早期肠内营养对严重烧伤患者免疫功能的影响

严重烧伤患者免疫稳态失衡,是并发全身性感染及多器官功能不全的重要原因之一.肠道是外科应激的中心器官,已有实验结果提示:早期肠内营养能更好地维护肠道结构功能[1-2],降低烧伤后高代谢反应[3].动物实验结果表明,早期肠内营养可保护肠道免疫系统,有调节免疫细胞活性和细胞因子产生等作用[4].本研究以烧伤患者为对象,观察早期肠内营养对机体炎性介质和全身免疫功能的影响.     

老年胃癌患者手术后早期肠内营养对预后的影响研究

目的探讨老年胃癌患者手术后早期肠内营养对预后的影响。方法选择我院2010年3～12月收治的老年胃癌手术患者84例,随机将患者分为两组,每组42例,肠内营养组采用早期肠内营养支持,而肠外营养组则给予肠外营养支持,并对两组患者的营养和免疫等相关指标进行比较分析。结果与肠外营养组相比,肠内营养组患者的体重、血清白蛋白、前白蛋白、转铁蛋白等相关营养指标均明显改善,差异均具有统计学意义（P〈0.05）;与此同时,肠内营养组患者的IgG、IgA、IgM及CD-3～＋、CD-4～＋、CD-8～＋、CD-4～＋/CD-8～＋外周血T淋巴细胞亚群等免疫指标均显著改善,差异均具有统计学意义（P〈0.05）。结论老年胃癌手术后早期肠内营养支持对于患者预后具有十分重要的临床意义,值得进一步推广和应用。     

早期肠内营养护理对烧伤患者营养状况、胃肠道耐受性的影响

目的 探究早期肠内营养护理对烧伤患者营养状况、胃肠道耐受性的影响。方法 选取2017年1月-2022年12月盐城市第一人民医院烧伤整形科收治的70例烧伤患者作为研究对象,应用随机数字表法分为早期组和常规组,每组35例。早期组给予早期肠内营养护理（即入院12 h后行肠内营养护理）,常规组给予常规肠内营养护理（即入院48 h后行肠内营养护理）,比较两组营养状况、胃肠道耐受性及并发症发生情况。结果 早期组实施后血清白蛋白、血清转铁蛋白和淋巴细胞计数均高于常规组,差异有统计学意义（P ＜0.05）;早期组腹痛、腹胀、腹泻及恶心呕吐症状积分均低于常规组,差异有统计学意义（P ＜0.05）;早期组并发症总发生率为5.71%,低于常规组的22.86%,差异有统计学意义（P ＜0.05）。结论 早期肠内营养护理可帮助烧伤患者营养状况恢复至正常水平,且有助于提升胃肠道耐受性,减少各种相关并发症的发生风险,促进患者康复。     

严重烧伤患者早期肠内营养治疗的研究进展

严重烧伤会导致持续性的代谢亢进,研究显示尽早开展肠内营养治疗与改善严重烧伤患者预后、降低病死率、减少胃肠道并发症和感染性并发症等存在相关性。本文介绍了严重烧伤患者早期肠内营养治疗的营养益处及非营养益处（维持肠黏膜功能和结构的完整性及促进创面愈合）、营养治疗介入的时机和途径、能量评估方法及营养监测等,旨在为早期肠内营养治...     

危重烧伤患者早期应用肠内营养的进展

烧伤后由于肠粘膜结构和功能受损 ,导致肠道细菌移位而引发全身感染 ,已被众多的实验及临床研究证实。近年研究表明 ,早期肠道营养能维护肠道功能 ,减少肠道细菌移位。笔者就烧伤后肠道细菌移位的发生机制、早期肠道营养在维护肠道功能中的作用、特殊营养物质的肠道功能保护作用及危重患者早期肠内营养实施中产生“肠内营养不耐受”的原因 ,进行文献综述。一、烧伤后肠道细菌移位发生的可能机制严重烧伤后先于创面出现的全身侵袭性感染的原因 ,曾经是困惑烧伤学科的难题 ,因而激发了国内外学者的研究兴趣。 2 0世纪 80年代初经动物实验证实 …     

