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1.
二巯丙磺钠是职业病临床常用的金属毒物解毒剂,近年广泛用于毒鼠强中毒的解毒治疗.我们在治疗群体汞中毒患者的过程中,1位患者在肌内注射二巯丙磺钠后出现严重的急性大疱性过敏反应,以往资料未见报道,现报告如下.  相似文献   

2.
二巯丙磺钠是职业病临床常用的金属毒物解毒剂,近年广泛用于毒鼠强中毒的解毒治疗.我们在治疗群体汞中毒患者的过程中,1位患者在肌内注射二巯丙磺钠后出现严重的急性大疱性过敏反应,以往资料未见报道,现报告如下.  相似文献   

3.
二巯丙磺钠是职业病临床常用的金属毒物解毒剂,近年广泛用于毒鼠强中毒的解毒治疗.我们在治疗群体汞中毒患者的过程中,1位患者在肌内注射二巯丙磺钠后出现严重的急性大疱性过敏反应,以往资料未见报道,现报告如下.  相似文献   

4.
二巯丙磺钠是职业病临床常用的金属毒物解毒剂,近年广泛用于毒鼠强中毒的解毒治疗.我们在治疗群体汞中毒患者的过程中,1位患者在肌内注射二巯丙磺钠后出现严重的急性大疱性过敏反应,以往资料未见报道,现报告如下.  相似文献   

5.
二巯丙磺钠是职业病临床常用的金属毒物解毒剂,近年广泛用于毒鼠强中毒的解毒治疗.我们在治疗群体汞中毒患者的过程中,1位患者在肌内注射二巯丙磺钠后出现严重的急性大疱性过敏反应,以往资料未见报道,现报告如下.  相似文献   

6.
二巯丙磺钠是职业病临床常用的金属毒物解毒剂,近年广泛用于毒鼠强中毒的解毒治疗.我们在治疗群体汞中毒患者的过程中,1位患者在肌内注射二巯丙磺钠后出现严重的急性大疱性过敏反应,以往资料未见报道,现报告如下.  相似文献   

7.
二巯丙磺钠是职业病临床常用的金属毒物解毒剂,近年广泛用于毒鼠强中毒的解毒治疗.我们在治疗群体汞中毒患者的过程中,1位患者在肌内注射二巯丙磺钠后出现严重的急性大疱性过敏反应,以往资料未见报道,现报告如下.  相似文献   

8.
二巯丙磺钠是职业病临床常用的金属毒物解毒剂,近年广泛用于毒鼠强中毒的解毒治疗.我们在治疗群体汞中毒患者的过程中,1位患者在肌内注射二巯丙磺钠后出现严重的急性大疱性过敏反应,以往资料未见报道,现报告如下.  相似文献   

9.
二巯丙磺钠是职业病临床常用的金属毒物解毒剂,近年广泛用于毒鼠强中毒的解毒治疗.我们在治疗群体汞中毒患者的过程中,1位患者在肌内注射二巯丙磺钠后出现严重的急性大疱性过敏反应,以往资料未见报道,现报告如下.  相似文献   

10.
二巯丙磺钠是职业病临床常用的金属毒物解毒剂,近年广泛用于毒鼠强中毒的解毒治疗.我们在治疗群体汞中毒患者的过程中,1位患者在肌内注射二巯丙磺钠后出现严重的急性大疱性过敏反应,以往资料未见报道,现报告如下.  相似文献   

11.
Inorganic arsenic is embryotoxic and teratogenic in chicks, golden hamsters, mice, and rats. Certain dithiol chelators have been reported to protect against arsenite-induced lethality and to decrease arsenic body burden. The present study evaluated the influence of BAL (2,3-dimercapto-1-propanol) and DMPS (sodium 2,3-dimercapto-1-propanesulfonic acid), a water-soluble analogue of BAL, on arsenic-induced embryotoxic and teratogenic effects in the mouse. A series of four BAL or DMPS injections was administered sc to pregnant mice immediately after a single ip injection of 12 mg/kg of sodium arsenite given on Day 9 of gestation and at 24, 48, and 72 hr thereafter. Controls received sc corn oil with or without arsenite. Amelioration by BAL and DMPS of arsenite developmental toxicity was assessed at 15, 30, and 60 mg/kg/day, and 75, 150, and 300 mg/kg/day, respectively. BAL given following arsenite was not able to ameliorate the developmentally toxic effects of arsenite seen in mice, whereas treatment with DMPS at 150 and 300 mg/kg showed significant protective effects against arsenite embryotoxicity and teratogenicity. DMPS administration at 300 mg/kg also protected the dams against arsenite-induced maternal toxicity.  相似文献   

