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1.
PURPOSE: To examine the relationship between coffee and caffeine intakes and intraocular pressure (IOP). MATERIALS AND METHODS: The Blue Mountains Eye Study examined 3654 participants aged 49+ years in an area west of Sydney, Australia. A detailed medical history questionnaire included average daily intakes of coffee and tea. The eye examination included Goldmann applanation tonometry and automated perimetry. Participants using glaucoma medications or who had previous cataract or glaucoma surgery or signs of pigmentary glaucoma/pigment dispersion, were excluded. Mean and maximum IOP calculations were used. RESULTS: Participants with open-angle glaucoma (OAG) who reported regular coffee drinking had significantly higher mean IOP (19.63 mm Hg) than participants who said that they did not drink coffee (16.84 mm Hg), after multivariate adjustment, P = 0.03. Participants consuming > or = 200 mg caffeine per day had higher mean IOP (19.47 mm Hg) than those consuming < 200 mg caffeine per day (17.11 mm Hg), after adjusting for age, sex, and systolic blood pressure (SBP), P = 0.06. This association did not reach statistical significance after multivariate adjustment. No association between coffee or caffeine consumption and higher IOP was found in participants with ocular hypertension (OH) and those without open-angle glaucoma. CONCLUSIONS: In participants with open-angle glaucoma, this study identified a positive cross-sectional association between coffee consumption/higher caffeine intakes and elevated intraocular pressure.  相似文献   

2.
动态轮廓眼压计的临床应用   总被引:1,自引:0,他引:1  
目的 探讨动态轮廓眼压计(OCT)在原发性开角型青光眼(POAG)、高眼压症(OHT)、正常眼压性青光眼(NTG)及正常对照人群眼压和眼压脉动振幅(OPA)测量中的临床应用价值及影响因素.方法 选取POAG、OHT、NTG及正常对照组各30例,分别采用Goldmann压平眼压计(GAT)测量眼压,DCT测量眼压及OPA,并测量中央角膜厚度(CCT)、中央角膜曲率(CCV)以及心率、收缩压、舒张压等指标,以了解这些指标对OPA的影响.各组统计量两两比较采用q检验.各统计量之间的相关分析采用Pearson相关分析,对于多个变量之间的线性关系采用多重线性回归分析.结果 DCT测量POAG、OHT、NTG及对照组的眼压值分别为(21.68±2.02)、(23.37±2.65)、(18.43±3.08)、(17.04±2.07)lnln Hg(1 mm Hg=0.133 kPa);GAT测最的眼压值分别为(21.18±2.95)、(23.28±5.95)、(16.39±3.60)、(14.66±2.27)mm Hg.两者测量结果的差异无统计学意义(t=1.338,1.445,1.682,1.803;P=0.197,0.151,0.136,0.081).POAG、OHT、NTG及对照组的OPA值分别为3.03±1.13,3.53±1.43,2.21±0.55,2.87±0.60,组间比较差异有统计学意义(F=21.311,P=0.000);OPA值与心率、收缩压、舒张压、GAT测量值、CCT均相关,与年龄无明显相关性.结论 DCT测量结果与GAT有良好的一致性,受干扰因素少,可信度高;POAG、NTG、OHT患者和正常人的OPA存在差异,其中NCT患者OPA值明显较低,提示各组间眼内血液动力学状况的差异,OPA可能对青光眼的诊断及治疗具有一定的潜在价值.  相似文献   

3.
BACKGROUND: Lower socioeconomic status (SES) is associated with higher morbidity and mortality in many countries. Present evidence suggests that glaucoma has similar risk factors to major chronic diseases such as cardiovascular disease. This study investigates the association between SES and intraocular pressure (IOP), an important risk factor for glaucoma. METHODS: The Tanjong Pagar Study was a population-based cross-sectional survey of Chinese people aged 40-79 years, who were randomly selected from the Singapore electoral register. Of the 2000 people selected, 1717 were considered eligible and 1090 were examined in clinic and included in the present study. IOP was measured using applanation tonometry. SES was assessed using a standardised questionnaire; education and income were used as the main explanatory variables. The effect of systolic blood pressure (SBP) was also examined. RESULTS: Participants with lower levels of education and income had higher mean IOP (both p<0.01). These associations remained after adjusting for age and central corneal thickness, a strong independent predictor. SBP was strongly associated with both SES and IOP (both p<0.01). Adjusting for SBP attenuated the association between SES and IOP. CONCLUSION: Participants with lower education and income have a higher mean IOP. This effect may be mediated, in part, by an association of education and income with SBP. This is the first study to suggest that there is a social gradient in the distribution of the only major modifiable risk factor for glaucoma. Increasing similarities exist between the causation models of chronic diseases and that of glaucoma.  相似文献   

