visual loss associated with compression of the optic chiasm by pituitary tumours may be transient or permanent, possibly related to the extent of irreversible retrograde degeneration to the retinal ganglion cells. The pattern electroretinogram (PERG) N95 component is thought to rise in relation to retinal ganglion cell function and hence may be a potential prognostic indicator for visual function following decompressive surgery. METHODS: The notes and electrodiagnostic records of 72 eyes from 36 patients with chiasmal compression were retrospectively analysed. RESULTS: The postoperative change in visual field was found to be associated with the PERG N95:P50 ratio (p=0.01). Improvement in visual field was shown by a greater proportion of eyes with a normal N95:P50 ratio (65%) than with an abnormal ratio (27%). No change in visual field occurred in 26% of the eyes with a normal N95:P50 ratio compared with 67% of those with an abnormal ratio. Only 8% of eyes showed a worsening of visual field following surgery, in similar proportions for eyes with normal and abnormal N95:P50 ratios. There was no significant relationship with visual acuity. CONCLUSION: The PERG is a useful visual prognostic indicator in the preoperative assessment of chiasmal compression.  相似文献   

18.
PURPOSE: To better understand the relationship between the amplitude of the pattern electroretinogram (PERG) and visual loss, measured with static automated perimetry. METHODS: Transient PERGs were recorded in 15 patients (31-77 years) and 16 normal individuals (26-65 years). An eye was considered to have glaucomatous damage only if there was an abnormal disc, an abnormal 24-2 Humphrey visual field result (pattern stand deviation, glaucoma hemifield test, and cluster) and an abnormal multifocal visual evoked potential. All the worse (more affected) eyes of the patients and six of the better eyes met these criteria. The N95 amplitude of the PERG was measured from the positive peak (P50) at approximately 50 ms to the trough at approximately 95 ms. The ratio of N95 to P50-the N95 amplitude divided by the P50 amplitude-was also measured. RESULTS: First, the PERG was within normal limits for 4 (26.7%) of the worse eyes. Overall, 6 (28.6%) of the 21 eyes that met the criteria for glaucomatous damage had normal PERGs on both PERG measures. Because the normal individuals were younger than the patients, an even larger number of normal PERGs might be expected with an age-appropriate control group. Second, the N95 amplitude was nonlinearly related to visual field sensitivity when sensitivity was plotted on a linear plot. Small field losses were associated with disproportionately large losses in PERG amplitude. Third, the PERG from both eyes of a patient were very similar, even when the visual fields suggested very different levels of damage. CONCLUSIONS: These results are consistent with the view that very early damage can affect the PERG, even before the visual field shows a loss. At the same time, it is clear that patients with clear glaucomatous damage can have normal-appearing PERGs. An explanation is proposed to account for these findings.  相似文献   

19.
Purpose To evaluate the ability of full-field and hemifield pattern electroretinogram (PERG) parameters to differentiate between healthy eyes and eyes with band atrophy (BA) of the optic nerve. Methods Twenty-six eyes from 26 consecutive patients with permanent temporal hemianopic visual field defects and BA of the optic nerve from previous chiasmal compression and 26 healthy subjects were studied prospectively. All patients were submitted to an ophthalmic examination including Humphrey 24-2 SITA Standard automated perimetry. Full-field and hemifield (nasal and temporal) stimulation transient pattern electroretinograms (PERG) were recorded using checkerboard screens. Amplitudes and peak times for the P50 and N95 as well as the overall P50+N95 amplitude were measured. The intraocular N95:P50 amplitude ratio was calculated. Comparisons were made using Student’s t-test. Receiver operating characteristic (ROC) curves were used to describe the ability of PERG parameters to discriminate the groups. Results Full-field P50, N95, and P50+N95 amplitude values were significantly smaller in eyes with BA than in control eyes (< 0.001). Nasal and temporal hemifield PERG studies revealed significant differences in N95 and P50+N95 amplitudes measurements. No significant difference was observed regarding peak times or N95:P50 amplitude ratios. Nasal and temporal hemifield PERG values did not differ significantly in eyes with BA or in controls. Using the 10th percentile of normals as the lower limit of normal, 16 of 26 eyes were considered abnormal according to the best discriminating parameters. Conclusions Transient PERG amplitude measurements were efficient at differentiating eyes with BA and permanent visual field defects from normal controls. Hemifield stimulation PERG parameters were unable to detect asymmetric hemifield neural loss, but further studies are required to clarify this issue. Study registered on ClinicalTrial.gov number: NCT00553761  相似文献   

20.
Diagnostic value of transient pattern electroretinogram (PERG), recorded by skin electrodes, was compared with Goldmann perimetry in cases of ocular hypertension and glaucoma. According to the assumption that the PERG mostly reflects activity of the retinal glanglion cells, and histological evidence that 30–50% atrophy of the retinal ganglion cells is necessary to cause defects in visual field, we wanted to assess if i) this method could be more sensitive in detecting early glaucomatous damage than routine Goldmann perimetry in eyes with normal or only borderline elevated intraocular pressure in the time of PERG recording (first group of patients), and ii) how the PERG amplitude corresponds to ganglion cell loss, expected in the eyes with already detectable initial glaucomatous visual field defects, according to Goldmann II/2 isopter, with normal or borderline elevated intraocular pressure in the time of PERG recording (second group).In the group with no visual field defects subnormal amplitude of the major positive component of the PERG, N1-P1, was detected in three of 30 eyes (10%), while in the group with initial visual field defects N1-P1 amplitude was subnormal in 6 of 11 eyes (54%).The amplitude of the major negative PERG component, P1-N2, was found normal in all eyes of the first group and subnormal in 5 eyes (45%) of the second group.Abbreviations PERG pattern electroretinogram - VFD visual field defect - IOP intraocular pressure  相似文献   

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