Conserved pan-cancer microenvironment subtypes predict response to immunotherapy

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Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer

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Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

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A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma

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Activating a collaborative innate-adaptive immune response to control metastasis

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The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance

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Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

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KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer

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Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice

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STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma

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CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis

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Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma

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An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes

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SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy

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Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas

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Gut microbiota-mediated nucleotide synthesis attenuates the response to neoadjuvant chemoradiotherapy in rectal cancer

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Induction of tumor cell autosis by myxoma virus-infected CAR-T and TCR-T cells to overcome primary and acquired resistance

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Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer

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IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment

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IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer

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