首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到19条相似文献,搜索用时 171 毫秒
1.
应用超微细胞化学方法,对放置TCu220c IUD前后月经正常和放器后月经过多子宫内膜各14例,在增生晚期和分泌晚期分别作ACP及AKP细胞化学观察;并对电镜照片进行电子计算机图象处理,作酶活性定量比较。结果提示,以ACP为标志的溶酶体酶活性增加在TCu220cIUD所致月经过多中起作用;AKP与TCu220c IUD所致月经过多似无明显相关。  相似文献   

2.
目的:探讨长期放置国产TCu200c宫内节育器(IUD)的变化。方法:对24只放置15年左右(13-17年)的国前TCu200c宫内节育器采用金相,扫描电镜、有谱仪、X射线衍射仪检查等方法,进行铜管的金相及表面沉积物和尾丝表面形貌及成分分析。结果:铜管金相均有腐蚀,有的甚至腐蚀后导致铜管脱落,铜管上沉积物元素为Ca,Cu,S,Si,Cr等,结构为CaCO3,Cu2O,Cu。尾丝形貌没有明显改变,但有的丝质变硬,变脆,其表面沉积物为CaCO3。结论:TCu200cIUD放置15年左右铜管明显腐蚀,表面沉积物增多,带器者在临床上未发现明显异常。  相似文献   

3.
TCu220c宫内节育器放置15年左右金相及表面沉积物分析   总被引:2,自引:0,他引:2  
目的探讨长期放置国产TCu220c宫内节育器(IUD)的变化.方法对24只放置15年左右(13~17年)的国前TCu220c宫内节育器采用金相、扫描电镜、能谱仪、X射线衍射仪检查等方法,进行铜管的金相及表面沉积物和尾丝表面形貌及成分分析.结果铜管金相均有腐蚀,有的甚至腐蚀后导致铜管脱落,铜管上沉积物元素为Ca、Cu、S、Si、Cr等,结构为CaCO3、Cu2O、Cu.尾丝形貌没有明显改变,但有的丝质变硬、变脆,其表面沉积物为CaCO3.结论TCu220cIUD放置15年左右铜管明显腐蚀,表面沉积物增多,带器者在临床上未发现明显异常.  相似文献   

4.
本文选择34例健康妇女,于放置释放20μg/日左旋18-甲基炔诺酮宫内节育器(LNG-IUD-20)前与一年后子宫内膜作形态计量学研究,并与以前放置释放2μg/日左旋18-甲基炔诺酮的宫内节育器(LNG-IUD-2)子宫内膜作比较。结果表明:LNG-IUD-20与LNG-IUD-2对子宫内膜增殖抑制和炎性反应有类似作用,其形态学变化无剂量依赖性影响。本研究结果结合临床资料说明:LNG-IUD-20在不增加任何副作用的情况下起到了比LNG—IUD—2更有效的作用。  相似文献   

5.
放置含铜硅胶V型宫内节育器的远期临床观察   总被引:4,自引:0,他引:4  
对放置国产含铜硅胶V型宫内节育器(IUD)5~18年的妇女350例(VCu200IUD组),与放置同样年限不锈钢金属IUD且同期取器的妇女350例(金属IUD组)的子宫内膜变化及IUD形态进行对照研究。结果:VCu200IUD组的妊娠率明显低于金属IUD组,虽然部分VCu200IUD出现铜丝氧化、融蚀,中心扣断脱致IUD变形及硅胶管钙盐沉积,但放置VCu200IUD妇女的子宫内膜无恶性病变发生。提示:如经x线检查IUD形态及铜丝尚较完整,且放置IUD的妇女无月经紊乱发生,仍可继续放置VCu200IUD。  相似文献   

6.
本文选择34例健康妇女,于放置释放20μg/日左旋18-甲基炔诺酮宫内节育器前与一年后子宫内膜作形态计量学研究,并与以前放置释放2μg/日左旋18-甲基炔诺酮的宫内节育器子宫内膜作比较,结果表明:LNG0IUD-20与LNG-UD-2对子宫内膜增殖抑制和炎性反应有类似作用,其形态学变化无剂量依赖性影响,本研究结果结合临床资料说明:LNG-IUD-20在不增加任何副作用的情况下起到了比LNG-IUD  相似文献   

7.
长期放置TCu220C宫内节育器子宫内膜形态计量学研究   总被引:4,自引:0,他引:4  
目的:观察长期放置TCu220C宫内节育器(IUD)的子宫内膜病变情况,探讨其安全性。方法:随机选择放置TCu220CIUD5-12年的妇女100例为IUD组,用宫腔定位取IUD压迹外及压迹外1cm处的子宫内膜,以年龄配比选取100例未首放置IUD妇女的子宫内膜为对照。两组内膜常规制片,HE染色后光镜下进行形态计量。结果:压迹外1cm处子宫内基本正常,所见病变毕奶于压迹处,炎中例皆有,以淋巴细胞浸  相似文献   

