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1.
中老年人群血浆同型半胱氨酸水平调查   总被引:2,自引:0,他引:2  
目的 :了解无锡市中老年人群血浆同型半胱氨酸水平。方法 :以年龄在 35~ 6 4岁 ,分别来自城区和农村的 12 2 6人为研究样本 ,对其血浆同型半胱氨酸水平的特点进行统计学分析。结果 :研究人群血浆同型半胱氨酸平均水平为 9 1μmol/L ,各年龄组之间随年龄增长而升高 ,男性血浆同型半胱氨酸平均水平高于女性。结论 :无锡市中老年人群血浆同型半胱氨酸水平高于美国人群 ,中老年男女性别之间、各年龄组之间同型半胱氨酸平均水平差异有非常显著性 ,城乡之间差异无显著性。  相似文献   

2.
侯玥  程义勇  王冬兰  陈伟强  李树田  洪燕 《营养学报》2005,27(6):452-454,459
目的:了解知识分子血清同型半胱氨酸水平及其相关影响因素。方法:在天津、广州、成都三座城市大专院校、科研院所选择年龄40~69岁,138名具有高级职称的知识分子作研究对象,对其应激水平、血清同型半胱氨酸、唾液皮质醇水平以及相关影响因素进行调查分析。结果:研究对象血清同型半胱氨酸平均水平为20.6±0.8μmol/L。高水平唾液皮质醇组的血清同型半胱氨酸水平明显高于低水平唾液皮质醇组。各年龄组之间比较,40~49岁年龄组受试者血清同型半胱氨酸水平最高。男性血清同型半胱氨酸平均水平高于女性。将受试者血清同型半胱氨酸水平进行地区间的比较,天津受试者的血清同型半胱氨酸平均水平最高,成都居中,广州最低。结论:知识分子血清同型半胱氨酸水平显著高于正常人群。应激水平、性别、居住地对同型半胱氨酸水平有明显影响。  相似文献   

3.
目的了解西宁地区健康人群同型半胱氨酸水平。方法采用雅培公司的荧光偏振免疫分析试剂盒,对西宁地区80例健康人的血浆同型半胱氨酸(Hcy)进行检测,同时进行人口学特征、吸烟、饮酒及饮食情况调查。结果研究人群高Hcy血症的检出率较高,为30.7%;血浆Hcy平均水平为10.49μmol/L,年龄越大,血浆Hcy水平越高,男性高于女性。结论西宁地区18岁~24岁健康人群血浆Hcy水平存在年龄、性别差异;高Hcy血症的检出率较高。  相似文献   

4.
目的:探讨老年高血压患者同型半胱氨酸的变化及意义.方法:采取研究对象的静脉血,各采血3~5mL,血浆同型半胱氨酸(Hcy)的测定主要采取荧光标记免疫检测法,具体的采样方法以IMX?Homocysteine?检测系统和试剂盒为主.结果:实验组患者与对照组患者在年龄、BMI、TC、HDL、LDL、TG之间比较有差异,差异有统计学意义(P<0.05);对照组中年龄小于60岁人群的Hcy为(10.8±3.2)mmol/L,60~74岁人群的Hcy为(12.8±2.6)mmol/L.结论:血Hcy对老年原发性高血压病的诊断具有较高的价值,也可能参与老年原发性高血压病的发生及血管病变形成.  相似文献   

5.
目的:探讨某地区离退休人群血浆中同型半胱氨酸(Hcy)水平的变化,探讨高Hcy血症与心血管疾病传统危险因素的关系,为老年人群健康体检预防心血管疾病提供理论依据和指导。方法:收集2013年十堰市地区东风公司离退休职工2200例血浆Hcy检测结果,按年龄与性别做分组统计。选取高Hcy血症人群分为高血压组、心电图异常改变组、吸烟组、高脂血症组、高血糖组。结果:本次老年体检人群高Hcy血症312例,占本次体检人群的14.18%,不同年龄组不同性别间的Hcy水平比较差异无统计学意义(P&gt;0.05);高血压组、心电图异常改变组、高脂血症组、高血糖组Hcy平均水平均高于健康对照组,差异有统计学意义(P&lt;0.05);高Hcy血症在高血压组发生率最高,其次为心电图异常改变组。结论:老年人群中高Hcy血症与心血管传统危险因素呈正相关,在健康体检中定期检测Hcy,对干预治疗老年人群心血管疾病有积极作用。  相似文献   

