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1.
维生素D(vitamin D,VD)作为一类常见的营养元素,不仅在调节钙稳态和骨骼健康方面具有明确的作用,近年来有研究表明其与男性生殖可能存在密切关系。本文通过阐述VD的代谢、VD与男性性激素、精子质量以及妊娠结局的关系,以进一步说明VD对男性生育力的重要影响。了解VD对男性生殖的影响及其机制可为临床诊疗提供新的思路和方法。  相似文献   

2.
维生素D调节钙和磷吸收,促进骨骼的生长和重构。越来越多的研究证实,维生素D在高血压、肿瘤、自身免疫性疾病、2型糖尿病等疾病的发生和发展中起重要作用。研究发现,维生素D受体(VDR)广泛分布于卵巢、子宫、输卵管、宫颈、乳腺、睾丸、精子等生殖器官、组织与细胞中。关于维生素D的活性代谢产物的生理作用已进行了广泛研究,但其在人类生殖中的报道较少。现本文就维生素D缺乏对女性生殖系统功能的影响做一综述。  相似文献   

3.
维生素D作为脂溶性类固醇衍生物,在生理上具有维持骨质钙磷代谢平衡的功能,有研究显示在免疫系统、内分泌系统、心血管系统疾病及部分肿瘤、炎症发生发展中维生素D发挥促细胞分化、凋亡的作用。维生素D主要通过调节维生素D受体的表达介导靶基因转录过程,实现抗肿瘤的生物学效应。近年来有研究发现在子宫内膜癌组织中存在维生素D受体的表达,提示其可能与子宫内膜癌进展有关,可能是子宫内膜癌治疗的潜在靶点。随着对抗肿瘤机制的深入探索,维生素D及其类似物被用于肿瘤内分泌治疗。综述维生素D受体生物学基础、维生素D抗肿瘤作用及其在子宫内膜癌中应用的相关研究。  相似文献   

4.
多囊卵巢综合征(polycystic ovary syndrome,PCOS)是妇科及生殖医学科常见的一种内分泌疾病,生殖功能障碍与糖脂代谢紊乱常同时存在,具有多起因、异质性。研究表明维生素D水平在PCOS患者中普遍低于正常值,且与PCOS人群的胰岛素抵抗(insulin resistance,IR)、肥胖、高雄激素血症、生殖力下降、远期并发症、卵巢功能及抑郁症发生等相关,通过维生素D补充治疗及生活方式改变或许可以改善上述情况,进而提高PCOS患者的生殖力及生活质量。  相似文献   

5.
子宫肌瘤是妇科常见的良性肿瘤,严重影响女性的生活质量。目前临床治疗子宫肌瘤的思路是根据个体差异制定不同的保守治疗方案或手术治疗方案,但这些治疗方案都存在弊端。多年来,医学界一直在寻找更佳的治疗子宫肌瘤的方案,维生素D与子宫肌瘤之间的关系也因此被发现。作为一种类固醇类化合物,维生素D在人体各器官组织中起到重要作用。已证实的与维生素D有关的妇产科疾病包括不孕症、多囊卵巢综合征和早产等。近十年的研究证实,人体内维生素D水平降低是子宫肌瘤发生、发展的危险因素之一,目前也有研究发现补充维生素D及其类似物可以起到治疗子宫肌瘤的作用。  相似文献   

6.
化疗是治疗妇科肿瘤的主要手段之一.但是,目前临床所应用的化疗药物存在较严重的毒性,限制了其在临床上的应用.近年研究发现维生素D(VD)和维生素D受体(VDR)除了已熟知的维持血清钙离子平衡和骨结构的生理功能外,还与肿瘤有密切关系.体内外试验证明VD有抑制肿瘤细胞增殖和诱导分化的作用.VD和VDR与妇科肿瘤关系的研究.  相似文献   

7.
许多  朱伟杰  王自能 《生殖与避孕》2005,25(11):686-689
钙结合蛋白Calbindin-d28k(CaBP-d28k)是一种维生素D依赖性钙结合蛋白,参与了多种生殖事件。本文综述了CaBP-d28k的结构特点,在雌(女)性生殖系统的表达、作用及其调节。  相似文献   

