Cross-sectional epidemiological study on neurotoxicity of solvents in paints and lacquers

Summary In a multi-disciplinary retrospective study we examined 105 house painters employed for at least ten years (median 27 years, range 10–36 years). Fifty-three workers from various professions (non-painters), who were matched with regard to age, occupational training and socio-economic status served as the control group. In both groups no cases of a clinically manifest polyneuropathy or encephalopathy were found. The neurophysiological examinations (EEG and NCV-measurement) showed no differences in painters and controls that would indicate adverse effects of organic solvents. There were no cases with neuroradiological findings of a diffuse cerebral atrophy. Furthermore the evaluation of certain brain structures (ventricular diameter, cella media index) of the CAT films did not reveal any significant differences. In the neurobehavioral tests significant differences in the results were only found in the subtests change of personality and short term memory capacity in a subgroup of painters with repeated prenarcotic symptoms at the workplace. Ambient air monitoring measurements at 30 representative work-places showed that the concentrations of the main components of the solvent-mixtures were well below the MAK-values. The results of the Erlangen Painter Study does not confirm former epidemiologic findings from other countries, mainly Denmark. However, there are some aspects, such as minor solvent exposure in German house painters, insufficient diagnostic and etiological procedures as well as mis-classifications which may explain the different experiences.     

Lead exposure in indoor firing ranges

Summary Higher air lead levels (time-weighted average 660, range 112–2238 g/m³) were measured in firing ranges where powder charges were employed than in ranges where air guns were used (4.6, range 1.8–7.2 g/m³); levels in the latter were in turn higher than those in ranges used for archery (0.11, range 0.10–0.13 g/m³) Twenty-two marksmen who used powder charges had significantly increased blood lead levels during the indoor shooting season (before: median 106, range 32–176 g/l; after: 138; range 69–288 g/l; P = 0.0001), while 21 subjects who mainly used air guns displayed no significant increase (before: median 91, range 47–179 g/l; after: 84; range 20–222 g/l). Thirteen archers had significantly lower levels than the pistol shooters before the season (P = 0.006), and showed a significant decrease during the season (before: median 61, range 27–92 g/l; after: 56; range 31–87 g/l; P = 0.04). At the end of the indoor season, there was a significant association between weekly pistol shooting time and blood lead levels.     

Incidence of leukaemia and brain tumours in Finnish workers exposed to ELF magnetic fields

Summary The relative incidence of leukaemia, acute myeloid leukaemia (AML) and central nervous system (CNS) tumours among workers presumably exposed to extremely low frequency (ELF) magnetic fields (MFs) was studied. The study population consisted of all male industrial workers in Finland aged 25 to 64 years during 1971–1980 according to the Population Census in 1970. The occupations were grouped into three exposure categories according to the probability of exposure. The category of probable exposure included electrical occupations and the category of possible exposure included occupations where electric motors or welding are common. All other occupations were included to the category of no exposure. Cancer incidence rates in different occupational groups during 1971–1980 were obtained after linking the census records with the national death certificates and the files of the Finnish Cancer Registry. The adjusted relative risks (with 95% confidence limits) in the categories of probable and possible exposure were for all leukaemia 1.9 (1.0–3.5) and 1.4 (1.1–1.8), for AML 1.5 (0.5–4.7) and 1.4 (0.9–2.1), and for CNS tumours 1.3 (0.7–2.3) and 1.3 (1.0–1.6), respectively. The results are concordant with earlier studies suggesting elevated risk among workers exposed to ELF magnetic fields.     

Mechanism for bone disease found in inhabitants environmentally exposed to cadmium: decreased serum 1α, 25-dihydroxyvitamin D level

Summary To investigate the mechanism for bone disease caused by exposure to cadmium serum samples were collected from 5 itai-itai disease patients, 36 Cd-exposed residents with renal tubular damage and 17 non-exposed individuals and analyzed for 1,25-dihydroxyvitamin D[1, 25(OH)₂D], parathyroid hormone, ₂-microglobulin, calcium and inorganic phosphorus. Measurement of percentage tubular reabsorption of phosphate (%TRP) were performed only on the Cd-exposed subjects. Serum 1, 25(OH)₂D], levels were lower in itai-itai disease patients and cadmium-exposed subjects with renal damage than in non-exposed subjects. Parathyroid hormone and ₂-microglobulin concentrations in serum were higher in the Cd-exposed subjects. Decrease in serum 1,25(OH)₂D levels were closely related to serum concentrations of parathyroid hormone, ₂-microglobulin and %TRP. This study suggests that cadmium-induced bone effects were mainly due to a disturbance in vitamin D and parathyroid hormone metabolism, which was caused by the cadmium-induced kidney damage.     

