阴茎背神经选择性切断术对阴茎头体感诱发电位的影响

目的 研究阴茎背神经选择性切断术对阴茎头体感诱发电位(GPSEP)的影响.方法 原发性早泄(PPE)患者21例,分别检测手术前及术后1个月、3个月GPSEP的潜伏期和波幅变化.结果 阴茎背神经选择性切断术后患者的GPSEP潜伏期比术前显著延迟(P<0.05),GPSEP振幅也较术前降低,差异具有统计学意义(P<0.05).结论 阴茎背神经选择性切断术可降低PPE患者GPSEP.     

原发性早泄病人阴茎头兴奋性与阴茎背神经局部解剖学关系

目的研究原发性早泄病人阴茎头敏感度与阴茎背神经局部解剖学的关系。方法收集2015年1月至12月在我院泌外二科行阴茎背神经选择性切断术的47例病人,术前阴茎生物震感测定仪检测阴茎头敏感度,对测定结果和手术中游离出阴茎背神经结果进行统计学分析。结果 47例病人手术中发现阴茎背神经数目为6支1例,8支7例,9支7例,10支6例,11支12例,12支5例,13支6例和14支3例。术前病人满意率(32±6)%,性伴侣满意度(25±9)%。术后显效42例,占89.36%,好转4例,占8.51%;无变化者1例,占2.13%。术后病人满意率(85±9)%,性伙伴满意率(82±11)%。阴茎头敏感度最大3.47V,最小1.59V,平均2.63V。术前阴茎头敏感度、阴茎体敏感度均与术中阴茎背神经数目成负相关性,阴茎头与阴茎体敏感度无明显相关性。结论 (1)阴茎生物震感阈值测定法是一种无创、可定量和重复性好的阴茎背神经兴奋性筛选方法;(2)本研究中病人阴茎头敏感度平均值为2.63V,阴茎体敏感度平均值为3.06V;(3)本研究结果提示阴茎头敏感度越高的部位阴茎背神经分布越多,越稠密。     

阴茎背神经选择性切断术提高阴茎感觉阈值的临床分析

目的 观察阴茎背神经选择性分支切断术治疗原发性早泄(PPE)的临床疗效,及在勃起状态下手术前后的阴茎震动感觉阈值变化.方法 对116例PPE实施阴茎背神经选择性切断术,观察手术治疗前后的的平均阴道内射精潜伏期、患者及配偶性交满意度评分.使用生物振动测试仪测定阴茎勃起状态下的振动感觉阈,测定部位为示指、阴茎头、阴茎干的皮肤.结果 116例PPE术后射精潜伏期延长显效为78例,好转27例,总有效率为90.51%,无效1 1例.患者及其配偶的性交满意度评分在术后较术前均显著提高(P<0.01).阴茎勃状态下,PPE手术治疗后的阴茎头、阴茎干振动感觉阈值显著高于术前(P<0.01).结论 阴茎背神经选择性分支切断术治疗PPE的疗效确切.     

阴茎背神经局部解剖学研究及其临床意义

目的:研究正常人阴茎背神经数目、走行和分布及其在阴茎背神经选择性切断术治疗原发性早泄手术中的应用价值。方法:解剖38具成年男性尸体阴茎,显露阴茎背神经,记录阴茎背神经的数目及走行、分布。选择314例原发性早泄患者行阴茎背神经选择性切断术,患者年龄20～45岁,病程1～22年。结果:38具尸体阴茎背神经平行分布于阴茎背侧和两侧面,4具尸体阴茎背神经分支分布到阴茎腹侧面;38具尸体阴茎背神经数目为(3.6±1.2)支,其中7支1例,6支1例,5支6例,4支9例,3支14例,2支7例。314例原发性早泄患者阴茎背神经数目为(7.0±1.9)支:其中5支64例,6支56例,7支52例,8支40例,9支33例,10支28例,11支25例,12支11例,13支5例。手术后阴道内射精潜伏期为(4.31±1.87)min,性生活满意度为(61±17)%,与手术前[(1.24±0.32)min;(23±6)%]相比,差异有显著性(P均<0.01)。结论:阴茎背神经数目异常增多可能是原发性早泄的病理学基础,阴茎背神经选择性切断术治疗原发性早泄安全、有效。     

