沙眼衣原体泌尿生殖道感染患者人白细胞抗原DQA1基因多态性研究

目的对沙眼衣原体泌尿生殖道慢性持续感染患者人白细胞抗原DQA1基因多态性展开分析,旨在探讨最佳治疗方法实现有效预防与控制。方法随机选取2011年6月-2013年6月接受治疗的50例沙眼衣原体泌尿生殖道慢性持续感染患者、50例沙眼衣原体泌尿生殖道一般感染患者和50名健康人员,采用聚合酶链反应-序列特异性引物对3组病例进行HLA-DQA1等位基因分型,对临床数据进行统计分析,研究沙眼衣原体泌尿生殖道慢性持续感染与HLA-DQA1等位基因的相互关系。结果 3组150例受检者经过HLA-DQA1等位基因分布率测定后,持续感染组中,HLA-DQA10101、DQA10102、DQA10103、DQA10104、DQA10201、DQA10301、DQA10302、DQA10401、DQA10501,分布率分别为10.0%、22.0%、6.0%、6.0%、6.0%、38.0%、6.0%、6.0%、6.0%;其中HLA-DQA10102及DQA10501相比于一般感染组及健康组,数据差异有统计学意义(P<0.05)。结论 HLA-DQA10102及HLA-DQA10501分别对沙眼衣原体泌尿生殖道慢性持续感染的易感基因、控制引发沙眼衣原体泌尿生殖道慢性持续感染存在一定影响,PCR-SSP应用于HLA-DQA1等位基因多态性检测快速、有效,值得临床广泛推广。     

沙眼衣原体感染对生殖道菌群及妊娠结局的影响

目的分析生殖道沙眼衣原体感染、基因型分布及其对生殖道菌群和妊娠结局的影响。方法选取承德市中心医院妊娠期女性1 220例,依据是否感染沙眼衣原体将其分为感染组、未感染组,比较其基线资料、生殖道菌群和妊娠结局,巢式聚合酶链反应(PCR)检测沙眼衣原体外膜蛋白A,分析其基因型分布,比较不同基因型分布的沙眼衣原体感染患者生殖道菌群和妊娠结局。结果 61例妊娠期女性发生沙眼衣原体感染(5.00%),感染组白细胞计数、血小板计数高于未感染组(P0.05);感染组阴道菌群密集度、菌群多样性、炎症反应与未感染组比较差异有统计学意义(P0.05);感染组胎膜早破、产褥病、早产、低出生体质量儿、新生儿肺炎、新生儿感染发生率高于未感染组(P0.05);61例沙眼衣原体感染孕妇中单基因型占60.65%(D型、E型、F型分别占13.11%、22.95%、14.75%),双重基因型感染、多重基因型感染分别占29.51%、9.84%;不同基因型分布的沙眼衣原体感染孕妇生殖道菌群比较,无统计学差异;单基因型沙眼衣原体感染孕妇胎膜早破、早产、新生儿肺炎发生率低于双重基因型感染、多重基因型感染孕妇(P0.05)。结论生殖道沙眼衣原体感染对孕妇生殖道菌群及妊娠结局有一定影响,且沙眼衣原体感染基因型分布有一定特征,其中双重基因型、多重基因型感染患者的妊娠结局受影响更大。     

泌尿生殖道沙眼衣原体感染的研究进展

泌尿生殖道沙眼衣原体感染已成为最常见的性传播疾病之一。患者通常无症状或症状不明显,因此,可携带很长时间不能被诊断,导致严重的晚期并发症,如:输卵管炎、异位妊娠和不孕。该文综合近年来有关沙眼衣原体感染的研究,对沙眼衣原体感染的流行病学、沙眼衣原体感染与不孕、沙眼衣原体感染的筛查方法和治疗作以综述。     

泌尿生殖道沙眼衣原体感染的研究进展

泌尿生殖道沙眼衣原体感染已成为最常见的性传播疾病之一.患者通常无症状或症状不明显,因此,可携带很长时间不能被诊断,导致严重的晚期并发症,如：输卵管炎、异位妊娠和不孕.该文综合近年来有关沙眼衣原体感染的研究,对沙眼衣原体感染的流行病学、沙眼衣原体感染与不孕、沙眼衣原体感染的筛查方法和治疗作以综述.     

