Developing an enhanced recovery after surgery program for oncology patients who undergo hip or knee reconstruction surgery

Enhanced recovery after surgery(ERAS) protocols are applied in orthopedic surgery and are intended to reduce perioperative stress by implementing combined evidence-based practices with the cooperation of various health professionals as an interdisciplinary team. ERAS pathways include pre-operative patient counselling, regional anesthesia and analgesia techniques, post-operative pain management, early mobilization and early feeding. Studies have shown improvement in the recovery of patients who followed an ERAS program after hip or knee arthroplasty, compared with those who followed a traditional care approach. ERAS protocols reduce post-operative stress, contribute to rapid recovery, shorten length of stay(LOS) without increasing the complications or readmissions, improve patient satisfaction and decrease the hospital costs. We suggest that the ERAS pathway could reduce the LOS in hospital for patients undergoing total hip replacement or total knee replacement. These programs require good organization and handling by the multidisciplinary team. ERAS programs increase patient's satisfaction due to their active participation which they experience as personalized treatment. The aim of the study was to develop an ERAS protocol for oncology patients who undergo bone reconstruction surgeries using massive endoprosthesis, with a view to improving the surgical outcomes.     

Total knee arthroplasty in patients with prior ipsilateral hip fusion.

Sixteen total knee arthroplasties performed between 1977 and 1985 in 13 patients with prior ipsilateral hip arthrodesis or ankylosis were studied to determine the preferred sequence and long-term follow-up of procedures in this clinical setting. Twelve of 16 underwent fusion takedown and total hip arthroplasty prior to knee replacement. The average age at total knee arthroplasty was 52.7 years and the average time from hip fusion to total knee arthroplasty was 36.3 years. Mean follow-up after total knee arthroplasty was 5.5 years (range, 2.3 to 10 years). The Hospital for Special Surgery knee score increased from a mean of 31.8 preoperatively to 72.2 after surgery. In patients who had conversion of the hip fusion prior to knee replacement, knee scores were 28 before and 72.5 after both procedures. Patients who retained their hip fusion had mean scores of 43.5 and 72.1, respectively. None of the knees has been removed and 14 of 16 had no pain at last follow-up. One had mild pain and one had moderate pain attributed to pes anserine bursitis. Although the numbers are small, this experience reveals that takedown of the fusion with total hip arthroplasty is an effective technique before performing the knee replacement. Though successful in some instances, the experience is too small to show that if hip fusion is in good position, knee replacement without fusion takedown is acceptable.     

Acute Postoperative Herpes Zoster With a Sciatic Nerve Distribution After Total Joint Arthroplasty of the Ipsilateral Hip and Contralateral Knee

The differential diagnosis of a patient with acute onset of hip pain during the postoperative recovery period after total hip arthroplasty includes sciatic nerve injury, infection, incisional pain, hardware, or simply muscular issues related to overactivity. Moreover, because the rash of herpes zoster develops after 4 or 5 days of pain, it is difficult to diagnose herpes zoster during the early period. A number of reports have been issued on herpes zoster after surgery or trauma, but no report is available on herpes zoster development with a sciatic nerve distribution after ipsilateral total hip arthroplasty. The authors report the case of 75-year-old woman with herpes zoster with a sciatic nerve distribution after 2 primary total joint arthroplasties of a hip and knee.     

The influence of bariatric surgery on hip and knee joint pain: a systematic review