选择性显微阴茎背神经切断术治疗原发性早泄的临床观察

目的:评价显微镜下选择性阴茎背神经切断术治疗原发性早泄(PPE)的效果。方法:2010年9月至2012年10月,选择原发性早泄78例,行显微镜下选择性阴茎背神经切断术,切除分支5支9例,6支17例,7支15例,8支14例,9支8例,10支6例,11支6例,12支3例。术后随访12月。记录治疗前、治疗后患者阴道内射精潜伏时间(IELT)和性交满意度分值。结果:治疗前后IELT分别为(0.86±0.32)min和(6.65±3.9)min,有显著性差异(P<0.01)。治疗前后患者性交满意度分值分别为(7.32±2.52)分和(12.32±3.76)分,有显著性差异(P<0.01)。治疗前后配偶性交满意度分值分别为(4.46±1.36)分和(12.73±1.45)分,有显著性差异(P<0.01)。结论:显微镜下选择性阴茎背神经切断术治疗原发性早泄安全、有效。     

阴茎背神经切断术治疗原发性早泄

目的探讨阴茎背神经切断术的手术方法和效果。方法选取我院2005～2008年,采用阴茎背神经切断术治疗原发性早泄病例218例,结合国内外资料及本组病例进行回顾性分析。结果本组病例诊断明确,有确定的手术指征,术后1个月开始过性生活,疗效显著167例,好转36例,有效率93．12％,无效15例,性伴侣满意度87％。结论阴茎背神经切断术经临床实践认为,治疗原发性早泄安全有效,是治疗原发性早泄的有效方法。     

阴茎背神经切断术治疗早泄

目的评价阴茎背神经切断术治疗早泄的效果。方法自1997~2006年门诊早泄患者19例行阴茎背神经切断术治疗早泄。局麻下于阴茎背侧距冠状沟0.5~1cm处做2~3cm横切口,切开深筋膜,暴露左右两侧之阴茎背神经,并切除部分神经分支。记录患者手术前后阴道内射精潜伏时间和夫妻双方性交满意度。结果19例患者术前平均阴道内射精潜伏时间和性交满意度分别为(1.01±0.58)min(0.10~1.90min)和(14.89±6.08)%(5%~25%),术后平均射精潜伏期和性交满意度分别为(4.14±2.99)min(0.40~9.10min)和(57.47±28.28)%(10%~87%),手术前后相比P<0.01。19例中15例有效,有效率为78.95%,4例无效,2例出现术后轻度局部疼痛,1周后缓解。结论阴茎背神经切断术是一种治疗早泄的有效方法,适用于治疗年轻且不合并ED的患者。     

选择性阴茎背神经分支切断术治疗原发性早泄

目的:评价选择性阴茎背神经分支切断术治疗原发性早泄(PPE)的安全性和有效性。方法:2003年9月～2006年12月,对483例PPE实施了选择性阴茎背神经分支切断术,患者年龄21～71岁,平均32岁。术中保留两条分支,其余分支均予以切除。切除分支3支者89例,4支者183例,5支者125例,6支者38例,7支者32例,8支者12例,9支者3例,10支者1例。手术后4周开始性生活,随访3～36月。结果:术后所有病例阴茎敏感性均下降,射精潜伏期延长显效352例,好转93例,无效38例,总有效率92.13%。无切口感染,无切口出血,无勃起功能障碍。结论:选择性阴茎背神经切断术致阴茎敏感性下降效果确切,治疗PPE安全、有效。     