8.
绝经后应用激素替代治疗妇女的子宫内膜细胞形态观察   总被引:17,自引:0,他引:17  
魏杨  薛加强 《中华妇产科杂志》1997,32(7):432-435,I039
目的;观察绝经后应用激素替代治疗(HRT)妇女子宫内膜细胞的形态改变;建立子宫内膜的监测方法。方法:应用塑料管负压法,吸取绝经后妇女60例(非RT组)和应用HRT3-18个月妇女41例(HRT组)的子宫内膜细胞,进行细胞病理学诊断。结果:非HRT组内膜细胞萎缩型为51.7%,吞噬细胞为68.3%;随着年龄增长及绝经时间的延长,萎缩型增加。HRT组萎缩型和吞噬细胞分别为12.2%和17.0%,明显低  相似文献   

9.
目的:探讨左炔诺孕酮宫内缓释系统(曼月乐)治疗子宫内膜单纯性增生过长的疗效及可能作用机制。方法:选取2011年11月—2012年2月门诊应用曼月乐治疗子宫内膜单纯性增生过长的患者60例,观察放置曼月乐6个月后的子宫内膜活检病理变化及经阴道超声测量子宫内膜厚度、子宫动脉血流[阻力指数(RI)、搏动指数(PI)]及月经模式的改变。结果:2例由于阴道持续性点滴出血提前取出,58例子宫内膜转归正常。放置曼月乐前后子宫内膜厚度、RI分别为(1.52±0.33) cm、(0.62±0.14)cm和0.64±0.07、0.79±0.08,差异均有统计学意义(P<0.05或P<0.01),PI分别为1.98±0.51、1.96±0.04,差异无统计学意义(P>0.05)。放置曼月乐后经量明显减少,24例表现为月经稀发,32例表现为闭经。结论:曼月乐是治疗子宫内膜单纯性增生过长的简单有效方法,对子宫动脉血流的影响是其可能的作用机制。  相似文献   

10.
目的 了解宫腔形宫内节育器(Cu300)及TCu220C、TCu380A3种宫内节育器(IUD)放置10年的临床效果。方法 全国7个IUD临床应用中心,对2699例随机放置Cu300、TCu220C和TCu380A的农村妇女,共观察10年。结果 使用10年时,Cu300、TCu220C和TCu380A的带器妊娠率,分别为2.56、4.82和4.01/100妇女,Cu300明显低于其他两种IUD(P<0.05)。脱落率分别为4.54、5.46和9.68/100妇女,TCu380A显著高于其他两种IUD(P<0.001)。因出血、疼痛取出率分别为6.71、5.58和6.80/100妇女,3种IUD比较,差异无显著意义(P>0.05)。使用10年时,3种IUD的续用率分别为74.86、66.22和63.56/100妇女,以Cu300续用率最高,TCu380A最低(P<0.01)。结论 Cu300、TCu220C和TCu380A的避孕效果好,可推广使用。  相似文献   

11.
Liu Z  Chen Q  Ni X 《中华妇产科杂志》1998,33(4):232-234
OBJECTIVE: To investigate the morphologic changes of endometrial spiral arterioles and its relationship with bleeding pattern after insertion of gamma-shape copper indomethacin-medicated (gamma CuI) and T-shape copper (TCu 220C) intrauterine devices (IUD). METHODS: Endometrium specimens of late secretory phase were obtained from fertile age women: 10 from preinsertion, 10 obtained after insertion of TCu 220C IUD, and 9 obtained after insertion of gamma CuI IUD. Samples were sectioned serially and morphometric analysis of endometrial spiral arterioles was performed under light microscope. RESULTS: The average cross section area (Area), maximum diameter (Dmax) and minimum diameter (Dmin) of spiral arterioles in both spongeous and dense layers of endometrium increased significantly after insertion of TCu 220C IUD. After insertion of gamma CuI IUD, the Area and Dmax increased in dense layer only, though less obviously than that occurred in TCu 220C group. However, the Dmin increased more obviously in both spongeous and dense layers than after insertion of TCu 220C IUD, implying that the shape of spiral arterioles was more regular in gamma CuI group. CONCLUSION: gamma CuI IUD has less effects on the morphological changes of endometrial spiral arterioles, and this may relate to its indomethacin-contained which causes less bleeding.  相似文献   