Obesity increases the risk of osteoarthritis and the chance of needing joint replacement arthroplasty to reduce lower limb joint pain. Although nonsurgical weight loss interventions can reduce hip and knee joint pain, bariatric surgery may be a more feasible treatment option for people with severe obesity. However, it is unclear whether weight loss through bariatric surgery can positively influence hip and knee joint pain. Our objective was to evaluate the influence of bariatric surgery on hip and knee joint pain in people with obesity by conducting a systematic review of the literature. The PubMed, EMBASE, and Cochrane bibliographic databases were searched for studies published between 1947 and September 2019. Risk of bias of the identified studies was independently assessed by 2 reviewers using JBI’s Critical Appraisal Checklist for Case Series and the Newcastle-Ottawa Scale. This review included 23 studies, all of which evaluated knee pain and 9 of which also evaluated hip pain. Reported results regarding hip pain intensity and the proportion of participants with hip pain were too limited to draw useful conclusions. Reported results regarding knee pain suggest that weight loss after bariatric surgery reduced knee pain intensity, as well as the proportion of participants with knee pain. The overall risk of bias of the majority of included studies (83%; n = 19) was judged to be unclear to high. Four small studies were judged as having a low risk of bias. Results of this systematic review suggest that bariatric surgery can positively influence hip and knee joint pain, but conclusive evidence is lacking because most of the included studies were judged as having plausible bias overall and in their key domains. Well-designed randomized controlled trials evaluating the influence of bariatric surgery on hip and knee joint pain using standardized joint pain measures are needed.     

Postoperative blood salvage using the Cell Saver after total joint arthroplasty

The purpose of this study was to investigate whether the salvage in the recovery room of blood from the drainage tubes of patients who had total joint arthroplasty was both feasible and efficacious. The cases of seventy-four patients who had seventy-six consecutive total hip or knee arthroplasties were studied prospectively. Intraoperative salvage of blood was performed using the Cell Saver. After closure of the fascial layer or joint capsule, the drainage tubes were connected to the Cell Saver in the operating room and remained connected in the recovery room for a mean of 2.9 hours. Blood that was collected in the recovery room was then processed and transfused back to the patient. The average amount of blood that was salvaged after different types of arthroplasty varied. The addition of bone cement to the acetabular side during primary total hip replacement decreased the amount of postoperative bleeding and of salvaged blood (p = 0.018), whereas cementing the femoral component had no statistically significant effect. Revision total hip replacement also resulted in more bleeding and in the collection of more blood in the recovery room than did primary total hip replacement (p = 0.03), especially if cement was not used (p less than 0.001). There were no statistical differences in the amount of blood that was collected in the recovery room after unilateral, bilateral, primary, or revision total knee replacement.(ABSTRACT TRUNCATED AT 250 WORDS)     

80岁以上高龄患者人工关节置换手术的疗效和并发症研究

目的研究80岁以上高龄患者人工关节置换手术治疗的疗效以及并发症的发生情况。方法对80岁以上高龄患者行人工关节置换手术,21例为全髋关节置换,18例为全膝关节置换。研究两组患者人工关节置换手术的疗效以及并发症的发生情况。结果全髋关节置换手术的生化指标TP、ALB降低;指标在治疗前后的差异均具有统计学意义(P<0.05)。全膝关节置换手术前后的TP、ALB差别不大,差异无统计学意义(P>0.05)。GLB增高、A/G减小,差异具有统计学意义(P<0.05)。BMD和CRP在术前和出院时变化不大(P>0.05)。疼痛、功能、下肢畸形于人工全髋关节置换术前,术后1、6个月评分逐渐增加,总差异具有统计学意义(P<0.05)。疼痛、关节功能、活动度、肌力状态、屈膝畸形、稳定性于人工全膝关节置换术前,术后1、6个月评分逐渐增加,总差异具有统计学意义(P<0.05)。并发症:全髋关节置换术切口皮肤坏死1例;全膝关节置换术深静脉栓塞1例;假体周围骨折2例;无死亡病例。结论 80岁以上人工关节置换手术在严格掌握适应证的情况下可以有效地避免术后并发症发生。     

Do pain referral patterns determine patient outcome after total hip arthroplasty?

