磨光作业工人手传振动剂量分析

为了解工业生产中各种类型打磨工具的振动加速度 ,采用 1 2种打磨机的振动测试数据 ,分析比较各种打磨机的振动危害程度。结果表明 ,手持砂轮机和角向磨光机的频率计权振动加速度 (ahw)较高 ,波动较大 ;座式砂轮机ahw较稳定 ,棒砂轮机ahw最低。由于工人每日使用手持砂轮机的时间较长 ,其 4h等能量频率计权振动加速度 [ahw(4) ]最高 ,角向磨光机次之 ,使用这些工具的多数工人的ahw(4) 明显超过 5m/s2卫生限值 ;使用石英砂纸打磨机ahw(4) 在 5m/s2 上下波动 ;棒砂轮机的ahw(4) <5m/s2 。提示 ,减轻手传振动危害的关键是控制接振时间 ,打磨工具中尤其应控制手持砂轮机的使用时间     

接振家兔血管内皮细胞bcl-2、bax表达及意义

目的探讨局部接振家兔血管内皮细胞bcl-2、bax基因表达变化及其意义。方法家兔随机分为低剂量接振组[接振强度ahw（4）3.03m/s^2]、高剂量接振组[接振强度ahw（4）12.30m/s2]和对照组。2个接振组接振时间为45d,接振后沿后肢股血管分支取相同部位肌肉作病理切片,免疫组化染色,于光镜下观察所取组织的病理变化及凋亡相关基因bcl-2、bax的表达情况。结果接振组血管内皮细胞破坏性变化,中膜平滑肌增生,管腔内微血栓形成;接振组血管内皮凋亡抑制基因bcl-2表达高于对照组,bax基因表达较对照组明显升高且差异有统计学意义（P〈0.01）,bcl-2/bax比值较对照组显著降低（P〈0.05）。结论局部振动可导致家兔血管内皮细胞凋亡,2者的变化可能与手臂振动病的发病有一定关系。     

飞机铆接工具振动参数分析

为了解飞机铆接工具产生的振动危害,以便有针对性地采取防护措施,对铆工常用的各种工具的振动加速度进行了测试和分析。结果表明,铆钉机的振动加速度低于顶把,在所测3种顶把中,以小顶把的振动加速度为最高,大顶把振动加速度为最低。铆手的4 h等能量频率计权振动加速度〔ahw(4)〕为20.8 m/s2,顶手的ahw(4)为176.7 m/s2,均超过5 m/s2的卫生限值。如果工人不使用小顶把和中顶把而只使用大顶把,同样的接振时间计算出其ahw(4)为61.3 m/s2。提示,顶把产生的振动危害大于铆钉机,而各种顶把中小顶把振动危害最大,使用大顶把能够明显减轻手传振动的危害。     

局部振动对家兔血浆内皮素浓度的影响

目的　探讨局部振动对血浆内皮素浓度的影响及其与振动性血管损伤之间的关系。方法　将家兔随机分为A组 (接振强度 4.90m/s2 )、B组 (接振强度 15 .31m/s2 )、C组 (接振强度 2 6 .2 6m/s2 )和 1个对照组 ,分别于不同接振时间测定各组家兔血浆内皮素浓度。结果　接振后 10、2 0、30d ,A组的血浆内皮素浓度分别为 (4 5 .71± 3.6 2 )pg/ml、(5 1.97± 4.46 )pg/ml、(5 5 .37± 5 .5 3)pg/ml;B组分别为 (5 2 .5 6± 8.0 0 )pg/ml、(6 3.2 4± 6 .73)pg/ml、(72 .98± 9.2 4)pg/ml;C组分别为 (6 4.77± 5 .0 8)pg/ml、(83.6 4± 9.36 )pg/ml、(82 .5 6± 6 .41)pg/ml。随接振时间的延长和接振剂量的增大 ,血浆内皮素浓度有升高的趋势 ,振动试验后 ,各试验组血浆内皮素浓度均高于对照组 ,差异有显著性 (P <0 .0 5 ,P <0 .0 1)。结论　局部振动可致家兔血浆内皮素浓度增高 ,这种增高与振动性血管损伤有一定联系     

