正常足与(足母)外翻足横弓形态的对比性研究

[目的]比较研究正常足和外翻足横弓的形态,探讨横弓在外翻发生发展中的作用。[方法]对35名外翻患者65只足和30名正常人60只足,在负重位和非负重位足正位X线片和前足轴位X线片上分别测量外翻角(hallux valgus angle,HVA),第1、2跖骨间角(fist intermetatarsalangle,IMA),各跖骨头、籽骨到足底的距离。[结果]外翻足HVA平均30·8±8.9°,第1、2跖骨间角为16.5±2·6°;正常足HVA为10·2±2·0°,第1、2跖骨间角7·9±1·6°。外翻足与正常足比较第1跖骨头向下移位,第2、3跖骨头距足底的距离明显低于正常足。腓侧籽骨向外上方移位,胫侧籽骨向外侧移位。[结论]外翻足横弓塌陷,籽骨脱位,第2、3跖骨头过早、过重负重易产生疲劳性骨折、跖骨痛和足底胼胝体。     

正常足与拇外翻足的足底压力研究

目的 对正常足与拇外翻足的足底压力进行测量。方法 运用自行研制的足底生物力学测试系统对３０名健康人６０足,４５例拇外翻患者８９足进行了行走时足底压力的测试。结果 重度拇外翻组３１足和正常组相比,第一跖骨头下压力明显减低,第二跖骨头下明显增另,第三,五跖骨头下压力有增高的趋势。结论正常人前足第一跖骨关下压力最高,并向外侧递减,重度拇外翻足前足第一跖骨头下压力明显减低,第二跖骨头下压力明显增高。     

正常足与外翻足前足承重比例与跖骨头下压力的研究

目的从生物力学角度探讨外翻足前足承重比例及跖骨头下压力的改变情况.方法将测试对象分为正常组(160足)、轻中度外翻组(100足)、重度外翻组(56足)三组,运用我所生物力学室研制的足底压力测试系统,对正常足与外翻足足底压力进行测试,并将结果进行统计分析.结果轻中度外翻足前足承重比例较正常足增加,重度外翻足前足承重比例介于正常足与轻中度外翻足之间.外翻足存在着前足压力外移的趋势,这种改变和畸形的程度相关.结论从生物力学角度证明,外翻前足承重比例及各跖骨头下压力的变化随外翻畸形程度增加出现不同程度的变化.     

正常足与踇外翻足第一序列的测量及其临床意义

目的探讨踇外翻的病理、发病机制、分型以及手术方式的选择。方法对正常足245足和踇外翻足141足进行以下参数的测量和统计学分析踇外翻角(HVA)、跖间角(IMA)、趾间角(IPA)、近侧关节固角(PASA)、远侧关节固角(DASA)、跖楔角(MCA)。结果踇外翻组PASA、MCA均大于正常组,IPA却小于正常组,而两组DASA比较差异无显著性意义。两组均可见随着HVA的增大,IPA减小。踇外翻组可见(1)随着HVA的增大,PASA有增大的趋势,而IMA无明显的变化规律;(2)IMA增大者,MCA也增大,差异具有统计学意义,而HVA与MCA无统计学的联系。结论踇外翻的病理因素包括IPA、PASA及IMA。踇外翻可分为六型Ⅰ型,IPA增大为主,IPA≥22°,而PASA、IMA均在正常值范围内;Ⅱ型,单纯HVA增大,HVA≥20°,而IPA、IMA、PASA均在正常值范围内;Ⅲ型,以PASA增大为主,IMA可以正常或轻度增大,PASA≥11°,而IMA≤15°;Ⅳ型,以IMA增大为主,其又可分为两个亚型,Ⅳa型,10°≤IMA≤15°,Ⅳb型,IMA>15°,而PASA在正常值范围内;Ⅴ型,混合型,IMA>15°,PASA≥11°;Ⅵ型,跖趾骨关节炎型。每一型各有不同的发病机制,应采用不同的手术方式。     