6.
目的探讨血浆同型半胱氨酸和脑梗死之间的关系。方法测定120例脑梗死患者及41例健康对照者的血浆同型半胱氨酸、维生素B12和叶酸水平。结果脑梗死组的血浆同型半胱氨酸水平(17.15±4.63)μmol/L显著高于对照组(10.12±2.62)μmol/L,P<0.01;血浆同型半胱氨酸水平与叶酸和维生素B12均呈负相关;男女患者之间同型半胱氨酸的差异有显著性(P<0.01);高血压脑梗死患者的同型半胱氨酸水平高于单纯脑梗死患者(P<0.01)。结论同型半胱氨酸是脑梗死的一个重要发病因素,血浆同型光胱氨酸水平与叶酸和维生素B12均呈负相关,雌激素水平对血浆同型半胱氨酸也有影响,高同型半胱氨酸血症与高血压性脑梗死有关。  相似文献   

7.
目的研究吸烟与高同型半胱氨酸血症的相互关系,了解控烟对同型半胱氨酸的影响,并对社区控烟措施的有效性进行评价。方法采用社区干预研究对高同型半胱氨酸血症的吸烟人群49人实施控烟措施,在控烟前后分别检查血浆同型半胱氨酸的浓度,及采用开放式的调查问卷,以面谈方式询问了解吸烟情况,干预观察时间为6个月。通过方差分析和t检验比对干预前后吸烟情况与血浆同型半胱氨酸浓度的差异。结果干预后吸烟数量下降有统计学意义(P<0.01),干预后吸烟平均水平有明显下降。干预前后血浆同型半胱氨酸浓度有差异,干预后平均血浆半胱氨酸浓度有所下降,差异有统计学意义(t=10424,P<0.01),干预前、后吸烟数量与同型半胱氨酸血浆浓度线性相关,r=0.659和r=0.599。结论吸烟与高同型半胱氨酸密切相关,吸烟情况和血浆同型半胱氨酸浓度在控烟措施实施后均有下降,证明本次社区控烟措施有一定效果,减少吸烟对高同型半胱氨酸血症有保护意义。  相似文献   

8.
目的探讨原发性肝癌患者血浆同型半胱氨酸(totalhomocysteine,tHcy)水平的变化及其与Child分级的关系。方法分别测定33例原发性肝癌患者(按Child-pugh分级为3组)和30例健康人群(男19例,女11例)血浆同型半胱氨酸、叶酸、胆红素、ALT、GGT的水平,对检测结果进行分析。结果原发性肝癌Child-Pugh分级各级患者血浆同型半胱氨酸水平明显升高(P<0.01),且随着ChildA、B、C分级的升高而递增,各级间比较差异有显著性意义(P<0.05);同型半胱氨酸浓度(对数值)与原发性肝癌患者Child-Pugh得分呈负相关(r=-0.4733,P<0.01)。结论原发性肝癌患者随着肝损害程度的逐渐加重,血浆同型半胱氨酸水平逐渐升高,同型半胱氨酸可作为反映原发性肝癌患者肝损伤的灵敏的生化指标。  相似文献   

9.
目的:了解无锡市中老年妇女血浆叶酸水平.方法:以年龄在35~64岁,分别来自城区和农村的623名妇女为研究对象,对其血浆叶酸水平进行统计学分析.结果:研究人群血浆叶酸平均水平为20.5 nmol/L,平均叶酸缺乏率为1.8%,城区妇女血浆叶酸平均水平高于农村妇女,冬春季节血浆叶酸水平高于夏秋季节.结论:无锡市中老年妇女血浆叶酸水平高于我国北方地区妇女,城区与农村、冬春季节与夏秋季节中老年妇女血浆叶酸水平有非常显著性差异.  相似文献   