牛磺酸和维生素C对砷致小鼠小脑神经毒性保护作用

目的观察砷对小鼠小脑单胺神经递质浓度影响,为探讨砷的神经毒作用机制提供依据。方法 70只昆明种小鼠,随机分为对照组、As2O31、2、4 mg/L染毒组及牛磺酸干预组(As2O34 mg/L+牛磺酸150 mg/kg和维生素C干预组(As2O34 mg/L+维生素C 45 mg/kg),每组10只(高剂量染砷组20只),连续染毒60 d,取小脑,用高效液相色谱法测小脑去甲肾上腺素(NE)、多巴胺(DA)和5-羟色胺(5-HT)浓度。结果对照组小鼠小脑NE、DA和5-HT浓度分别为188.96、45.30、148.42 ng/g;As2O31、2、4 mg/L染毒组小鼠小脑NE、DA和5-HT浓度分别为92.65、12.36、147.26 ng/g和37.18、9.44、105.0 ng/g及22.35、7.40、65.58 ng/g。染砷组小鼠小脑单胺类神经递质浓度明显低于对照组(P<0.05),牛磺酸和维生素C干预组小鼠小脑单胺类神经递质浓度,明显高于染砷组。结论牛磺酸和维生素C能拮抗砷致小鼠小脑5-HT、DA和NE浓度降低作用。     

噪声对幼鼠学习记忆与海马单胺类神经递质的影响

目的观察噪声对幼鼠学习记忆及海马单胺类神经递质的影响,探讨噪声对幼鼠学习记忆的影响机制。方法将24只SD幼鼠,随机分为噪声组和对照组,噪声组在80 dB(A)噪声下持续暴露1个月,用Morris水迷宫测试幼鼠学习记忆能力,用高效液相色谱-电化学法检测幼鼠海马单胺类神经递质多巴胺(DA)、去甲肾上腺素(NE)和5-羟色胺(5-HT)的含量。结果 Morris水迷宫定航实验噪声组幼鼠4 d的平均逃避潜伏期分别为64.54 s、31.98s、14.69 s、6.95 s,均较对照组明显延长(P<0.05);空间搜索实验噪声组幼鼠跨台次数为6.75次、距离百分比为25.19%、时间百分比为23.90%,均较对照组明显降低(P<0.01)。高效液相色谱-电化学法检测发现噪声组幼鼠海马DA、NE和5-HT的含量分别为253.18 ng/g、140.01 ng/g、114.21 ng/g,均较对照组明显减少(P<0.01)。结论噪声暴露下幼鼠海马DA、NE、5-HT含量降低,幼鼠学习记忆能力下降。 更多还原     

高碘暴露儿童智商与单胺类神经递质的关系研究

目的探讨高碘对儿童智力和单胺类神经递质的影响以及单胺类神经递质与智商高低的关系。方法根据水中碘化物质量浓度从天津市滨海新区和静海区中选取适碘地区(10μg/L≤水中碘化物质量浓度150μg/L)、高碘一区(150μg/L≤水中碘化物质量浓度300μg/L)和高碘二区(水中碘化物质量浓度≥300μg/L),按照整群随机抽样的方法从中抽取399名(7～12)岁儿童,采用《中国联合型瑞文测验》(中国农村版)测定儿童智商,采用ELISA测定血浆单胺类神经递质多巴胺(DA)、5-羟色胺(5-HT)、去甲肾上腺素(NE)和肾上腺素(E)的含量。结果高碘二区儿童的IQ值为109. 59±14. 24,低于适碘地区和高碘一区儿童,差异有统计学意义(均P0. 05)。高碘二区儿童的DA质量浓度为(321. 69±104. 95) ng/m L,高于适碘地区和高碘一区,5-HT质量浓度为(142. 62±71. 64) ng/m L,比另外两个地区质量浓度低,差异均有统计学意义(均P0. 05)。而NE和E的含量在3组地区无统计学差异(均P0. 05)。阈值分析显示碘暴露与DA呈明显的非线性关系,当儿童尿碘水平在492. 75μg/L以下,血浆DA质量浓度随尿碘水平的升高而明显升高。DA与IQ也呈明显的非线性关系,当儿童DA质量浓度小于80. 0 ng/m L,体内DA每升高1 ng/m L,智商升高0. 1分;当DA质量浓度在(80. 0～359. 8) ng/m L范围内,DA每升高1 ng/m L,智商降低0. 1分。而尿碘对5-HT、NE和E的影响以及5-HT、NE和E与智力的关系均未见显著的线性关系或阈值效应。结论碘暴露过多儿童的DA代谢紊乱可能与其智商降低有关,且DA与智商存在阈值效应。     