正常足与拇外翻足前足承重比例与跖骨头下压力的研究

目的 从生物力学角度探讨外翻足承重比例及跖骨头下压力的改变情况。方法将测试对象分为正常组(160足)、轻中度(足母)外翻组(100足)、重度(足母)外翻组(56足)三组,运用我所生物力学室研制的足底压力测试系统,对正常足与(足母)外翻足足底压力进行测试,并将结果进行统计分析。结果 轻中度(足母)外翻足前足承重比例较正常足增加,重度(足母)外翻足前足承重比例介于正常足与轻中度(足母)外翻足之间。(足母)外翻足存在着前足压力外移的趋势,这种改变和畸形的程度相关。结论 从生物力学角度证明,(足母)外翻前足承重比例及各跖骨头下压力的变化随(足母)外翻畸形程度增加出现不同程度的变化。     

Grice距下关节固定术治疗儿童足外翻

Ｇｒｉｃｅ距下关节固定术治疗儿童足外翻彭阿钦，吴希瑞，王汉林，吴春生，林振福１９５２年Ｇｒｉｃｅ报道了通过距骨窦植骨造成关节外距下关节固定，矫正儿童后足外翻畸形这一手术方法（以下简称Ｇｒｉｃｅ手术）。其最大优点是在矫正足外翻的同时不影响足的生长。自１...     

(足母)外翻及相关畸形的综合手术治疗探讨

目的：评价综合手术治疗Mu外翻与前足相关畸形的效果。方法：回顾性分析本院收治的中、重度Mu外翻合并前足畸形患者289例307足的临床资料，应用综合矫形手术治疗效果。结果：优良率：85．6％，患者对术后足外形及功能满意，前足痛改善。结论：对于中、重度Mu外翻患者，除纠正Mu趾外展外翻外，还应注意伴发畸形的处理，综合矫形手术不失为一种可以考虑的手术方法。     

微创截骨张力带矫正足(足母)外翻

[目的]研究改良小切口手术治疗足躅外翻的新疗法.[方法]采用小切口手术治疗,行骨赘切取、跖骨颈斜形截骨、关节囊张力带矫正畸形、可吸收螺丝钉内固定、石膏托制动方法,术后6周去除外固定,可下床适当活动.随访26例,时间13～30个月,平均21个月. [结果]优26例(50足),占89.7％;良2例(4足),占6.94％;差1例(1足),占3 4％.优良率达96.6％.[结论]微创截骨张力带矫形治疗足(足母)外翻,手术简捷,术后恢复快,合并症少,畸形复发率低,是值得推广应用的新方法.     

足(足母)外翻手术后畸形复发的翻修手术策略

(足母)外翻畸形矫正手术在骨科临床十分常见,目前有超过150种术式在临床中被应用[1～3].任何手术都有一定的并发症,(足母)外翻手术也存在10％～55％的并发症[4],其中最常见的就是畸形复发[1、9、21].而处理这些复发的有症状的(足母)外翻对医生和患者都具有挑战性.目前处理这种并发症的文献并不是很多[5-6],本文就此进行综述.     

Is the recovery profile of mivacurium independent of the rate of decay of its plasma concentration in patients with normal plasma cholinesterase activity?

Background: The duration of action of muscle relaxants is poorly correlated to the rate of decay of their plasma concentration. The plasma concentration of mivacurium may rapidly decrease below its active concentration because of the extensive hydrolysis of mivacurium. By inflating a tourniquet on one upper limb for 3 min after the administration of atracurium, mivacurium or vecuronium, we studied the influence of the initial decline of their plasma concentration on their effect. Methods: In 50 patients anaesthetised with thiopental, isoflurane and fentanyl, the effect of bolus doses of 0.15 or 0.25 mg . kg^?1 mivacurium (MIV 15, MIV 25), 0.3 or 0.5 mg . kg^?1 atracurium (ATR 30, ATR 50) and 0.06 or 0.1 mg . kg^?1 vecuronium (VEC 06, VEC 10) were measured on both arms (evoked response of the adductor pollicis to train-of-four stimulation every 12 s), a tourniquet being applied on one arm just before and during 3 min after the muscle relaxant bolus. Results: Tourniquet inflation of 3 min almost abolished the neuromuscular effect of mivacurium. In the vecuronium groups and in the ATR 50 group, tourniquet inflation did not modify the maximum degree of depression of the twitch response. Also, the duration of action of vecuronium was unaffected by the tourniquet. In the ATR 30 group, times to return of the twitch response to 25% (duration 25%) and 75% (duration 75%) of control response were significantly shorter in the cuffed arm, 23 min vs 27 min, and 41 min vs 45 min, respectively. In the ATR 50 group, only duration 25% was significantly shorter in the cuffed arm (41 min vs 45 min). Conclusion: The results suggest that the rate of decline of the plasma concentration of mivacurium is so rapid, that a very low and almost clinically ineffective concentration is present as soon as 3 min after its administration. The results also indicate that the recovery from a mivacurium-induced neuromuscular blockade is not influenced by the rate of decay of its plasma concentration in patients with genotypically normal plasma cholinesterase.     

