首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献,搜索用时 125 毫秒
1.
糖尿病周围神经病变是糖尿病常见慢性并发症之一 ,是引起糖尿病患者致残生命质量下降的常见原因。我科于 2 0 0 0年5月至 2 0 0 2年 7月应用前列腺素E1治疗糖尿病周围神经病变5 6例 ,疗效满意 ,报道如下。1 资料和方法1·1 临床资料  2 0 0 0年 5月~ 2 0 0 2年 7月住院 2型糖尿病患者 10 4例 ,其中 :男 5 6例、女 48例。平均年龄 ( 5 2± 10 )岁。糖尿病病程 ( 9 5± 5 3 )年。神经病变 ( 3 0± 1 5 )年。随机分为前列腺素E1,治疗组 5 6例和对照组 48例 ,两组病例在性别、年龄、糖尿病病程及神经病变方面无统计学差异。血糖保持平稳 …  相似文献   

2.
糖尿病视网膜病变 (DR)是糖尿病常见微血管并发症之一 ,亦是目前世界上四大致盲疾病之一 ,其发病机制目前尚未阐明。本文分析了胰岛素分泌功能对 2型糖尿病 DR患者的影响 ,探讨血糖及胰岛素分泌功能与 DR的关系。1 对象与方法1.1 对象  2型糖尿病 10 6例 ,男 5 9例 ,女 4 7例 ,年龄 35~ 79岁 ,平均 (5 9.6 9±9.4 2 )岁 ,病程 0~ 2 3年 ,均为我院收治的患者。 2型糖尿病诊断符合 1999年 WHO糖尿病诊断和分类标准 ,按有无 DR分为两组 :1糖尿病合并 DR组 5 2例 ;2糖尿病无 DR5 4例。两组的性别、年龄、体质指数及血压水平差异均无…  相似文献   

3.
糖尿病患者常并发广泛的血管病变。受损的血管内皮易引起血小板粘附、聚集、活化而释放和激活许多促凝物质〔1〕。为了解糖尿病患者血小板数量和形态的改变情况 ,对糖尿病患者血小板四项参数进行分析。选取符合 1985年 WHO糖尿病诊断标准的 2型糖尿病患者 87例为病例组 ,其中男 4 7例 ,女 4 0例 ,平均年龄 (5 6 .9±15 .3)岁 ,无冠心病、肾病并发症。门诊健康体检者 92例为对照组 ,其中男 5 9例 ,女 33例 ,平均年龄 (5 2 .3± 12 .7)岁 ,均为尿糖阴性 ,血糖、血脂、肝功能、肾功能指标正常 ,内科检查正常。观察指标为血小板计数 (PL T)、…  相似文献   

4.
目的研究分析2型糖尿病合并青光眼患者的临床特点和发病机制,为其临床治疗提供理论依据。方法对2010年7月-2013年3月期间,我院收治的224例2型糖尿病合并青光眼患者的临床资料进行回顾性分析。结果本研究中所涉及的224例2型糖尿病合并青光眼患者中有80例患者合并患有闭角型青光眼,占3.2%,38例患者合并患有开角型青光眼,占10.4%,74例患者合并患有新生血管性青光眼,占28%,32例患者合并患有其他继发性青光眼,占513%。其中82例患者合并患有糖尿病视网膜病变,其中6例患者为闭角型青光眼合并糖尿病视网膜病变,占7.5%,6例患者为开角型青光眼合并糖尿病视网膜病变。结论2型糖尿病合并青光眼是临床中较为多见的疾病类型,青光眼的发生与血糖控制之间具有密切的关系,但是其对糖尿病患者的视网膜病变具有一定的保护功能。  相似文献   