8.
<正> 锌是人体必需的微量元素,正常男子的前列腺、睾丸与精液中含量较高,在人类的生殖机能中可能起着重要作用。近十多年来国内外对微量元素在男性生殖功能和生殖内分泌功能间的关系进行了广泛的研究,但各家报道的结果不一致。如何衡量体锌指标;  相似文献   

9.
目的 了解各年龄段儿童,尤其是年长儿体内维生素D的营养状况及与骨碱性磷酸酶的相关程度.方法 对215例确诊为佝偻病和无法确定但有多汗、睡眠障碍、肌痛等相关症状儿童采用液相色谱串联质谱法测定25-羟维生素D,部分年长儿病例同时测定骨碱性磷酸酶.结果 各年龄段25-羟维生素D水平普遍偏低,随着年龄增长维生素D水平呈递减趋势,年长儿维生素D的营养状况最差,各组间差异有统计学意义(P<0.05).不同性别间比较差异无统计学意义(P>0.05).年长儿25-羟维生素D与骨碱性磷酸酶之间无相关性(P>0.05).结论 各年龄段儿童均需关注维生素D的补充,年长儿尤其要重视.骨碱性磷酸酶不能反映年长儿的维生素D水平.  相似文献   

10.
肌纤维痛是一种慢性病,它能引发全身数十处的疼痛和肿胀.由于该病的诱发原因尚不清楚,故治疗效果不佳.因此,许多病人尝试选择各种方式治疗,包括改变饮食方式.有证据表明,对饮食进行微调可以缓解肌纤维痛的症状.以下五项饮食指南对缓解肌纤维痛有一定帮助,在征询医生意见后不妨一试. 1.增加维生素D的摄入 许多成年人体内维生素D不足,而维生素D对肌纤维痛患者至关重要,缺乏维生素D可导致出现某种肌纤维痛症状.因此,所有患者都应进行体内维生素D测试.一项研究发现,因体内维生素D含量低而导致肌纤维痛的患者需服用2倍于体内维生素D正常者的止痛片,才能缓解症状.科研人员由此建议患者服用维生素D补充剂,尤其在冬季更为需要.  相似文献   

11.
Vitamin D is a fat-soluble pro-hormone that plays an important role in bone homeostasis; beside this principal function, vitamin D promotes modulation of cell growth, neuromuscular and immune function, and reduction of inflammation. In addition, several in vitro and in vivo studies have demonstrated that vitamin D deficiency could increase the risk of cancer, autoimmune and cardiovascular diseases. Moreover, vitamin D plays also an important role in female reproduction, because vitamin D receptors are expressed in ovarian tissue, endometrium, fallopian epithelial cells as well as in decidua and placenta. We aimed to review the most updated evidence, which suggests a link between vitamin D metabolism and the development of some gynaecological diseases, such as endometriosis, uterine fibroids and polycystic ovary syndrome.  相似文献   

12.
The active form of vitamin D (1,25-dihydroxyvitamin D(3), 1,25[OH](2)D(3)) has well-established effects on bone metabolism and mineral homeostasis. However, recently it has become clear that 1,25(OH)(2)D(3) has potent antiproliferative and immunomodulatory actions that are not immediately linked to its role as a skeletal regulator. Both the nuclear receptor for 1,25(OH)(2)D(3) (vitamin D receptor, VDR) and the vitamin D-activating enzyme 1alpha-hydroxylase are expressed in a wide variety of nonclassic tissues, highlighting the potential for local autocrine-paracrine responses rather than traditional endocrine effects. Prominent among the tissues that express 1alpha-hydroxylase is the placenta-decidua, and this has raised important questions concerning the potential role of locally generated 1,25(OH)(2)D(3) as a modulator of fetal-placental development and function. When bound to the VDR, 1,25(OH)(2)D(3) regulates key target genes associated with implantation, such as HOXA10, whereas the potent immunosuppressive effects of 1,25(OH)(2)D(3) suggest a role in implantation tolerance. These observations are further supported by data from our group showing increased expression of 1alpha-hydroxylase and VDR in first-trimester trophoblast and decidua from human pregnancies. Studies by other groups have reported abnormal expression of 1alpha-hydroxylase in preeclamptic pregnancies, revealing a potential role for 1,25(OH)(2)D(3) as a regulator of placentation. The effect of vitamin D on reproduction has been further endorsed by murine gene knockout models for 1alpha-hydroxylase and VDR, both of which are infertile. These observations and others are discussed in this article in which we postulate an active role for 1,25(OH)(2)D(3) in placenta-decidua. In particular, we describe how induction of the vitamin D-activating enzyme 1alpha-hydroxylase in early gestation might provide a mechanism by which environmental or dietary vitamin D can influence fetal-placental development.  相似文献   

