首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到19条相似文献,搜索用时 156 毫秒
1.
甲氨蝶呤治疗输卵管妊娠后的生殖状态   总被引:1,自引:0,他引:1  
目的 总结甲氨蝶呤(MTX)治疗输卵管妊娠后的生殖状态。方法 收集我院1997年3月-2002年8月确诊为输卵管妊娠并符合保守条件的患者6l例,应用MTX全身治疗,对其中46例随诊1-7年。结果 MTX治疗后宫内妊娠率71.7%,异位妊娠率8.7%。初孕即为输卵管妊娠者,保守治疗后宫内妊娠率为74.2%,再次异位妊娠率6.5%;第2次为输卵管妊娠者,保守治疗后宫内妊娠率为58.3%,再次异位妊娠率16.7%;第3次为输卵管妊娠者,保守治疗后无妊娠。结论 选择合适的早期患者采用MTX治疗是安全、价廉、可靠的治疗方法,也可获得满意的远期生殖状态。  相似文献   

2.
目的 探讨米非司酮 (RU4 86 )治疗异位妊娠成功后的宫内再孕率。方法 回顾性分析我院1 996年 1月~ 2 0 0 2年 1月之间收治的 98例有生育要求的、药物保守治疗成功的异位妊娠患者的临床资料 ,其中5 8例为米非司酮 (RU4 86 )治疗成功 ,4 0例为甲氨蝶呤 (MTX)全身治疗成功 ,并经门诊及电话随诊。结果 RU4 86治疗者宫内再孕率 5 1 7% ,MTX治疗者宫内再孕率 5 2 5 % ,两者比较差异无显著性 (P >0 0 5 )。结论 RU4 86保守治疗的宫内再孕率和MTX保守治疗的宫内再孕率比较无明显差异 ,而且前者无明显副作用 ,血 β -hCG下降明显 ,患者更易接受  相似文献   

3.
输卵管妊娠保守性手术96例手术   总被引:3,自引:0,他引:3  
目的:探讨输卵管妊娠保守性手术及不同手术方式的近期效果及妊娠结局。方法:对96例未破裂型输卵管妊娠中77例行输卵管线型切开术,19例行输卵管伞端胚囊挤出术。绒毛肿植部位注射甲氨蝶呤20-30mg。结果:2.4%的患者发生持续性异位妊娠,均为行伞端挤出术患者。宫内妊娠率为41.5%,重复异位妊娠率为25.6%。对侧输卵管正常者,宫内妊娠率及重复异位妊娠率分别为70.5%和22.8%;当时侧输卵管异常或已被切除者,宫内妊娠率又重复异位妊娠率为7.9%和28.8%。结论:绒毛种植部位注射甲氨蝶呤可降低持续性异位妊娠率,而伞端绒毛挤出术后发生持续性异位妊娠的可能性较大,应尽量避免。  相似文献   

4.
体外受精-胚胎移植后发生异位妊娠17例临床分析   总被引:16,自引:0,他引:16  
目的 探讨体外受精-胚胎移植后异位妊娠的发生率、高危因素及诊断、治疗方法。方法 对我院1998年3月至1999年12月接受体外受精-胚胎移植治疗后妊娠的432例资料进行回顾性分析。结果 432例中宫内妊娠415例,异位妊娠17例(包括宫内外同时妊娠4例),异位妊娠发生率为3.9%。其中因输卵管病变发生异位妊娠14例(82.4%),非输卵管病变发生异位妊娠3例(17.6%)。年龄、促排卵方案及移植胚胎的时间与异位妊娠的发生无关。结论 异位妊娠的发生与输卵管病变有关,妊娠早期测定β-人绒毛膜促性腺激素(β-hCG)和行B超监测,有利于异位妊娠的早期诊断和治疗。  相似文献   