阴茎头重建术治疗早期阴茎癌——阴茎部分切除+大腿内侧薄层皮片移植

目的:探讨早期阴茎癌阴茎部分切除术后阴茎头重建、保留性器官功能的最佳方法。方法:2012年1月~2015年6月,采用阴茎部分切除+大腿内侧薄层皮片移植行阴茎头重建术治疗6例早期阴茎癌。随访0.5~3年,平均1.8年。结果:阴茎疲软状态下长度:术前(6.5±1.2)cm,术后(4.5±1.8)cm;勃起后长度:术前(12.8±2.3)cm,术后(9.1±2.1)cm。重建阴茎头感觉恢复迅速,术后3个月100%感觉恢复。术后随访见重建阴茎头皮肤呈淡红色,柔软,1年后接近正常阴茎头皮肤,远期未见皮片萎缩及瘢痕形成。6例术后均能正常勃起,无任何不适,性生活时感觉良好,与术前相似,患者及性伴侣均满意。所有病例未见复发及转移。结论:阴茎部分切除+大腿内侧薄层皮片移植行阴茎头重建治疗早期阴茎癌,具有方法简便、疗效确切及并发症少等优点,是目前早期阴茎癌根治性切除肿瘤,同时又最大限度保留性器官功能的最好方法之一。     

改良式阴茎背神经切断术治疗原发性早泄

目的 探讨改良式阴茎背神经切除术的效果.方法 回顾分析广州、乐清、哈尔滨三家三级医院在2008年7月到2010年5月期间开展的338例该项手术.对术后的疗效,并发症给予客观的评价.结果 对338例原发性早泄患者中的87例经2年以上随访,显效率59.8%.术后射精潜伏期没有明显变化5例,阴茎麻木感2例,勃起功能障碍1例,阴茎血肿1例,切口感染2例.结论 改良式阴茎背神经切断术治疗原发性早泄安全,有效.     

Fate of the retained reservoir after replacement of 3-piece penile prosthesis

PURPOSE: We evaluated patients who underwent surgery for implant malfunction to determine whether retaining the reservoir was associated with an increased risk of erosion or infection. We also reviewed the literature to study possible risk factors for reservoir erosion. MATERIALS AND METHODS: We reviewed the records of 85 patients who underwent 98 procedures for replacement of a malfunctioning 3-piece penile implant. Of these patients 13 underwent 2 replacement procedures. At the time of primary surgery the reservoir was placed in either the retropubic space or extraperitoneally in the lower lateral abdomen if the patient had undergone prior pelvic surgery. During surgery for replacement of the malfunctioning implant the cylinders and pump were removed, and the reservoir of the original 3-piece device was retained. During followup patients were assessed for implant function and the development of any complication such as infection and/or reservoir erosion into the bladder or bowel. RESULTS: Infection developed in 1 patient and implant malfunction occurred in 13 but no patient had erosion of the retained reservoir. All 85 patients had a functioning implant at a mean followup of 50 months (range 12 to 148). Review of the literature suggests that prior pelvic surgery and infection are major risk factors for reservoir erosion. CONCLUSIONS: Retaining the reservoir during replacement of malfunctioning 3-piece implants is not associated with a significant risk of erosion and routine removal is not necessary. Prior pelvic surgery and infection appear to be risk factors for reservoir erosion.     

阴茎转移癌18例临床分析

目的探讨阴茎转移癌的临床特点、诊治方法及预后。方法回顾性分析18例阴茎转移癌患者的临床及随访资料并复习相关文献。18例患者原发肿瘤包括膀胱癌8例,前列腺癌4例,直肠癌2例,结肠癌、肾癌、食管癌和肺癌各1例。其中9例患者接受了阴茎切除+静脉化疗,5例患者仅接受静脉化疗未行阴茎切除术,2例患者仅接受了阴茎局部放疗,1例肾癌患者仅接受了索拉菲尼靶向治疗。结果本组18例患者中,从确诊原发肿瘤至出现阴茎转移时间为1~100月,平均(18.7±1.9)月。从确诊阴茎转移至患者死亡时间为4~23月,平均(10.2±1.7)月。所有18例患者均死于出现阴茎转移2年内。结论阴茎转移癌是一种罕见且预后较差的疾病,即使进行治疗,多数患者仍死于确诊阴茎转移1年内。逆行性静脉途经是发生阴茎转移的主要机制。阴茎切除仅限于缓解局部症状而不应常规应用。     

A pilot phase-II prospective study to test the 'efficacy' and tolerability of a penile-extender device in the treatment of 'short penis'

OBJECTIVE

To assess a commonly marketed brand of penile extender, the Andro‐Penis® (Andromedical, Madrid, Spain), widely used devices which aim to increase penile size, in a phase II single‐arm study powered to detect significant changes in penile size, as despite their widespread use, there is little scientific evidence to support their potential clinical utility in the treatment of patients with inadequate penile dimensions.

