原发性膀胱印戒细胞癌1例报告并文献复习

目的：探讨原发性膀胱印戒细胞癌的临床特征。方法：报告1例原发性膀胱印戒细胞癌患者的临床资料。患者因间歇性肉眼血尿就诊,术前检查未找到任何膀胱外病灶,行膀胱全切除术＋输尿管造瘘术。结果：术后病检报告为膀胱印戒细胞癌。患者术后转肿瘤科化疗,目前正在随访中。结论：原发性膀胱SRCC非常罕见,进展快、恶性程度高,局部浸润性生长,有早期扩散转移倾向,预后差。其确诊主要依靠病理组织学检查。     

原发性前列腺印戒细胞癌(附二例报告及文献复习)

目的：探讨原发性前列腺印戒细胞癌的临床特点。方法：分析2例原发性前列腺印戒细胞癌患者的临床资料，结合文献得以讨论。结果：2例患者年龄分别为64岁和73岁，临床表现为排尿困难、膀胱刺激症及会阴不适。组织学：印戒状癌细胞呈圆形，胞质丰富透明，胞核呈新月状位于细胞一侧，核分裂像多见。免疫组化染色PCA（ ）、PAP( )、AR( )、低分子CK( )，CEA（-）、AB/PAS（-）。1例D期患者行双侧睾丸切除及氟他胺治疗，术后6个月死于广泛转移；1例B2期患者行根治性前列腺切除、双侧睾丸切除、内分泌和局部放射治疗，随访25个月未见复发和转移。结论：原发性前列腺印戒细胞癌是一种罕见、高度恶性的肿瘤，确诊需依赖组织病理学及免疫组织化学检查。     

原发性前列腺印戒细胞癌三例报告

20 0 0年 11月至 2 0 0 1年 8月 ,我院收治原发性前列腺印戒细胞癌患者 3例 ,报告如下。临床资料　本组 3例 ,年龄 6 2～ 72岁 ,平均 6 5岁。排尿困难 3例 ,其中 2例因尿潴留入院。直肠指诊前列腺质硬2例 ,其中 1例质坚如石 ,触及结节 1例。1例尿流率测定 :ＭＦＲ 2 .5ｍｌ/ｓ     

原发性前列腺印戒细胞癌诊疗分析

目的 提高对原发性前列腺印戒细胞癌临床特点的认识和诊治水平. 方法 原发性前列腺印戒细胞癌患者23例.年龄57～90岁,平均74岁.有排尿症状者18例,体检偶然发现PSA升高者5例.实验室检查PSA平均45.3(7.4～126.8)ng/ml.MRI多示外周带有异常区呈T1w低信号、T2W高信号,增强后明显强化,中央带见增生结节,呈混杂信号.其中行前列腺癌根治术7例,2例切缘阳性者术后辅以全雄激素阻断治疗及体外放射治疗,16例行全雄激素阻断治疗,其中11例因存在下尿路梗阻而行前列腺绿激光汽化术,3例行体外放射治疗.23例均行消化道内镜或钡餐检查排除转移性印戒细胞癌. 结果 23例均经病理证实为印戒细胞癌,其中纯印戒细胞癌6例,混有典型前列腺癌成分17例,其中典型癌成分均为Gleason评分7～10分的高级别低分化前列腺癌.免疫标记PSA、前列腺酸性磷酸酶均为阳性,AB/PAS阴性,CEA阴性21例.TNM临床分期Ⅱ期7例,Ⅲ期10例,Ⅳ期6例.20例平均随访24(6～56)个月,8例生存6～42个月后因肿瘤转移死亡,5例12～21个月后出现生化复发,失访3例. 结论 原发性前列腺印戒细胞癌侵袭性强、转移快且累及前列腺外各种脏器、复发早,早期诊断及综合治疗或能提高远期生存率.     

膀胱原发性印戒细胞癌伴发前列腺腺癌1例报告及文献复习

目的:探讨膀胱原发性印戒细胞癌(primary signet ring cell carcinoma of the bladder.PSRCC)伴前列腺癌的临床特征及诊治方法。方法:总结1例膀胱PSRCC伴前列腺癌患者的资料,检索Pubmed、CBM数据库相关文献并复习。结果:膀胱镜检病理示膀胱印戒细胞癌。血PS A:12.73 ng/ml,FPSA:0.737 ng/ml,FPSA/PSA:0.06。前列腺穿刺活检示前列腺腺癌,Gleason评分3+3。行经尿道膀胱肿瘤切除术(TURBT)术和最大限度雄激素阻断治疗,术后1 6个月膀胱癌复发。结论:膀胱PSRCC临床少见,浸润性强,进展快,诊断主要依靠病理和免疫组织化学检查,对于膀胱PSRCC伴发前列腺癌首选根治性膀胱前列腺切除术治疗,预后差。     