胃肠术后早期肠内营养对患者预后影响的Meta分析

目的系统评价早期肠内营养对胃肠手术患者的预后影响。方法检索PubMed、Cochrane Library、中国生物医学文献数据库（CBM）、中国知网、万方和维普等数据库中有关术后早期肠内营养的临床随机对照研究,采用Jadad质量评价量表对纳入文献进行质量评价,提取营养指标、肠功能恢复指标、术后并发症及卫生经济学指标等结局资料,应用RevMan5．2软件进行Meta分析。结果11项临床随机对照研究共计1087例病例纳入分析,其中术后24h内予以肠内营养者541例（早期营养组）,术后予以常规营养支持或单纯静脉输液者546例（对照组）。Meta分析结果显示．早期营养组患者术后血浆白蛋白和前白蛋白水平较对照组明显升高（WMD=2．87,95％CI：1．03。4．71：WMD=0．04,95％CI：0．02-0．05）,术后肠通气恢复时间较对照组明显缩短（WMD=4．10,95％CI：-5．38—2．82）,术后并发症发生率明显降低（RR=0．64,95％CI：0．44—0．93）。结论胃肠道手术后予以早期肠内营养,可以较好地改善患者的营养状况、促进肠道功能恢复并降低术后并发症发生率,是一种安全、有效的治疗方法。     

综合护理对大面积烧伤患者心理行为及预后的影响

目的:探究综合护理对大面积烧伤患者心理行为及预后的影响。方法:选取笔者医院收治的62例大面积烧伤患者,随机分为对照组和观察组,每组31例。对照组患者予以常规护理手段,观察组患者予以综合护理,比较两组患者护理满意度、疼痛情况、抑郁及焦虑情况、生活质量、创面愈合及并发症发生情况。结果:观察组患者创面愈合时间、汉密尔顿抑郁评分(HMAD)、汉密尔顿焦虑评分(HAMA)、视觉模拟疼痛评分(VAS)、创面感染、肺部感染、压力性损伤的并发症发生率均显著低于对照组,差异具有统计学意义(P0.05)。观察组患者创面愈合率、护理满意度评分、生活质量评分均显著高于对照组,差异具有统计学意义(P0.05)。结论:综合护理能够促进大面积烧伤患者创面愈合,缩短愈合时间,缓解疼痛,改善患者在治疗期间的抑郁情况,降低HAMD评分。     

早期淋巴细胞/血小板比值对大面积烧伤患者预后的意义

目的:分析大面积烧伤患者早期淋巴细胞/血小板比值（LPR）的变化趋势及特点,探讨LPR对患者预后的意义。方法:采用回顾性病例系列研究方法。2008年1月—2018年12月,海军军医大学第一附属医院收治符合入选标准的大面积烧伤患者244例,其中男181例、女63例,年龄（44±16）岁,烧伤总面积为60.0%（42.0%...     

早期肠内营养支持对腹部手术患者营养及免疫的影响

腹部手术患者由于胃肠动力学受到干扰,手术创伤导致分解代谢增强,机体往往处于免疫抑制状态[1],因而术后常需要营养支持。随着对肠功能的再认识,尤其是肠道黏膜屏障、细菌易位及肠道是应激反应的一个中心器官等概念的确立,肠内营养支     

早期肠内营养对22例重症急性胰腺炎预后的影响

重症急性重症胰腺炎（severeacutepanereatitis,SAP）十分凶险,占急性胰腺炎的20％～30％,其病死率在20％左右。目前,营养支持在治疗SAP过程中起着重要作用。长期完全肠外营养（totalpar．enteralnutrition,TPN）使肠道功能无法维持,将导致肠黏膜免疫屏障损害,出现肠道细菌移位,增加并发症发生率。而适时肠内营养（enteralnutrition,EN）能够减少细菌移位和胰腺继发感染发生率引。     

肠内营养预适应对胃癌术后患者早期肠内营养相关并发症及胃肠功能的影响

目的提高胃癌术后患者早期肠内营养胃肠道耐受性和促进胃肠功能恢复。方法将88例行胃癌根治术后拟早期肠内营养的患者随机分为观察组40例和对照组44例,观察组术前3d开始在常规饮食的基础上口服肠内营养液予以预适应,对照组术前常规饮食。结果观察组术后腹胀、腹泻、腹痛发生率显著低于对照组,首次进食流质时间、首次排气、首次排便时间显著优于对照组(P0.05,P0.01)。结论胃癌手术患者术前口服肠内营养能实现胃肠道预适应,能有效降低术后早期肠内营养胃肠道并发症发生率,促进术后胃肠道功能恢复。     