12.
白鸿  张寿林  孙承业 《现代预防医学》2006,33(6):868-869,872
目的:观察急性毒鼠强中毒的临床表现,评价二巯丙磺钠对毒鼠强中毒的疗效。方法:将55例急性毒鼠强中毒患者随机分入对照组和治疗组,给予相应的治疗,并观察其临床表现和治疗效果。结果:急性毒鼠强中毒以中枢神经系统损伤的表现为主,二巯丙磺钠在控制抽搐时间、地西泮用量及精神症状持续时间等方面与对照组差异无统计学意义。结论:二巯丙磺钠对急性毒鼠强中毒无明显治疗效果。  相似文献   

13.
Survival rates were determined in three groups of male CF-1 mice, treated ip with single and multiple doses of zinc sulfate and/or l-lysine, each alone and in combination, followed by administration of an acute toxic dose of ethanol 1 hr post-treatment. Significant protective effects were observed in all pretreated groups. Zinc and lysine (combined)-treated groups showed a maximal protective effect. Blood ethanol determinations were also made in mice similarly pretreated with zinc sulfate (5 μg/kg) and/or l-lysine (2.5 g/kg) ip and subjected to 4.55 g/kg ethanol ip 1 hr post-treatment. Blood ethanol values were significantly lower in the lysine-treated group (P < 0.05) at 0.5 hr and the zinc-lysine group (P < 0.001) at 1 hr. The zinc-treated group showed a steeper ethanol disappearance curve beyond 2 hr. Histological evaluations of livers from treated and ethanol control animals showed no pathological changes in any group.  相似文献   

14.
Oxygen (100% at 1 atmosphere) did not protect mice against death from acute sulfide poisoning as compared with animals maintained under air at 1 atmosphere. Sodium thiosulfate had a small, but statistically significant (P less than .05) protective effect against death due to sodium sulfide, whether the mice were maintained under air or oxygen. Pretreatment with sodium nitrite, however, increased the acute intraperitoneal lethal dose for 50% survival of the group (LD50) of sodium sulfide 2.5 times. Neither oxygen, thiosulfate, nor the combination potentiated the protective effects of nitrite against sulfide poisoning. Antidotal effects of nitrite in acute sulfide poisoning were demonstrated in rats. The therapeutic efficacy of nitrite in acute poisoning is clearly superior to that of oxygen, which is the more widely recommended antidote.  相似文献   

15.
美金刚对急性毒鼠强中毒小鼠的实验治疗研究   总被引:6,自引:0,他引:6       下载免费PDF全文
目的 研究非竞争性NMDA受体拮抗剂美金刚对急性毒鼠强中毒小鼠的治疗作用。方法根据正交实验设计原理,选用L9(3^4)正交表,以存活时间、惊厥出现时间和抽搐出现时间为指标,测试美金刚对急性毒鼠强中毒小鼠的治疗效果。结果 美金刚明显延长急性毒鼠强中毒小鼠的存活时间,改善惊厥症状,延缓抽搐的出现,及早用药治疗效果好。结论 美金刚对急性毒鼠强中毒有治疗作用,建议可在临床上试用。但在正确掌握中毒指征及给药剂量方面,尚需进一步研究。  相似文献   

16.
甲基对硫磷与灭多威杀虫剂混配中毒的实验治疗   总被引:2,自引:1,他引:1  
目的 探讨肟类药物氯解膦定(PAM_C1)和(吡啶-2-醛肟-1-1-甲基)-(4-氨基甲酰基-吡啶-1-甲基)醚氯盐(HI-6)对甲基对硫磷与灭多威杀虫剂混配中毒动物的保护作用,并比较肟类、阿托品(At)及At与肟类联合应用的疗效。方法 小鼠和大鼠灌胃染毒后,经腹泻注射生理盐水、肟类、At及At与肟类药物,记录各组动物的中毒表现和死亡结局,并测定血和脑中胆碱酯酶(ChE)活力。结果 各治疗组和对照组相  相似文献   