5.
目的观察腹腔镜保守性手术治疗输卵管妊娠后患者生育状况并探讨其影响因素。方法对2001年1月至2004年5月佛山市第一人民医院接受腹腔镜保守性手术治疗的162例输卵管妊娠患者(A组),观察其术后输卵管通畅程度、再次宫内妊娠率、异位妊娠再发等情况,并与同期接受输卵管大部分切除的96例患者(B组)进行对比分析;采用Logistic回归分析术前血人绒毛膜促性腺激素(HCG)水平等因素对术后生育结局的影响。结果腹腔镜保守性手术组与患侧输卵管大部分切除术组术后持续性异位妊娠发生率分别为8.02%、1.04%;随访2~5年,保守性手术组和患侧输卵管大部分切除术组再次宫内妊娠率分别为71.6%、38.5%,两组比较差异有统计学意义(P〈0.05)。在单因素分析中,腹腔镜保守性手术治疗输卵管妊娠术后宫内妊娠率分别与术前血HCG水平、包块大小、盆腔粘连情况、患侧输卵管破裂与否、对侧输卵管闭锁与否、术后患侧或对侧输卵管通畅与否、既往异位妊娠病史相关(P〈0.05);在多因素分析中,术后宫内妊娠率与术前血HCG水平、盆腔粘连情况、患侧输卵管术后通畅与否、既往异位妊娠病史相关(P〈0.05)。结论腹腔镜保守性手术治疗输卵管妊娠具有微创、安全及再次宫内妊娠率高等优点。术前血HCG水平、盆腔粘连情况、患侧输卵管术后通畅与否、既往异位妊娠病史是影响术后宫内妊娠率的相对独立因素。对于严重盆腔粘连或重复同侧输卵管妊娠者,不建议行保守性手术。  相似文献   

6.
目的:探讨宫内外复合妊娠(HP)腹腔镜治疗的有效性、安全性及对妊娠结局的影响。方法:回顾性分析2011年1月—2018年1月天津市中心妇产科医院收治的宫内妊娠合并输卵管妊娠共34例,探讨腹腔镜手术治疗的可行性和妊娠结局。结果:34例患者均为宫内妊娠合并单侧输卵管妊娠,其中特殊病例包括:宫内双胎妊娠合并右侧输卵管妊娠1例,宫内妊娠合并右侧输卵管间质部妊娠1例,双子宫右侧宫腔妊娠合并左侧输卵管妊娠1例。所有患者均行腹腔镜手术治疗,手术时间15~110 min,平均(45.21±8.33)min;术中出血5~200 mL,平均(33.04±10.12)mL,其中3例因术前腹腔出血超过800 mL行输血治疗。术后患者无发热、切口感染和术后并发症,超声检查提示宫内妊娠状态正常,患者恢复良好。除胚胎停育行人工流产1例和失访1例外,余33例新生儿(1例双胎妊娠分娩)均为活产,未见新生儿发育畸形。结论:对于妊娠早期的宫内妊娠合并单侧输卵管妊娠患者,腹腔镜手术去除输卵管异位妊娠安全有效,术后未增加医源性流产率及新生儿出生缺陷发生率。  相似文献   

7.
输卵管妊娠保留输卵管手术后综合疗法的宫内妊娠探讨   总被引:3,自引:1,他引:3  
张建青  芦莉 《生殖与避孕》1997,17(4):241-244
对输卵管妊娠52例有生育要求者,其中28例行切开输卵管壶腹部取胚胎术,10例行输卵管峡部破裂口修补术,7例行输卵管伞部成形术,5例行输卵管峡部端端吻合术,2例行输卵管子宫角部植入术。术后给MTX与中药等综合治疗2~5个月,对其中45例行输卵管通畅检查,双侧输卵管通畅4O例,通畅率为88.9%;有41例宫内妊娠,妊娠率为78.9%,另有1例再次异位妊娠。提示:对有生育要求的输卵管妊娠尽量根据输卵管的不同情况采用相应的手术方法,并应用有效的术后综合措施,对保留患者的生育功能和提高妊娠率有重要意义。  相似文献   

8.
MTX治疗异位妊娠的再孕情况及副作用   总被引:45,自引:1,他引:45  
MTX治疗异位妊娠的再孕情况及副作用漆洪波,蔡汉钟(630010重庆医科大学第二临床学院)异位妊娠的传统治疗是切除患侧输卵管。采用保守性手术治疗,可保留患者的生育能力,增加再孕机会,术后再孕率为40%~72%。随着β-hCG放射免疫连续测定、阴道超声...  相似文献   

