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1.
美金刚对急性毒鼠强中毒小鼠的实验治疗研究   总被引:6,自引:0,他引:6       下载免费PDF全文
目的 研究非竞争性NMDA受体拮抗剂美金刚对急性毒鼠强中毒小鼠的治疗作用。方法根据正交实验设计原理,选用L9(3^4)正交表,以存活时间、惊厥出现时间和抽搐出现时间为指标,测试美金刚对急性毒鼠强中毒小鼠的治疗效果。结果 美金刚明显延长急性毒鼠强中毒小鼠的存活时间,改善惊厥症状,延缓抽搐的出现,及早用药治疗效果好。结论 美金刚对急性毒鼠强中毒有治疗作用,建议可在临床上试用。但在正确掌握中毒指征及给药剂量方面,尚需进一步研究。  相似文献   

2.
急性毒鼠强中毒临床分析   总被引:2,自引:0,他引:2       下载免费PDF全文
探讨急性毒鼠强中毒的临床表现和诊治。18例均为口服中毒,主要表现为头晕、头痛,恶心,呕吐,乏力及抽搐,惊厥,治疗为洗胃,促排泄、向液净化及保护心、肝、脑。  相似文献   

3.
急性毒鼠强中毒主要引起中枢神经系统兴奋性增强,表现为四肢抽搐、惊厥,甚至呼吸衰竭。我们测定了患者的血清肌酸激酶和乳酸脱氢酶,探讨其变化规律与抽搐严重程度的相关关系。  相似文献   

4.
二巯丙磺钠及合用安定对毒鼠强急性中毒动物的保护作用   总被引:16,自引:1,他引:15  
[目的 ]探讨二巯丙磺钠及合用安定对毒鼠强急性中毒动物的保护作用。 [方法 ]通过小鼠、大鼠急性毒性实验 ,观察二巯丙磺钠解毒作用的时效关系 ;观察二巯丙磺钠及合用安定的保护作用及对大鼠脑电的影响。 [结果 ]二巯丙磺钠须在染毒前 2 0min腹腔注射 (ip) ,才能发挥良好的解毒作用 ,二巯丙磺钠与毒鼠强混合后灌胃 (ig) ,不能降低毒鼠强的毒性 ;二巯丙磺钠、安定均能提高毒鼠强中毒小鼠的LD50 ,降低毒鼠强中毒大鼠的死亡率 ,两药合用保护作用更佳。染毒前 30minip二巯丙磺钠能抑制毒鼠强中毒大鼠强直性惊厥波的产生 ,染毒后静脉注射 (iv)安定能消除产生的强直性惊厥波。 [结论 ]二巯丙磺钠和安定对毒鼠强急性中毒动物有一定的保护作用 ,两者合用效果更佳  相似文献   

5.
一起毒鼠强食物中毒的调查分析   总被引:4,自引:2,他引:2  
本起毒鼠强食物中毒26人,属人为投毒所致,检测剩余中毒食物,病人呕吐物及被毒死狗的胃内容物,其毒鼠强含量分别为0.15、0.05、0.08mg/kg,经及时抢救治疗,无中毒死亡病例发生。当前预防毒鼠强中毒的主要措施是禁止非法生产销售毒鼠强等违禁鼠药行为。  相似文献   

6.
毒鼠强学名四次甲基二砜四胺 ,性质稳定[1] 。毒鼠强中毒作用非常迅速 ,临床表现除一般的胃肠道症状外 ,主要表现为神经系统的中毒症状 ,其毒性强 ,无特效解毒药[2 ] 。国家对毒鼠强的检验尚无统一的标准方法 ,迫切需要建立一种快速、灵敏、准确可靠的检验毒鼠强的方法。 2 0 0 0年 12月用气相色谱火焰光度检测器测定食物中毒样本中的毒鼠强 ,样本处理简单 ,测定快速 ,准确度、精密度、检出限等符合实验要求。1 实验部分1 1 原理 根据毒鼠强的理化性质[1] ,用苯提取毒鼠强。火焰光度检测器是对含硫、磷化合物有高选择性和高灵敏度的一种…  相似文献   

7.
毒鼠强食物中毒98例调查分析   总被引:3,自引:1,他引:2  
本起毒鼠强食物中毒 98例属人为投毒所致 ,检测残留中毒食物与病人呕吐物各 1份 ,其毒鼠强含量分别为0 .0 3mg/ kg和 0 .13mg/ kg。98例中毒病人均辅以二巯基丙磺酸钠注射治疗 ,解毒作用非常明显。毒鼠强的中毒机理与二巯基丙磺酸钠的解毒机理均有待进一步的研究与探讨。当前减少与杜绝毒鼠强中毒的主要干预措施是严厉打击并取缔非法生产和销售毒鼠强等违禁鼠药的行为  相似文献   