13.
Vitamin D: the secosteroid hormone and human reproduction.   总被引:1,自引:0,他引:1  
Vitamin D is a secosteroid with an endocrine mechanism of action which is sequentially synthesized in humans in the skin, liver and kidneys. The active hormone, 1alpha,25-dihydrocholecalciferol [1,25(OH)2D3], is often considered only in terms of its role in controlling calcium and phosphorus homeostasis. However, cumulative evidence points to the presence of vitamin D receptors in many tissues. The present article summarizes key points regarding the participation of vitamin D in pregnancy and breastfeeding. During pregnancy, sufficient vitamin D concentrations are needed not only to address the growing demand for calcium on the part of the fetus, but also to participate in fetal growth, development of the nervous system, lung maturation and fetal immune system function. Hypovitaminosis D has been related to the development of diabetes, pre-eclampsia and fetal neurological disorders. During pregnancy and lactation, calcium from the maternal skeleton is mobilized, with a rise in bone turnover and a reduction in bone mass. It is advisable for pregnant and nursing women to maintain adequate levels of vitamin D, through small doses of solar exposure to facilitate natural formation of the hormone or by ingesting appropriate vitamin supplements. Further studies are needed to clarify the many gaps in knowledge and elucidate the role of vitamin D in the context of reproduction. Confirmation of experimental observations relating to the risks of hypovitaminosis D would have important public health implications.  相似文献   

14.
Vitamin D is a secosteroid with an endocrine mechanism of action which is sequentially synthesized in humans in the skin, liver and kidneys. The active hormone, 1α,25-dihydrocholecalciferol [1,25(OH)2D3], is often considered only in terms of its role in controlling calcium and phosphorus homeostasis. However, cumulative evidence points to the presence of vitamin D receptors in many tissues. The present article summarizes key points regarding the participation of vitamin D in pregnancy and breastfeeding. During pregnancy, sufficient vitamin D concentrations are needed not only to address the growing demand for calcium on the part of the fetus, but also to participate in fetal growth, development of the nervous system, lung maturation and fetal immune system function. Hypovitaminosis D has been related to the development of diabetes, pre-eclampsia and fetal neurological disorders. During pregnancy and lactation, calcium from the maternal skeleton is mobilized, with a rise in bone turnover and a reduction in bone mass. It is advisable for pregnant and nursing women to maintain adequate levels of vitamin D, through small doses of solar exposure to facilitate natural formation of the hormone or by ingesting appropriate vitamin supplements. Further studies are needed to clarify the many gaps in knowledge and elucidate the role of vitamin D in the context of reproduction. Confirmation of experimental observations relating to the risks of hypovitaminosis D would have important public health implications.  相似文献   

15.
Glutathione and glutathione-related enzymes are pivotal for the normal functioning of several important biological processes in humans. Glutathione and glutathione-related enzymes are involved in the metabolism and detoxification of cytotoxic and carcinogenic compounds as well as reactive oxygen species. The role of reactive oxygen species in reproduction was the subject of many investigations, and there is compelling evidence for the involvement of these species in the physiology and pathology of both male and female reproductive systems. The glutathione/glutathione-related enzyme system was extensively studied in gynaecological oncology, but to a lesser extent in other topics related to reproduction. In this paper a review is provided on the glutathione/glutathione-related enzyme system in reproduction. Attention is given to its role as a detoxicating system, and as an early marker for disease.  相似文献   