5.
上海市中心城区2型糖尿病患者视网膜病变现况调查   总被引:2,自引:0,他引:2  
目的评价上海市中心城区成年人2型糖尿病患者糖尿病视网膜病变的患病率及相关因素。方法采用整群抽样方法选取上海市中心城区30岁以上已诊断为2型糖尿病的患者1039例,其中资料完整者767例纳入本研究。结果(1)767例患者完成1534张眼底摄片,其中不能分级者95例(12.4%),可以分级者672例(87.6%);(2)非增殖期糖尿病视网膜病变145例,占可分级2型糖尿病患者的21.6%,其中轻度59例(8.8%)、中度75例(11.2%)、重度11例(1.6%),增殖期糖尿病视网膜病变9例(1.3%);(3)糖尿病视网膜病变者较非病变者年龄更长,糖化血红蛋白、尿素氮和肌酐更高,逐步logistic回归分析显示糖尿病病程及空腹血糖水平为糖尿病视网膜病变的危险因素。结论上海市中心城区30岁以上已诊断2型糖尿病患者视网膜病变的现患率为22.9%,空腹血糖和糖尿病病程是影响因素。  相似文献   

6.
青海高原地区糖尿病视网膜病变调查   总被引:4,自引:0,他引:4       下载免费PDF全文
糖尿病视网膜病变 (diabeticretinopathy ,DR)是糖尿病微血管并发症中极为严重的病变 ,不同国家和地区DR的发病率差异较大 ,我们对世居在青海高原西宁市 (海拔 2 2 6 0m)和玉树州 (海拔 35 70m)糖尿病患者DR的发病情况进行了调查分析。1.临床资料 :收集自 1998~ 2 0 0 1年经我院及玉树州医院内分泌科按 1985年WHO制定的糖尿病诊断标准分为单纯性和增殖性 ,确诊为糖尿病患者共 5 30例 ,西宁市 380例 ,Ⅰ型糖尿病 5 2例 ,Ⅱ型糖尿病 32 8例 ;玉树州 15 0例 ,Ⅰ型糖尿病 18例 ,Ⅱ型糖尿病 132例 ;男 32 0例 ,女 2 2 8例 ,年龄 2 5~ 78岁…  相似文献   

7.
目的探讨阻塞型睡眠呼吸暂停低通气综合征(OSAHS)对2型糖尿病患者周围神经病变的影响。方法选择85例2型糖尿病患者行多导睡眠图监测及下肢肌电图检查,根据呼吸暂停低通气指数分为OSAHS组和对照组,对比两组患者周围神经病变情况,分析2型糖尿病周围神经病变与OSAHS的相关性。结果OSAHS组47例,对照组38例。OSAHS组呼吸暂停低通气指数为(44.3±23.4)次/h,明显高于对照组的(2.6±1.5)次/h,平均血氧饱和度及最低血氧饱和度分别为0.917±0.037、0.728±0.101,均低于对照组的0.956±0.016、0.890±0.033,差异均有统计学意义(P〈0.05或〈0.01)。OSAItS组27例(57.4%,27/47)合并周围神经病变,对照组12例(31.6%,12/38)合并周围神经病变,OSAHS组合并周围神经病变发生率明显高于对照组,差异有统计学意义(P〈0.01)。两组胫神经运动神经传导速度比较差异无统计学意义(P〉0.05),OSAHS组腓神经运动神经传导速度、胫神经感觉神经传导速度及腓神经感觉神经传导速度均低于对照组[(44.3±4.1)m/s比(46.7±3.6)m/s、(34.1±5.1)m/s比(37.7±4.2)m/s、(36.2±4.7)m/s比(40.7±3.1)m/s],差异有统计学意义(P〈0.05)。多因素Logistic回归分析结果显示,病程(OR=2.12,95%C1:0.68~5.13,P=0.032)、OSAHS(OR=1.52,95%CI:0.42~4.61,P=0.026)与糖尿病周围神经病变相关。结论OSAHS可能与2型糖尿病患者的周围神经病变相关。  相似文献   