8.
二巯基丙磺酸钠救治毒鼠强中毒14例报告   总被引:1,自引:1,他引:0  
目的 以二巯基丙磺酸钠为主治疗毒鼠强中毒。方法 二巯基丙磺酸钠0.125~0.25g肌注,1~3次/d,硫代硫酸钠0.64~2.56g稀释静滴,1次/d。结果 治疗毒鼠强中毒14例,全部治愈。结论 二巯基丙磺酸钠、硫代硫酸钠治疗毒鼠强中毒有效。  相似文献   

9.
毒鼠强急性中毒的诊断与分级研究   总被引:3,自引:0,他引:3       下载免费PDF全文
分析96例次急性毒鼠强中毒病例接毒史,血、尿、洗胃液毒鼠强含量与临床表现间的关系。结果接毒史不明确的占40.6%(39/96)。误服者占80.7%(46/57)。血、尿毒鼠强含量随抽搐、意识障碍加重呈增加趋势。全身抽搐病例血毒鼠强含量中位数0.152μg/ml,高于无抽搐0.024μg/ml、局部抽搐0.046μg/ml(P〈0.01);重度意识障碍病例血毒鼠强含量中位数0.144μg/ml,高于无障碍0.027μg/ml(P〈0.01)、轻度障碍病例0.046μg/ml(P〈0.05)。血毒鼠强所反映的负荷.效应关系较尿毒鼠强紧密。提示血、尿、洗胃液毒鼠强含量是毒鼠强中毒诊断的特异指标,血毒鼠强含量、抽搐、意识障碍可作为毒鼠强中毒诊断的分级指标。  相似文献   

10.
重庆市2001~2002年毒鼠强中毒浅析   总被引:1,自引:1,他引:0  
重庆市 2 0 0 1~ 2 0 0 2年屡屡发生剧毒急性鼠药毒鼠强中毒事件。据卫生部门统计 ,共发生以食物为载体的毒鼠强中毒事件 3 6起 ,进食人数 42 6人 ,中毒人数 2 91人 ,死亡 47人 ,进食中毒率为 68.3 1% ,中毒死亡率为 16.15% (见表1)。表 1 重庆市 2 0 0 1~ 2 0 0 2年 3 6起毒鼠强中毒事件统计以食物为载体中毒起数中毒发生单位中毒原因家庭个体摊贩食堂学校投毒自服 进食人数中毒人数死亡人数中毒人群中毒时间36 31 31 1 351 42 6 2 91 47各年龄性别四季均有发生1 毒鼠强属禁用品毒鼠强是一种对人、畜均具有剧烈毒性的灭鼠药。国外早已…  相似文献   

11.
目的:探讨重症风湿性瓣膜病的手术及围手术期治疗方法。方法:31例患者手术采用含钾机血灌注下行瓣膜置换术。AVR4例,MVR21例,DVR6例。结果:围手术期死亡3例,病死率9.7%。并发症:低心排14例,持续室性心律失常4例,癫痫大发作1例,急性肾功能不全1例。结论:术前正规强心利尿、营养支持治疗和审慎评估,术中良好心肌保护及细致的术后管理对降低重症瓣膜病的手术病死率十分重要。  相似文献   

12.
Dyslexia is a reading problem disorder. It can be a direct result of epilepsia for some kids. The researchers have done the study on 30 school kids that suffer from epilepsia. All the children had Audiometry which was normal in all cases. The orthophonic exam has done in all cases, founding a prononciation and speaker disorder also there is disorder at the psychometric test The purpose of the study research is to define the different profiles of dyslexia on the epileptics, then to check the importance of collaboration between Otorhinolaryngologists, Neurologists and Orthophonists to take care of the epileptic kids having dyslexia.  相似文献   

13.
甄林波 《现代保健》2013,(21):147-149
目的:探讨单孔钻颅冲洗并外引流术治疗慢性硬膜下血肿的临床效果。方法:选取31例慢性硬膜下血肿患者为研究对象,观察单孔钻颅冲洗并外引流术后患者的临床疗效及复发情况,分析临床疗效及影响血肿复发的因素。结果:31例患者治疗后神经功能分级较治疗前显著改善,比较差异有统计学意义(P〈0.05);术后并发症包括2例颅内血肿,4例因脑萎缩导致硬膜下积液,2例非张力性气颅,1例癫痫,经保守治疗后缓解或消失。随访6个月,28例患者治愈,3例患者复发,复发率为9.68%。复发患者术前凝血功能障碍、颅脑CT显示血肿为混杂密度率、中线移位超过10mm的比例均高于治愈患者,比较差异有统计学意义(P〈0.05)。结论:单孔钻颅冲洗引流术治疗慢性硬膜下血肿效果显著,术后并发症较低,术前凝血功能障碍、混杂密度血肿或中线移位较大等因素会影响治疗转归。  相似文献   