4.
PURPOSE: To evaluate whether the amplitude of day-and-night intraocular pressure (IOP) profiles influences the rate of progression of chronic open-angle glaucoma. METHODS: The hospital-based clinical observational study included day-and-night profiles of IOP measurements performed on 458 patients (855 eyes) with chronic open-angle glaucoma or ocular hypertension. The 24-h pressure profiles obtained by Goldmann applanation tonometry contained measurements at 0700, noon, 1700, 2100, and midnight. RESULTS: In the whole study population, IOP amplitude was significantly (P<0.001) and positively associated with the mean (r=0.26), minimal (r=-0.23) and maximal (r=0.59) IOP values. Taking the whole study population, glaucoma progression was not associated with the IOP amplitude (P=0.09). After adjustment for age, neuroretinal rim area and the other IOP measurements, age (P<0.001) and neuroretinal rim area (P=0.05) remained as significant predictive factors in the selected Cox model. In the normal-pressure glaucoma group (n=174 eyes), progression was significantly positive associated with the minimal IOP value (P<0.001), the mean of the IOP values (P=0.024), and, less significantly (P=0.037) and negatively, with the pressure profile amplitudes. In the high-pressure glaucoma group (n=681 eyes), rate of glaucoma progression was not associated with the IOP amplitude (P=0.734) or the other IOP parameters. CONCLUSIONS: Taking into account the highly significant associations between the IOP amplitude and the mean, minimal and maximal IOP values suggests that it is the IOP itself, and less the pressure amplitude, which has the main influence on the rate of the glaucoma progression.  相似文献   

5.
BACKGROUND: Mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism has been reported to be associated with longevity in Japanese individuals, with experimental findings concluding that mt5178 A is an anti-atherogenic genotype. The aim of this study was to determine whether mt5178 A/C polymorphism influences intraocular pressure (IOP), and its relationship with the development of arteriosclerosis. METHODS: Four hundred and forty-nine male volunteers who had visited a general hospital for medical check-up between August 1999 and August 2000 were enrolled. Of these, 386 Japanese men who had not undergone any medical treatment for hypertension, ocular hypertension or glaucoma were selected as subjects of this study. After these subjects were genotyped, a cross-sectional study regarding the relationship between genotype and IOP was conducted. RESULTS: Mean IOP was significantly higher in men with mt5178 C (13.3 mmHg) than in those with mt5178 A (12.7 mmHg) (P = 0.037). This significant difference in mean IOP between the two genotypes remained evident after adjusting for age, body mass index, blood pressure, habitual smoking and habitual drinking. Interactions between mt5178 A/C polymorphism and habitual smoking or daily alcohol consumption with regard to IOP were observed. According to multiple regression analysis, habitual smoking was significantly associated with IOP in men with mt5178 A (P for trend = 0.020), while daily alcohol consumption was significantly associated with IOP in those with mt5178 C (P for trend = 0.021). CONCLUSION: Longevity-associated mitochondrial DNA 5178 A/C polymorphism may be associated with IOP in Japanese men.  相似文献   