8.
目的探讨血清胱抑素c与2型糖尿病微血管病变及下肢动脉病变的关系。方法选取2型糖尿病患者191例,测定血清胱抑素C、总胆固醇(Tc)、低密度脂蛋白胆固醇(LDL—C)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL—C)、尿素氮、肌酐及24h尿微量白蛋白、尿常规,行眼底检查或眼底荧光造影,下肢动脉彩色多普勒超声检查。根据上述检查结果将患者分为无并发症组(34例)、微血管病变组(42例)、下肢动脉病变组(53例)、微血管病变和下肢动脉病变组(62例),比较四组血清胱抑素C,并进行相关性分析。结果四组TC、LDL-C、TG、HDL-C比较差异均无统计学意义(P〉0.05);微血管病变组、下肢动脉病变组、微血管病变和下肢动脉病变组病程、血清胱抑素C均明显大于无并发症组[(8.9±3.5)、(9.1±4.2)、(11.5±5.8)年比(5.0±3.5)年,(1.37±0.28)、(1.20±0.22)、(1.67±0.30)mg/L比(0.93±0.22)mg/L],并且微血管病变和下肢动脉病变组血清胱抑素C明显高于微血管病变组和下肢动脉病变组,差异均有统计学意义(P〈0.01)。多因素Logistic回归分析结果显示,病程、血清胱抑素C是影响糖尿病微血管病变(OR=1.378,95%CI1.124—1.690,P=0.020;OR=16.052,95%CI 2.402—118.207,P=0.004)和下肢动脉病变(OR=1.084,95%CI 0.981—1.197,P=0.014;OR=11.248,95%CI 2.810~45.031,P=0.001)的相关因素。结论2型糖尿病微血管病变及下肢动脉病变除了与病程有关外,还与血清胱抑素C有关,胱抑素C可能成为预测糖尿病血管并发症发生和发展的生物学指标。  相似文献   

9.
糖尿病患者可出现多种皮肤损害 ,约6 1%的 2型糖尿病患者伴发皮肤病变〔1〕。近 2年诊治 2型糖尿病伴发皮肤病变 132例 ,占同期糖尿病住院患者的 38.6 %(132 / 342 ) ,总结报告如下。2型糖尿病患者男 5 8例 ,女 74例 ,年龄 4 2~ 73岁 ,平均 (5 6 .8± 11.5 )岁 ,病程3周~ 15年。主要皮肤病变有 :感染 76例(5 7.6 % ) ,其中癣菌及白色念珠菌感染 4 7例 (6 1.8% ) ,金黄色葡萄球菌感染 2 5例(31.9% ) ,疱疹病毒感染 4例 (5 .3% ) ,6 0岁以上病例占 6 0 .5 % (46 / 76 ) ,糖化血红蛋白 (Hb A1 c) >8.0 %者 4 7例 (6 1.8% ) ,5例下肢湿性坏疽…  相似文献   

10.
目的探讨脑干听觉诱发电位(BAEP)对糖尿病神经病变患者听神经中枢段受累情况的检测价值。方法用丹麦产DANTEC的KEYPOINT4th诱发电位仪对48例糖尿病神经病变患者组及年龄和性别与之匹配的2型糖尿病(DM)且临床检查未发现周围神经病变的患者组进行BAEP检测。结果糖尿病神经病变组BAEP波Ⅲ潜伏期(3.7±0.21)ms与无神经系统症状的DM患者组(3.4±0.18)ms比较差异有统计学意义(P〈0.01);Ⅰ~Ⅲ峰间潜伏期分别为(2.9±0.18)和(2.6±0.14)ms,P〈0.01及Ⅲ~Ⅴ峰间潜伏期(2.12±0.24)和(1.97±0.19)ms,P〈0.01。结论BAEP检测对判断糖尿病神经病变患者听神经中枢段是否受累及受累部位有意义。  相似文献   

11.

Background

Diabetes Mellitus is common metabolic disease worldwide. Its complications in the Ethiopian care setup has not been well documented. The objective of this study was to assess the pattern and distribution of diabetic complications among patients having follow-up at Jimma University specialized Hospital diabetic clinic.

Methods

A cross sectional study based on record review of 305 patients, selected using systematic sampling with replacement was carried out in October 2008. The data were analyzed using SPSS for Windows version 13.0.