12.
FHIT expression in neoplastic, hyperplastic, and normal endometrium   总被引:2,自引:0,他引:2  
Fragile histidine triad (FHIT), a candidate of tumor suppressor protein, expression was examined on paraffin-embedded specimens in proliferative, secretory, hyperplastic, and neoplastic human endometrium by immunohistochemistry. The results of FHIT immunoreactivity in endometrial carcinomas were compared with prognostic indicators as well as with p53 overexpression. Forty-four cases of endometrial carcinoma, 30 normal functional (15 proliferative, 15 secretory), and 24 hyperplastic endometrium (12 without atypia, 12 with atypia) specimens were studied using polyclonal FHIT antibody. The streptavidin-biotin-peroxidase detection system was used, and the intensity and the distribution of immunoreactivity were evaluated semiquantitatively. There were no significant differences in FHIT expression in the proliferative, secretory, hyperplastic, either with or without atypia, or carcinomatous endometria. No significant difference in FHIT expression of endometrial carcinomas was detected when prognostic parameters or p53 overexpression were considered. Loss or reduced FHIT expression was not found to predict disease-free or cumulative survivals. This study showed that loss or reduction in FHIT protein expression is present in normal functional and hyperplastic endometria as well as in neoplastic endometrium. FHIT protein seems not to be involved directly in endometrial carcinogenesis, but rather, it regulates cell proliferation both in physiologic and in pathologic conditions of endometrium.  相似文献   

13.
A random sequential comparative study of three models of the Copper T intrauterine contraceptive device (IUD) was undertaken in 1,792 women. For 7 months, the TCu 300 and TCu 220C were randomly inserted, and then the TCu 380A and 220C were randomly inserted for the next 12 months. The log-risk method of life-table analysis of event rates was performed at the end of each of the first 3 years of use of each device. The TCu 380A had the lowest pregnancy rate during each year of use, although the difference was not significant. At the end of each of the first 2 years, the TCu 300 was removed significantly less than the TCu 220C and TCu 380A for bleeding and pain. At the end of three years, the rates of removal for bleeding and pain for the TCu 380A and TCu 300 were similar and lower than that for the TCu 220C, but the overall difference was not significant. There were no differences among the devices for any other relevant use-related reasons. The TCu 380A was removed for other medical reasons significantly more frequently than the other devices at the end of 2 and 3 years. Adjusting for parity did not alter the results. The findings of this study suggest that the copper sleeves along the horizontal arms together with copper wire on the vertical arm in the TCu 380A model provide greater protection against intrauterine pregnancy, whereas the copper sleeves along the vertical arm as in the TCu 220C caused increased removals for bleeding and pain. The TCu 380A should be studied in a larger number of patients for a longer period of time to determine its clinical effectiveness. It may become the IUD of choice for all women irrespective of parity.  相似文献   

14.
Cytosol receptors for progesterone were assayed in human endometrial tissue during the proliferative and secretory phases of the menstrual cycle and in the hyperplastic and carcinomatous endometrium. The assays were performed utilizing a technique involving prior treatment of the cytosol extract with dextran-coated charcoal to remove endogenous progesterone. The results showed that the progesterone receptor activity was higher during the later proliferative and early secretory phases of the menstrual cycle. Hyperplastic and carcinomatous endometrium also contained specific cytosol receptor for progesterone, and the binding activity of the hyperplastic endometria and endometrial polyps was comparable to that found during the later proliferative phase of the menstrual cycle. No apparent correlation between the progesterone receptor level and the morphologic degree of differentiation in Grades 1 and 2 adenocarcinomas of the endometrium was observed.  相似文献   

15.
目的:探讨SHH,Notch信号通路和其下游信号分子Gli-1、Hes-1在人子宫内膜癌的表达及意义。方法:应用免疫组织化学方法检测37例正常人子宫内膜、增生内膜和子宫内膜癌中SHH、Notch信号的表达,同时采用RT-PCR方法检测上述新鲜组织中Gli-1、Hes-1的表达。结果:子宫内膜增生组和子宫内膜癌组SHH、Notch的表达均强于正常组(P<0.05)。正常组和子宫内膜增生组Gli-1的表达类似,在子宫内膜癌组表达较低;正常组和子宫内膜增生组Hes-1的表达类似,在子宫内膜癌组表达升高。经随访,本研究选取的病例现均存活。结论:SHH和Notch表达与子宫内膜癌的发生密切相关,Gli-1和Hes-1主要参与子宫内膜癌的进展变化,但可能作用不同。  相似文献   