6.
目的 观察早期原发性青光眼行超声乳化联合人工晶状体植入术后眼内压(IOP)控制情况,分析与术后IOP控制效果相关的影响因素.方法 回顾性选择原发性闭角型青光眼(PACG)43例(43只眼)和原发性开角型青光眼(POAG)早期患者32例(32只眼),均行标准3.2mm透明角膜切口白内障超声乳化联合折叠人工晶状体植入术,术后2年定期随访.手术成功标准为:术后IOP保持在6~21mmHg,青光眼神经病变及相应视野缺损无明显进展,无需再行抗青光眼手术治疗.结果 白内障超声乳化联合人工晶状体植入术后,PACG组有28例(65.1%)、POAG组有12例(37.5%)术后IOP控制良好,2年累计生存率之间存在差异(P<0.05).PACG组成功与失败病例在术前IOP(33.0±5.3)mmHg vs(40.1±3.6)mmHg,P<0.01、抗青光眼药物数量(2.9±0.9vs4.1±0.4,P<0.01)、房角粘连范围(2.9±0.5)钟点vs(4.2±0.8)钟点,P<0.01)之间的差异具有统计学意义,而POAG组成功与失败病例在术前IOP(25.3±3.4)mmHgvs(35.4±3.6)mmHg,P<0.01、抗青光眼药物数量(1.2±0.4vs2.8±0.9,P<0.01)之间的差异具有统计学意义.Cox逐步回归分析发现,在PACG组中术前IOP(P<0.05,RR=1.17)、PAS(P<0.01,RR=3.971),在POAG组中术前IOP(P<0.01,RR=1.284),与相应两组术后生存时间具有相关性.结论 在术前PACG患者考虑到IOP和房角粘连范围、POAG患者考虑到IOP的条件下,超声乳化联合人工晶状体植入术对于伴有白内障的早期原发性青光眼,是一种可供选择的有效的控制眼内压的治疗方法.
Abstract:
Objective To assess and find associated factors for favorable postoperative intraocular pressure (IOP) after cataract phacoemulsification with intraocular lens implantation in patients with primary glaucoma on early stage.Methods Forty-five patients (43 eyes) with primary angle closure glaucoma (PACG) and 32 patients with primary open angle glaucoma (POAG) were retrospectively selected.All patients had undergone standard 3.2mm limbal incision phacoemulsification,and 2 years of routine follow-up after cataract surgery.Success was defined as an IOP between 6-21mmHg,with fewer antiglaucoma medications needed than those during pre-operation,no obvious progressions of glaucomatous neuropathy and its coincident visual field loss,and no need of additional glaucoma surgery.Results After phacoemulsification with intraocular lens implantation,there were 28 cases (65.1%) in PACG group and 12 cases (37.5%) in POAG group with well controlled postoperative IOP,and the different of 2-year survival rate was statistically significant (P <0.05).There were significant different in the pre-IOP (33.0± 5.3mmHg vs 40.1 ± 3.6mmHg,P <0.01),the number ofantiglaucoma medications (2.9± 0.9 vs 4.1± 0.4,P<0.01) and the extent of peripheral anterior synechiae (PAS) (2.9±0.5 clock hours vs 4.2± 0.8 clock hours,P <0.01) between success and failure cases in PACG group.The pre-IOP (25.3±3.4 mmHg vs 35.4±3.6 mmHg,P<0.01),the number of antiglaucoma medications (1.2± 0.4 vs 2.8± 0.9,P <0.01) were significant different between the success and failure cases in POAG group.Cox stepwise regression analysis found that pre-IOP (P <0.05,RR=1.17) and the extent of PAS (P <0.01,RR=3.971) in PACG group and the pre-IOP (P<0.01,RR=1.284) in the POAG group was significant associated with the corresponding survival time after cataract surgery.Conclusions Phacoemulsification with intraocular lens implantation may be an alternative procedure for effective IOP control of the patients with primary glaucoma on early stage coexisting with cataract on considering pre-IOP and the extent of PAS in PACG and pre-IOP in POAG.  相似文献   

7.
目的:探讨高眼压青光眼滤过手术中恶性青光眼的手术处理,应用前房注气技术联合可调整缝线,可解除睫状环阻滞,减少恶性青光眼的发生。

方法:高眼压闭角型青光眼患者30例,初诊眼压大于60mmHg,经详细检查,符合复合式小梁切除手术适应证,药物降眼压,手术前眼压大于45mmHg。采用复合式小梁切除术,手术中完成巩膜瓣缝线后,出现无前房高眼压(睫状环阻滞)状态,采取加缝巩膜瓣可调整缝线并行前房注射消毒空气形成前房。

结果:术后随访6mo,30例均未出现恶性青光眼,前房深度稳定,25例眼压小于18mmHg,5例滤泡局限后眼压22~28mmHg。

结论:高眼压状态下行青光眼滤过手术,手术中出现高眼压无前房(睫状环阻滞)状态的机会很高,本文通过集中归纳30例此类手术情况,认为手术中加缝巩膜瓣可调整缝线并采用前房注射消毒空气形成前房的方法可以缓解术中睫状环阻滞,避免此类青光眼术后发生恶性青光眼情况。  相似文献   


8.