PATIENTS AND METHODS

Fifteen patients were required to test the efficacy of the device, assuming an effect size of >0.8. Eligible patients were counselled how to use the penile extender for at least 4 h/day for 6 months. Penile dimensions were measured at baseline and after 1, 3, 6 and 12 months (end of study). The erectile function (EF) domain of the International Index of EF was administered at baseline and at the end of the study. Treatment satisfaction was assessed using an institutional unvalidated five‐item questionnaire.

RESULTS

After 6 months the mean gain in length was significant, meeting the goals of the effect size, at 2.3 and 1.7 cm for the flaccid and stretched penis, respectively. No significant changes in penile girth were detected. The EF domain scores improved significantly at the end of study. Treatment satisfaction scores were consistent with acceptable to good improvement in all items, except for penile girth, where the score was either ‘no change’ or ‘mild improvement’.

CONCLUSIONS

Penile extenders should be regarded as a minimally invasive and effective treatment option to elongate the penile shaft in patients seeking treatment for a short penis.     

阴茎缺损的治疗进展

阴茎为男性的重要外生殖器官,主要具有排尿、排精和性交功能。战伤、创伤、外伤以及某些疾病如阴茎癌均可造成阴茎完全或部分缺损,严重导致尿流改道和丧失性交能力,给患者精神和生活上造成巨大的创伤。因此阴茎缺损的修复日益受到患者和医生的高度重视,理想的治疗应达到具有良好的外形和感觉、通畅的站立排尿、顺利完成性交3个方面的和谐统一。目前阴茎缺损临床治疗主要采用阴茎再植术、阴茎延长术及阴茎再造术;随着移植免疫、组织配型、免疫抑制剂的研究进展,以及动物异体肢体移植的长期存活等令人鼓舞的结果,为人体异体阴茎移植治疗阴茎缺损奠定了坚实的基础;组织工程技术构建阴茎组织绝大部分尚处于实验阶段,如何在临床上将构建的组织与自体组织有效的融合,在重建阴茎外观的基础上,使之发挥持久的功能将是一项值得继续研究的课题。     

Implantation of AMS 700 LGX penile prosthesis preserves penile length without the need for penile lengthening procedures

Implantation of an inflatable penile prosthesis (IPP) is a well-established definitive solution for erectile dysfunction when conservative treatments fail. Penile implants may shorten the penis. The AMS 700 LGX IPP is in common use but reports on its mechanical reliability, medium-term postsurgical patient satisfaction, and mean penile length preservation are lacking. We investigate the mean penile length, mechanical reliability, and patient satisfaction at 6 and 12 months after implantation of the AMS 700 LGX. This prospective study consecutively enrolled men undergoing first-time IPP implant surgery from February 2009 to April 2012. Stretched flaccid penile length, penile length at 50% and 100% of stiffness (P50 and P100) and International Index of Erectile Function (IIEF) and Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) scores, were measured at 6 and 12 months postsurgery. Of 45 patients who underwent AMS 700 LGX implantation (median age 61 years) and completed 6 months’ follow-up, 36 (80%) completed the study. A significant difference in stretched flaccid penile length was seen between 6 and 12 months (P = 0.033). P100 was also significantly increased at 6 and 12 months, with a mean 10% increase (1.3 ± 0.4 cm) from baseline to 12 months. Differences in mean IIEF scores at 6 and 12 months were significant for the desired domain (P = 0.0001) and for overall satisfaction (P = 0.002); however, mean EDITS scores at 6 and 12 months were not significantly improved. AMS 700 LGX is a powerful tool for preserving penile length in men undergoing penile prosthesis implantation.     