后肢接振对家兔脑组织血管内皮活性物质及ATP酶活力的影响

目的探讨振动对脑组织血管内皮活性物质及ATP酶活力的影响,及其与振动性神经损伤的关系。方法将24只新西兰家兔随机分为低接振强度、中接振强度、高接振强度和对照组,测定各组脑组织中血管内皮活性物质及ATP酶活力。结果随接振剂量的增大,舒张血管物质一氧化氮(NO)、一氧化氮合酶(NOS)有降低趋势,缩血管物质内皮素(ET)有升高趋势,Na -K -ATP酶和Ca2 - Mg2 -ATP酶活力有降低趋势;高强度、中强度组各指标与对照组的差异均有统计学意义(P<0．05,P< 0．01)。结论局部振动可使脑组织血管内皮活性物质及ATP酶活力发生改变,此变化与振动性神经损伤有一定关系。     

50 Hz磁场暴露对大鼠海马单胺类神经递质的影响

目的探讨50 Hz磁场不同强度、不同暴露时间对不同年龄大鼠海马组织中单胺类神经递质含量的影响.方法将学习记忆能力基本同等的32只雄性SD青龄(2～3月)大鼠随机分为4组(50 Hz磁场暴露剂量分别为0.1、1.2、1.6 mT的暴露组和对照组),每组8只.暴露组大鼠每天在游迷宫之前进行磁场暴露2 h,对照组假暴露2 h,连续10 d.按照上述方法,另设1.2mT的暴露组和对照组,连续暴露90d;1.6mT的暴露组和对照组,连续暴露10 d后,停止暴露30 d;大龄(18个月)大鼠0.1 mT暴露组和对照组,连续暴露8个月.采用高效液相色谱电化学法,检测大鼠海马组织中单胺类神经递质[去甲肾上腺素(NE)、肾上腺素(E)、多巴胺(DA)和5-羟色胺(5-HT)]的含量.结果10 d暴露结果显示,1.2和1.6mT组大鼠海马组织中NE、E和DA含量高于对照组(P＜0.05),1.6mT组的5-HT含量高于对照组(P＜0.05).1.2mT组青龄大鼠经过90d的较高强度的磁场暴露后,NE、DA和5-HT含量降低有统计学意义(P＜0.05).1.6mT10 d磁场暴露的青龄大鼠停止磁场暴露30d后,再检测大鼠海马组织的单胺类神经递质,发现NE、E、DA和5-HT含量与对照组比较,差异均没有统计学意义.大龄大鼠0.1 mT磁场暴露8个月,海马组织NE、DA及5-HT含量都在不同程度上低于对照组(P＜0.05),E的变化不明显.结论短期(10d)的磁场暴露对青龄大鼠海马组织中单胺类神经递质含量的影响存在强度效应关系,较高强度(1.2 mT、1.6 mT)的磁场暴露可以提高青龄大鼠海马组织中NE、DA和5-HT的含量,但促进作用是暂时、可恢复的;随着较高强度暴露时间的延长(1.2mT,90d),促进作用可逆转为抑制作用.50 Hz磁场暴露可引起海马组织中单胺类神经递质含量的改变,可能与磁场暴露引起的大鼠学习记忆能力改变有关.     

长期稀土钇暴露对大鼠学习记忆能力影响

目的 观察不同剂量稀土Y3 长期摄入对大鼠脑组织中单胺类神经递质以及抗氧化系统的影响,探讨稀土影响学习记忆能力的可能机制.方法 刚断乳大鼠饮用含稀土Y3 为0,53.4,5 340 mg/L的饮用水,子代饮水同亲代.子代喂食6个月后测定其脑组织中多巴胺(DA)、去甲肾上腺素(NE)、5-羟色胺(5-HT)、5-羟吲哚乙酸(5-HIAA)、单胺氧化酶(MAO)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、活性氧(ROS)和丙二醛(MDA)的含量或活性.结果 低剂量组大鼠脑组织中DA、NE、5-HIAA、5-HT、MDA的含量,SOD、CAT、ROS活力无明显变化(P>0.05);高剂量组大鼠脑组织中DA、NE的含量有下降趋势(P>0.05),5-HT、5-HIAA含量明显降低(P<0.05),ROS活力、MAO活力、MDA含量明显升高(P<0.05).结论 长期摄入高剂量的稀土Y可导致大鼠脑组织中单胺类神经递质含量的变化和抗氧化系统的损伤,可能是导致学习记忆能力下降的原因之一.     