Objective

Elevated intraocular pressure (IOP) contributes to the progression of visual defects such as glaucoma. This study determined whether metabolic syndrome (MetS) and cardiovascular risk factors are associated with IOP in South Korean men.

Methods

We analyzed data on 4875 men who participated in the Korean National Health and Nutrition Examination Survey 2008–2010. We recorded the values for age, weight, height, body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), insulin, homeostasis model assessment of estimated insulin resistance (HOMA-IR), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), non-HDL-C (NHDL-C), and TG/HDL-C, as well as sociodemographic factors. IOP was measured using Goldmann applanation tonometry.

Results

Weight, BMI, WC, SBP, DBP, FBG, insulin, HOMA-IR, TC, LDL-C, TG, NHDL-C, TG/HDL-C, and the prevalence of MetS differed significantly among the three groups with IOP (P<0.05). Mean IOP was higher in subjects who were obese and had hypertension, diabetes mellitus, MetS, abdominal obesity, high TG, high FBG, or high BP compared with normal subjects (P<0.005). Analysis using Pearson''s correlation coefficient showed that all cardiometabolic risk factors were significantly associated with IOP (P<0.005), with the exception of WC and HDL-C. A multivariate linear regression analysis showed that IOP was positively correlated with BMI, SBP, DBP, FBG, HOMA-IR, TC, LDL-C, TG, NHDL-C, and TG/HDL-C after adjusting for all covariates (all P<0.05).

Conclusions

Cardiometabolic risk factors, including the components of MetS, are associated with increased IOP.  相似文献   

9.
PURPOSE: To assess the relation of arterial blood pressure (BP) and intraocular pressure (IOP) in an adult population not using glaucoma medications. DESIGN: Cross-sectional population-based study. METHODS: The Beijing Eye Study 2006, a population-based, cross-sectional cohort study, included 3,253 subjects (age, 45 years or more). The mean age was 60.4 +/- 10.1 years. Seated BP and applanation tonometric IOP were measured, and their relation was assessed in regression models. RESULTS: After exclusion of subjects who had closed anterior chamber angles and an IOP of more than 21 mm Hg or who were receiving topical antiglaucomatous treatment, the study included 2,981 subjects. In multivariate regression analysis, IOP was correlated significantly with systolic BP (P < .001; 95% confidence interval [CI], 0.011 to 0.022), diastolic BP (P < .001; 95% CI, 0.008 to 0.029), central corneal thickness (P < .001; 95% CI, 0.031 to 0.037), and myopic refractive error (P = .006; 95% CI, -0.103 to -0.015). Neither age (P = .17) nor body mass index (P = .20) were significantly associated with IOP. CONCLUSIONS: IOP is associated significantly with systolic and diastolic BP.  相似文献   

10.
目的:探讨中等强度有氧运动对健康青年人眼压的影响。方法:前瞻性研究。选取中南大学爱尔眼科学院2016级、2017级硕士研究生28例(28眼),其中男14例,女14例,所有受试者均在同一跑步机进行中等强度运动,速度为7~9 km/h。采用iCare-pro眼压计测量右眼眼压,臂式血压计测量血压,根据公式“眼灌注压=2/3平均动脉压-眼压”计算。分别收集运动前,运动期10、20、30 min,休息 10、30 min共6个时间点的数据。采用重复测量方差分析对数据进行分析。结果:最终纳入27例(27 眼):①不同时间点眼压总体差异有统计学意义(F=75.0,P<0.001),运动期10、20、30 min较运动前眼压均降低,差异均有统计学意义(P<0.001)。②不同时间点收缩压、舒张压总体差异均有统计学意义(F=31.7,P<0.001;F=19.7,P<0.001),运动期10、20、30 min收缩压、舒张压较运动前均升高,差异均有统计学意义(P<0.001)。③不同时间点眼灌注压总体差异有统计学意义(F=56.9,P<0.001),运动期10、20、30 min眼灌注压较运动前均升高,差异均有统计学意义(P<0.001)。④运动后休息 10 min,眼压、收缩压、舒张压、眼灌注压与运动前差异均无统计学意义。结论:中等强度有氧运动使健康青年人眼压降低,血压及眼灌注压升高,运动后休息10 min,眼压、血压、眼灌注压均恢复至运动前水平并趋于稳定。  相似文献   

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