Clinical Applicability of a New Tactile Sensor for Evaluating Rigidity of the Penis: A Comparative Study with Rigiscan

Background: A new tactile sensor was developed for detecting hardness of living tissue by Omata et al. in 1992. This paper reports applicability of the sensor for evaluation of penile rigidity.
Methods: Nine patients from a group of 12 patients with penile erectile dysfunction were selected as subjects of this study. All patients agreed to artificial erection and monitoring of penile rigidity by a new tactile sensor and the Rigiscan system. The 9 patients selected all developed more than 1 cm circumferential expansion of the penis after an injection of smooth muscle relaxant into the corpus cavernosum.
The sensor equipment consisted of a piezoelectric element that vibrated, and a pickup that detected vibration frequency. When the end of the sensor was pressed against a surface of the penis, the resonance frequency of the sensor changed and indicated rigidity of the organ. Rigidity of the penile shaft was simultaneously monitored with the sensor and the Rigiscan system before and after an injection of 40mg papaverine or 20μg prostaglandin E₁. The sensor's measurements of rigidity were compared with those of Rigiscan.
Results: Reproducibility of rigidity measured with the tactile sensor was satisfactory. Statistical analysis was made on 85 simultaneous pairs of rigidity values from the tactile sensor and Rigiscan. The analysis indicated significant correlation between the values.
Conclusion: The tactile sensor as well as Rigiscan will be of use for evaluating rigidity of the penis.     

Total phallic reconstruction after penile amputation for carcinoma

OBJECTIVE

To report our experience of total phallic reconstruction (TPR) with the use of the radial‐artery free flap (RAFF) in patients who have had a subtotal penectomy for penile or urethral cancer, as the goal of TPR is the creation of a sensate and cosmetically acceptable phallus with an incorporated neourethra that allows the patient to void while standing, and with the insertion of a penile implant to resume sexual activities, improving quality of life.

PATIENTS AND METHODS

The notes of the 15 patients who had undergone RAFF TPR between January 1998 and May 2008 were reviewed retrospectively. The surgical outcome, cosmesis of the phallus, complications, eventual need for revision surgery and patient satisfaction were recorded during the follow‐up.

RESULTS

This technique allowed the reconstruction of a cosmetically acceptable phallus in all patients. After a median (range) follow‐up of 20 (1–68) months all patients were satisfied with the cosmesis and size of the phallus, and 14 were able to void while standing. Among the seven patients who have subsequently had insertion of a penile prosthesis, five can now engage in sexual intercourse. Urethral strictures and fistulae were the commonest complications in, respectively, three and four cases, and one patient had his penile prosthesis explanted because of infection.

CONCLUSIONS

RAFF phalloplasty is an excellent technique for TPR, giving excellent cosmetic and functional results.     

The correlation between penile tumescence measured by the erectometer and penile rigidity by the RigiScan

BACKGROUND: The goal of this study was to evaluate the correlation between increments of penile tumescence and penile rigidity measured by the erectometer and the RigiScan, respectively. METHODS: Nocturnal penile tumescence (NPT) was measured in 25 volunteers (mean age, 49.5 years). The erectometer and the RigiScan were used simultaneously for a total of 47 nights. We studied the correlation between maximum penile circumferential changes determined by the erectometer and penile rigidity patterns measured by the RigiScan. RESULTS: Maximum circumferential changes during NPT measured by the erectometer were well correlated to those determined by the RigiScan (correlation coefficient, 0.719). In addition, penile circumferential changes measured by the erectometer corresponded well to the penile rigidity pattern determined by the RigiScan (P=0.0001). Specifically, maximum penile circumferential changes of more than 30 mm and less than 10 mm had 70% positive predictive value and 100% negative predictive value for predicting the normal rigidity pattern, respectively. CONCLUSIONS: Penile circumferential changes measured by the erectometer were well correlated to penile rigidity measured by the RigiScan, particularly when the increments were larger than 30 mm or less than 10 mm. These results suggested that the erectometer was a useful tool to estimate the penile rigidity patterns of the RigiScan.