9.
近年来,随着人工流产、药物流产以及相应的盆腔炎症的增加,导致异位妊娠发病率也增加。为探索提高有生育要求异位妊娠患者术后宫内孕率的有效治疗方案,我科对1995年3月~2002年2月确诊为输卵管异位妊娠、并行输卵管切开取胎术的90例患者进行中西医结合治疗3个月,并跟踪随访2年内宫内孕情况,现将结果报告如下。  相似文献   

10.
目的:探讨在急诊情况下行输卵管保守性手术的安全可行性及疗效.方法:回顾分析开腹保守性手术治疗输卵管妊娠48例的手术方法,随访术后宫内妊娠率及重复异位妊娠率.结果:术后2年宫内妊娠率为72.96%,重复异位妊娠率为6.25%.无一例持续性异位妊娠发生.结论:输卵管妊娠保守性手术是一种可行的手术方法.提高手术技能,能提高手术成功率,降低保守性手术的并发症,为患者创造自然受孕的机会.  相似文献   

11.
Thirty-four women with unruptured tubal ectopic pregnancy (EP) were randomly assigned to undergo salpingotomy without tubal suturing (n = 15) or salpingotomy with tubal suturing (n = 19). The reproductive performance of these patients was compared with 24 patients who underwent salpingectomy for their EP (historical control). Using life table analysis, the cumulative probability of intrauterine pregnancy (IUP) at 12 and 24 months was 45% and 45% after salpingotomy without tubal suturing and 21% and 47% after salpingotomy with tubal suturing, respectively. The cumulative probability of IUP after salpingectomy (21% and 26% at 12 and 24 months, respectively) was significantly lower than after salpingotomy with or without tubal suturing. There was no difference in the cumulative probability of EP after salpingotomy with or without tubal suturing, but it was significantly higher than after salpingectomy. In 18 women who subsequently underwent laparoscopy or laparotomy, no significant difference was found between the degree of adhesions after salpingotomy with or without tubal suturing. These findings suggest that IUP after conservative treatment is higher than after salpingectomy, but recurrent EP is also higher. Intrauterine pregnancy occurs earlier after salpingotomy without tubal suturing than after salpingotomy with tubal suturing. This might be because of rapid return of tubal function after healing by secondary intention.  相似文献   

12.
ObjectiveTo evaluate the fertility outcomes of salpingectomy compared with those of salpingostomy among patients treated for tubal ectopic pregnancies, including a separate analysis of women with risk factors along with a review of the surgical technique.Data SourcesSystematic review and meta-analysis from 1990 to the present through PubMed, Embase, CINAHL, and Ovid MEDLINE. The search string included “tubal pregnancy” or “ectopic” as well as “salpingectomy” and various terms describing salpingotomy.Methods of Study SelectionArticles studying women who underwent surgical management of an ectopic pregnancy and the contrasted outcomes of salpingectomy vs salpingostomy were reviewed. The primary outcomes included subsequent intrauterine pregnancy (IUP) and repeat ectopic pregnancy (REP).Tabulation, Integration, and ResultsTwo randomized controlled trials (RCTs), which consisted mostly of patients classified as low risk, and patients from 16 cohort studies were included. In the RCTs, there was no significant difference in the odds of subsequent IUP in patients who underwent a salpingectomy compared with those who were treated with salpingotomy (odds ratio [OR] 0.97; 95% confidence interval [CI], 0.71–1.33). However, a significant and clinically meaningful difference was noted in the cohort studies, with the patients having a lower chance of IUP after salpingectomy (OR 0.45; 95% CI, 0.39–0.52). No significant difference was noted in the OR for a REP in the randomized trials (OR 0.77; 95% CI, 0.41–1.47), but the patients followed in the cohort studies had a cumulatively higher risk of REP after a salpingostomy (OR 0.73; 95% CI, 0.60–0.90).The subgroup analysis examining women within the studies with risk factors for tubal pathology found an even more impressive lowering in the odds of a subsequent IUP in patients classified as at-risk who were treated with salpingectomy (OR 0.30; 95% CI, 0.17–0.54), with a change in the direction of the odds for an REP rate favoring those who were treated with salpingostomy (OR 1.96; 95% CI, 0.88–4.35).ConclusionSalpingectomy has clear advantages over salpingostomy, and RCTs consisting mainly of patients classified as low risk show no difference in outcomes between salpingectomy and salpingostomy. However, in cohort studies inclusive of all patients, the likelihood of a subsequent spontaneous IUP is decreased in patients treated with salpingectomy, and salpingostomies may be especially underused in women with risk factors for tubal disease.  相似文献   