Membranes in Artificial Organs

Abstract: Membrane processes play a pivotal and enabling role in modern replacement therapy for acute and chronic organ failure and in the management of immunologic diseases. In fact, virtually all contemporary extracorporeal blood purification methods employ membrane devices, and the next generation of artificial organs and tissue engineering therapies are almost certain to be similarly grounded in membrane technology. In this short essay, we comment on the similarities and differences among synthetic membranes and their natural counterparts and also provide a critical overview of the demographics and technology of hemodialysis, hemofiltration, apheresis, oxygenation, and emerging membrane technologies and applications.     

Reduction of Plasma Fibrinogen, Immunoglobulin G, and Immunoglobulin M Concentrations by Immunoadsorption Therapy with Tryptophan and Phenylalanine Adsorbents

Abstract Immunoadsorption (1A) therapy with tryptophan (TR-350) or phenylalanine (PH-350) adsorbents has been used to reduce the concentration of serum antibodies in human lymphocyte antigen (HLA)-immunized patients. Other forms of plasma purification have been reported to reduce the level of fibrinogen, which affects the blood properties. In this study we investigated the effects of IA therapy using both adsorbents on plasma fibrinogen and immunoglobulins G and M in 13 patients (8 patients were treated with TR-350, and 5 patients were treated with PH-350). During each session 1 plasma volume (2.8 ± 0.4 L of plasma) was processed through the immunocolumn and then returned to the patient together with the blood cells. Compared with the pretreatment values, the plasma fibrinogen, IgG, and IgM concentrations were significantly reduced after IA therapy (p < 0.01 for TR-350; p < 0.04 for PH-350). There was a positive correlation between the degree of reduction of plasma proteins and the number of IA treatments given. A nonpara-metric test (Wilcoxon's signed-rank test or the Mann-Whitney test) was used for statistical analysis. We conclude from our study that IA therapy effectively lowers the plasma levels of fibrinogen, IgG, and IgM and thus can be considered a valuable alternative to other blood purification methods.     

Dilemma of Membrane Biocompatibility and Reuse

Abstract: Numerous articles have been published on the multiple use of dialyzers and on the effect of different reprocessing chemicals and techniques on the dialyzer biocompatibility and performance. The results often appear contradictory, especially those comparing standard biocompatibility parameters. Despite this confusion, a discerning review of the published works allows certain limited conclusions to be drawn. Reprocessing of used hemodialyzers changes the biocompatibility profile of a dialyzer as defined by the parameters complement activation. leukopenia, and cytokine release. The effect of reprocessing depends on the chemicals and reprocessing technique applied and also on the type of membrane polymer being subjected to the reprocessing procedure. Reports of pyrogenic reactions indicate that the flux of the membrane also influences how suitable it is for safe reuse. An increased risk of allergic and pyrogenic reactions appears to be associated with dialyzer reuse. Furthermore, there has been a lack of investigations into the immunologic effect of the layer of adsorbed and chemically altered proteins that remains on the inner surface of reprocessed dialyzers. We conclude that the clinical benefit of dialyzer reuse cannot be generally accepted from a biocompatibility point of view.     

The analgesic effect of racemic ketamine in patients with chronic ischemic pain due to lower extremity arteriosclerosis obliterans