10.
目的探索2017年天津市滨海新区30岁以上健康体检人群血清同型半胱氨酸(Hcy)水平分布特点,概述高同型半胱氨酸血症群体的异常状况,并对年龄、性别、血脂水平等影响因素作出相关分析。方法随机选取2017年3-9月天津市泰达医院30岁以上健康体检者709例为研究对象,检测血清Hcy和血脂项目,得出血清Hcy在性别、年龄上的分布特点,分析影响血清Hcy水平的相关因素。结果各年龄组间血清Hcy水平的性别比较差异均有统计学意义(P0.01);多元线性相关分析显示,性别、年龄与HDL-C和血清Hcy水平相关,差异有统计学意义(P0.05)。结论健康人群血清Hcy水平受性别、年龄和HDL-C等多因素影响,异常率处于较高水平,应定期检测以做好心脑血管疾病的预防。  相似文献   

11.
Epidemiological studies of calcium and osteoporosis have been hampered by the lack of a suitable tool for assessing calcium intake. This report describes a new frequency and amount questionnaire for measuring present and past calcium intake in the elderly. The validity of the questionnaire was tested against two commonly used standards of dietary assessment, five-day duplicate diets and seven-day weighed dietary inventories. The resulting correlation coefficients were, respectively, r = 0.76 and r = 0.69, while that for repeatability was r = 0.84. Furthermore, the questionnaire categorized subjects into thirds of the distribution of intake with almost no gross misclassification. It is suggested that the present findings may be extended to the majority of normal, healthy elderly subjects, implying wide application for the questionnaire in the assessment of calcium intake in the elderly.  相似文献   

12.
This paper examines media coverage of 'breast cancer genetics', and explores its implications for public understanding. We present a content analysis of coverage in British newspapers and look at a variety of popular forms, including women's magazines, television soap opera and radio drama. Genetic/inherited risk receives a great deal of coverage across a wide range of media formats and outlets. Much of this attention has focused on individuals from 'high risk families' and dilemmas around prophylactic mastectomies. Through examining media coverage, combined with interviews with media personnel and their sources, we show why this story proved so attractive to the media and highlight the different production values which influence coverage. Finally, we introduce preliminary findings from focus group discussions to demonstrate how such 'human interest' framing has engaged audience attention and influenced public understandings. The paper concludes by highlighting the implications for analysing, predicting, and engaging with, media representations of science.  相似文献   

13.
Antibiotics represent one of the most important drug groups used in the management of bacterial infections in humans and animals. Due to the increasing problem of antibiotic resistance, assurance of the antibacterial effectiveness of these substances has moved into the focus of public health. The reduction in antibiotic residues in wastewater and the environment may play a decisive role in the development of increasing rates of antibiotic resistance. The present study examines the wastewater of 31 patient rooms of various German clinics for possible residues of antibiotics, as well as the wastewater of five private households as a reference.To the best of our knowledge, this study shows for the first time that in hospitals with high antibiotic consumption rates, residues of these drugs can be regularly detected in toilets, sink siphons and shower drains at concentrations ranging from 0.02?μg·L?1 to a maximum of 79?mg·L?1. After complete flushing of the wastewater siphons, antibiotics are no longer detectable, but after temporal stagnation, the concentration of the active substances in the water phases of respective siphons increases again, suggesting that antibiotics persist through the washing process in biofilms. This study demonstrates that clinical wastewater systems offer further possibilities for the optimization of antibiotic resistance surveillance.  相似文献   

14.
深圳公立医院管理体制改革实行政事分开、管办分开,在理事会架构下按法定机构模式组建市医管中心,落实公立医院运营管理自主权.作者从当前公立医院管理体制的弊端入手,介绍了深圳市进行公立医院管理体制改革的基本思路及改革方案设计的主要举措,深入剖析了的改革方案的特点,并对改革效果进行了预测.  相似文献   

15.
Red cell membranes, prepared from red blood cells of rats exposed to 4, 10, or 20 ppm nitrogen dioxide (NO2) for 1 to 10 days, were examined for evidence of changes in membrane components. Appreciable changes were not found in contents of phospholipid and cholesterol during exposure to 10 ppm NO2. By contrast, protein content altered with the time of exposure. Moreover, changes in protein composition were observed by employing sodium dodecyl sulfate — polyacrylamide gel electrophoresis. Twenty-four-hour exposure to NO2 at the concentration above 10 ppm resulted in a marked increase in the percentage of lysophosphatidylethanolamine (LysoPE) to the total phospholipids. The prolonged exposure to 10 ppm NO2 gave rise to a further increase in LysoPE, whereas the percentage of phosphatidylethanolamine (PE) showed a gradual decrease. A 1-day exposure to 4.0 ppm NO2 also caused an increase in sialic acid content and decreases in those of PE and hexose. In addition to contents of these components the percentage of LysoPE increased 5 days after exposure and the elevated values were maintained up to the end of exposure period. These results demonstrate that red blood cells in circulation exhibit different membrane properties in terms of lipid and carbohydrate composition during 10 days of exposure to 4.0 ppm NO2.  相似文献   