Results

Larger proportion, 189 (62.0%), of patients had type II diabetes and 163 (53.4%) of them were diabetic for less than 5 years. Seventy three of the 76 (96.1%) patients with type II diabetes mellitus had hypertension. Acute complications were observed in 93 (30.5%) of the patients of which Diabetic Ketoacidosis was documented in 66(71.0%).Forty eight (45.7%) of patients had proteinuria, 90 (29.5%) had peripheral neuropathy, 13(6.8%) had impotence. Diabetic foot ulcer, skin and/or subcutaneous tissue infection, dental problems and tuberculosis were documented in 14(4.5%), 31(10.0%), 31(10.0%), and 17(5.6%) patients, respectively. Any of the chronic complications were not different by sex of the patient but age had statistically significant association with hypertension, visual disturbance and neuropathy (p< 0.05). Type of diabetes had statistically significant association with all the tested complications except infection (P<0.05) where most of the complications occurred in type II diabetics. Statistically significant association was observed between the duration of the diabetes and impotence and visual disturbances (p < 0.05).

Conclusion

The majority of patients were type II diabetics. Acute complications were observed more commonly among type I diabetics and DKA was the commonest acute complication. The frequency of chronic complications was high. Increased occurrence of retinopathy, peripheral neuropathy, hypertension and nephropathy was observed with longer duration of illness. Impotence and diabetic nephropathy were more common in type II diabetics. The study showed that age, sex, type of diabetes mellitus and duration of diabetes were significantly associated with the development of diabetic complications.  相似文献   

12.
According to the most recent classification of diabetes mellitus the latent autoimmune diabetes in adults belongs to the group of type 1 autoimmune diabetes mellitus, as a slowly progressive form. It is not clear whether LADA is a distinct clinical entity or it is a part of the clinical spectrum of type 1 diabetes mellitus. The authors compare the antropologic (body mass index, waist to hip ratio), immunologic (occurrence of islet cell cytoplasmic autoantibodies and autoantibodies against glutamic acid decarboxylase and tyrosin phosphatase), genetic (HLA DR and DQ alleles known to be associated to type 1 diabetes mellitus) characteristics and occurrence of the features of the metabolic syndrome in the groups of type 1 and type 2 diabetes and LADA. 81 type 1 and 190 type 2 diabetics and 38 LADA patients were involved into the study. Freshly diagnosed type 1 diabetics served for controls of the autoantibody study: 48 patients manifested < or = 16 years of age and 89 type 1 diabetics manifested above 16 years of age. The three main diabetic groups differed in age: the average age in the type 1, type 2 and LADA groups were 37, 63 and 58 years respectively. There was no difference among the three groups in gender. The duration of the disease differed significantly between the type 2 and LADA groups (4.0 and 8.0 years respectively). In spite of the shorter duration of the disease in the LADA group, compared to the type 2 diabetics the frequency of insulin dependency was significantly higher in the LADA (81.6%) than in the type 2 group (46.7%). The BMI and WHR were comparable between the type 1 and LADA patients (average values were 23 and 0.83 in type 1 patients and 23.25 and 0.89 in LADA). The type 2 group differed significantly from type 1 and LADA (average values were 29.1 and 0.5). The concentration of glycated hemoglobin was comparable in the three groups. But there was a significant difference in HbA1c concentration between the freshly diagnosed subgroups of type 1 and LADA patients: 10.85% and 8% respectively. The fasting C-peptid levels were significantly higher in the sera of type 2 diabetics (0.75 pmol/l) compared to type 1 (0.2 pmol/l) and LADA patients (0.29 pmol/l). There was a significant difference in C-peptid concentrations between the type 1 and LADA groups, too. The insulin deficiency in LADA seemed to be not as severe as in type 1 diabetes. The serum total cholesterol and triglyceride levels were significantly higher and the HDL cholesterol concentration significantly lower in type 2 diabetics comparing to type 1 and LADA patients and there was no significant difference in this respect between the type 1 and LADA groups. The frequency of occurrence of hypertension differed no significantly between type 2 and LADA, but that of in type 1 diabetes was significantly lower than both type 2 and LADA. The occurrence of multiple autoantibodies (ICA + GADA + anti-IA2) was much more frequent in type 1 diabetes compared to LADA. In the sera of LADA patients the occurrence of ICA and GADA alone or ICA + GADA was characteristic (31.5% - 21.1% - 15.8% respectively). There was no difference between type 1 diabetes and LADA in the occurrence of the alleles of the MHC kown to be associated with type 1 diabetes. The occurrence of the haplotypes HLA DQ2/DR3 and/or DQ8/DR4 was observed in two thirds of type 1 diabetic and LADA patients. Chronic diabetic complications were observed in all of the groups and there was only a secondary connection of the complications with the type of the diabetes. Based on the results the authors suggest that LADA is a part of the clinical spectrum of type 1 diabetes of autoimmune origin.  相似文献   