Background : Ketamine in sub-dissociative doses has been shown to have analgesic and phantom-Limb pain, where conventional treatment has often failed. Chronic ischemic pain due to lower extremity arteriosclerosis obliterans often responds poorly to analgesics, and the pain-generating mechanisms are not well understood.
Methods : Eight patients with rest pain in the lower extremity due to arteriosclerosis obliterans were given sub-dissociative doses of 0.15, 0.30, or 0.45 mg/kg racemic ketamine and morphine 10 mg as a 5-min infusion on four separate days in a cross-over, double-blind, randomised protocol. Plasma levels of (S)- and (R)-ketamine and their nor-metabolites were analysed with an enantioselective high-performance liquid chromatography (HPLC) method. Pain levels were evaluated with a visual analogue scale (VAS).
Results : Individual pain levels were highly variable during and after all the infusions but the pooled pain levels showed a dose-dependent analgesic effect of ketamine with a transient but complete pain relief in all patients at the highest dose (0.45 mg/ kg). Side-effects, mainly disturbed cognition and perception, were pronounced and dose-dependent. Morphine 10 mg had an analgesic peak at 20 min and 5/8 patients had complete pain relief. The remaining 3 patients also had high baseline pain scores, indicating a higher analgesic potency for the 0.30 and 0.45 mg/ kg ketamine doses than for morphine 10 mg.
Conclusion : We have demonstrated a potent dose-dependent analgesic effect of racemic ketamine in clinical ischemic pain. Due to a narrow therapeutic window, this analgesic effect is probably best utilised in combination with other analgesics.     

Intravenous endotoxin does not increase tissue extravasation of albumin in rats

Background : It is unclear whether activation of the inducible nitric oxide synthase (iNOS) increases or decreases the extravasation of plasma.
Methods : Chloralose anaesthetised male Wistar rats received E. coli lipopolysacharide (LPS), 3 mg kg^-1 i.v., or the corresponding volume of saline, 3 or 5 h before the end of the experiment. Mean arterial pressure (MAP) and heart rate (HR) were recorded. Tissue clearance of radio-labelled albumin, during the last 2 h of each experiment, was determined by a double-isotope method. In separate animals, the serum concentration of nitrite and nitrate was determined, 5 h after LPS or the solvent.
Main Results : LPS initially decreased MAP and lastingly increased HR. In the 3-h LPS animals (n=8), tissue plasma clearance was lower in the heart and calf muscle and increased only in diaphragm, compared to corresponding control animals (n=8). In the 5-h LPS rats, clearance was lowered (n=8) in the entire gastrointestinal tract and in testes, compared to controls (n=8). The serum nitrite/nitrate concentration was higher in animals given LPS (n=6) than in controls (n=6).
Conclusion : After LPS, tissue clearance of albumin was not increased in any major tissue, in spite of increased serum levels of NO end products. Apparently, after activation of iNOS, the augmented release of NO is not necessarily associated with increased albumin extravasation.     

Adrenaline markedly improves thoracic epidural analgesia produced by a low-dose infusion of bupivacaine, fentanyl and adrenaline after major surgery: A randomised, double-blind, cross-over study with and without adrenaline

Background: Basic pharmacological research indicates that there are synergistic antinociceptive effects at the spinal cord level between adrenaline, fentanyl and bupivacaine. Our clinical experience with such a mixture in a thoracic epidural infusion after major surgery confirms this. The objectives of the present study were to evaluate the effects on postoperative pain intensity, pain relief and side effects when removing adrenaline from this triple epidural mixture. Methods: A prospective, randomised, double-blind, cross-over study was carried out in 24 patients after major thoracic or abdominal surgery. Patients with only mild pain when coughing during a titrated thoracic epidural infusion of about 10 ml · h^?1 of bupivacaine 1 mg · ml^?1, fentanyl 2 μg · ml^?1, and adrenaline 2 μg · ml^?1 were included. On the 1^st and 2^nd postoperative days each patient was given a double-blind epidural infusion, at the same rate, with or without adrenaline. The effect was observed for 4 h or until pain when coughing became unacceptable in spite of a rescue analgesic procedure. Rescue analgesia consisted of up to two epidural bolus injections per hour and i.v. morphine if necessary. All patients received rectal paracetamol 1 g, every 8 h. Fentanyl serum concentrations were measured with a radioimmunoassay technique at the start and end of each study period. Main outcome measures were extent of sensory blockade and pain intensity at rest and when coughing, evaluated by a visual analogue scale, a verbal categorical rating scale, the Prince Henry Hospital pain score, and an overall quality of pain relief score. Results: The number of hypaesthetic dermatomal segments decreased (P <0.001) and pain intensity at rest and when coughing increased (P <0.001) when adrenaline was omitted from the triple epidural mixture. This change started within the first hour after removing adrenaline. After 3 h pain intensity when coughing had increased to unacceptable levels in spite of rescue analgesia (epidural bolus injections and i.v. morphine). Within 15–20 min after restarting the triple epidural mixture with adrenaline, pain intensity was again reduced to mild pain when coughing. Serum concentration of fentanyl doubled from 0.22 to 0.45 ng · ml^?1 (P <0.01), and there was more sedation during the period without adrenaline. Conclusions: Adrenaline increases sensory block and improves the pain-relieving effect of a mixture of bupivacaine and fentanyl infused epidurally at a thoracic level after major thoracic or abdominal surgery. Serum fentanyl concentrations doubled and sedation increased when adrenaline was removed from the epidural infusion, indicating more rapid vascular absorption and systemic effects of fentanyl.     