13.
In the period July 1983 to March 1985, 264 women had surgery for ectopic pregnancy at Grady Memorial Hospital; 76 had postoperative hysterosalpingograms. Of these, 55 (76.4%) women were followed up for 3 to 41 months (mean, 23.8) to determine subsequent fertility. During the follow-up period, 30 pregnancies occurred among the 55 patients; 24 were intrauterine and 6 were repeat ectopic pregnancies. In the surgical group of 39 patients with salpingectomy, 60.8% of those desiring pregnancy achieved an intrauterine pregnancy. Of the 12 patients with salpingostomy, the three who desired pregnancy achieved it (100%). In the tubal abortion group, the two women desiring pregnancy conceived (100%). There were six repeat ectopic pregnancies (10.9%). Of the ectopic pregnancies, one occurred in the salpingectomy group (2.6%), four in the salpingostomy group (33.3%), and one in the tubal abortion group (25%). Five of the six ectopic gestations were found in the contralateral fallopian tube. Hysterosalpingographic evidence of contralateral tubal patency was a good prognostic indicator for subsequent intrauterine pregnancy. By contrast, one half of study patients with findings suggesting tubal occlusion still achieved an intrauterine pregnancy.  相似文献   

14.
输卵管妊娠后再次妊娠的探讨   总被引:22,自引:0,他引:22  
对输卵管妊娠后有生育要求的58例行输卵管切除术,15例行输卵管开窗术,30例应用药物保守治疗。结果:103例治疗后67例宫内妊娠,9例再次异位妊娠。  相似文献   

15.
The aims of this work were the evaluation of the reproductive outcome after ectopic pregnancy, and the assessment of the role of infertility risk factors and treatment's strategy. All patients in the population-based register of the urban area around Lille, Northern France, were followed-up. 345 women treated between April 1994 and March 1997, who were trying to become pregnant were interviewed by telephone every 6 months and then every year. The cumulative pregnancy rates were calculated by the Kaplan-Meier estimation. Associations between infertility risk factors and intrauterine pregnancy were tested by the logrank test, and by a Cox model for multivariate analysis. The mean duration of follow-up was 22 months, and 228 (66%) women had obtained a new pregnancy at the time of the analysis. 23 (10%) of the first pregnancies were recurrences. For women for whom EP occurred with an IUCD (17 patients), the 1 year intrauterine pregnancy (IUP) reached 67%. For the others, the 1 year IUP rate was 56%, and reached 67% after 2 years. After adjusting factors associated with fertility with a Cox regression, 3 factors seemed to lower reproductive performances: age > 35 years, previous history of infertility, and anterior tubal damage. More than half the women treated for EP obtained spontaneously a normally progressive pregnancy after 1 year. Reproductive performances are associated with characteristics of the patients, but do not depend on radical or conservative treatment.  相似文献   

16.
Study ObjectiveTo evaluate future pregnancy rates beyond gestational week 24 after cornual resections for interstitial pregnancies, subsequent modes of delivery, and the rate of later uterine ruptures.DesignA single-center historic cohort with follow-up registry data (Canadian Task Force classification II-2).SettingDepartment of Gynecology, Oslo University Hospital, Oslo, Norway.PatientsForty consecutive women with interstitial ectopic pregnancies were treated in the study period from 2005 to 2016, 33 of whom were treated with laparoscopic cornual resection (3 converted to laparotomy). Twenty-six of the 33 women were presumed still fertile after treatment (cases) and thereby age and parity matched with a reference group of 52 women with an equal follow-up time having undergone salpingectomy for tubal (noninterstitial) ectopic pregnancies (controls) (ratio 1:2). Subsequent fertility data for both groups were retrieved from medical records and the national Medical Birth Registry of Norway.InterventionsNone, data extracted from the patients’ medical records and the Medical Birth Registry of Norway.Measurements and Main ResultsThe incidence of interstitial pregnancies among the ectopic pregnancies was 3%. The median time to follow-up for cases and controls was 76 and 71 months, respectively. Subsequent pregnancy rates beyond gestational week 24 were equal in both groups (46% [cases] and 54% [controls]). Cesarean delivery in subsequent pregnancies was more common among women having undergone cornual resections (60% vs 18%, p = .006). Only 2 subsequent uterine ruptures were encountered.ConclusionCornual resection as treatment for interstitial pregnancies seems to have no added detrimental effect on subsequent pregnancy rates compared with salpingectomy for noninterstitial tubal ectopic pregnancies. However, they more often lead to elective cesarean deliveries in subsequent pregnancies.  相似文献   

