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1.
1996~ 2 0 0 1年 ,应用斑贴试验系列抗原诊断试剂盒(南京医学院皮肤免疫研究所研制 )。对临床拟诊断为接触性皮炎、湿疹、荨麻疹的门诊患者做斑贴试验。现将结果分析如下。临床资料1 一般资料  82例中男 30例 ,女 5 2例 ;年龄 10~ 72岁 ,平均 38岁 ;接触性皮炎 2 2例 ,湿疹 34例 ,荨麻疹 2 6例。所有患者均在停用抗组胺药 4 8小时 ,停皮质类固醇激素 1周后进行斑贴试验 ,其中接触性皮炎患者在皮疹消退后进行 ,湿疹患得在皮疹减轻后进行。2 斑贴试验方法 采用“辩敏牌”斑贴试验标准化筛选抗原及FinnChamber斑试器。试剂盒…  相似文献   

2.
目的探讨皮炎湿疹类患者主要变应原种类分布情况。方法对178例皮炎湿疹类患者依据疾病类型分为面部皮炎组(103例)、手部湿疹组(48例)和外阴湿疹组(27例),均进行斑贴试验,并以同期40例健康者作为对照。结果三组患者斑贴试验总阳性率为74.16%,面部皮炎患者阳性率为69.90%,手部湿疹患者阳性率为79.17%,外阴湿疹患者阳性率为81.48%,对照组阳性率为5.00%,四组阳性率差异有统计学意义(χ~2=67.859,P0.01),3组患者间差异无统计学意义(χ~2=2.357,P0.05);常见过敏原依次为硫酸镍(25.28%)、卡巴混合物(19.66%)、芳香混合物(19.10%)、重铬酸钾(16.85%)、对苯二胺基质(13.48%),男女性患者斑贴试验卡巴混合物阳性率分别为31.48%、14.52%,差异有统计学意义(χ~2=6.854,P0.01);3组病例中均有超过半数的病例存在2种及以上的阳性变应原。结论硫酸镍、卡巴混合物、芳香混合物、重铬酸钾、对苯二胺基质是引起湖州地区皮炎湿疹类患者的主要变应原,通过斑贴试验寻找相应变应原,可指导患者避免接触含有此类物质的物品,对预防复发具有重要意义。  相似文献   

3.
187例湿疹、接触性皮炎等医务人员患者斑贴试验结果分析   总被引:5,自引:0,他引:5  
目的 探讨湖南地区医务人员湿疹、接触性皮炎等皮肤病的致敏因素。方法 对长沙市部分医院及湖南省部分地区医院患该种皮肤病的工作人员进行斑贴试验。结果 187例患者对1种或1种以上变应原呈阳性反应者共122例,阳性率65.2%,其中湿疹患者斑试阳性55/102(53.9%),接触性皮炎患者斑试阳性41/57(71.9%)。结论 湿疹皮炎患病与环境、职业有关,医务人员应加强在工作中的自我防护,防止湿疹皮炎的发生。  相似文献   

4.
[目的]通过斑贴试验能较为准确地确定皮炎湿疹类疾病的致病因素,提供正确的防治方法.[方法]随机选择门诊接触性皮炎和湿疹患者126例进行斑贴试验.[结果] 对斑贴试验所用抗原出现1种阳性反应者81例(78.6%),2种以上阳性者35例(33.9%).接触性皮炎与湿疹均可由不同种类的过敏原引起,差异有非常显著性(χ2=187.35 ,P<0.01;χ2=137.75,P<0.01).[结论]接触性皮炎与湿疹具有各自不同的常见致敏原,与地区及从事的职业有直接关系.  相似文献   

5.
深圳市宝安地区151例斑贴试验结果分析   总被引:1,自引:0,他引:1  
目的分析与研究深圳市宝安区接触性皮炎和湿疹患者主要的接触性致敏原及其特点。方法用瑞敏牌斑贴试验试剂对确诊为皮炎和湿疹的患者做斑贴试验。结果 151例患者中阳性者100例,阳性率66.22%。结论斑贴试验有助于明确慢性湿疹和皮炎患者的接触性致敏原及其性质,对临床治疗有重要的指导作用。  相似文献   