16.
Unemployment is considered to be a public health concern sincedeterioration in the health of the unemployed is often anticipated.However, for some groups, such as miners, unemployment mightimprove health due to a cessation of potentially harmful occupationalexposures. This study evaluates the health of 79 miners in oneSwedish iron-ore mine, and 226 age-matched controls from thegeneral population, during one year after the closure of themine. The participants received a questionnaire regarding medicalhistory and subjective symptoms at the beginning of the studyperiod, and after one year. Statistically significant negativeeffects on self-reported health attributable to unemploymentwere not found, although neuropsychiatric symptoms were morecommon among the unemployed miners. The miners reported a statisticallysignificant improvement in grip force (p=0.031). They had asignificantly higher prevalence of symptoms associated withmining related exposures when compared with the population controls;pain in the upper extremities [relative risk (RR)=2.27, 95%confidence interval (Cl)=1.44–3.59), back pain (RR=1.84;Cl=1.237–2.75), vasospastic disease of the fingers (RR=2.05;Cl=1.18–3.57) and obstructive respiratory symptoms (attacksof dyspnea and wheezing: RR=3.67; Cl=1.167–11.6).  相似文献   

17.

Context

Tularemia is a zoonosis affecting humans and hares in France. We describe the results of surveillance in both species, in 2007 and 2008.

Methods

Human tularemia cases are mandatorily notifiable in France since 2003. In hares, surveillance relies on volunteer hunter associations in all districts of the country. Data from mandatory reports and volunteer surveillance in 2007/2008 were analyzed and compared with previous results.

Results

In 2007/2008, 144 cases were reported in humans and 117 cases in hares. This was a 100% increase compared to previous years. Human cases differed from those of previous years only by the frequency of contact with breeding animals. Human cases without any documented risk exposure were also more frequent.

Conclusion

An increase of tularemia cases occurred in 2007/2008 in both species. Complementary studies are needed to identify the species reservoir in France to understand the causes of this peak of cases.  相似文献   

18.
19.
Occupational health hazards in mining: an overview   总被引:1,自引:0,他引:1  
This review article outlines the physical, chemical, biological, ergonomic and psychosocial occupational health hazards of mining and associated metallurgical processes. Mining remains an important industrial sector in many parts of the world and although substantial progress has been made in the control of occupational health hazards, there remains room for further risk reduction. This applies particularly to traumatic injury hazards, ergonomic hazards and noise. Vigilance is also required to ensure exposures to coal dust and crystalline silica remain effectively controlled.  相似文献   

20.
This paper provides an overview of the production and use of nanomaterials (NMs), particularly in the UK. Currently, relatively few companies in the UK are identifiable as NM manufacturers, the main emphasis being the bulk markets in metals and metal oxides, and some niche markets such as carbon nanotubes and quantum dots. NM manufacturing in the UK does not reflect the global emphasis on fullerenes, nanotubes and fibres. Some assumptions have been made about the types of NM that are likely to be imported into the UK, which currently include fullerenes, modified fullerenes and other carbon-based NMs including nanotubes. Many university departments, spin-offs and private companies have developed processes for the manufacture of NMs but may only be producing small quantities for research and development (R&D) purposes. However, some have the potential to scale up to produce large quantities. The nanotechnology industry in the UK has strong R&D backup from universities and related institutions. This review has covered R&D trends at such institutions, and appropriate information has been added to a searchable database. While several companies are including NMs in their products, only a few (e.g. manufacturers of paints, coatings, cosmetics, catalysts, polymer composites) are using nanoparticles (NPs) in any significant quantities. However, this situation is likely to change rapidly. There is a need to collect more information about exposure to NPs in both manufacturing and user scenarios. As the market grows, and as manufacturers switch from the micro- to the nanoscale, the potential for exposure will increase. More research is required to quantify any risks to workers and consumers.  相似文献   

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