Quality of life outcome and patient satisfaction after total hip arthroplasty are complex phenomena and many confounding determinants have been identified. Degenerative disease of the hip joint may present with variable patterns of pain referral in the lower limb. However the effect of varied preoperative pain referral patterns on patient outcome and satisfaction after total hip arthroplasty has not previously been examined. From 2000 to 2003, 236 eligible patients scheduled to undergo primary total hip arthroplasty were prospectively enrolled. The principal pain referral pattern (as hip, thigh or knee) was identified in all patients. Health related quality of life (HRQOL) was examined using the Harris Hip score (HHS), the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) and the 36-Item Short-Form Health Survey (SF-36) pre-operatively, 1 year and 2 years postoperatively and with the HHS at 3 months postoperatively. All patients were followed up for a minimum of 2 years. The frequency of the pain referral distributions were; hip pain 41%, knee pain 32% and thigh pain 27%. Patients in all groups were comparable preoperatively with respect to age, HHS, and both mean and domain specific WOMAC and SF-36 scores. The mean duration of symptoms was significantly greater in patients with knee pain when compared to the remaining two pain patterns. All patients demonstrated improvements in HHS, SF-36 and WOMAC scores after surgery. At all times postoperatively there were significant differences in mean HHS and mean and domain specific WOMAC and SF-36 scores between patients with hip or thigh pain and those with knee pain (p < 0.001). While notable, differences between hip and thigh pain were not as consistent however. Based on these findings, it appears that pre-operative pain referral patterns of hip arthritis are among the determinant factors for patient outcome and satisfaction after total hip arthroplasty, as measured using validated HRQOL scoring systems.     

髋膝关节置换术前预测深静脉血栓形成的多因素分析

[目的]通过对髋、膝关节置换术前患者的相关危险因素的分析,个体化预测其术后下肢深静脉血栓形成(deepveinthrombosis,DVT)的可能性.[方法]2006年4月～2011年11月共309例(髋关节病变113人、膝关节病变196人)接受髋、膝关节置换术的无DVT的患者被纳入研究.所有患者在围术期均接受正规的物理及药物预防血栓治疗.术后第3～10d根据患者病情复查双下肢深静脉彩超了解是否形成血栓.最后,通过术后DVT组与非DVT组的各种术前危险因素的对比分析,提出术前预测术后DVT的公式.[结果]309名患者中术后发生DVT者82例,其中髋关节12例,膝关节70例;单关节置换术后38例,双关节同时置换术后44例.通过判别分析,发现年龄、谷草转氨酶、肌酐、一次手术关节数量、凝血酶原时间和D-二聚体定量与髋、膝关节置换术后DVT的相关性较强,并得出函数预测公式.所有患者平均随访3.5年(4～71个月),均未发生症状性肺栓塞,也未发生明确的肝素类药物副作用.[结论]即使在围术期正规抗凝治疗的前提下,髋、膝关节置换术后DVT的发生率仍然较高.术前如开展个体化预测,能提示对高危人群给予更积极、合理的干预,从而减少术后DVT相关的并发症.     

Determining patient concerns before joint arthroplasty

Despite the prevalence of studies relating to hip and knee arthroplasties, no Canadian studies exist in the literature regarding patients' perceptions and concerns prior to undergoing these procedures. A 32-question, 5-point Likert scale questionnaire was developed and administered to a Canadian cohort. One hundred fifty-six knee and 85 hip arthroplasty patients returned the survey. Results consistently showed complications arising from surgery, ways to reduce pain after surgery, and ability to walk properly again as the 3 top concerns for patients whether stratified by age, sex, residential status or joint replacement type. Other results discussed include resources used by patients to become better informed about joint arthroplasty, differences in Western Ontario and McMaster Universities Index of Osteoarthritis scores between groups, and significant differences in patient concerns as determined by ridit analyses.     

Experimental studies of bone remodeling in total hip arthroplasty.

Experimental studies of bone remodeling after total hip arthroplasty are reviewed. Most of the studies have been motivated by the introduction of cementless hip replacements in which porous coatings are used to provide fixation by bone ingrowth. Stress shielding is thought to be the main factor responsible for bone loss after hip replacement. Experimentally, design features related to (1) the nature of the bone-implant interface and (2) stem stiffness have been tested to determine if the effects of stress shielding can be decreased. The dominant long-term design feature controlling bone remodeling in hip replacement appears to be stem stiffness.     