泌尿生殖系淋球菌、沙眼衣原体、解脲支原体感染分析

泌尿生殖系淋球菌、沙眼衣原体、解脲支原体感染分析苏明权穆士杰祝道成马越云张荣于文彬丁振若用聚合酶链反应技术对我院门诊泌尿生殖系感染患者中的淋球菌、沙眼衣原体、生殖道支原体进行检测，以了解西安地区淋球菌、沙眼衣原体、生殖道支原体感染的状况。一、材料与方...     

泌尿生殖道炎患者沙眼衣原体感染的调查

泌尿生殖道炎患者沙眼衣原体感染的调查梁绍伶，陈基纯沙眼衣原体是性传播疾病的主要病原之一，４０％的非淋菌性尿道炎由此引起。其临床表现与淋球菌及其他病原引起的泌尿生殖道炎症相似，但治疗药物明显不同。为了明确这类病人的病因，给予有效的治疗，我们开展了衣原体...     

723例健康体检者生殖道沙眼衣原体感染的调查

目的 了解沙眼衣原体在人群中的感染情况，为临床防治沙眼衣原体提供依据。方法 询问受检者生殖道感染症状并采集生殖道粘膜标本进行沙眼衣原体检测。结果 在723例受检者中，沙眼衣原体阳性率为5．4％，男女之间无明显差异。在沙眼衣原体阳性受检者中，有自觉症状者占66．7％，无症状者为33．3％。结论 人群中生殖道沙眼衣原体感染率较高；大部分沙眼衣原体感染者可出现生殖道感染症状，但相当一部分人不出现感染症状；沙眼衣原体阳性者以青壮年居多。     

泌尿生殖道沙眼衣原体感染检测分析

<正>泌尿生殖道疾病是临床上常见的性传播疾病[1-2],尤以沙眼衣原体感染为主,近年来其发病率呈逐年上升趋势,女性发病率较高。患者早期临床症状不明显,表现较为隐匿,严重者可引起男女不孕不育,因此,研究泌尿生殖道沙眼衣原体感染情况,有助于疾病的诊断与治疗。现对2009年1月-2014年12月本院泌尿生殖道沙眼衣原体感染检测情况进行分析。1对象与方法     

女性生殖道沙眼衣原体感染与避孕方式

近年来在许多国家和地区的性传播疾病中,沙眼衣原体感染的发病率和危害性已远超过淋球菌感染而居首位,成为严重的危害健康和社会问题。本文综述了近年来有关女性泌尿生殖道沙眼衣原体感染的发病率与避孕方式关系的研究进展。     

女怀生殖道沙眼衣原体感染与避孕方式

近年来在许多国家和地区的性传播疾病中，沙眼衣原体感染的发病率和危害性已远超过淋球菌感染而居首位，成为严重的危害健康和社会问题。本文综述了近年来有关女性泌尿生殖道沙眼衣原体感染的发病率与避孕方式关系的研究进展。     

含铜宫内节育器与沙眼衣原体感染的关系

目的探讨含铜宫内节育器（IUD）与沙眼衣原体（CT）感染的关系。方法以整群抽样方法抽取诸城市郊五个自然村2003～2004年生殖道感染干预工程病例2527份,对检验结果、检查结果等情况进行回顾性资料分析。结果沙眼衣原体感染24例,感染率0．95％,感染者中放置含铜宫内节育器3例,放置惰性宫内节育器12例,未放置宫内节育器者9例。结论含铜宫内节育器可降低沙眼衣原体感染率,而放置惰性宫内节育器并没有增加沙眼衣原体感染率。     

Association of Chlamydia trachomatis with persistence of high-risk types of human papillomavirus in a cohort of female adolescents

