Second Primary Malignant Neoplasms: A Clinicopathological Analysis from a Cancer Centre in India

Context: Patients diagnosed with a cancer have a life time risk of developing another de novo malignancydepending on various inherited, environmental and iatrogenic risk factors. Of late the detection of new primaryhas increased mainly due to refinement in both diagnostic and treatment modalities. Cancer victims are survivinglonger and thus are more likely to develop a new metachronous malignancy. Aims: To report our observed trendof increase in prevalence of both synchronous and metachronous second malignant neoplasms among cancervictims and to review the relevant literature. Settings and Design: A hospital based retrospective collection ofprospective data of patients diagnosed with second denovo malignancy. Materials and Method: The study wasconducted over a 5 year period from July 2008 to June 2012. All patients diagnosed with a histologically provensecond malignancy as per Warren Gate’s criteria were included. Various details regarding sex, age at presentation,synchronous or metachronous, treatment and outcome were recorded. Conclusions: The occurrence of multipleprimary malignancies is not rare. Awareness of the possibility alerts the clinician in evaluation of patients witha known malignancy presenting with unusual sites of metastasis. Individualizing the treatment according to thestages of the primaries will result in durable cancer control particularly in synchronous double malignancy.     

Malignant histiocytosis in the oropharynx

Malignant histiocytosis is characterized by systemic, progressive, and invasive proliferation of malignant histiocytes. The disorder is typically accompanied by fever, general fatigue, lymphadenopathy, and hepatosplenomegaly. A case of a 21-year-old woman with primary malignant histiocytosis of the oropharynx is reported. Histologic diagnosis from the biopsy specimen was confused by infiltration of normal-appearing histiocytes and inflammatory cells. The titers of Epstein-Barr virus and the Paul-Bunnell test were elevated without atypical lymphocytes. The patient died 3.5 months after the onset of symptoms. Autopsy revealed systemic neoplastic proliferation of malignant histiocytes. A review of literature on this subject revealed no cases of malignant histiocytosis primarily involving the oropharynx.     

多原发恶性肿瘤的病理诊断和免疫组织化学研究

本文报道62例多原发恶性肿瘤(MPMN)的免疫组织化学在病理诊断中的意义,尤其是51例发生在同一系统、同一器官或对称性器官,且组织结构相似的MPMN,颇难定原发或继发。通过免疫组织化学(CEA、HCG和K_(12))研究发现:MPMN的不同癌灶中,3种免疫组化染色常不相同。而对照组中,原发灶和继发灶两者反应基本一致。研究结果提示,MPMN灶可能具有各自的代谢和功能特性。应用免疫组化方法可能有助于与继发性癌瘤相鉴别。     

以乳腺局限性增厚为特征的早期乳腺癌19例临床分析

目的：探讨乳腺局限体增厚在早期乳腺癌中的意义。方法：乳腺Ｘ射照相术显示腺体结构异常、硝粒样钙化者,手术切检确诊。结果：１９例乳腺癌临床分期ＴOＮoＭo,病理分期７ 例为ＴｉｓＮｏＭｏ。随访１～５年１１例,５～１０年５例,１０～１３年,无瘤生存率皆为１００％。结论：乳腺局限性增厚为早期乳腺癌重要体征之一。中年以上妇女乳腺局限 性腺体增厚庆详细检查,数月不见好转甚至有坟大趋势时应及时手术切除检查以明确诊断     

Primary oesophageal carcinoma in teens.

Seven teenaged patients with primary oesophageal carcinoma, treated at our hospital in the last 6 years are presented and their management discussed. Five patients had localised disease. Three of them underwent total oesophagectomy, one was given radical radiotherapy, and one was lost to follow-up. Two patients had metastatic disease at presentation. The primary oesophageal carcinoma in this age group may not be so rare as reported in the literature and must be considered in the differential diagnosis of dysphagia. Like their older counterparts, the outcome depends on the stage of the disease and is not influenced by age per se.