振动性血管损伤的生物监测指标的实验研究

目的探讨振动性血管损伤的生物监测指标。方法将新西兰兔分为A组（接振强度3．04m／s^2）、B组（接振强度6．13m／s^2）、c组（接振强度12．26m／s^2）和1个对照组，分别于不同接振时间测定各组新西兰兔血浆内皮素、血管紧张素Ⅱ和一氧化氮的浓度。结果随接振时间的延长和接振强度的增高，血浆内皮素和血管紧张素Ⅱ的浓度有升高的趋势（P〈0．05，P〈0．01），而一氧化氮的浓度有降低的趋势（P〈0．05，P〈0．01）。结论振动导致内皮素、血管紧张素Ⅱ浓度的增高和一氧化氮浓度的降低，可能与振动性血管损伤有一定的关系，因此，选择内皮素、血管紧张素Ⅱ、一氧化氮作为振动性血管损伤的生物监测指标有一定意义。     

局部接触振动家兔血清某些指标变化的实验研究

目的探讨局部接触振动(简称接振)家兔血清白细胞介素-8(IL-8)及血浆血栓烷素B2(TXB2)浓度的变化趋势及其意义。方法24只家兔随机分为接振组(又分为低剂量A组3.03m/s2、中剂量B组6.13m/s2、高剂量C组12.30m/s2)和无接振对照D组。接振组接振45d,分别于接振实验前、接振第15、30、45天经耳中动脉采血,用放射免疫法测其血清IL-8及血浆TXB2浓度。结果①与接振前比较,低剂量组IL-8浓度第30、45天明显降低,差异有显著性(P<0.05,P<0.01);中、高剂量组第15、30、45天血清IL-8浓度显著降低(P<0.01);与对照组比较,接振第15天中、高剂量组血清IL-8浓度降低有意义(P<0.05,P<0.01);接振第30天高剂量组血清IL-8浓度降低有显著性;而第45天各组血清IL-8浓度降低均有显著性(P<0.01)。②与接振前比较,3个实验组接振后各个时间的TXB2浓度均较实验前增高,差异具有显著性(P<0.05,P<0.01);与对照组比较,接振后TXB2浓度明显上升(P<0.05,P<0.01)。结论局部振动可导致家兔血清IL-8浓度的降低,及血浆TXB2浓度的升高,两者的变化可能与手臂振动病的发病有一定关系。     

后肢接振对家兔免疫功能的影响

目的　探讨局部振动对家兔免疫功能的影响及意义。方法　将家兔随机分为高强度振动组、中强度振动组、低强度振动组并进行接振试验。分别在试验前及试验第 10、2 0、3 0d对家兔进行血清IgA、IgG、IgM及补体C3 、补体C4的测定分析。结果　接振组家兔随接振时间的延长与接振剂量的增大 ,IgG、IgM、IgA、补体C3 、补体C4均有下降或显著下降的趋势(P <0 .0 5 ,P <0 .0 1)。结论　局部振动所导致机体的免疫功能下降 ,可能使机体对感染的易感性增强。     

局部振动对家兔脑组织去甲肾上腺素和多巴胺影响的实验研究

目的探讨振动对脑组织去甲肾上腺素和多巴胺的影响及其与振动性神经病发病机制的关系。方法将家兔按不同强度分组进行接振45 d后,测定对照组和实验组家兔脑组织中的去甲肾上腺素(noradrenalin,NE)和多巴胺(dopamine,DA)含量。结果与对照组比较,各实验组NE含量显著降低(P<0.01);实验组DA含量显著降低,其中,中、高剂量组与对照组比较,差异有统计学意义(P<0.01)。结论振动对中枢神经系统产生影响,其可能与振动性神经病的发病机制有关。     

局部振动对家兔血浆内皮素和降钙素基因相关肽浓度的影响

探讨局部振动对血浆内皮素（endothelin,ET)和降钙素基因相关肽（calctionin gene-related peptide,CGRP)浓度的影响及其意义。[方法]对不同接振时间、不同接振强度的家兔进行了血浆ET和CGRP浓度的测定与分析。[结果]实验组家兔血浆ET浓度较对照组有升高趋势,而CGRP浓度有下降趋势;随接振时间的延长和接振剂量的增大,变化更明显。[结论]局部振动可导致血浆ET浓度的升高和CGRP浓度的降低,这种变化可能与振动性血管损伤的发生机制有关。     

Changes over a workshift in aesthesiometric and vibrotactile perception thresholds of workers exposed to intermittent hand transmitted vibration from impact wrenches.