The multiply injured child

Blunt trauma is the principal cause of childhood death in many developed countries. This review outlines the differences between adults and children with respect to resuscitation and treatment of orthopaedic injuries in a child with polytrauma. Recent advances in techniques of fracture stabilization are reported.     

Utilisation des médicaments prokinétiques en réanimation : indications et limites ?

Enteral feeding is often limited by gastric and intestinal motility disturbances in critically ill patients, particularly in patients with shock. So, promotility agents are frequently used to improve tolerance to enteral nutrition. This review summaries the pathophysiology, presents the available pharmacological strategies, the clinical data, the counter-indications and the principal limits. The clinical data are poor. No study demonstrates a positive effect on clinical outcomes. Metoclopramide and erythromycin seems to be the more effective. Considering the risk of antibiotic resistance, the first line use of erythromycin should be avoided in favor of metoclopramide.     

Anesthésie générale chez l’enfant : quid des pratiques en 2010 ?

Introduction

The practice of pediatric anesthesia requires a regular update of scientific knowledge and technical skills. To provide the most adequate Continuing Medical Education programs, it is necessary to assess the practices of pediatric anesthesiologists. Thus, the objective of this survey was to draw a picture of the current clinical practices of general anesthesia in children, in France.

Material and methods

One thousand one hundred and fifty questionnaires were given to anesthesiologists involved in pediatric cases. These questionnaires collected information on various aspects of clinical practice relative to induction, maintenance, recovery from general anaesthesia and also classical debated points such as children with Upper Respiratory Infection (URI), emergence agitation, epileptoid signs or anaesthetic management of adenoidectomy. Differences in practices between CHG (general hospital), CHU (teaching hospital), LIBERAL (private) and PSPH (semi-private) hospitals were investigated.

Results

There were 1025 questionnaires completed. Fifty-five percent of responders worked in public hospitals (CHG and CHU); 77% had a practice that was 25% or less of pediatric cases. In children from 3 to 10 years: 72% of respondents used always premedication and two thirds performed inhalation induction in more than 50% of cases. For induction, 53% used sevoflurane (SEVO) at 7 or 8%. Respondents from LIBERAL used higher SEVO concentrations. Tracheal intubation was performed with SEVO alone (37%), SEVO and propofol (55%) and SEVO with myorelaxant (8%), 93% of respondents used a bolus of opioid. For maintenance, the majority of respondents used SEVO associated with sufentanil; desflurane and remifentanil were more frequently used in CHU. Two thirds of respondents used N₂O. Depth of anesthesia was commonly assessed by hemodynamic changes (52%), end tidal concentration of halogenated (38%) or automated devices based on EEG (7%). In children with URI, 98% of respondents used SEVO for anesthesia. To control the airway 42% used a tracheal tube, 30% a laryngeal mask and 20% a facial mask. Emergence agitation was an important concern for two thirds of respondents, while epileptoid signs were considered as important by only 20%. Eighty-nine percent of respondents practiced anesthesia for adenoidectomy. Anesthesia was induced by inhalation of SEVO 7–8% (41%), 6% (39%) or 4% (12%), 66% put an intravenous line (less frequently in LIBERAL). 67% of the responders managed adenoidectomy without any device to control the airway (more frequently in LIBERAL), 32% administrated a bolus of opioid (less frequently in LIBERAL).

Discussion

This survey demonstrated that the practices regarding general anesthesia in children are relatively homogenous. Most of the differences appeared between LIBERAL and the others structures; the anaesthetic management for adenoidectomy illustrates these findings.