17.
Laparoscopic treatment of tubal pregnancy   总被引:1,自引:0,他引:1  
Seventeen tubal pregnancies were treated successfully with a laparoscopic procedure over the past four years. Four different laparoscopic techniques were used: salpingectomy, partial salpingectomy (midtube resection), fimbrial expression, and salpingotomy. "Preventive hemostasis" using vasopressin has made salpingotomy our treatment method of choice. Ruptured tubal pregnancy was not considered a contraindication to laparoscopic treatment. Four of the six women who were trying to conceive and were followed for longer than six months have had documented intrauterine pregnancies; one woman subsequently developed a contralateral tubal pregnancy which was treated by laparoscopic salpingotomy. Tubal ectopic pregnancy, even in the presence of rupture, can be managed effectively by a variety of laparoscopic techniques with benefits including minimal incision, short hospitalization, early return to full activity, and in many cases, a patent tube.  相似文献   

18.
Reproductive outcome after methotrexate treatment of tubal pregnancies   总被引:15,自引:0,他引:15  
OBJECTIVE: To evaluate reproductive outcome after ectopic pregnancy (EP) treated with methotrexate (MTX) and to assess the relative contribution of various risk factors to future fertility. DESIGN: Telephone follow-up interviews in a cohort of patients treated for EP. SETTING: University hospital. PATIENT(S): A cohort of 158 patients treated with MTX for tubal pregnancies between April 1991 and March 1999. INTERVENTION(S): Assessment of fertility outcomes. MAIN OUTCOME MEASURE(S): Cumulative pregnancy rates for intrauterine and ectopic pregnancies. RESULT(S): Thirty-two patients (20.2%) were lost to follow-up. Of 126 patients, 93 (73.8%) sought to become pregnant, and of these 93 women, 76 (81.7%) did. Sixty-four pregnancies were spontaneous, and 12 resulted from in vitro fertilization (IVF). No pregnancies occurred in the group not trying to become pregnant. Of the 64 spontaneous pregnancies, 52 (81.2%) were intrauterine, with 12 (18.7%) resulting in miscarriages, and 12 (18.7%) were recurrent ectopic pregnancies. The cumulative intrauterine pregnancy rate was 57.5% after 1 year and 66.9% after 2 years. The cumulative ectopic pregnancy rate was 15.4% after 1 year and 23.7% after 2 years. After adjusting for factors associated with fertility with a Cox regression, only one factor was associated with poor reproductive performance: previous history of infertility. CONCLUSION(S): Within 1 year of seeking to become pregnant, more than half the women previously treated medically for EP conceived and had ongoing pregnancies. Our analysis indicates that fertility depends more on the patients' previous medical history than on her treatment for EP.  相似文献   

19.
OBJECTIVE: To analyze risk factors for ectopic pregnancy (EP) after in vitro fertilization (IVF). DESIGN: A retrospective study of IVF pregnancies was performed between November 1983 and December 1989. SETTING: This study was conducted in a tertiary care center, the Port-Royal University Hospital. PATIENTS: Patients' records were reviewed for 48 EP and 508 intrauterine pregnancies obtained by IVF. INTERVENTIONS: Forty-six salpingectomies were performed for EP after IVF. MAIN OUTCOME MEASURE: We evaluated the impact on the ectopic rate of tubal status, the type of ovarian stimulation and luteal phase support, and the number of embryos transferred. RESULTS: Forty-three of 48 EP occurred in patients with tubal infertility. The rate of EP was significantly higher when the indication was tubal (11.1%) than when it was endometriosis (2.1%) or unexplained infertility (3.4%). Pathological findings revealed tubal lesions in all 46 salpingectomies. CONCLUSIONS: Ectopic pregnancy after IVF appears related to pre-existing tubal pathology. However, routine prophylactic salpingectomy to prevent the risk of EP does not appear justified.  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号