come on,寻找性高潮的魔杖

<正>性福需要妥协性生活是人的生理活动,也是人的心理行为,它作为发展爱情,巩固爱情的一种载体和途径,对维护夫妻和谐,营造幸福生活,有着十分重要的意义。而"性福"则是经过夫妻双方"妥协"出来的灵肉交融的愉悦和乐趣。     

Climatic Influences on Cryptoccoccus gattii Populations,Vancouver Island,Canada, 2002–2004

Vancouver Island, Canada, reports the world’s highest incidence of Cryptococcus gattii infection among humans and animals. To identify key biophysical factors modulating environmental concentrations, we evaluated monthly concentrations of C. gatti in air, soil, and trees over a 3-year period. The 2 study datasets were repeatedly measured plots and newly sampled plots. We used hierarchical generalized linear and mixed effect models to determine associations. Climate systematically influenced C. gattii concentrations in all environmental media tested; in soil and on trees, concentrations decreased when temperatures were warmer. Wind may be a key process that transferred C. gattii from soil into air and onto trees. C. gattii results for tree and air samples were more likely to be positive during periods of higher solar radiation. These results improve the understanding of the places and periods with the greatest C. gattii colonization. Refined risk projections may help susceptible persons avoid activities that disturb the topsoil during relatively cool summer days.     

Toxicity Prediction of Antibiotics on Luminescent Bacteria, Photobacterium phosphoreum, Based on Their Quantitative Structure–Activity Relationship Models

Acute toxicity (EC_50–30 min) and chronic toxicity (EC_50–24 h) of 21 antibiotics on Photobacterium phosphoreum was observed and Quantitative structure–activity relationship (QSAR) models were developed, respectively. By comparing these two QSAR models, the following model was established, log(1/EC_50–24 h) = 1.8283 + 1.1503log(1/EC_50–30 min) + 0.2872Elomo − 0.0901DM + 0.0003PMIZ + 0.0088PSA − 0.0382SD, r ² = 0.8513, where Elomo is lowest occupied molecular energy, DM is dipole moment, PMIZ is principal moment of inertia Z, PSA is polar surface area, and SD is sum of degrees. It provides a good way for us to obtain EC_50–24 h from EC_50–30 min, because the later is far easier to observe than the former.     

Chronic effects of 2,2′-dichlorobiphenyl on reproduction,mortality, growth,and respiration ofDaphnia pulicaria

Previous studies have shown toxic effects of polychlorinated biphenyls (PCBs) on aquatic life only in the g/L range, well above normal ambient concentrations.Daphnia pulicaria was isolated from Lake Erie and exposed to 50 ng/L to 10 g/L of 2,2-dichlorobiphenyl (DCB) in lifetable and physiological studies. Reproduction, mortality, growth, and respiration were measured for periods up to the entire lifespan of the animal with and without the use of an organic surfactant. One experiment was conducted for three generations of the daphnid continuously exposed to DCB.Significant mortality and inhibition of reproduction were found at levels as low as 50–100 ng/L in lifetable studies, and no safe level could be determined. These are among the lowest levels ever reported for a PCB congener to cause significant biological effects. A unique, yet repeatable, dose-re-sponse curve occurred in lifetables with maximum inhibition at low to intermediate concentrations. Inhibition at the highest level tested, 10 g/L, occurred only after continuous exposure for three generations. Increasing concentrations of DCB stimulated growth, while respiration experiments yielded variable results.     

Neighbourhood influences on health in Montréal, Canada

This paper examines neighbourhood effects on health within a large Canadian city--Montréal. Our approach is to consider that individual health outcomes are determined both by individual and neighbourhood characteristics and we consciously take on the problem of neighbourhood definition by developing 'natural' neighbourhoods. Our data come from the Montréal health region sample of the 2000/1 Canadian Community Health Survey, a comprehensive national survey that contains information on health outcomes as well as behavioural and socio-demographic information. Respondents were placed into 'naturally' defined neighbourhoods as opposed to arbitrary geostatistical units, responding to calls in the literature to develop more meaningful units of analysis. We also compare the 'natural' neighbourhood approach with the use of standard census tracts as the unit of analysis. Results show significant between-neighbourhood variation in health status with about 3% of the variance in the Health Utilities Index captured at the neighbourhood level, even after controlling for a variety of socio-demographic and behavioural variables at the individual level. Models using census tracts as the unit of analysis had remarkably similar results to the 'natural' neighbourhood models, suggesting that census tracts are good proxies for natural neighbourhood boundaries in studies of neighbourhood effects on health.     