16.
Folates are group B vitamins involved in the one-carbon metabolism. They are required for purine and pyrimidine, and thus DNA synthesis, as well as for the remethylation of homocysteine into methionine which is further metabolized into S-adenosylmethionine, the universal methyl donor for transmethylation of DNA. By this way, folates play a key role in epigenetic regulation of gene expression. Folate deficiency, either by insufficient nutritional uptake or linked to some single nucleotide polymorphism, will lead to an impaired DNA synthesis and repair, a hypomethylation of DNA and other molecules, and homocysteine accumulation. This situation has been associated with several pathologies, such as cardiovascular and neurodegenerative diseases, and pregnancy complications. However, much less is known until now about the impact of one-carbon metabolism on initial events of human reproduction, from gametogenesis to early embryonic development. The present review will deal with these aspects of folate metabolism with respect to male and female fertility.  相似文献   

17.
Pregnancy is associated with an increased risk of vitamin D deficiency beyond that of the general population. The aim of the current analysis was to synthesize the current evidence on the dose–outcome relationship of vitamin D/serum 25 hydroxyvitamin D (25-OHD) and complications during pregnancy. An additional aim was to estimate the economic burden attributable to inadequate levels of serum 25-OHD. Published literature on the effects of vitamin D supplementation/serum 25-OHD on pregnancy complications, including randomized control trials and non-interventional studies, was searched in bibliographic databases including Pubmed, Google Scholar, Scopus and EMBASE. A positive and significant treatment effect was obtained for pre-eclampsia (OR?=?0.75 95% CI 0.662–0.843), but not for preterm birth (OR?=?0.783, 95% CI 0.49–1.251) or small for gestational age (OR?=?0.76 95% CI 0.38–1.28). Inadequate vitamin D accounted for 14.04% of risk for pre-eclampsia. It is estimated that addressing vitamin D inadequacy in pregnant women in England and Wales would reduce the number of cases of pre-eclampsia by 4126; and would result in a net saving of £18.6 million for the NHS in England and Wales. The current results suggest that based on current evidence a public health policy preventing vitamin D inadequacy in pregnant women is likely to have a positive impact on the NHS budget in England and Wales. This is contingent upon further evidence regarding the vitamin D dose-pregnancy outcome relationship becoming available.  相似文献   

18.
BackgroundVitamin D has important functions outside of bone metabolism. Deficiency has been associated with several adverse outcomes during pregnancy such as preeclampsia and prematurity. There is an increasing body of literature on this topic with studies performed to date having produced contradictory results.ObjectiveTo synthesize the literature about vitamin D deficiency and its association with preeclampsia and prematurity in order to determine if maternal vitamin D insufficiency and/or deficiency during pregnancy is associated with the prevalence of preeclampsia and prematurity.DesignA systematic review and meta-analysis of observational and interventional studies.MethodsTwo independent researchers reviewed the included studies according to PRISMA reporting guidelines. A protocol for this review was registered in PROSPERO with the registration number: “CRD42019136318”. Three electronic databases (PubMed, ScienceDirect and Web of Science); were searched in order to identify eligible studies. Observational and interventional studies were selected which had been published in the last 6 years, and analysed the association between maternal vitamin D concentrations during pregnancy and the development of preeclampsia and/or preterm birth. Data were extracted and presented in tables and figures. Fixed and random-effects meta-analyses were performed on the studies which provided enough sample data to calculate odds ratios. Results from both statistical methods were compared. Meta-analysis cut-off points for vitamin D insufficiency and deficiency were defined as <75nmol/L and <50nmol/L, respectively.ResultsFifty-five studies met the inclusion criteria. Fixed-effects meta-analysis of the interventional studies indicated that vitamin D supplementation acts as a prevention factor for preeclampsia and prematurity. Fixed-effects meta-analysis of observational studies concluded that vitamin D insufficiency and deficiency are associated with a higher risk of developing preeclampsia. However, prematurity and vitamin D were only associated when maternal vitamin D concentrations was <75 nmol/L. Random-effects meta-analysis found no significant association between vitamin D, preeclampsia and prematurity in either observational or interventional studies.ConclusionHigher vitamin D concentrations during pregnancy could be associated with a decreased risk of preeclampsia and prematurity but statistical significance of associations depends on the study design used. Well-designed clinical trials with vitamin D supplementation are needed in order to better define associations.  相似文献   

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