6.
于春润 《中国卫生产业》2013,(26):118-118,120
目的分析皮炎湿疹类皮肤病患者的致敏源,探讨常见的致病因素,以期对皮炎、湿疹类皮肤病有更好的治疗和诊断。方法对2012年2月—2013年2月在我院皮肤门诊确诊的45例皮炎湿疹类皮肤病患者进行诊断性斑贴试验,并对不同组之间的试验结果进行比较和分析。结果选用20种标准抗原对45例患者进行试验,有37例患者对其中的17种抗原出现了1种或多种阳性抗原反应,总的阳性率高达82.22%,且其中硫酸镍的阳性率为35.13%,重铬酸钾的阳性率为29.72%,卡巴混合物的阳性率为27.02%,其余为芳香混合物、硫柳汞、氯化钴的混合物。且接触性皮炎的阳性率为80.23%,湿疹的阳性率为73.33%,过敏性皮炎的阳性率为71.25%,复发性皮炎的阳性率为75%,脂溢性皮炎的阳性率为50%。结论硫酸镍、卡巴混合物、重铬酸钾是引发患者皮肤病的主要致病因素,接触性的过敏原是引发皮炎湿疹类皮肤病的一个主要原因,斑贴试验可以有效的诊断皮炎湿疹类皮肤病。  相似文献   

7.
目的探讨溧水地区常见变应原种类,以更好地预防和治疗过敏性皮肤病。方法应用"瑞敏"牌斑贴试剂盒对180例(面部皮炎106例,手部湿疹47例,外阴湿疹27例)过敏性皮肤病患者进行皮肤斑贴试验,并以36例健康者为对照。结果过敏组斑贴试验阳性率74.44%,高于对照组(2.78%)(χ2=66.58,P0.01),3组病例间差别无统计学意义。常见过敏原依次为硫酸镍(23.89%)、卡巴混合物(20.00%)、芳香混合物(19.44%)、重铬酸钾(17.22%)、对苯二胺基质(13.89%);3组病例中均有超过半数的病例存在2种及以上的阳性变应原;男女性患者斑贴试验阳性率差异有统计学意义的变应原,分别为卡巴混合物(33.33%,13.82%)、芳香混合物(12.28%,22.76%)。结论硫酸镍、卡巴混合物、芳香混合物、重铬酸钾、对苯二胺基质是引起溧水地区皮炎湿疹类患者的主要变应原。  相似文献   

8.
通过问卷调查及斑贴试验对常见环境接触因素在48例手部皮炎患者发病中的作用进行了研究。结果确诊接触性皮炎7例(14.6%),其中5例为职业性接触性皮炎;其余41例为可疑接触性皮炎。手部皮炎患者斑贴阳性率偏低(51%);洗涤剂引起或加重患者病情的占41.7%。水引起或加重患者病情的占39.6%;说明刺激因素在手部皮炎中也很重要。可疑接触性皮炎患者斑贴阳性率为46.3%,接触过敏因素在这部分患者发病中的作用仍不能忽视。明确斑贴试验阳性结果与疾病的联系是进一步必须研究的课题。  相似文献   

9.
面部接触性皮炎的病因分析   总被引:1,自引:0,他引:1  
面部接触性皮炎的病因分析广东省珠海市人民医院皮肤科(香洲康宁路,519000)黄惠新接触性皮炎在职业性皮炎中占有一定比例,斑贴试验是公认的鉴定接触性皮炎致敏原的方法。为了解本地区面部接触性皮炎的常见病因,我们对门诊76例面部接触性皮炎患者进行了斑贴试...  相似文献   

10.
目的研究环境接触性因素在面部皮炎发病中的作用。方法通过常见环境过敏原斑贴试验及问卷调查,对60例面部皮炎患者进行了研究。结果28例(46.7%)确诊为接触性皮炎,其中1例职业性接触性皮炎;10例其他原因皮炎;22例不能排除环境接触因素的作用,为可疑接触性皮炎。这些患者斑贴阳性率为60%,仍不能忽视接触过敏因素的作用。结论斑贴试验阳性结果与疾病的联系是寻找病因或加重因素的关键。  相似文献   