13.
14.
It is well known that patients suffering from an autoimmune disease are more prone to develop another one, too. The authors have previously shown frequent occurrence of celiac disease in patients with type 1 diabetes mellitus compared to the background population. Autoimmune thyroid disease, the most common autoimmune disease associated with type 1 diabetes mellitus, generally occurs after the manifestation of diabetes, in the second decade of life. The aim of the study was to investigate the prevalence of thyroid autoimmunity as well as the frequency of autoimmune thyroid disease in patients with type 1 diabetes mellitus. Their aim was also to compare the prevalence of autoimmune thyroid disease in patients with type 1 diabetes mellitus and in those with type 1 diabetes mellitus and celiac disease. Methods: Screening was performed in 268 patients with type 1 diabetes mellitus alone and in 48 children with type 1 diabetes mellitus and celiac disease, with anti-peroxidase and anti thyroglobulin antibody. In case of autoantibody positivity, testing thyroid function and ultrasonography confirmed the autoimmune thyroid disease. According to the results, frequency of autoantibody positivity was significantly higher in diabetic patients suffering from celiac disease (type 1 diabetes mellitus: 43 (16%), type 1 diabetes mellitus + celiac disease: 16 (33,3%), p < 0,01). Hypothyroidism due to thyroiditis was also more prevalent in patients with type 1 diabetes mellitus and celiac disease. Conclusions: Due to increased risk, the authors emphasise the need of frequent screening for autoimmune thyroid disorder in patients with type 1 diabetes mellitus and celiac disease.  相似文献   

15.
目的探讨血清对氧磷脂酶1活性与2型糖尿病血管并发症的关系。方法以对氧磷为底物测定2型糖尿病各组患者及健康老年人血清对氧磷脂酶1活性。结果 2型糖尿病组与健康对照组血清对氧磷脂酶1活性差异有统计学意义(P〈0.01);2型糖尿病合并血管病变组与2型糖尿病组血清对氧磷脂酶1活性差异有统计学意义(P〈0.01)。结论对氧磷脂酶1活性在2型糖尿病及并发血管病变患者中均显著降低,提示对氧磷脂酶1活性的降低参与了糖尿病血管并发症的发生。  相似文献   

16.
目的探讨2型糖尿病(T2MD)患者甲状腺功能血清学多指标间的相关性,以及甲状腺激素水平对大血管和微血管病变的影响。方法回顾性研究2014年12月—2017年12月锦州市中心医院收治的276例T2MD患者,以是否患有亚临床甲减作为分组标准,将患者分为单纯2型糖尿病组(T2DM组)147例和2型糖尿病合并亚临床甲减组(T2DM+SCH组)129例,观察比较两组血管并发症发生率、甲状腺激素与血管并发症及生化指标的相关性;多因素logistic回归分析合并亚临床甲减的T2MD患者的血管病变危险因素。结果 (1)微血管病变与病程、TSH和SBP呈正相关(P0.05),与TT3、FT4和FT3呈负相关(P0.05);(2)大血管病变与病程、年龄、吸烟史、TSH、SBP、UA和LDL-C均呈正相关(P0.05);(3)有吸烟史的糖尿病合并亚临床甲减患者大血管病变发生率比非吸烟者增加1.63倍,TSH与合并亚临床甲减的T2DM患者大血管病变和微血管病变均存在相关性。结论甲状腺激素水平对T2MD患者血管病变存在直接影响,对糖尿病血管并发症具有诊断效能。  相似文献   

