坚持到底还是半途而废?--决策2:化疗

写给读者的话:我们听到了一些朋友对我们登在第一期的文章的反馈.谢谢大家的关注.我想特别强调一点,我写这一组文章的意图,是想表达作为患者和家属,我们要理智地面对疾病,了解它,研究它,积极地参与和配合医生的诊断治疗决策和实施.眼下,社会上对于医院和医生的妖魔化倾向严重,医患关系成为一个非常敏感的问题,我们看到许多对于医生的指控是以偏概全不符合事实的.     

由内而外的改变

在以往的生活中我一直是个成功的人,女人该有的我都拥有:一份很棒的职业--在达尔马提亚出版社下属的一家儿童读物出版公司任副总经理;我信奉上帝;拥有爱我的懂得体贴的丈夫、朋友和家人;我曾经周游世界,有无数的记忆和旅游纪念品为证.我一直比较善解人意并且能够出色地处理各种问题.可以说我就是一个成功女士的典型.     

癌症病人的爱国情怀

2006年9月9日,天高云淡,秋风送爽.上午9时,一声发令枪响,"北京第二十届卢沟桥醒狮越野跑比赛"的队伍从抗日战争雕塑园出发了.这是为纪念中国人民抗日战争和世界反法西斯战争胜利61周年组织的一次活动.     

GAS7在人骨肉瘤中的表达及其意义

Objective： To detect the expression of GAS7 in osteosarcoma and discuss its significance. Methods： Immunohistochemistry SABC method was applied to detect GAS7 expression in specimens of 54 osteosarcoma and 15 osteochondroma cases. Results： The positive expression rate of GAS7 was 74.7% （40/54） in the group of osteosarcoma and 0% （0/15） in the group of osteochondroma. There was a significant difference in the comparison of GAS expression in these two groups （P 〈 0.05）. GAS7 was higher expressed in the samples which complicated with relapse or pulmonary metastasis than the control group （P 〈 0.05）. There was no significant association between GAS7 expression and the size of tumor, the gender or the age of the patients （P 〉 0.05）. Conclusion： The hyper-expression ot GAST may play an important role in the initiation and development of human osteosarcoma.     

面向2008面向健康生活让我们齐步走!--记北京癌症患者及社会各界万人健康长走活动

8月29日为29届奥委会接旗日,象征和平、团结、友谊的五环旗帜将从雅典传到北京,来到神州大地,这预示着2008年北京奥运会周期的开始.为了铭记这一历史时刻,在中华人民共和国卫生部、首都精神文明建设委员会办公室、国家中医药管理局、白求恩医科大学北京校友会支持下;由中华慈善总会、中国抗癌协会癌症康复会主办的<九九方元迎奥运癌症患者及社会各界万人健康长走--手拉手迈向2008工程启动仪式>在京隆重举行.     

诈骗艾滋知多少

艾滋病病毒的致病机制很特殊,它一旦进入人体,寄生在T4淋巴细胞内最核心的部位,与细胞核的遗传物质DNA整合为一体,病毒随免疫细胞DNA复制而复制.因此,它成了在全球不可根治的一种"超级瘟疫".在世界各国,对防治艾滋病投入了巨大的人力、财力,众多医学专家们绞尽了脑汁,直至今天尚无有效疫苗可防,更无药物可根治,临床医生束手无策,只能做到一些对症治疗,减轻病人的痛苦,延缓病情,但无法挽救病人的生命,这是科学家公认的结论.     

触碰医学的温度 ——北京大学肿瘤医院淋巴肿瘤内科朱军主任门诊纪实

“医学倘若缺乏必要的人文关怀,就会失去应有的人性温度。” 把病人当作一个真实的人,体恤其受疾病袭击时的痛苦,面临生命危险时的悲伤以及对于爱抚和同情的渴望——是医学人文的应有之意。 数月前,笔者有过一次旁听朱军主任出诊的经历,至今,那个充满人情味的场面还刻在脑海里。他解读病情时的睿智幽默,让患者轻松起来;介绍方案时的通俗明晰,让医学不再陌生;关注病患内心冷暖,让淋巴瘤不再可怕……谈话间不时发出的笑声,弥漫在空气里,让诊室气氛温暖而愉悦。     

冬令补膏四款

琼玉膏人参120克,鲜地黄800克,白茯苓(去黑皮)245克,白蜂蜜500克.将人参、茯苓研细末,白蜜用洁净纱布滤去杂质,鲜地黄捣取汁(捣时盛器要用陶器,不要用铜、铁器),然后将参、苓、蜜、地黄汁拌匀放入瓷瓶内,用净纸二三十层封口,放锅内隔水蒸三天三夜,而后用蜡纸数层包紧瓷瓶,放入井口约4小时去火毒,而后取出瓷瓶,再放入锅内蒸24小时即成.每次10～30毫升,每日2次,温开水送服.可补气血,填精髓,适用于中老年人平时保健之用.     

狗可当医生的助手

今年是农历的狗年,有很多说狗的文章见诸报端,比如说狗忠勇、勤劳,助狩猎,帮放牧……狗能帮助追凶擒敌,能搜寻毒品,大家都早已司空见惯,习以为常了,狗的很多非凡的表现都源于它有一个灵敏的鼻子.令我们最感兴趣的是,在<现代癌症综合治疗问题>中,麦克洛科报告,利用狗的嗅觉可早期诊断肺癌和乳腺癌,这一题目的确新颖而有趣,很快在网上和报纸上纷纷转载.我们杂志的对象是癌症康复者更值得高度关注.     