Athletic activity after total joint arthroplasty

Demand for total joint arthroplasty is projected to increase in the first three decades of the twenty-first century. With increasing frequency, patients who have a hip or knee replacement expect to, and choose to, participate in athletics following rehabilitation. In general, patients who have had a hip or knee replacement decrease their participation in, and intensity of, athletic activity following the total joint arthroplasty. The orthopaedic literature on athletic activity after total joint arthroplasty is limited to small retrospective studies with short-term follow-up. Expert opinion regarding appropriate athletic activity after total joint arthroplasty is available from the Hip Society and the Knee Society. When patients who have undergone joint replacements choose to participate in athletic activity, orthopaedic surgeons should provide information with which to evaluate the risk of sports activity and recommend appropriate athletic activity.     

Total hip and knee arthroplasty in juvenile rheumatoid arthritis

Total hip or knee arthroplasty is indicated in patients with juvenile rheumatoid arthritis when there is marked functional impairment and/or severe disabling pain from advanced structural hip or knee joint involvement. Relief of pain and dramatic improvement in function can be achieved in most patients. When both the hip and knee are involved, hip arthroplasty should probably be done first. Regional anesthesia is preferable. Careful preoperative planning is essential because custom prostheses are often required. Small bone size, osteoporosis, and soft-tissue contractures make the surgery technically demanding. Skeletal immaturity is not an absolute contraindication to surgery. Component loosening is the most frequent late complication in hip arthroplasty. It is less common in condylar metal-to-plastic knee arthroplasty in which patellar complications predominate. Cementless arthroplasty has an evolving role in the patient with juvenile rheumatoid arthritis and, to date, is more often used in the hip than in the knee.     

Total joint arthroplasty for steroid-induced osteonecrosis in cardiac transplant patients

Ten cardiac transplant patients have had bilateral total hip or knee surgery for treatment of osteonecrosis secondary to corticosteroid immunosuppression. Nine had bilateral total hip arthroplasty and one had bilateral total knee arthroplasty for osteonecrosis of the tibial plateaus. The only immediate postoperative complication was in a single hip patient who had a nonfatal pulmonary embolism. Two patients died from cardiovascular causes; the remaining eight had excellent results from arthroplasty, with an average Harris hip rating of 95 at a mean follow-up period of 34 months. No patient had required revision surgery and radiographic follow-up examination has revealed no evidence of loosening of any of these cemented arthroplasties. One patient developed a late hematogeneous sepsis of one hip seven years after replacement from atypical mycobacterium three months following renal transplantation, which was done 11 years after cardiac transplantation. Total joint arthroplasty has resulted in excellent clinical and radiologic results in this patient population. Despite the increased risks of major surgery in these immunocompromised transplant recipients, total joint arthroplasty appears to be a safe and effective method of treatment of osteonecrosis of the hip.     

Enhanced recovery after surgery (ERAS) in hip and knee replacement surgery: description of a multidisciplinary program to improve management of the patients undergoing major orthopedic surgery

Enhanced recovery after surgery (ERAS) protocols aim to develop peri-operative multidisciplinary programs to shorten length of hospital stay (LOS) and reduce complications, readmissions and costs for patients undergoing major surgery. The aim of this study is to evaluate the effects of an ERAS pathway for total hip (THR) and knee (TKR) replacement surgery in terms of length of stay, incidence of complications and patient satisfaction. Patients scheduled for hip and knee replacement were included in the study. The main aspects of this program were preoperative education/physical therapy, rational choice of the anesthetic technique, optimization of multimodal analgesia, reduction of incidence of urinary retention and catheterization, active management of risk for blood loss and deep vein thrombosis, and early mobilization of the patients. All patients had 6 months predicted and planned follow-up appointments. Primary outcomes of the study were the mean LOS, readmission and complication rates. Secondary Outcomes were percentage of Knee Injury & Osteoarthritis Outcome Score (KOOS) and Hip disability and Osteoarthritis Outcome Score (HOOS) increase and patient’s satisfaction. We consecutively enrolled 207 patients who underwent total joint arthroplasty, 78 hip and 129 knee joint replacements. The mean length of stay (LOS) for patients of the two groups was 4.3 days for ASA 3-4 patients subjected to TKR and THR, in ASA 1-2 patients 3.6 days for TKR and 3.9 days for THR respectively. Postoperative satisfaction level was higher than 7 (very satisfied) in 94.4% of the cases. All patients were discharged home: 61.8% continued physical therapy in complete autonomy, 23.7% supported by a home-physiotherapist and only 14.5% needed the attendance to a physiotherapy center on a daily basis. The overall incidence of major complications was 3.4%. The implementation of an ERAS program for hip and knee replacement surgery allows early patient’s discharge and a quick return to independency in the daily activities. IV.     