Come on,自制一场销魂“初夜”

谈起初夜,恐怕没有多少人能够一脸幸福。新婚之夜的繁忙、对性事的无知,甚至对初夜的过分期待,都可能让初夜变成失望。聪明的爱人会骄傲地说:我不想在遗憾中追悔,因为我总会想办法打造新的初夜。     

Dissipation of cyanazine and metolachlor on a clay loam soil,Ontario, Canada, 1987–1990

Dissipation of cyanazine and metolachlor was determined following two and three applications, respectively, to a clay loam soil at the Animal Research Centre Farm, Ottawa between 1987 and 1990. Residue decline, leachability into the soil profile, movement into tile drainage water, and contamination of the groundwater of the two herbicides were measured. The amount of each herbicide applied to the soil surface was accounted for in the upper layer during the first week following treatment.Cyanazine disappeared from the upper 15 cm of the soil in 181 days in 1987 and 90 days in 1988, with a calculated half-life disappearance of 27 and 12 days respectively. Residues of cyanazine were not detected in the soil profile below 15 cm or in tile drainage water. A single residue was detected in a sample of groundwater in 1988 at the detection level of 0.01 g/L.The decline of metolachlor was followed in the upper 15 cm of the soil for 332, 364 and 370 days respectively in 1987, 1988 and 1989 and the half-life disappearance of 80, 99 and 142 days were calculated. Residues of metolachlor were detected between 15 and 30 cm but not below 30 cm in the soil profile. Metolachlor was detected in some tile drainage waters throughout the study period 1987–90. Between 0.003 and 0.01% of the metolachlor applied to the surface appeared in tile drainage water following each of three applications. Metolachlor was present in groundwaters 1.2 to 4.6 m deep between the fall of 1988 to the summer of 1989. It was estimated that by the end of the season between 0.06 and 0.19% of the metolachlor moved into the shallow groundwater between the depths of 1.2 and 4.6 m.Contribution Number 1730 from Animal Research Centre.     

Endocrine-Disrupting Effects of Nonylphenol, Bisphenol A, and p,p′-DDE on Rana nigromaculata Tadpoles

No abstract available.     

Small area variations in health related behaviours; do these depend on the behaviour itself, its measurement, or on personal characteristics?

In this paper we examine the patterning, by small areas, of four health related behaviours (smoking, alcohol consumption, diet, and exercise) in the West of Scotland, after controlling for a range of individual/household characteristics, using multilevel models. Smoking and drinking were measured both as binary and as continuous variables, and diet and exercise were each measured in two ways: 'good' (health promoting) and 'bad' (health damaging). 'Area effects' (unattributed variation by post code sector) were found for 'bad' diet only. 'Good' and 'bad' diet, 'bad' exercise patterns and current smoking were associated with postcode sector deprivation. For 'bad' diet this effect was found only for individuals in more affluent households, and for 'good' exercise and current smoking the association with area deprivation differed between adolescents and adults. We conclude that the influence of area on health related behaviours varies according to the behaviour and the way it is measured, and that the influence of area deprivation and/or of area can vary by age and household deprivation.     

The Impact of Sexual Satisfaction,Functioning, and Perceived Contraceptive Effects on Sex Life on IUD and Implant Continuation at 1 Year

Introduction

Contraceptives improve women's lives and public health, but many women discontinue their contraceptive method owing to dissatisfaction. An underexamined aspect of contraceptive discontinuation is sexual acceptability, or how contraception affects sexual experiences. Investigators' aims were two-fold: 1) to document changes in multiple domains of women's sexual experiences with their intrauterine device (IUD) or contraceptive implant over time and 2) to examine whether these sexuality factors were associated with method continuation at 12 months.

More cost-sharing,less cost? Evidence on reference price drugs

This paper evaluates the causal effects of changes in reference prices (RP) on prices, copayments, and overall expenditures for off-patent pharmaceuticals. With reference pricing, firms set prices freely and the health plan covers the expenses only up to a certain threshold. We use quarterly data of the German market for anti-epileptics at the package level and at the active substance level and exploit that the RP has been adjusted in some of the active substances but not in others in a difference-in-differences framework. At the product level, we find that a lower RP reduces prices for both brand-name drugs and generics, but leads to higher copayments, especially for brand-name drugs. At the aggregate level, we find that a lower RP leads to savings for the public health insurer since revenues decrease substantially for brand-name firms and, to a lesser extent, also for generic firms. Overall expenditures (payments by the health insurer and the patients) for brand-name drugs decrease in proportion to the decrease in the RP, while the adjustment does not significantly influence overall expenditures for generics.     

Effect of COVID-19 vaccination on mortality by COVID-19 and on mortality by other causes,the Netherlands,January 2021–January 2022

BackgroundWe aimed to estimate vaccine effectiveness (VE) against COVID-19 mortality, and to explore whether an increased risk of non-COVID-19 mortality exists in the weeks following a COVID-19 vaccine dose.MethodsNational registries of causes of death, COVID-19 vaccination, specialized health care and long-term care reimbursements were linked by a unique person identifier using data from 1 January 2021 to 31 January 2022. We used Cox regression with calendar time as underlying time scale to, firstly, estimate VE against COVID-19 mortality after primary and first booster vaccination, per month since vaccination and, secondly, estimate risk of non-COVID-19 mortality in the 5 or 8 weeks following a first, second or first booster dose, adjusting for birth year, sex, medical risk group and country of origin.ResultsVE against COVID-19 mortality was > 90 % for all age groups two months after completion of the primary series. VE gradually decreased thereafter, to around 80 % at 7–8 months post-primary series for most groups, and around 60 % for elderly receiving a high level of long-term care and for people aged 90+ years. Following a first booster dose, the VE increased to > 85 % in all groups. The risk of non-COVID-19 mortality was lower or similar in the 5 or 8 weeks following a first dose compared to no vaccination, as well as following a second dose compared to one dose and a booster compared to two doses, for all age and long-term care groups.ConclusionAt the population level, COVID-19 vaccination greatly reduced the risk of COVID-19 mortality and no increased risk of death from other causes was observed.