Human papillomavirus (HPV) infection is a necessary but not sufficient cause of cervical cancer. While chlamydia infection has been associated with cervical cancer, the meaning of this association remains unclear. The authors' objective was to investigate this association by evaluating whether concurrent genital tract infections are associated with HPV persistence, a precursor to cervical cancer. Interview data and biologic samples for HPV, Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and bacterial vaginosis testing were collected from female adolescents in an Atlanta, Georgia, longitudinal cohort study at 6-month visits (1999-2003). Associations with persistence (detection of the same HPV type at two sequential visits (visit pair)) were assessed among subjects with 2-5 visits and > or =6 months of follow-up. Associations were evaluated by logistic regression using methods for correlated data. Type-specific persistence of high-risk HPV types was detected in 77 of 181 (43%) analyzed visit pairs. Concurrent infection with C. trachomatis was independently associated with persistence of high-risk HPV types (adjusted odds ratio = 2.1, 95% confidence interval: 1.0, 4.1). Infection with more than one HPV type at the initial visit was also associated with high-risk persistence (adjusted odds ratio = 2.8, 95% confidence interval: 1.6, 4.9). The association between chlamydia infection and cervical cancer may be due to an effect of chlamydia infection on persistence of high-risk HPV.     

Need for screening for genital Chlamydia trachomatis infection in Australia

Genital Chlamydia trachomatis is the most common notifiable sexually transmissible infection in Australia and is associated with significant complications, particularly for women. There is no screening program for chlamydia in Australia despite this infection fulfilling the criteria for screening--it is easily diagnosed with acceptable self-administered tests and early treatment prevents complications. Screening for chlamydia reduces the prevalence of infection and the rate of complications and is recommended by several Western countries including the United States, England and Canada. If a screening program was introduced in Australia, several issues would first need to be addressed including who would be screened, how often would they be screened and where would screening be offered. We discuss these issues in this paper in an effort to advance the debate and the introduction of chlamydia screening in Australia.     

Prevalence of asymptomatic carriers of Chlamydia trachomatis among pregnant and non-pregnant women in south-western Greece

One-hundred-ninety-three pregnant and seventy five non-pregnant women, aged 18–35 years, were examined for endocervical infection with Chlamydia trachomatis using an enzyme immunoassay technique on cervical specimens. Chlamydia trachomatis was discovered in 7.2% of the pregnant women and in 10.6% of the non-pregnant ones. There was no correlation between chlamydia infection and either previous vulvovaginitis, previous pregnancies or pregnancy outcome. However, younger, more highly educated women with high sexual promiscuity tended to be more frequently colonized.     

Testing for cervical Chlamydia trachomatis infection in an inner city practice.

The aims of the study were to find the prevalence of cervical Chlamydia trachomatis infection in women attending for a speculum examination, to examine possible risk factors, and to see if we could develop a rational policy for testing for chlamydia in our deprived inner London practice. During 18 months 409 women aged 17-45 (mean 28) who attended for a cervical smear or vaginal examination were tested for chlamydia using the direct immunofluorescent test. They were assessed for possible risk factors: age less than 25, more than one sexual partner in the previous 3 months, sexual contact with men with urethritis, past history of chlamydia infection, purulent vaginal discharge, cervicitis and abnormal cervical cytology. Thirty-six women (8.8%) were chlamydia positive. Chlamydia infection was significantly associated with the presence of purulent vaginal discharge or an inflammatory cervical smear. In view of the prevalence of chlamydial cervicitis, the lack of symptoms and signs, and the potential consequences of untreated infection, ideally all young women in this population should be offered screening when they attend for a speculum examination. If this is not practical, chlamydia testing might be offered to women thought to be in high-risk groups including those with purulent vaginal discharge or an inflammatory cervical smear.     