新型冠状病毒肺炎疫情下髋/膝关节置换术互联网+延续管理模式的构建及应用效果分析

目的探讨新型冠状病毒肺炎疫情下髋/膝关节置换术互联网+延续管理模式的构建与应用效果。方法选择疫情爆发后2020年1月20日至1月31日在华西医院骨科行髋/膝关节置换手术的34例病人纳入观察组,采用互联网+延续管理模式;同时将2019年12月1日至12月20日行髋/膝关节置换手术的34例病人纳入对照组,采用传统延续管理模式。出院当天、出院后2周和出院后1个月,采用Harris髋关节功能评分和美国特种外科医院(Hospital for Special Surgery,HSS)膝关节功能评分评价两组病人髋/膝关节恢复情况,华西心晴指数量表(HEI)评价病人情绪障碍程度;记录术后并发症和病人延续护理满意度。结果观察组病人在互联网+延续管理模式下,未出现新型冠状病毒肺炎确诊病例,情绪亦未受疫情影响。出院后2周和1个月,观察组的髋/膝关节功能评分均高于对照组,差异均有统计学意义(P均<0.05)。两组病人均未发生与髋/膝关节置换术相关的并发症。观察组病人延续护理满意度为100%,优于对照组的85.29%,差异有统计学意义(χ~2=5.397,P=0.020)。结论新型冠状病毒肺炎疫情下,髋/膝关节置换术病人采用互联网+延续管理模式,有效避免了新型冠状病毒肺炎交叉感染,促进了关节置换术后关节功能恢复,且病人心理状况未受疫情影响,无相关并发症发生,保障了病人的医疗安全,提高了延续管理满意度。     

Measuring improvement following total hip and knee arthroplasty using patient-based measures of outcome

BACKGROUND: Patient-derived outcome scales have become increasingly important to physicians and clinical researchers for measuring improvement in function after surgery. The goal of the present study was to evaluate the ability of health-status instruments to measure early functional recovery after total hip and total knee arthroplasty. METHODS: Four hundred and six patients undergoing total hip arthroplasty and 266 patients undergoing total knee arthroplasty completed health-status questionnaires preoperatively and six months postoperatively to determine the standardized response mean. In the second phase of the study, a group of patients undergoing knee and hip arthroplasty were evaluated with several instruments before and after surgery to test for postoperative ceiling effects. RESULTS: The standardized response mean at six months was 1.7 for the MODEMS Hip Core, 1.2 for the MODEMS Knee Core, and 1.5 and 1.1 for the Physical Component Summary of the SF-36 for patients managed with hip and knee replacement, respectively. A standardized response mean of 1.0 is generally satisfactory for measuring improvement in orthopaedic surgery. In Phase 2 of the study, the vast majority of patients who had a score of 95 to 100 (that is, a maximum or near-maximum score) on the joint-specific scales generally believed that the hip or knee was normal and could not be better. CONCLUSIONS: The MODEMS, Oxford, and WOMAC scales all demonstrated a ceiling effect following total knee and total hip arthroplasty. These scores likely reflected the patients' perception of the status of the knee or hip rather than an inability to measure their improvement beyond the highest possible score. The Physical Component Summary score of the SF-36 had similar standardized response means when compared with hip and knee-specific instruments, and, therefore, consideration should be given to using this scale without a joint-specific scale for the measurement of improvement following total knee and total hip replacement, as a way to decrease responder burden (that is, the time required to complete the questionnaires).     