妇科肿瘤专题特邀组稿专家李力教授简介

李力,女,医学博士,教授、主任医师、博士生导师.1980年毕业于第三军医大学医疗系:1992年第三军医大学研究生大队学员,授医学硕士;1997年重庆医科大学研究生院学员,授医学博士.现任第三军医大学第三附属医院(大坪医院)妇产科主任、全军计划生育优生优育技术中心主任、重庆市宫颈癌防治研究所所长.     

Results of the treatment of children with recurrent gliomas with lomustine and vincristine

Gliomas comprise over 50% of all childhood brain tumors. Treatment of recurrent childhood gliomas has been disappointing and the effectiveness of therapy has been difficult to judge because of the variable natural history of the disease. Information gathered recently has suggested that treatment with [1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea)] (CCNU) and vincristine (VCR) after radiotherapy is effective in prolonging survival in children with newly diagnosed anaplastic gliomas. The authors have used these same drugs--CCNU (100 mg/m2) and VCR (1.5 mg/m2 up to a maximum dose of 2 mg)--in 6-week cycles for a maximum of eight cycles in children with recurrent gliomas. To date, 15 patients have been treated; five patients had malignant gliomas and ten low-grade gliomas. Three children showed improvement, five had stable disease, and seven had progressive disease. Of the five patients with malignant gliomas, four progressed within two cycles of treatment and one had stable disease for 7 months on treatment and then relapsed. Seven of ten children with low-grade gliomas benefitted from treatment and six remain in continuous remission a median of 16 months after initiation of therapy. Three of these children are off all therapy 21, 30, and 30 months after treatment, respectively. Therapy was well tolerated and toxicity consisted primarily of reversible bone marrow suppression. The authors conclude that CCNU and VCR chemotherapy is effective in children with recurrent low-grade gliomas and can result in relatively long-term disease stabilization. In limited experience of the authors, it is not of benefit in children with recurrent anaplastic lesions.     

老年食管瘤和贲门癌合并心电图异常外科治疗83例分析

评价老年食管癌和贲门癌合并心电图异常对外科手术的影响。方法：作者经手术治疗65岁以上老年食管癌和贲门癌共138例，其中术前合并心电图异常者83例，占60．1％（83／138）；术前除左束支传导阻滞、广泛性心肌供血不足、陈旧性及亚急性心肌梗塞患者给予7－10天心脏保护性药物治疗外，余均未作任何特殊性治疗。结果：术后共发生井发症9例次，占10．8％（9／83），其中心跳骤停1例次，急性心肌梗塞1例次，重度房颤2例次，胸胃局灶性坏死穿孔5例次，均经抢救性（和／或手术）治疗痊愈，本组无死亡者。结论：老年食管癌和贲门癌患者合并心电图异常，并不一定是心功能异常，并不一定影响外科手术治疗。     

Staging and evaluation of the patient with lymphoma

Patients who have non-Hodgkin's lymphoma or Hodgkin lymphoma most often present for medical attention because of signs or symptoms referable to enlarged lymph nodes or other disease-related symptoms (such as fevers, night sweats or fatigue). Less often, enlarged lymph nodes or splenomegaly may be incidental findings during evaluation for other medical issues. Determination of the extent of disease and accurate assessment of responses are necessary for appropriate management. Newer technologies have improved the ability to evaluate patients and to conduct clinical trials, leading to more effective therapies. This article addresses the advances in staging and evaluation of patients who have lymphoma, specifically examining the use of positron emission tomography.     

Invivo control of tumor-growth with the association of ionidamine with radiation and or hyperthermia

The effect of lonidamine (LND) in association with fractionated doses of radiation and/or hyperthermia on tumor growth has been evaluated. The results may be summarized as follows: (i) the fractionation of the radiation dose, in spite of the higher dose delivered (20 Gy) does not increase tumor growth delay when compared to that obtained with a single irradiation treatment. A similar behaviour was also found when the fractionated irradiation was associated with LND. (ii) Hyperthermia is less effective than radiation in controlling tumor growth, but its effect is potentiated by LND although to a lesser extent that with radiation. (iii) LND delivered together with hyperthermia and radiation arrests tumor growth, and leads to the disappearance of the tumor in 75% of mice. The possible mechanisms underlying these effects are discussed.     

Associations of bread and pasta with the risk of cancer of the breast and colorectum

BackgroundCarbohydrate foods with high glycemic and insulinemic potential may influence cancer risk possibly through the insulin/growth-factor axis. Two staple carbohydrate foods of the Mediterranean diet, bread and pasta, have different glycemic and insulinemic responses and hence may affect cancer risk differently.Materials and methodsWe studied the association of bread and pasta with breast and colorectal cancer risk using data from two Italian case–control studies. These studies included 2569 women with histologically confirmed breast cancer and 1953 men and women with colorectal cancer. Controls were 2588 and 4154, respectively, admitted to the same hospitals as cases for acute, non-neoplastic conditions. Multivariate odds ratios (ORs) were obtained after allowance for relevant confounding factors.ResultsThe ORs of breast cancer for the highest versus the lowest quintile were 1.28 (95% confidence interval, CI: 1.03–1.58, P-trend = 0.0342) for bread and 1.07 (95% CI: 0.88–1.31, P-trend = 0.7072) for pasta. The association with bread remained virtually unchanged with postmenopause and overweight. The ORs of colorectal cancer in women for the highest versus the lowest quintile were 2.02 (95% CI: 1.46–2.80, P-trend = 0.0002) for bread and 1.37 (95% CI: 1.00–1.88, P-trend = 0.0164) for pasta. The associations remained significant only for bread in strata of menopausal status and in women with overweight. No significant associations were seen in men for either bread or pasta.ConclusionsOverall, these two cancer case–control studies showed stronger positive associations with bread than pasta in women, particularly if overweight, suggesting possible hormonal-related mechanisms.