原发性膀胱印戒细胞癌1例报告

<正>1病例资料患者男,53岁。因肉眼血尿2月余入院。既往无家族遗传病史,无肝炎、结核病、高血压、糖尿病、心脏病史。体检:下腹部可触及大小约5cm×5cm包块,质硬,无活动度,双肾区有压痛。辅助检查:尿常规示血尿,癌胚抗原85.62μg/L,前列腺特异抗原(prostate-specific antigen,PSA)0.9μg/L。B超示:盆腔内探及15cm×7cm×9cm非均质低回声肿块,突向膀胱内,边界不清,回声不均,肿块外侧向腹壁突起,分界不     

脐尿管印戒细胞癌1例报告

脐尿管印戒细胞癌（urachal signet ring cell carcinoma,USRCC）是一种罕见的恶性肿瘤。2009年8月海南省农垦总医院收治1例,报告如下。     

胃低分化腺癌合并印戒细胞癌睾丸转移1例报告并文献复习

目的:探讨我院1例罕见胃印戒细胞癌睾丸转移的临床病理特点,免疫组织化学在睾丸转移瘤与原发肿瘤鉴别诊断中的应用。方法:回顾分析了我院收治1例睾丸肿瘤患者,1年前曾行胃贲门癌根治性全胃切除术,术后病理报告提示低分化印戒细胞癌,术后未予以放化疗,此次外院睾丸穿刺活检病理报告为低分化腺癌浸润或转移,考虑患者的病情及预后,行患侧根治性睾丸切除术。结果:术中见睾丸略增大,约4cm×3cm×2cm,质地硬,颜色呈淡红色,附睾大小、质地无异常。术后病理证实胃低分化腺癌合并印戒细胞癌转移。随访半年,临床症状好转。结论:胃印戒细胞癌睾丸转移非常罕见,特定的免疫组织化学指标可以有助于诊断。     

原发性肺印戒细胞癌1例

正患者男,50岁,因"咳嗽、咳痰伴痰中带血1月余"入院;既往吸烟24余年。查体未见明显异常。实验室检查:神经元特异性烯醇化酶(neuron-specific enolase, NSE)35.04 ng/ml,细胞角蛋白19片段(cytokeratin-19-fragment, CY211)9.45 ng/ml,胃泌素释放肽前体(progastrin-releasing peptide, proGRP) 19.50 pg/ml。CT:右肺中     

Primary signet ring cell carcinoma of the prostate: Report and review of 42 cases

We report a case of primary signet ring cell carcinoma of the prostate in a 75-year-old man. Serum prostate specific antigen (PSA) level at presentation was 9.3 ng/mL. The tumor was confined within the right prostate lobe and the patient was treated with neoadjuvant hormonal therapy and radical prostatectomy. He was alive with no evidence of disease 12 months after surgery. None of the tumor was stained with periodic acid-Schiff and Alcian blue. Immunohistochemically, the tumor was positive for PSA and prostatic acid phosphatase and negative for carcinoembryonic antigen. We reviewed 41 previously reported cases of signet ring cell carcinoma of the prostate, examining both histopathological and clinical information.     

Primary signet ring cell carcinoma of female urethra

A 69-year-old woman presented with difficulty in urination and bloody fluid discharge from the urethra. Based upon a diagnosis of primary urethral carcinoma, she underwent total cysto-urethrectomy and hysterectomy with pelvic lymph node dissection and urinary diversion of ileal conduit. Microscopically, the tumor was composed of mucinous adenocarcinoma and signet ring cell carcinoma. There was no recurrence 17 months after the surgery.     

Urachal signet ring cell carcinoma

Urachal adenocarcinoma is a rare neoplasm associated with poor prognosis. We report a case of urachal signet ring cell carcinoma in a 65-year-old man. He was admitted with a chief complaint of microscopic hematuria. Cystoscopic examination and transurethral biopsy showed an urachal tumor. After undergoing radical cystectomy and intravenous chemotherapy, the patient developed bilateral hydronephroses as a result of bilateral ureteral metastases and bowel obstraction because of the Para-aortic lymphnode metastasis. He has been alive for 5 years after three courses of chemotherapy and a bypass operation.     