11.
Epidemiological studies of calcium and osteoporosis have been hampered by the lack of a suitable tool for assessing calcium intake. This report describes a new frequency and amount questionnaire for measuring present and past calcium intake in the elderly. The validity of the questionnaire was tested against two commonly used standards of dietary assessment, five-day duplicate diets and seven-day weighed dietary inventories. The resulting correlation coefficients were, respectively, r = 0.76 and r = 0.69, while that for repeatability was r = 0.84. Furthermore, the questionnaire categorized subjects into thirds of the distribution of intake with almost no gross misclassification. It is suggested that the present findings may be extended to the majority of normal, healthy elderly subjects, implying wide application for the questionnaire in the assessment of calcium intake in the elderly.  相似文献   

12.
This paper examines media coverage of 'breast cancer genetics', and explores its implications for public understanding. We present a content analysis of coverage in British newspapers and look at a variety of popular forms, including women's magazines, television soap opera and radio drama. Genetic/inherited risk receives a great deal of coverage across a wide range of media formats and outlets. Much of this attention has focused on individuals from 'high risk families' and dilemmas around prophylactic mastectomies. Through examining media coverage, combined with interviews with media personnel and their sources, we show why this story proved so attractive to the media and highlight the different production values which influence coverage. Finally, we introduce preliminary findings from focus group discussions to demonstrate how such 'human interest' framing has engaged audience attention and influenced public understandings. The paper concludes by highlighting the implications for analysing, predicting, and engaging with, media representations of science.  相似文献   

13.
深圳公立医院管理体制改革实行政事分开、管办分开,在理事会架构下按法定机构模式组建市医管中心,落实公立医院运营管理自主权.作者从当前公立医院管理体制的弊端入手,介绍了深圳市进行公立医院管理体制改革的基本思路及改革方案设计的主要举措,深入剖析了的改革方案的特点,并对改革效果进行了预测.  相似文献   

14.
Red cell membranes, prepared from red blood cells of rats exposed to 4, 10, or 20 ppm nitrogen dioxide (NO2) for 1 to 10 days, were examined for evidence of changes in membrane components. Appreciable changes were not found in contents of phospholipid and cholesterol during exposure to 10 ppm NO2. By contrast, protein content altered with the time of exposure. Moreover, changes in protein composition were observed by employing sodium dodecyl sulfate — polyacrylamide gel electrophoresis. Twenty-four-hour exposure to NO2 at the concentration above 10 ppm resulted in a marked increase in the percentage of lysophosphatidylethanolamine (LysoPE) to the total phospholipids. The prolonged exposure to 10 ppm NO2 gave rise to a further increase in LysoPE, whereas the percentage of phosphatidylethanolamine (PE) showed a gradual decrease. A 1-day exposure to 4.0 ppm NO2 also caused an increase in sialic acid content and decreases in those of PE and hexose. In addition to contents of these components the percentage of LysoPE increased 5 days after exposure and the elevated values were maintained up to the end of exposure period. These results demonstrate that red blood cells in circulation exhibit different membrane properties in terms of lipid and carbohydrate composition during 10 days of exposure to 4.0 ppm NO2.  相似文献   

15.
The risk of heat exhaustion at a deep underground metalliferous mine was assessed in relation to thermal conditions prevailing on the surface. For each day of a 1-year prospective case series of heat exhaustion, surface 24-h mean wet and dry bulb temperatures were recorded. From this data, 24-h mean wet bulb globe temperatures were derived using certain assumptions. The three surface temperature variables were significantly higher on those days on which heat exhaustion occurred, compared to those days on which it did not occur (P < 0.001). The relative risk of heat exhaustion on days when the 24-h mean wet bulb globe temperature was in the range 26.0-28.0 degrees C was 4.82 (95% confidence interval 2.12-10.96). Surface temperature data could be used at this mine to warn miners about the risk of heat exhaustion.  相似文献   