强化精氨酸肠内营养对烧伤患者营养状况和细胞免疫的影响

Objective To investigate the effects of arginine enriched enteral nutrition (EN) on nu-tritional status and cellular immunity of severely burned patients. Methods Randomized, single blind, parallel and positive control investigation was employed in the study. Thirty severely burned patients were di-vided into enteral immune nutrition (EIN) group and EN group. Sixteen patients in EIN group received en-teral nutrition enriched with arginine, while the other 14 patients in EN group received standard enteral nu-trition. Nutritional support was continued for 14 days. Gastrointestinal reaction of patients in 2 groups was observed. Fasting venous blood was drawn from patients of both groups before receiving nutrition treatment and on the morning of 7th, 14th day of treatment. Level of serum protein, hepatic function parameters, renal function parameters, fasting-blood glucose, and subpopulations of T lymphocytes in peripheral blood were determined. Results (1) Incidence of gastrointestinal side effect in EIN group (25.0%) was close to that of EN group (21.4% , P>0.05). (2) Compared with pre-treatment days, levels of prealbumin and transferrin in serum of patients in 2 groups on 7th and 14th post-treatment days were significantly increased (P<0.05 or P<0.01), but there was no significant difference between 2 groups. The level of total serum protein on 14th day of treatment of patients was significantly increased in both groups, and that of EIN group (66±7 g/L)was significantly higher compared with that in EN group (64 ± 11 g/L, P<0.05). The level of serum albumin (29±5, 32±5 g/L, respectively) of patients in EIN group on 7th and 14th day of treat-ment were significantly higher than that (26±4 g/L, P <0.05) in pre-treatment days, however there was no significant difference in EN group. (3) There was no significant difference in respect of hepatic function, renal function, and fasting-blood glucose between pre-treatment and post-treatment periods in both groups (P>0.05). (4) The ratio of CD4+ , CD8+ on 14th day of treatment in EIN group was close to that of pre-treatment level. In EN group, cell percentage of CD4+ significantly decreased, while that of CD8+ significantly increased (P<0.05), and CD4+ was significantly higher [(56±8) %] in EIN group than that in EN group [(55±12) % , P <0.05]. In both groups, cell percentage of CD3+ was significantly higher than that in pre-treatment days (P<0.05), while there was no obvious change in CD4+/CD8+. Conclusions Arginine enriched enteral nutrition can effectively improve nutritional status and cellular immune function of burn patients.     

强化精氨酸肠内营养对烧伤患者营养状况和细胞免疫的影响

Objective To investigate the effects of arginine enriched enteral nutrition (EN) on nu-tritional status and cellular immunity of severely burned patients. Methods Randomized, single blind, parallel and positive control investigation was employed in the study. Thirty severely burned patients were di-vided into enteral immune nutrition (EIN) group and EN group. Sixteen patients in EIN group received en-teral nutrition enriched with arginine, while the other 14 patients in EN group received standard enteral nu-trition. Nutritional support was continued for 14 days. Gastrointestinal reaction of patients in 2 groups was observed. Fasting venous blood was drawn from patients of both groups before receiving nutrition treatment and on the morning of 7th, 14th day of treatment. Level of serum protein, hepatic function parameters, renal function parameters, fasting-blood glucose, and subpopulations of T lymphocytes in peripheral blood were determined. Results (1) Incidence of gastrointestinal side effect in EIN group (25.0%) was close to that of EN group (21.4% , P>0.05). (2) Compared with pre-treatment days, levels of prealbumin and transferrin in serum of patients in 2 groups on 7th and 14th post-treatment days were significantly increased (P<0.05 or P<0.01), but there was no significant difference between 2 groups. The level of total serum protein on 14th day of treatment of patients was significantly increased in both groups, and that of EIN group (66±7 g/L)was significantly higher compared with that in EN group (64 ± 11 g/L, P<0.05). The level of serum albumin (29±5, 32±5 g/L, respectively) of patients in EIN group on 7th and 14th day of treat-ment were significantly higher than that (26±4 g/L, P <0.05) in pre-treatment days, however there was no significant difference in EN group. (3) There was no significant difference in respect of hepatic function, renal function, and fasting-blood glucose between pre-treatment and post-treatment periods in both groups (P>0.05). (4) The ratio of CD4+ , CD8+ on 14th day of treatment in EIN group was close to that of pre-treatment level. In EN group, cell percentage of CD4+ significantly decreased, while that of CD8+ significantly increased (P<0.05), and CD4+ was significantly higher [(56±8) %] in EIN group than that in EN group [(55±12) % , P <0.05]. In both groups, cell percentage of CD3+ was significantly higher than that in pre-treatment days (P<0.05), while there was no obvious change in CD4+/CD8+. Conclusions Arginine enriched enteral nutrition can effectively improve nutritional status and cellular immune function of burn patients.     