4种抗生素治疗宫颈沙眼衣原体感染的疗效观察

目的:比较4种抗生素临床治疗宫颈沙眼衣原体感染的疗效。方法:258例生殖道沙眼衣原体感染患者按就诊号分为4治疗组,莫西沙星组(n=63);克拉霉素组(n=63);阿奇霉素组(n=65);米诺环素组(n=67)。分别于治疗结束后的第21天和第60天行宫颈拭子沙眼衣原体检测,根据实验室检查结果判断疗效。结果:4组微生物学转阴率分别为88.89%,71.43%,75.38%和86.57%;莫西沙星组与克拉霉素和阿奇霉素组在转阴率上差异有统计学意义(P<0.05)。第60天检测复发率分别为3.7%,8.9%,4.1%和3.5%,各组间无统计学意义。结论:4种抗生素对沙眼衣原体感染均有效,莫西沙星和米诺环素治疗沙眼衣原体生殖道感染疗效较好,本结果为临床选择用药提供了一定的实验依据。     

女性生殖道沙眼衣原体感染与输卵管性不孕的临床分析

目的:探讨女性生殖道沙眼衣原体感染与输卵管性不孕的关系。方法:从86例输卵管性不孕妇女(观察组)的宫颈及输卵管内取样,用聚合酶链反应(PCR)检测沙眼衣原体,并从50例正常妊娠妇女(对照组)的宫颈及输卵管提取样本作为对照。结果:宫颈沙眼衣原体感染率在两组间无明显差异,但观察组输卵管沙跟衣原体感染率为20.93％,明显高于对照组(4.00％),两组比较有显著性差异(P<0.05),输卵管不同病变间的沙眼衣原体阳性率无明显差异。结论:输卵管性不孕妇女的输卵管沙眼衣原体感染率高,生殖道沙眼衣原体感染是输卵管性不孕的重要因素。     

Prevalence and correlates of Chlamydia infection in Canadian street youth.

PURPOSE: To determine the prevalence and correlates of Chlamydia trachomatis in Canadian street youth. METHODS: A cross-sectional study of street youth between the ages of 15-24 years was conducted over a 9-month period in seven large urban centers across Canada. Youth were recruited through "drop-in" centers, outreach work, and mobile vans in each city. Information was collected through a nurse-administered questionnaire. Youth were asked to provide urine to test for chlamydia trachomatis by polymerase chain reaction. Separate logistic regression models were run for males and females controlling for age. RESULTS: The prevalence rate of chlamydia was 8.6% in 1355 youth (95% CI = (7.1%, 10.1%)). Higher prevalence rates were found in females than in males (10.9% vs. 7.3%, respectively) and in Aboriginal youth than in non-Aboriginal youth (13.7% vs. 6.6%, respectively). Four variables were associated with increased risk of chlamydia infection in females: Aboriginal status; self-perceived risk; having no permanent home; and having been in foster care. One predictor of chlamydia for males was having had a social worker. CONCLUSIONS: A high prevalence of chlamydia was found in this vulnerable population in comparison to other Canadian youth. Having been in foster care and having had a social worker were found to have a strong association with chlamydia.     

孕妇沙眼衣原体感染的快速诊断方法研究进展

妊娠期感染沙眼衣原体后 ,可导致胎膜早破、早产、低体重儿甚至死胎。敏感性高且特异性强的快速诊断方法 ,不仅可以早期诊断沙眼衣原体感染 ,而且对控制本疾病的母婴传播及预防并发症的发生有重要作用。     

Implementation of chlamydia screening in a general practice setting: a 6-month pilot study

OBJECTIVE: To determine whether screening for asymptomatic Chlamydia trachomatis infection could be undertaken in the context of a smear clinic or other sexual health consultation in general practice. METHODS: A prospective, opportunistic, cohort study was undertaken in a general practice setting. The participants were asymptomatic women aged 16-24 years and men aged 16-34 years who were screened for Chlamydia trachomatis by testing endocervical swabs or first-voided urine samples. The main outcome measure was the uptake of the screening offer and the presence or absence of chlamydia infection as indicated by the test result. RESULTS: A total of 115 patients (109 women and six men) were offered screening. Eighty-one (70%) patients accepted, with five positive results, giving an overall prevalence of 6.2% (5/81, 95% CI 1-11%). Of those offered screening when having a smear, 8.3% (3/36, 95% CI 0-17%) were positive. CONCLUSION: Screening for chlamydia can be undertaken in the context of existing services offered in general practice (e.g. a smear clinic or consultation) where contraception/sexual health is discussed.