17.
目的 探讨2型糖尿病(T2DM)患者糖化血红蛋白变异指数(HGI)与糖尿病慢性并发症发病的关系。方法 采用整群随机抽样的方法,从常熟市34个乡镇中随机抽出12个乡镇,选取在抽中乡镇登记并纳入国家基本公共卫生服务管理的T2DM患者为研究对象。根据HGI数值,采用三分位数法将患者分为低HGI组、中HGI组和高HGI组,探索HGI水平与T2DM患者糖尿病慢性并发症之间的关联。单因素分析采用χ2检验,多因素分析采用多因素Logistic回归模型。结果 共10 246例T2DM患者纳入分析,其中年龄≥60岁者占66.41%,男性4 157例,女性6 089例。单因素分析显示,HGI与T2DM患者糖尿病慢性并发症、糖尿病视网膜病变有显著关联性(均P<0.01),而未发现HGI与糖尿病肾病、糖尿病神经病变及糖尿病足之间存在关联性(均P>0.05)。调整年龄、性别、文化程度、吸烟史、肥胖、血脂异常、糖尿病病程、糖尿病家族史等因素后,多因素Logistic回归分析显示,与低HGI组相比,高HGI组更容易发生糖尿病慢性并发症(OR=1.240,95% CI:1.091~1.409)和糖尿病视网膜病变(OR=1.240,95% CI:1.070~1.437)。结论 高HGI水平的T2DM患者可能更易发生糖尿病慢性并发症,尤其是糖尿病视网膜病变。  相似文献   

18.
The serum and urine level of beta-2-microglobulin was examined by the authors in different stages of nephropathy of 250 patients suffering from diabetes mellitus (I type 178 pts, II type 72 pts). Beta-2-microglobulin values measured in diabetic patients without renal microangiopathy did not show any difference compared with that of the controls. In patients with freshly discovered diabetes mellitus significantly decreased beta-2-microglobulin levels were found, probably due to the increased glomerular filtration rate. Increasing beta-2-microglobulin values indicating an early glomerular lesion--were observed in incipient diabetic nephropathy. These values were significantly higher compared with that of healthy individuals and diabetic patients without renal microangiopathy. In the IV stage of disease the serum and urine beta-2-microglobulin levels were equally found to be elevated, indicating an impaired function of proximal tubuli beside the vascular lesions. The most expressed beta-2-microglobulin value elevations were observed in the stage of nephropathy. The authors emphasize the importance of determination and common evaluation of 24 hours protein excretion and serum urine beta-2-microglobulin values the earliest diagnosis of incipient renal lesion. According to their results, the introduction of this method may be very useful for early indication and follow-up of specific renal complications in diabetes mellitus patients.  相似文献   

19.
史钊      董怡然      李顺平     《现代预防医学》2022,(6):1091-1098
目的 系统评价中国大陆糖尿病患者的健康效用值,为药物经济学评价与卫生技术评估提供基础数据。方法 计算机检索PubMed、Web of Science、Cochrane Library、Embase、CNKI、WanFang Data、VIP 和 CBM数据库,搜索各数据库建库至2020年04月10日。采用Stata 15.0软件对健康效用值进行meta分析。结果 最终纳入31篇文献,中国大陆糖尿病患者的健康效用值及95%CI为0.860(0.837~0.884),1型和2型糖尿病患者健康效用值及95%CI分别为0.790(0.779~0.801)和0.868(0.842~0.895)。在糖尿病并发症中,糖尿病外周神经病变、糖尿病眼部疾病、糖尿病肾脏疾病、糖尿病足的健康效用值均值及95%CI分别为0.779(0.753~0.806)、0.830(0.796~0.863)、0.751(0.725~0.776)、0.698(0.660~0.736),糖尿病合并脑血管疾病、中风、高血脂、心血管病、高血压、外周血管疾病的健康效用值均值及95%CI分别为0.741(0.731~0.752)、0.726(0.697~0.756)、0.847(0.831~0.862)、0.771(0.749~0.793)、0.797(0.766~0.829)、0.632(0.578~0.686)。结论 不同研究测量的糖尿病患者健康效用值异质性较大,糖尿病合并症与并发症给患者生命质量带来的影响较大。  相似文献   

20.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号