16.
Antibiotics represent one of the most important drug groups used in the management of bacterial infections in humans and animals. Due to the increasing problem of antibiotic resistance, assurance of the antibacterial effectiveness of these substances has moved into the focus of public health. The reduction in antibiotic residues in wastewater and the environment may play a decisive role in the development of increasing rates of antibiotic resistance. The present study examines the wastewater of 31 patient rooms of various German clinics for possible residues of antibiotics, as well as the wastewater of five private households as a reference.To the best of our knowledge, this study shows for the first time that in hospitals with high antibiotic consumption rates, residues of these drugs can be regularly detected in toilets, sink siphons and shower drains at concentrations ranging from 0.02?μg·L?1 to a maximum of 79?mg·L?1. After complete flushing of the wastewater siphons, antibiotics are no longer detectable, but after temporal stagnation, the concentration of the active substances in the water phases of respective siphons increases again, suggesting that antibiotics persist through the washing process in biofilms. This study demonstrates that clinical wastewater systems offer further possibilities for the optimization of antibiotic resistance surveillance.  相似文献   

17.
Unemployment is considered to be a public health concern sincedeterioration in the health of the unemployed is often anticipated.However, for some groups, such as miners, unemployment mightimprove health due to a cessation of potentially harmful occupationalexposures. This study evaluates the health of 79 miners in oneSwedish iron-ore mine, and 226 age-matched controls from thegeneral population, during one year after the closure of themine. The participants received a questionnaire regarding medicalhistory and subjective symptoms at the beginning of the studyperiod, and after one year. Statistically significant negativeeffects on self-reported health attributable to unemploymentwere not found, although neuropsychiatric symptoms were morecommon among the unemployed miners. The miners reported a statisticallysignificant improvement in grip force (p=0.031). They had asignificantly higher prevalence of symptoms associated withmining related exposures when compared with the population controls;pain in the upper extremities [relative risk (RR)=2.27, 95%confidence interval (Cl)=1.44–3.59), back pain (RR=1.84;Cl=1.237–2.75), vasospastic disease of the fingers (RR=2.05;Cl=1.18–3.57) and obstructive respiratory symptoms (attacksof dyspnea and wheezing: RR=3.67; Cl=1.167–11.6).  相似文献   

18.

Context

Tularemia is a zoonosis affecting humans and hares in France. We describe the results of surveillance in both species, in 2007 and 2008.

Methods

Human tularemia cases are mandatorily notifiable in France since 2003. In hares, surveillance relies on volunteer hunter associations in all districts of the country. Data from mandatory reports and volunteer surveillance in 2007/2008 were analyzed and compared with previous results.

Results

In 2007/2008, 144 cases were reported in humans and 117 cases in hares. This was a 100% increase compared to previous years. Human cases differed from those of previous years only by the frequency of contact with breeding animals. Human cases without any documented risk exposure were also more frequent.

Conclusion

An increase of tularemia cases occurred in 2007/2008 in both species. Complementary studies are needed to identify the species reservoir in France to understand the causes of this peak of cases.  相似文献   

19.
20.
The repeatability and validity of a questionnaire for upper limb and neck complaints were assessed in a population of 105 hospital outpatients with a range of upper limb and neck disorders (including cervical spondylosis, adhesive capsulitis, lateral epicondylitis, carpal tunnel syndrome and Raynaud's phenomenon). Subjects were asked to complete a modified Nordic-style upper limb and neck discomfort questionnaire on two occasions closely spaced in time. The repeatability of their responses was assessed by calculating a kappa coefficient (kappa), and the sensitivity and specificity of component items in the questionnaire were determined for specific diagnostic categories of upper limb and neck disorder. Symptom reports for pain in the upper limb and neck, pain interfering with physical activities, neurological symptoms and blanching were all found to be highly repeatable (kappa = 0.63-0.90). A number of regional pain reports proved to be very sensitive in relation to specific upper limb disorders, but, with the exception of reported finger blanching in patients with Raynaud's phenomenon, none proved to have a good specificity (range = 0.33-0.38). We conclude that a modified Nordic-style questionnaire is repeatable and sensitive, and is likely to have a high utility in screening and surveillance. However a complementary examination schedule of adequate specificity and repeatability is essential to establish a clinical diagnosis.  相似文献   

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