Clinicopathological characteristics of signet ring cell carcinoma of the stomach

BACKGROUND: Signet ring cell (SRC) carcinoma of the stomach is characterized by its poor prognosis and potential to infiltrate the wall of stomach, although survival studies comparing carcinomas with and without SRC features have yielded inconsistent results. This study compared the clinicopathological features and prognosis of patients with SRC carcinoma with those with non-signet ring cell carcinoma of the stomach (NSRC). METHODS: We reviewed the records of 2358 patients diagnosed with gastric carcinoma who were treated surgically between January 1980 and December 1999 at the Department of Surgery, Chonnam National University Hospital. There were 204 patients (8.7%) with SRC carcinoma as compared to 2154 with NSRC. RESULTS: Significant differences were noted in the mean patient age, mean tumour size, depth of invasion, prevalence of hepatic and regional lymph node metastases, tumour stage, and curability between the patients with SRC histology and NSRC. There were no statistically significant differences in patient gender, location, or peritoneal dissemination between patients with SRC carcinoma and NSRC. SRC carcinoma of the stomach had a higher prevalence of early gastric carcinoma (46.1%) than NSRC (21.7%). The overall 5-year survival of all the patients with SRC carcinoma was 60.2% as compared with 48.9% for the patients with NSRC (P < 0.01). Using Cox proportional hazards model, lymph node metastasis and curability were significant factors affecting the outcome. Signet ring cell histology itself was not an independent prognostic factor. CONCLUSIONS: Patients with SRC histology do not have a worse prognosis than patients with other types of gastric carcinoma.     

Prostate mucinous adenocarcinoma with signet ring cell

Prostate mucinous adenocarcinoma with signet ring cell is a rare neoplasm with only 11 cases reported to date. We present the 12th case of prostate mucinous adenocarcinoma with signet ring cell. The case was detected incidentally as a result of a biopsy taken from a lesion in the prostatic urethra during a urethrocystoscopy of a 47-year-old male patient who underwent an internal urethrotomy operation due to urethrostenosis. Endoscopic examination showed a loose, spongy, gray-white structure covering the prostatic urethra, especially the right lobe of the prostate. The diagnosis resulting from the pathological examination of the biopsy was prostate mucinous adenocarcinoma with signet ring cell. A total of 50 Gy radiotherapy was applied to the patient. In the 27th month of follow-up after treatment, thoracoabdominal computed tomography, bone scintigraphy, and tumor markers (PSA, CEA and CA19-9) were found to be normal.     

前列腺原发移行细胞癌（附1例报告）

目的 提高对前列腺原发移行细胞癌的认识，探讨其诊治方法。方法 通过诊治1例原发前列腺移行细胞癌（PTCC）患者，并复习相关国内外文献进行讨论。结果 患者行根治性前列腺膀胱切除术，病理证实为PTCC，免疫组化染色：S100阴性（-），CK阳性（＋＋＋），P53阳性（＋＋＋），PSA阴性（-），术后随访至今无瘤存活。结论 原发PTCC比较少见，其临床表现无特异性，确诊依靠病理学检查，其恶性程度高，对激素治疗不敏感。早期发现并手术，术后联合放疗有望提高疗效。     

进展期胃印戒细胞癌患者的临床病理特点与预后

目的研究进展期胃印戒细胞癌患者的临床病理特点及预后.方法对571例进展期胃癌患者的临床病理特点及术后5年生存率进行回顾性分析.结果进展期胃印戒细胞癌75例,多见于中老年女性（70.0%）,胃中部多发（46.7%）.肿瘤大小、淋巴结转移、肝脏转移、腹膜转移等方面与进展期胃非印戒细胞癌相比差异无统计学意义（P＞0.05）;大体分型以BorrmannⅢ型、Ⅳ型多见（P＜0.01）,且浸润深度T3、T4比胃非印戒细胞癌多见（P＜0.01）;行根治性手术后5年生存率为44%,与其他类型进展期胃癌根治性手术后5年生存率相比差异无统计学意义（P＞0.05）.结论进展期胃印戒细胞癌与其他组织学类型的胃癌相比恶性程度无差异.     

乳腺印戒细胞癌17例临床分析

目的 探讨乳腺印戒细胞癌的临床及病理特征.方法 对17例乳腺印戒细胞癌(signet ring cell carcinoma,SRCC)患者的临床及病理资料进行回顾性分析.结果 乳腺SRCC约占同期乳腺癌患者的2％ ～4.5％.10例患者就诊时伴淋巴结转移(58.8％),雌激素受体、孕激素受体阳性率分别为71.4％ (10/14)、64.9％ (9/14).7例患者于随访8个月～11年出现复发或转移,中位随访时间为40.5个月,3例患者入院时已伴远处转移.9例出现复发或转移的患者中,8例患者出现骨转移(88.9％),其中椎体转移6例(66.7％).乳腺SRCC患者治疗方式与同期乳腺癌相同,16例患者行手术治疗,14例患者同时接受化疗.其3年、5年无病生存率分别为53.0％(7/17)、23.0％(5/17).平均随访53个月,死亡率为41.2％ (7/17).结论 乳腺印戒细胞癌侵袭性强,受体阳性率高,且治疗后易出现复发转移,预后差.