17.
急性毒鼠强中毒的临床治疗评价   总被引:6,自引:0,他引:6  
目的 评价4种治疗方法对急性毒鼠强中毒的疗效,以及毒鼠强中毒对儿童智力发育的影响。方法 将86例入选急性毒鼠强中毒患者随机分为基础治疗组、丙戊酸钠组、二巯丙磺钠组和血液灌流组,给予相应治疗后观察治疗效果。另选30例毒鼠强中毒儿童,与健康儿童按年龄、居住地、性别、受教育情况和家庭经济状况等因素进行1:1配对,使用韦氏儿童智力量表中国修订本进行智商测定。结果 基础组、丙戊酸钠组与二巯丙磺钠组在癫痫控制时间、地西泮用量、出现精神症状及精神症状持续时间等治疗评价指标上,差异均无统计学意义;血液灌流治疗的13例患者中10例癫痫发作停止,3例发作次数明显减少,从每日10~16次减少到1~2次。血液灌流前后血浆中毒鼠强的含量并不降低。毒鼠强中毒儿童的总智商、言语智商和操作智商比对照儿童明显降低,均值分别比对照组降低了9.1、8.8和7.7分;中毒病情重的儿童总智商下降更明显,均值比对照组降低了15分。结论 二巯丙磺钠和丙戊酸钠对急性毒鼠强中毒的治疗效果并不优于单纯使用地西泮和苯巴比妥,血液灌流对毒鼠强中毒有肯定疗毒鼠强中毒对儿童的智力发育有一定影响。  相似文献   

18.
The protective effects of atropine, diacetylmonoxime (DAM), and diazepam separately and in combination were investigated in rats exposed to malathion. Malathion (500 mg/kg, ip) inhibited acetylcholinesterase (AchE) activity in RBC and brain and produced hyperglycemia and hyperlactacidemia with depletion of glycogen in liver, triceps, and brain of animals 2 hr after its administration. Atropine (20 mg/kg, ip) given immediately after malathion abolished hyperglycemia and glycogenolytic effect but exhibited no effect on the recovery of inhibited AchE activity. DAM (100 mg/kg ip) given immediately after malathion significantly reactivated the inhibited AchE activity both in RBC and brain. It also partially modified hyperglycemia and glycogenolytic effect. Diazepam (50 mg/kg, ip) slightly modified AchE and abolished hyperglycemia, hyperlactacidemia, and glycogenolytic effects. A combination of these drugs protected the animals from the acute toxic effects of malathion.  相似文献   

19.
The embryotoxic and teratogenic effects of methylmercury in experimental animals have been established by several investigators. The protective activity of 2,3-dimercaptopropanol (BAL) and sodium 2,3-dimercaptopropane-1-sulfonate (DMPS, a chelator used in the treatment of inorganic and organic mercury) on methylmercury chloride (MMC)-induced maternal and developmental toxicity in mice has been evaluated in the present study. BAL and DMPS were administered subcutaneously or by gavage to pregnant mice immediately after a single oral administration of 30 mg MMC/kg given on day 10 of gestation and at 24, 48, and 72 h thereafter. Amelioration by BAL and DMPS of MMC embryo/fetotoxicity was assessed at 15, 30, and 60 mg/kg/day and at 90, 180, and 350 mg/kg/day, respectively. Treatment with BAL did not ameliorate the maternal toxicity or the developmental toxicity of MMC observed in the mouse. In contrast, DMPS at 90, 180, and 360 mg/kg/day significantly reduced the maternal lethality of MMC, whereas treatment with 180 and 360 mg DMPS/kg/day showed significant protective activity against MMC-induced embryotoxicity and teratogenicity. Based on the present findings, DMPS might be a useful chelator against the maternal and developmental toxicity induced by methylmercury.  相似文献   

20.
二巯基丙磺酸钠合用安定对杀虫单急性中毒的...   总被引:5,自引:0,他引:5  
In mice, DMPS (250 mg/kg, i.v.) combined with diazepam (1.25 mg/kg, i.p.) could increase LD50 of p. o. SCD 5.3 times. DMPS (62.5 mg/kg, i.v.) antagonized completely the respiratory depression and neuromuscular blockade caused by SCD(7.5 mg/kg, i.v.) in rabbits. SCD (15 mg/kg, i.v.) caused tremor, tonic convulsion and the abnormal paroxysmal discharges in EEG in rabbits. DMPS (0.5 mg/kg, i.c.v) could not eliminate the abnormal paroxysmal discharges in EEG of rabbits. DMPS (62.5 mg/kg, i.v.) combined with diazepam (5 mg/kg, i.v.) completely and rapidly antagonize these toxic symptoms and the abnormal changes in EEG.  相似文献   

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