强化精氨酸肠内营养对烧伤患者营养状况和细胞免疫的影响

Objective To investigate the effects of arginine enriched enteral nutrition (EN) on nu-tritional status and cellular immunity of severely burned patients. Methods Randomized, single blind, parallel and positive control investigation was employed in the study. Thirty severely burned patients were di-vided into enteral immune nutrition (EIN) group and EN group. Sixteen patients in EIN group received en-teral nutrition enriched with arginine, while the other 14 patients in EN group received standard enteral nu-trition. Nutritional support was continued for 14 days. Gastrointestinal reaction of patients in 2 groups was observed. Fasting venous blood was drawn from patients of both groups before receiving nutrition treatment and on the morning of 7th, 14th day of treatment. Level of serum protein, hepatic function parameters, renal function parameters, fasting-blood glucose, and subpopulations of T lymphocytes in peripheral blood were determined. Results (1) Incidence of gastrointestinal side effect in EIN group (25.0%) was close to that of EN group (21.4% , P>0.05). (2) Compared with pre-treatment days, levels of prealbumin and transferrin in serum of patients in 2 groups on 7th and 14th post-treatment days were significantly increased (P<0.05 or P<0.01), but there was no significant difference between 2 groups. The level of total serum protein on 14th day of treatment of patients was significantly increased in both groups, and that of EIN group (66±7 g/L)was significantly higher compared with that in EN group (64 ± 11 g/L, P<0.05). The level of serum albumin (29±5, 32±5 g/L, respectively) of patients in EIN group on 7th and 14th day of treat-ment were significantly higher than that (26±4 g/L, P <0.05) in pre-treatment days, however there was no significant difference in EN group. (3) There was no significant difference in respect of hepatic function, renal function, and fasting-blood glucose between pre-treatment and post-treatment periods in both groups (P>0.05). (4) The ratio of CD4+ , CD8+ on 14th day of treatment in EIN group was close to that of pre-treatment level. In EN group, cell percentage of CD4+ significantly decreased, while that of CD8+ significantly increased (P<0.05), and CD4+ was significantly higher [(56±8) %] in EIN group than that in EN group [(55±12) % , P <0.05]. In both groups, cell percentage of CD3+ was significantly higher than that in pre-treatment days (P<0.05), while there was no obvious change in CD4+/CD8+. Conclusions Arginine enriched enteral nutrition can effectively improve nutritional status and cellular immune function of burn patients.     

强化精氨酸肠内营养对烧伤患者营养状况和细胞免疫的影响

Objective To investigate the effects of arginine enriched enteral nutrition (EN) on nu-tritional status and cellular immunity of severely burned patients. Methods Randomized, single blind, parallel and positive control investigation was employed in the study. Thirty severely burned patients were di-vided into enteral immune nutrition (EIN) group and EN group. Sixteen patients in EIN group received en-teral nutrition enriched with arginine, while the other 14 patients in EN group received standard enteral nu-trition. Nutritional support was continued for 14 days. Gastrointestinal reaction of patients in 2 groups was observed. Fasting venous blood was drawn from patients of both groups before receiving nutrition treatment and on the morning of 7th, 14th day of treatment. Level of serum protein, hepatic function parameters, renal function parameters, fasting-blood glucose, and subpopulations of T lymphocytes in peripheral blood were determined. Results (1) Incidence of gastrointestinal side effect in EIN group (25.0%) was close to that of EN group (21.4% , P>0.05). (2) Compared with pre-treatment days, levels of prealbumin and transferrin in serum of patients in 2 groups on 7th and 14th post-treatment days were significantly increased (P<0.05 or P<0.01), but there was no significant difference between 2 groups. The level of total serum protein on 14th day of treatment of patients was significantly increased in both groups, and that of EIN group (66±7 g/L)was significantly higher compared with that in EN group (64 ± 11 g/L, P<0.05). The level of serum albumin (29±5, 32±5 g/L, respectively) of patients in EIN group on 7th and 14th day of treat-ment were significantly higher than that (26±4 g/L, P <0.05) in pre-treatment days, however there was no significant difference in EN group. (3) There was no significant difference in respect of hepatic function, renal function, and fasting-blood glucose between pre-treatment and post-treatment periods in both groups (P>0.05). (4) The ratio of CD4+ , CD8+ on 14th day of treatment in EIN group was close to that of pre-treatment level. In EN group, cell percentage of CD4+ significantly decreased, while that of CD8+ significantly increased (P<0.05), and CD4+ was significantly higher [(56±8) %] in EIN group than that in EN group [(55±12) % , P <0.05]. In both groups, cell percentage of CD3+ was significantly higher than that in pre-treatment days (P<0.05), while there was no obvious change in CD4+/CD8+. Conclusions Arginine enriched enteral nutrition can effectively improve nutritional status and cellular immune function of burn patients.     