14.
A pregnant Somalian woman aged 28 years, in the Netherlands for the last five years, suffered from a progressive hemiparesis, epilepsia, behavioural problems and low fever. Brain MRI showed multiple lesions with contrast enhancement. Extensive serologic and parasitologic tests on serum and cerebrospinal fluid did not disclose any cause. A brain biopsy revealed only necrosis, but bacterial culture and polymerase chain reaction (PCR) supplied the diagnosis of 'tuberculosis'. PCR on the cerebrospinal fluid remained negative. In the meantime the chest X-ray showed miliary tuberculosis and a spine MRI thoracic spondylodiscitis and a large paravertebral abscess. Subsequently the patient was treated successfully with tuberculostatic agents. Her healthy child which was born by caesarean section was treated with the tuberculostatic agents as well.  相似文献   

15.
OBJECTIVE: Although a transient lesion in the splenium of the corpus callosum (SCC) has been reported predominantly regarding patients with epilepsia, it is of rare occurrence, and its underlying biological basis remains unknown. This is a report of an SCC lesion in a patient with anorexia nervosa (AN). METHOD: The patient was a 15-year-old girl with childhood-onset (11 years) and a protracted course of AN. On admission, the patient showed no apparent neurological abnormalities. Magnetic resonance imaging (MRI) scans revealed a circumscribed lesion in the SCC. We treated her with nutritional rehabilitation supplemented with B vitamins. RESULTS: One month later, the lesion completely disappeared, but her weight was not restored. CONCLUSION: Treatment with B-vitamin supplementation may be beneficial for the treatment of patients with AN, in cases in which the disorder develops at an early age before brain maturation (i.e., childhood-onset cases), along with an enduring course of malnutrition.  相似文献   

16.
This study compared the frequency of factors and diseases that contribute to the risks of oral contraceptive use among current users and non-users of oral contraception in order to evaluate the users' awareness of factors associated with complications during oral contraceptive use. Data from 5317 current users and 8863 non-users in the state of São Paulo, Brazil, were collected using questionnaires requesting information on the following variables: use of oral contraceptives, age, weight, smoking status, and the presence or history of hypertension, diabetes, cardiopathies, painful varicose veins, and epilepsy. Half of the users had some risk factors, and 17.4% were at high risk of complications from oral contraceptive use. Risk factors and diseases which appeared to be poorly known by the population as increasing the risk of oral contraceptive use were smoking, hypertension and painful varicose veins. Only a small percentage of the population appeared to know that these diseases and factors could increase the risk of health problems during oral contraceptive use. The results suggest a lack of information among users and providers on factors which are associated with an increased risk of health problems during use of oral contraceptives.
Resumen Este estudio comparó la frecuencia de factores y enfermedades que contribuyen al riesgo de los anticonceptivos orales (AO) entre usuarias y no usuarias corrientes de anticonceptivos orales a fin de evaluar el grado de conocimiento entre las usuarias de los factores asociados con complicaciones durante el uso de AO. Se recopilaron datos de 5317 usuarias y 8863 no usuarias corrientes del Estado de S@o Paulo, Brasil, utilizando cuestionarios en los que se solicitabe información acerca de las siguientes variables: uso de AO, edad, peso, fumadora/no fumadora y la presencia o historia de hipertensión, diabetes, cardiopatías, várices dolorosas y epilepsia. La mitad de las usuarias tenían algunos factores de riesgo y el 17,4% de ellas corrían un alto riesgo de complicaciones por el uso de anticonceptivos orales. Los factores de riesgo y enfermedades que parecían ser poco conocidos por la población como tendientes a aumentar el riesgo del uso de anticonceptivos orales eran el fumar, la hipertensión y las várices dolorosas. Sólo un pequeño porcentaje de la población parecía saber que estas enfermedades y factores podían aumentar el riesgo de problemas de salud durante el uso de anticonceptivos orales. Los resultados sugieren una falta de información de las usuarias y proveedores con respecto a factores que están asociados con un riesgo mayor de problemas de salud durante el uso de anticonceptivos orales.