OBJECTIVES: To investigate the changes over a workshift in fingertip tactile perception thresholds in users of impact wrenches exposed to intermittent hand transmitted vibration. A further aim was to assess the relation between acute changes in tactile sensation, sensorineural disorders, and vibration dose. METHODS: The study populations consisted of 30 workers exposed to vibration (16 men and 14 women) and 25 control manual workers (10 men and 15 women). Sensorineural disorders in the fingers and hands were graded according to the staging system of the Stockholm workshop scale. Tactile function was tested by measuring aesthesiometric thresholds (two point discrimination and depth sense perception) and vibrotactile perception thresholds at 16, 31.5, and 125 Hz before and after a workshift. Temporary threshold shift was then calculated as the difference between threshold measures before and after the shift. The measurement and assessment of exposure to vibration were made according to the international standard ISO 5349. The vibration dose accumulated over a workshift (m2s-4h) was estimated for each user of impact wrenches. Daily exposure to vibration was also expressed in terms of eight hour energy equivalent frequency weighted acceleration ((ahw)eq(8) in ms-2 rms). RESULTS: After adjustment for age and alcohol consumption, vibrotactile perception thresholds before exposure were greater in the workers exposed to vibration than in the controls. No differences in aesthesiometric thresholds before the shift were found between the study groups. Sensorineural disorders were mild in the workers exposed to vibration and minor neurological abnormalities were detected at the physical examination. Owing to the intermittent use of impact wrenches, the estimated mean (ahw)eq(8) for the subjects exposed to vibration was low (1.3 ms-2 rms). A significant temporary threshold shift in vibration perception at all test frequencies was found in the workers exposed to vibration but not in the controls. A significant increase in depth sense perception thresholds was found in the men exposed to vibration. The temporary threshold shift in vibration perception at 125 Hz, and to a lesser extent at 16 and 31.5 Hz, was associated with the severity of sensorineural disorders. In the workers exposed to vibration the temporary threshold shift in vibration sense at all test frequencies was positively related to the estimated dose of vibration received over a workshift. No significant relation was found between aesthesiometric threshold changes and vibration dose. CONCLUSIONS: Intermittent exposure to hand transmitted vibration over a workshift can cause a deterioration of tactile perception in the fingers of users of impact wrenches. Acute tactile dysfunction was related to both the estimated dose of vibration and the severity of sensorineural symptoms. The temporary threshold shift in vibration perception suggested that fast adapting skin mechanoreceptors such as Pacinian and Meissner corpuscles were mainly involved in the acute sensory impairment to the fingertips of the workers exposed to vibration. Changes in tactile perception can occur in workers with daily exposure to vibration that is considered to be associated with a minimal risk of adverse health effects induced by vibration.     

The study on hand-arm vibration syndrome in China

To review the main achievement and problems of study on hand-arm vibration syndrome in China. The epidemiological and clinical study indicate that HAVS was reported from almost provinces in China, the prevalence of VWF ranges from 2.5% to 82.8% in the workers with vibrating tool use. The exposure-response relationship between prevalence of VWF and intensity and duration of exposed to hand-transmitted vibration has confirmed. Diagnostic criteria of HAVS has been established and performed by Chinese government in 1985, and it was revised by government as a national standard for occupational health in 2002. The "hygienic standard for hand-transmitted vibration in workplace" as a national standard and the "methods of measurement and assessment for hand-transmitted vibration" as a recommend standard were published by government also. The limited value of exposed to hand-arm vibration was 5.0 m/s2 that is energy equivalent frequency-weighted acceleration for a period of 4 h (ahw(4)). There are some problems in this field of China need to further study in the future.     