16.
置入新型MCu功能性宫内节育器1050例24个月临床报告   总被引:6,自引:0,他引:6  
目的 :为了研究新型MCu功能性宫内节育器 (MCu IUD)的安全性、可接受性及临床效果。方法 :由 4个临床中心共放置MCu IUD10 5 0例 ,并随机抽样MCu IUD与TCu2 2 0C IUD各 10 9例 ,作临床效果对比观察。结果 :放置满 2 4个月时 ,随访率 >95 %。 10 5 0例使用MCu IUD者 2 4个月带器妊娠率为 0 2 9% ,脱落率为 0 ,续用率为 92 6 7%。放置MCu IUD与TCu2 2 0C IUD各 10 9例 ,观察 2 4个月 ,续用率分别为 93 5 8%和 81 6 5 % ;两组累积妊娠率分别为 0 92 %和2 75 % ;两组累积脱落率各为 0和 2 75 % ;两组因症取出率分别为 2 75 %和 9 17% ,差异均有显著性 ,P均 <0 0 5。副反应发生率MCu IUD组少于TCu2 2 0C IUD组 ,12个月时P <0 0 1,差异有非常显著性 ;2 4个月时差异无显著性。结论 :MCu IUD置、取方便 ,具有抗生育效果好、脱落率低、带器妊娠率低、副反应少、安全等特点 ,是当前应用效果比较理想的IUD。  相似文献   

17.
全国13省市共23个单位,对不锈钢金属单环、V Cu200及T Cu220c三种宫内节育器(IUD)进行随机临床多中心比较性研究。自1987年7月1日至1984年3月31日共接受对象6236例。五年末随访率为96.0%。60个月时每百妇女累积续用率以金单为最低,55.8%,V Cu及T Cu各为68.8%及72.4%。V Cu和T Cu的妊娠率分别为7.32%和7.24%,显著地低于金单的20.2%。60个月时金单、V Cu和T Cu的脱落率分别为19.0%、9.7%和5.6%,三者间呈显著性差异。因出血和/或疼痛取出率以金单为最低,二种带铜宫内节育器间无差别。三种IUD使用情况城市与农村间比较,城市的累积续用率均高于农村;妊娠、脱落和个人原因停用农村均高于城市。用Cox比例危险模型和似然比检验,发现金单的失败危险与以下因素有关:年龄、过去IUD使用史、劳动姿态、孕次和宫腔深度;前四个因素对VCu失败危险有影响;TCu失败危险除与前三个因有关外,哺乳期放器对其失败危险亦有影响。年龄和孕次均影响三种IUD的妊娠危险;过去IUD使用史分别作用于金单和VCu;宫腔深度分别影响金单和TCu的妊娠。T Cu的脱落仅受哺乳期放器影响;年龄、孕次、过去IUD使用史影响着VCu的脱落;金单脱落除上述三因素外,还受宫腔深度的影响,且前三个因素均呈极显著性差异。  相似文献   

18.
目的:探讨脯氨酸、谷氨酸和亮氨酸富集蛋白1(PELP1)在II型子宫内膜癌中的表达及其与雌激素受体(ER)的相关性。方法:免疫组化法检测84例子宫内膜癌及40例正常子宫内膜组织中PELP1和ER表达水平并对其进行相关性分析。结果:I型子宫内膜癌及增殖期子宫内膜组织中PELP1、ER阳性表达率高于II型子宫内膜癌及分泌期子宫内膜组织,差异均有统计学意义(P0.05);II型子宫内膜癌与分泌期子宫内膜组织比较,差异均无统计学差异(P0.05)。Pearson相关分析提示,PELP1与ER在I型子宫内膜癌组织中表达量呈正相关(rs=0.348,P=0.01),而在II型子宫内膜癌组织中无相关性(rs=0.268,P=0.144)。结论:PELP1在II型子宫内膜癌组织中的表达较少,且与ER表达无明显相关性。  相似文献   

19.
BACKGROUND: This study is designed to compare endometrial thickness measured by transvaginal ultrasound with endometrial pathology by dilatation and curettage. METHODS: Fifty-four women with postmenopausal bleeding were evaluated. Endometrial thickness, including both layers of the endometrium, was measured by transvaginal ultrasound after which fractional curettage was performed and samples taken were then dispatched for histologic examination. RESULTS: Median endometrial thicknesses of 5 mm, 8.5 mm and 6 mm were found for benign, hyperplastic and carcinomatous endometrium, respectively. Of the eight hyperplastic samples, two cases had 4 mm, and one case had 3mm endometrial thickness. Similarly, of the nine malignant samples, three cases had an endometrial thickness of 3 mm. Three mm has been found to be the best cut off point for endometrial abnormalities in postmenopausal bleeding with 100% sensitivity but low specificity (13%). CONCLUSION: Fractional curettage seems to be the best method for detecting endometrial abnormalities in women with postmenopausal bleeding.  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号