Accumulation of Selenium and Lack of Severe Effects on Productivity of American Dippers (Cinclus mexicanus) and Spotted Sandpipers (Actitis macularia)

Selenium has been found at elevated concentrations in water, sediments, and aquatic biota in the Elk River (British Columbia, Canada) and some of its tributaries downstream of several coal mines. Selenium water concentrations in those areas exceed Canadian and British Columbia guidelines and are above levels at which adverse effects to fish and waterfowl could occur. We compared selenium concentrations in the eggs of two riverine waterbirds, American dippers and spotted sandpipers, with measures of productivity: the number of eggs laid, egg hatchability, and nestling survival. In American dippers, the mean egg selenium concentration from the exposed areas, 1.10±SE 0.059 g/g wet weight, was indistinguishable from the reference areas, 0.96±SE 0.059 g/g wet weight. For spotted sandpipers, the mean egg selenium concentration in the exposed areas, 2.2±0.5 g/g wet weight, was significantly higher than in the reference areas, 1.2±0.14 g/g wet weight, but less than reported thresholds for waterfowl and other shorebirds. There were no significant differences in egg hatchability between dippers in reference and exposed areas, but reduced hatchability was apparent for sandpipers in exposed locations. Despite the slightly reduced hatchability in sandpipers, overall productivity was higher than regional norms for both species; thus, selenium did not affect the number of young recruited to local populations. We did not observe teratogenic effects in either species, although none was expected at these concentrations. Despite moderately high selenium concentrations in the water, mean egg selenium concentrations were less than predicted from uptake models. We hypothesise that the relatively low uptake of selenium into the eggs of the two waterbirds in this study is likely due to their lotic environments low biological transformation and uptake rates.     

Media reviews

Of the three films reviewed in this issue, only the first, All Women Have Periods, deals with both areas of sexuality and disability. The second film, A Masturbatory Story, deals with sexuality but not disability. The third film, A Different Approach, deals with disability but not sexuality. The reason I have included the last two films are that A Masturbatory Story is one of the best, most permission giving films I have seen on the subject of masturbation and A Different Approach while focusing on employment of the disabled, is one of the most entertaining and effective films I have seen dealing with attitudes.     

Aging and immigration: Who are the elderly?

Much U.S. research in aging and the social sciences of health compares beliefs, conditions, or behaviors of racial groups. In immigration studies, social identity is most often delineated by virtue of foreign origin with respect to a host country. Thus, nationality is often the marker of difference. The present article joins two generally separate streams of research, gerontologic and immigration research in the United States. The paper considers data from several studies of seniors in Cleveland, Ohio in the 1990s; the Black and White Caregivers and the Use of Services of Black and White Elderly. These are considered not in terms of their original research goals, but rather in terms of a reflective examination of assumptions regarding the identity of the elders and caregivers that framed the two studies. The results show that racial terms conceal, not reveal, the actual ethnic and therefore, cultural, affiliations of the seniors. We suggest that because racial classification is an impediment to, rather than a facilitator of, cultural comparisons, such terms should not be used to compare, predict or explain beliefs or behaviors. The revelation of distinct, highly varied ethnic groups within asserted homogeneous racial groups has implications for immigration studies. These are discussed in the final section as relates to psychiatric and social issues.     

Blood styrene concentrations in a “normal” population and in exposed workers 16 hours after the end of the workshift

Summary Blood styrene was measured by a gas chromatography-mass spectrometry method in 81 normal people and in 76 workers exposed to styrene. In the normal subjects, styrene was also tested in alveolar and environmental air. Styrene was found in nearly all (95%) blood samples. Average styrene levels in the normal subjects were 221 ng/1 in blood (Cb), 3 ng/1 in alveolar air (Ca) and 6 ng/1 in environmental air (Ci). Styrene levels did not differ significantly between smokers and non-smokers, 95% of values being below 512 ng/1 in Cb, 7 ng/1 in Ca and 15 ng/l in Ci. In workers with an average exposure to styrene of 204 g/l, at the end of the workshift, mean blood styrene concentration was 1211 g/l. In blood samples collected at the end of the Thursday shift, styrene levels were significantly higher (1590 g/1) than those found at the end of the Monday shift (1068 g/l. A similar difference was found in samples taken the morning after exposure (60 and 119 g/l, respectively). Significant correlations between blood and environmental styrene were found both at the end of the shift and the morning after exposure (r=0.61 and 0.41, respectively). In workers occupationally exposed to styrene, 16 h after the end of the workshift, blood styrene (94 g/l) was significantly higher than that found in the normal subjects (0.22 g/l). The half-life of blood styrene was 3.9 h.     

Correlation between vibration-induced white finger and symptoms of upper and lower extremities in vibration syndrome

Summary The correlation was investigated between the frequency of attacks of vibration-induced white finger (VWF) and numbness or coldness of the fingers and legs in patients with vibration syndrome. Some 1687 patients with vibration syndrome were examined and of these 342 chain-saw operators and 277 rock-drill operators had no disease other than vibration snydrome. Then subjects were matched by age and period of treatment within three years. In the last analysis, 20 in the VWF almost everyday group or in the never group, and 40 in the occasionally group were selected from the chain-saw operators, and from the rock-drill operators 32 in the VWF everyday or the never group and 64 in the occasionally group. The present study showed that, with the frequency of VWF attacks, patients had a higher prevalence of coldness not only in the fingers but also in the legs. These findings suggest a correlation between the severity of circulatory disturbances of the upper extremities and that of the lower ones in patients with vibration syndrome. Further studies on circulatory disturbances in the leg are required.     

The determinants of CABG patients' outcomes

This study examined the selfreported health status of 90 patients who had undergone Coronary Artery Bypass Grafting (CABG). Data were collected by the Short Form36 (SF36) instrument, administered twice at preoperative and postoperative periods. The reliability of the SF36 ranged from 0.68 to 0.93 in the analysis of preoperative and postoperative measures of health status. The CABG patients reported markedly lower health status on all eight SF36 dimensions at the preoperative period and considerable improvements on all dimensions at the postoperative period. The assessment of CABG patients' outcomes showed that perceived usefulness of the procedure contributed positively to their perceived health status when the effect of preoperative health status was controlled. Patients who perceived the CABG procedure as useful appeared to have more improved postoperative health status after the procedure.