Resumé Pour évaluer dans quelle mesure les utilisatrices et non utilisatrices de contraceptifs oraux sont sensibilisées aux facteurs associés à des complications, cette étude a comparé la fréquence des facteurs et des maladies qui contribuent au risque que présente l'utilisation de ces contraceptifs. Dans l'Etat de Sao Paulo (Brésil), des données ont été recueillies auprès de 5317 utilisatrices et 8863 non utilisatrices, au moyen de questionnaires demandant des renseignements concernant les variables suivantes: utilisation de contraceptifs oraux, âge, poids, tabagisme, présence ou antécédents d'hypertension, diabète, cardiopathies, varices douloureuses et épilepsie. La moitié des utilisatrices présentaient certains facteurs de risque et 17,4% des facteurs de risque élevé de complications résultant de l'utilisation de contraceptifs oraux. Les facteurs de risque et les maladies dont la population semblait mal connaître l'effet d'augmentation des risques qu'entrîne l'ingestion de contraceptifs oraux étaient le tabagisme, l'hypertension et les varices douloureuses. Un faible pourcentage seulement de la population paraissait savoir que ces maladies et facteurs pouvaient accroître les risques de problèmes de santé durant l'utilisation des contraceptifs oraux. Les résultats suggèrent que les utilisatrices et les pourvoyeurs des services de contraception ne sont pas suffisamment informés des facteurs associés à un risque accru de problèmes de santé durant l'utilisation des contraceptifs oraux.
  相似文献   

17.
目的探讨吸烟对慢性阻塞性肺疾病(chronicobstructivepulmonarydisease,COPD)患者凝血功能及白细胞介素6(interleukin-6,IL-6)及超敏C反应蛋白(high-sensitivityc—reactiveprotein,hs-CRP)水平的影响。方法慢性阻塞性肺疾病急性加重期住院患者90例作为病例组、100例健康体检者作为对照组。采用酶联免疫吸附测定(enzymelinkedimmunosorbentassay,ELISA)检测血清凝血四项及D二聚体、hs—CRP,放射免疫法(Radioimmunoas—say,RIA)分别测血清IL-6,比较检测指标在COPD加重期、缓解期及健康对照组的差异;比较检测指标在两组中吸烟者与不吸烟者之间的差异。结果病例组纤维蛋白原及D二聚体变化趋势与IL-6及hs.CRP相同,以上四项指标病例组明显高于对照组、病例组加重期显著高于缓解期、吸烟者显著高于不吸烟者;对照组吸烟者显著高于不吸烟者(均有P〈0.05)。结论吸烟与COPD加重期气道炎症和高凝状态有关,吸烟是影响COPD加重期病情稳定的重要因素,应倡导患者戒烟和尽早抗凝治疗。  相似文献   

18.
From 1962 to 1968, 127 poliovirus isolates (92 from clinical specimens and 35 from healthy subjects) were subjected to intratypic serodifferentiation by the modified Wecker and McBride techniques. The two techniques gave concordant results for 103 strains, 91 of which were classified as vaccine-like, 9 as nonvaccine-like, and 3 as intermediate; 20 were classified as vaccine-like by one technique and as intermediate by the other, and 4 as nonvaccine-like by one technique and as intermediate by the other. The origin of the nonvaccine-like strains is unknown, but it is unlikely that they had been circulating in the community long. An rct/40-marker test of the isolates revealed a higher positivity rate than that found in field trials of Sabin vaccine. The results indicate that wild poliovirus has been almost completely eradicated from Japan.  相似文献   

19.
Because they seemed to be an overlooked, underutilized, and underdeveloped means of contraception, cervical caps were offered to patients in a private gynecological practice and the first 413 acceptors were sent a detailed questionnaire about their experiences. The 371 who responded provided generous amounts of information helpful in assessing not only cap safety and effectiveness, which are dealt with herein, but also in assessing acceptability which is dealt with in the companion article that follows.With regard to safety considerations, “fcervical erosion” was not found to contraindicate cap use and no other significant safety hazards were encountered, although two concerns were suggested for further evaluation.The failure rate was 8.4 per 100 women per year by the life table method. Of 25 failures, 11 were labeled method failures and 14 were labeled human failures by the respondents themselves. The role of cap dislodgement as a cause of method failures is analyzed.It is concluded that caps are as safe and effective as diaphragms and that for many women they are the most suitable form of contraception available. It is reasonable to expect that they will soon be able to be approved for general use.  相似文献   

20.
淡水鱼精巢核蛋白和鱼精蛋白的提取及营养分析   总被引:11,自引:0,他引:11  
目的:研究提取淡水鱼精巢中的核蛋白和鱼精蛋白的工艺条件。方法:采用正交试验法。结果:通过筛选,确定了提取核蛋白的最佳工艺条件为:NaCl浓度1.0mol/L,NaCl用量为10倍,提取时间1h,95%乙醇用量为2倍。提取鱼精蛋白的最佳工艺条件为:H2SO4浓度为5.0%,用量为3倍,提取时间2h,95%乙醇用量为3倍。对鱼精蛋白和核蛋白的营养价值进行分析,核蛋白的DNA含量很高,必需氨基酸组成合理,精氨酸含量较高,也含有较多的锌;鱼精蛋白的蛋白质达到92.8%,精氨酸含量相对较高。结论:淡水鱼精巢核蛋白和鱼精蛋白是一种很好的蛋白质营养源,可作为治疗男性不育症的药源,而且鱼精蛋白也是一种很好的天然防腐剂。  相似文献   

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