低温与振动联合作用对周围循环功能及神经功能的影响

目的 探讨低温与振动联合作用对家兔周围循环功能与神经功能的影响.方法 将64只家兔随机分为对照组、低温组、接振组以及联合作用组,每组16只.试验前后测定血浆中内皮素(ET)、血管紧张素Ⅱ(Ang Ⅱ)、一氧化氮(NO)浓度以及感觉神经传导速度(SCV)、感觉神经动作电位波幅、感觉神经动作电位潜伏时、运动神经传导速度(MCV)、运动神经远端波幅、运动神经远端潜伏时的变化.结果 试验后低温组ET浓度、AngⅡ浓度、NO浓度以及SCV、动作电位波幅、动作电位潜伏时,MCV、远端波幅、远端潜伏时分别为(68.84±14.81)pg/ml、(544.01±70.20)pg/ml、(123.73±9.5s)nmol/ml、(25.36±6.96)m/s、(1.84±0.65)μV、(4.05±1.04)m/s、(27.40±6.05)m/s、(1.60±0.52)μV、(3.51±1.30)m/s;接振组分别为(70.22±15.02)pg/ml、(540.77±68.25)pg/ml、(129.46±11.99)nmol/ml、(27.69±6.16)m/s、(2.19±0.53)μV、(3.86±0.89)m/s、(30.03±5.21)m/s、(1.65±0.49)μV、(3.36±1.11)m/s;联合作用组分别为(88.47±13.20)pg/ml、(687.38±101.44)pg/ml、(70.66+4.99)nmol/ml、(20.82±3.65)m/s、(1.21±0.64)μV、(5.05±0.94)m/s、(19.97±4.37)m/s、(1.09±0.49)μV、(4.49±1.26)m/s.与试验前比较,试验后各试验组ET、AngⅡ浓度升高,NO浓度降低;神经传导速度减慢,波幅降低,潜伏时延长,差异均有统计学意义(P＜0.05).试验后,联合作用组ET、Ang Ⅱ浓度高于低温组和接振组,NO浓度低于低温组和接振组;联合作用组SCV、MCV慢于低温组和接振组,感觉神经动作电位潜伏时、运动神经远端波幅低于低温组和接振组,感觉神经动作电位潜伏时、运动神经远端潜伏时长于低温组和接振组,差异均有统计学意义(P＜0.05).对各指标进行析因分析,结果显示,低温与振动间存在协同作用(P＜0.05).结论 低温能够加剧振动性周围循环功能与神经功能损伤.     

A study on the vibration-dose limit for Japanese workers exposed to hand-arm vibration.

To obtain a vibration-dose limit for Japanese workers exposed to hand-arm vibration, the prevalences of vibration-induced white finger (VWF) and numbness of the hand were studied in 5 different groups of workers exposed to segmental vibration. In addition, the prevalence of primary Raynaud's phenomenon (PRP) in the general population without occupational vibration exposure was computed. The vibration levels in the exposed groups (except chain saw operators) ranged from 124.1-129.2 dB (reference value, 10(-6) m/s2). The prevalence of VWF in these groups was 2.2-4.8%. This value was not statistically significant (p greater than 0.05) when compared to the prevalence of PRP in the general Japanese population (2.7-2.9% in our study and 0.5-4.6% in other surveys in Japan). Although the prevalence of numbness of the hands fluctuated among the groups, no significant differences could be demonstrated. Our results were then compared to those of previous reports by literature study [319 papers on hand-arm vibration syndrome (HAVS) and 25 reports on PRP]. At a glance the Japanese population showed a lower prevalence for PRP compared to other countries, which suggested that exposure to cold and biological abilities should also be considered to assess vibration syndrome. A comparison of the vibration characteristics of different tools and the occurrence of VWF in the hands of workers in the literature with those of our data suggested that a daily hand-arm vibration exposure at a level lower than 2.5 m/s2 (128 dB, reference value 10(-6) m/s2) could possibly decrease the risk of VWF among workers exposed to segmental vibration.     

振动对家兔血浆内皮素及一氧化氮水平的影响

为探讨局部振动对血浆内皮素,一氧化氮浓度的影响,及其与振动性血管损伤之间的关系,对不同接振时间,不同接振强度 则定了血浆内皮素和一氧化氮浓度。结果表明,随接振时间的延长和接振剂量的增大,实验组血浆内皮素浓度有升高的趋势,血浆一氧化氮浓度有降低趋势。