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中国科学家因在特殊年代研发的青蒿素而获得诺贝尔奖,引发了对我国新时代生物医学科研管理策略的探讨。科学研究已进入大科学时代,对传统的科研管理模式提出了挑战。剑桥大学的生物医学成果显著,其科研管理体系较为完善,本文在介绍其科研管理经验的基础上,结合我国现状提出了相关建议。  相似文献   

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Abnormalities in jejunal flora and bile salt metabolism were most marked in the youngest members of a group of Gambian village children in the weanling age group. These may be linked with the profound change in diarrhoeal morbidity, particularly diarrhoea-induced growth impairment, which occurs as soon as breast-fed infants are regularly supplemented. The pathogenesis of these changes is not understood. The presence of small bowel colonization did not appear to be a causal factor but, it is speculated, its appearance may mark the development of a post-enteritis enteropathy which is responsible for the weanling diarrhoea syndrome and which is caused and perpetuated by traditional weaning foods.  相似文献   

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Sulfuric acid at concentrations of 0.1 to 1 mg/m3 produces an increase in pulmonary flow resistance and a decrease in pulmonary compliance in guinea pigs exposed for 1 hour. These changes are not rapidly reversible following termination of exposure. Sulfuric acid of 0.3 μm (MMD) was more irritant than a larger size of 1 μm.  相似文献   

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Duodenal ulceration was found to affect 30·5% of 72 male patients aged over 25 years, with sickle cell anaemia in Jamaica. As a group, these patients did not manifest the high gastric acid secretory rates which are generally associated with duodenal ulceration. There was a positive association with irreversibly sickled cells which are known to relate to vessel obstruction and tissue infarction. It is suggested that primary mucosal damage (presumably ischaemic in nature) may contribute to the development of duodenal ulcers in this condition.  相似文献   

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204 children between the ages of 1·5 and 6·5 years living in a West African village where the incidence of gingivitis and bleeding gums is about 40% of the population at the end of the rainy season, were given vitamin C or a placebo for 69 days, followed by a multivitamin supplement or placebo for 47 days. The condition of their gums was continuously monitored by trained field workers and by a paediatrician during the supplementation period, and was also assessed in greater detail by the paediatrician at the beginning and end of each treatment period. No benefit of either type of supplement could be detected, either on incidence of bleeding, or on over-all severity of gingivitis, although there was a clear-cut seasonal trend towards lower incidence of bleeding in both groups as the study progressed.  相似文献   

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