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微量法检测指血氟和血清氟的分析评价 总被引:2,自引:0,他引:2
为探讨指血氟和血清氟的关系 ,选不同接触氟的人群 77名和非接触氟者 13名 (D组 ) ;接触氟的人群分为直接接触氟 (A组 )、间接接触氟 (B组 )及其他工人 (C组 )三组。采集手指血和静脉血并分离出血清 ,用微量载样平口套头盐桥而形成微量加标对电极法 ,测定各组血清氟和指血氟。结果显示 ,指血氟含量在存放前后有明显差别 ;存放前当日测定的指血氟 ,在对照组与各氟接触组之间具有明显差别 ,依次为A >B>C >D组。血清氟比当日指血氟低。血清氟与当日指血氟的相关性较好 (r=0 88) ,回归方程为Y =0 6 2X+0 0 2 3。结果提示 ,当日检测的指血氟可代替血清氟来反映氟接触程度及机体氟负荷水平。 相似文献
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目的 为了解氟暴露对工人机体微量元素及过氧化氢酶的影响。方法 选氟作业工龄14年以上的60名男性电解工人作为氟暴露组。另选同样条件的非氟暴露工人30名为对照组,分别测定血中铜、锌、硒、氟的含量以及过氧化氢酶的活性。结果 氟暴露组工人血清中血氟明显地对照组工人,并有极显著性差异(P〈0.01);血清中铜、锌、硒的含量和过氧化氢酶的活性与对照组工人相比均有向损健康转变的趋势。结论 氟对机体微量元素和过 相似文献
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68名氟暴露工人分为两组,A组37人.口服“抗氟欣”两个月;B组31人为非服药对照组。另选非氟暴露对照组工人29人为C组。检测服药前后的血清F-、尿F-、尿BF浓度变化。结果表明,氟暴露可使工人血清F-、尿F-浓度升高;A组工人服药后与服药前比较,尿F-、尿BF均明显升高,血清F-浓度降低。提示“抗氟欣”具有一定的促氟排泄功能。 相似文献
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目的 探讨工业性氟病早期诊断指标.方法 选取长沙铝厂、湘乡氟化盐厂、湘潭磷肥厂和黄阳司磷肥厂140名氟作业工人为接氟组,不接触氟化物的长沙起重机厂职工76人为对照组,进行了血清氟、发氟、甲氟含量及血清中磷酸肌酸激酶(CPK)测定.同时在实验室分别对实验兔和大鼠进行亚急性和亚慢性实验,观察血清氟、毛发氟、骨氟含量变化;血清中磷酸肌酸激酶活性、唾液酸含量测定.结果 氟作业工人血清氟、发氟均显著高于对照组(P<0.01),血清氟含量与骨骼改变之间有依赖关系.血清中CPK与对照组比较差异极其显著(P<0.001),与工种、工龄和骨骼改变有一定关系.动物试验结果血清氟、发毛氟、骨氟含量均显著高于染毒前和对照组(P<0.01),且与染毒剂量、染毒时间呈正相关.血清中CPK活性和唾液酸水平均显著高于染毒前(P<0.01),且与染毒剂量和染毒时间呈正相关关系.结论 血清氟不仅是氟化物接触指标.对氟病的诊断具有一定参考价值.血清CPK活性和唾液酸水平升高可作为工业氟病早期诊断参考指标. 相似文献
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选择保鲜冷库作业工人53名、水产冷库作业工人53名作为低温作业暴露组,同时选择当地不接触低温作业的村民58人作为对照组,测量作业前后的体温、血压,并采集作业后静脉血测定一氧化氮合酶(NOS)活力及一氧化氮(NO)含量。结果显示冷藏保鲜组和水产冷冻组工人体温和血压作业后均低于作业前,血清NO含量和NOS活力均高于对照组,差异有极显著性(P<0.01)。 相似文献
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氟接触对工人血清微量元素和IL—6含量的影响 总被引:4,自引:0,他引:4
选取某铝厂工人66人,观察了血清氟、尿氟浓度,血清微量元素及IL6含量变化情况。结果显示。与对照组比较,氟接触组血清氟和尿氟浓度明显增高;血清Cu、Zn含量下降,Ca、Mg含量两组间无显著差别,血清IL6含量增加,其中高工龄组又高于低工龄组,增加率分别为361%和241%。提示机体接氟后免疫功能受损,同时机体通过增加IL6水平维持正常的免疫功能 相似文献
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目的 探讨氟对抗氧化活性的影响。方法 随机选择氟暴露工人20名、健康的非氟暴露工人15名,测量尿氟含量,外周血AKP、SOD、GSH-Px活性及Cu、Zn、Ca、Mg离子含量。另随机选择健康非氟暴露者10名,抽取静脉血,分离血清,均加入氟化钠,使反应体系中氟浓度分别达到0、2.63、10.52和21.04mmol/L;室温下反应30min后,测定AKP、SOD和GSH-Px活性。结果 氟暴露工人尿氟、血清AKP、全血GSH-Px活性高于非氟暴露者,而血精SOD活性和Cu、Zn、Ca、Mg含量低于非氟 暴露者。体外加氟实验显示,氟浓度21.04mmol/L组AKP活性高于对照组,而SOD和GSH-Px活性低于对照组。结论 氟可致抗氧化酶活性改变。 相似文献
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Occupational fluoride exposure and plasma fluoride levels in man 总被引:4,自引:0,他引:4
Mats Ehrnebo Jan Ekstrand 《International archives of occupational and environmental health》1986,58(3):179-190
Summary The individual fluoride exposure and the corresponding body fluid levels were studied in 41 workers in an aluminium plant in Sweden. During the shift (8 h) personal air samplings were performed and plasma fluoride levels determined. Pre- and post-shift urine fluoride excretion were also measured. The average total fluoride exposure was 0.91 mg/m3 of which 34% was gaseous fluoride (mean value 0.31 mg/m3 The mean fluoride plasma level before the shift was 23 ng/ml (1.2 M/l) and increased on average to 48 ng/ml (range 14–151 ng/ml) at the end of the shift. The plasma levels found were in no case remarkably high. There was a high correlation between fluoride renal clearance and urinary flow (r = 0.481; n = 38; P = 0.00232). A high fluid intake during the shift will thus increase the capacity of the kidney to excrete fluoride and decrease the levels of fluoride in the body. There was a significant correlation between the amount of gaseous fluoride and the area under the plasma concentration-time curve (r = 0.459; n = 40; P = 0.0029) and also the amount of fluoride excreted (r = 0.530; n = 40; P = 0.0004). When fluoride exposure and body burden are to be studied on an individual basis these two parameters give better quantitative information and are to be recommended instead of urine fluoride concentration measurements. The prevention of fluoride inhalation by using a safety-mask during the shift was also demonstrated. The workers who used a safety-mask during the whole shift reduced the inhalation of fluoride to 30 to 40% compared to those who did not use any mask.Supported by grants from the Swedish Work Environment Fund, grant no. 81-1100 and the Swedish Medical Research Council, grant no 6002 相似文献
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慢性氟中毒与环境中氟的关系 总被引:2,自引:0,他引:2
目的 为了查清西宁北川地区部分人群出现慢性氟中毒症状的原因 ,确定致病途径。方法 对西宁北川地区部分人群氟化物水平、环境、饮水和食物中的氟含量进行了测定。按国家规定的统一方法对随机抽取的区内不同年龄组人群调查氟斑牙患病情况 ( 3 3 67名 )和进行尿氟 ( 4 0 69名 )测定 ,并分析其与当地环境氟水平之间的关系。结果 氟班牙患病率达5 4 68% ,尿氟浓度为 ( 1 5 1± 1 12 )mg/L。甘蓝、小麦、大气和土壤含氟量分别超过相应的国家标准值或背景值 7 6、1 5、1 4、0 2 7倍。结论 工业氟污染是引起该区人群慢性氟中毒的主要原因 相似文献
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目的 分析上海市无机氟作业人群尿氟蓄积水平,探讨不同性别、年龄及职业接触水平对尿氟异常率的影响。方法 采集2012-2015年上海市职业健康监护临床检验系统中相关职业暴露人群4 999例及非暴露人群283例的班前清晨尿样;用氟离子选择电极测定方法进行分析;采用logistic回归进行多因素分析,控制年龄、性别、工龄及其他变量间的混杂效应。结果 2012-2015年上海市作业人群职业暴露组的尿氟≥1.6 mg/L者的异常率为14.38%,明显高于非暴露组(1.43%),两者的尿氟蓄积水平的几何均数分别为0.95 mg/L和0.46 mg/L。暴露组中,34~39岁的青年组与>50岁的中年组异常率最高,分别为19.15%和22.39%;男性尿氟异常率(16.87%)高于女性(6.85%),其中尿氟≥1.6 mg/L的异常人群中男性比例为87.36%;人群尿氟蓄积水平随着职业暴露时间的增加而逐渐缓慢提升,在尿氟≥1.6 mg/L人群中,职业暴露>20年者的异常率为23.28%,而<4年者的异常率为13.29%,高出75.17%。男性、年龄越大及工龄越长,发生尿氟异常值的风险越大;其相对危险性OR值依次分别为2.28、1.10和1.13。结论 职业健康监护面临着巨大的挑战,应尽快更新出台相关的国家标准,干预重点目标人群应为工龄长、>50岁、男性人群;同时应加强健康体检大数据的创新应用,完善评估健康需求机制,在新医改中有针对性地推出针对农民工的精准职业健康监护服务包。 相似文献
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Toxicokinetics of intravenous fluoride in rats with renal damage caused by high-dose fluoride exposure 总被引:1,自引:0,他引:1
Tomotaro Dote Koichi Kono Kan Usuda Hiroyuki Nishiura Teruaki Tagawa Kaori Miyata Masashi Shimahara Norihiro Hashiguchi Junko Senda Yoshihito Tanaka 《International archives of occupational and environmental health》2000,73(9):S90-S92
Fluoride (F) complexes are used in some fields of industry and medicine. F excretion mainly depends on kidney function. Urinary F concentration is measured to monitor the health of workers exposed to F. The toxicokinetics of F were studied by analyzing plasma concentration of F after intravenous injection of 2.86, 5.71 and 8.57 mg/kg into male Wistar rats. A dose-response relationship was recognized between these F doses and renal tissue injury. Blood samples were removed at 0, 10, 20, and 30 min, and after 1, 2, 3, 4, 5, and 6 h after injection. Plasma concentration-vs-time profiles were evaluated by a nonlinear least-squares method for fitting data to polyexponential equations and calculation of relevant pharmacokinetic parameters. Results indicated that a two-compartment model could describe the elimination of F from plasma. The # rate constant, total plasma clearance (Cl) and first-order rate constants (K21, Kel) decreased, and the half-time of the #-phase (t1/2#) was significantly prolonged with increasing dose. The kidney is the main target organ for F toxicity. Acute exposure to high doses of F damages renal tissue and causes renal dysfunction. The Cl of F is mainly dependent on renal F excretion. Since severe kidney damage markedly affected the toxicokinetics of F and decreased its elimination, other nephrotoxic indicators and measurement of plasma F concentration are necessary for monitoring high-dose F exposure. 相似文献
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