Results of total hip and total knee arthroplasties in patients with synovial chondromatosis

This retrospective analysis examines the outcome of total joint arthroplasty for severe arthritis in patients with synovial chondromatosis. All 11 patients treated with total hip arthroplasty (n = 7) or total knee arthroplasty (n = 4) returned for follow-up at a mean of 10.8 years after surgery. Pain and functional scores improved significantly in all patients. Knee range of motion improved in all patients. Synovial chondromatosis recurred in 1 knee (25%) and 1 hip (14%). Total joint arthroplasty is a valuable treatment option for these patients with predictable improvement in pain and function. Knee range of motion is likely to improve but may be less than expected for primary total knee arthroplasty. Patients remain at risk for recurrence.     

Analgesia for total hip and knee arthroplasty: a multimodal pathway featuring peripheral nerve block

Patients undergoing total hip and knee arthroplasty experience substantial and sustained postoperative pain. Inadequate analgesia may impede physical therapy and rehabilitative efforts and delay hospital dismissal. Traditionally, postoperative analgesia after total joint replacement was provided by either intravenous patient-controlled analgesia or epidural analgesia. Each, however, had disadvantages as well as advantages. Peripheral nerve blockade of the lumbosacral plexus has emerged as an alternative analgesic approach. In several studies, unilateral peripheral block provided a quality of analgesia and functional outcomes similar to those of continuous epidural analgesia and superior to those of systemic analgesia, but with fewer side effects because of their opioid-sparing properties. Peripheral nerve block techniques may be the optimal analgesic method following total joint arthroplasty.     

Total hip and total knee arthroplasty in juvenile rheumatoid arthritis

Total hip arthroplasty (THA) or total knee arthroplasty (TKA) is indicated for patients with juvenile rheumatoid arthritis (JRA) when marked joint destruction is present and pain or deformity compromises function despite optimal medical therapy. Relief of pain, reduction of the deformity, and dramatic improvement in functional status and quality of life can be achieved in most patients. Functional impairment and deformity rather than pain are usually the primary indications for THA or TKA. When there is both hip and knee involvement, hip arthroplasty should probably be done first. Regional anesthetic appears to be the anesthetic of choice. Careful preoperative planning and the availability of custom and minisized components are essential. Small bone size, osteoporosis, and severe soft tissue disease make the surgery technically demanding. Skeletal immaturity may not contraindicate surgery if the patient is otherwise bedridden with progressive deformity. In the hip trochanteric osteotomy is often necessary for adequate exposure, with the possible exception being a patient with juvenile ankylosing spondylitis who is subject to heterotopic bone formation. Although complete capsulectomy and psoas tenotomy may be necessary to relieve a hip flexion contracture, a soft tissue release that produces leg lengthening may lead to nerve palsy. In the hip component loosening has been less common in patients with JRA than in other young patients who have undergone THA, but it is still the most frequent cause of failure. In the knee preoperative and postoperative serial casts can aid in the correction of severe flexion contracture. Secondary patellar pain has been the most common cause of late failure. Patellar resurfacing should probably be performed at the time of the original knee arthroplasty in all patients with JRA.     

A Prospective Evaluation of 2 Different Pain Management Protocols for Total Hip Arthroplasty

Pain management after total hip arthroplasty has improved dramatically in the past decade. However, most protocols use opioid medications for pain control. In the current study, 100 patients were prospectively selected to receive a traditional narcotic-based patient-controlled analgesia protocol or a nonnarcotic oral protocol for pain management after primary total hip arthroplasty. Therapy programs were similar for both groups. Postoperatively, patients were followed daily for opioid use, medication adverse effects, pain control, and overall satisfaction. The nonnarcotic oral group showed lower mean pain scores during the first 24 hours after surgery. The satisfaction rate was high in both groups. Both protocols provided adequate pain control after total hip arthroplasty; the nonnarcotic pain management protocol resulted in significantly decreased opioid consumption and fewer adverse effects.