强化精氨酸肠内营养对烧伤患者营养状况和细胞免疫的影响

Objective To investigate the effects of arginine enriched enteral nutrition (EN) on nu-tritional status and cellular immunity of severely burned patients. Methods Randomized, single blind, parallel and positive control investigation was employed in the study. Thirty severely burned patients were di-vided into enteral immune nutrition (EIN) group and EN group. Sixteen patients in EIN group received en-teral nutrition enriched with arginine, while the other 14 patients in EN group received standard enteral nu-trition. Nutritional support was continued for 14 days. Gastrointestinal reaction of patients in 2 groups was observed. Fasting venous blood was drawn from patients of both groups before receiving nutrition treatment and on the morning of 7th, 14th day of treatment. Level of serum protein, hepatic function parameters, renal function parameters, fasting-blood glucose, and subpopulations of T lymphocytes in peripheral blood were determined. Results (1) Incidence of gastrointestinal side effect in EIN group (25.0%) was close to that of EN group (21.4% , P>0.05). (2) Compared with pre-treatment days, levels of prealbumin and transferrin in serum of patients in 2 groups on 7th and 14th post-treatment days were significantly increased (P<0.05 or P<0.01), but there was no significant difference between 2 groups. The level of total serum protein on 14th day of treatment of patients was significantly increased in both groups, and that of EIN group (66±7 g/L)was significantly higher compared with that in EN group (64 ± 11 g/L, P<0.05). The level of serum albumin (29±5, 32±5 g/L, respectively) of patients in EIN group on 7th and 14th day of treat-ment were significantly higher than that (26±4 g/L, P <0.05) in pre-treatment days, however there was no significant difference in EN group. (3) There was no significant difference in respect of hepatic function, renal function, and fasting-blood glucose between pre-treatment and post-treatment periods in both groups (P>0.05). (4) The ratio of CD4+ , CD8+ on 14th day of treatment in EIN group was close to that of pre-treatment level. In EN group, cell percentage of CD4+ significantly decreased, while that of CD8+ significantly increased (P<0.05), and CD4+ was significantly higher [(56±8) %] in EIN group than that in EN group [(55±12) % , P <0.05]. In both groups, cell percentage of CD3+ was significantly higher than that in pre-treatment days (P<0.05), while there was no obvious change in CD4+/CD8+. Conclusions Arginine enriched enteral nutrition can effectively improve nutritional status and cellular immune function of burn patients.     

强化精氨酸肠内营养对烧伤患者营养状况和细胞免疫的影响

Objective To investigate the effects of arginine enriched enteral nutrition (EN) on nu-tritional status and cellular immunity of severely burned patients. Methods Randomized, single blind, parallel and positive control investigation was employed in the study. Thirty severely burned patients were di-vided into enteral immune nutrition (EIN) group and EN group. Sixteen patients in EIN group received en-teral nutrition enriched with arginine, while the other 14 patients in EN group received standard enteral nu-trition. Nutritional support was continued for 14 days. Gastrointestinal reaction of patients in 2 groups was observed. Fasting venous blood was drawn from patients of both groups before receiving nutrition treatment and on the morning of 7th, 14th day of treatment. Level of serum protein, hepatic function parameters, renal function parameters, fasting-blood glucose, and subpopulations of T lymphocytes in peripheral blood were determined. Results (1) Incidence of gastrointestinal side effect in EIN group (25.0%) was close to that of EN group (21.4% , P>0.05). (2) Compared with pre-treatment days, levels of prealbumin and transferrin in serum of patients in 2 groups on 7th and 14th post-treatment days were significantly increased (P<0.05 or P<0.01), but there was no significant difference between 2 groups. The level of total serum protein on 14th day of treatment of patients was significantly increased in both groups, and that of EIN group (66±7 g/L)was significantly higher compared with that in EN group (64 ± 11 g/L, P<0.05). The level of serum albumin (29±5, 32±5 g/L, respectively) of patients in EIN group on 7th and 14th day of treat-ment were significantly higher than that (26±4 g/L, P <0.05) in pre-treatment days, however there was no significant difference in EN group. (3) There was no significant difference in respect of hepatic function, renal function, and fasting-blood glucose between pre-treatment and post-treatment periods in both groups (P>0.05). (4) The ratio of CD4+ , CD8+ on 14th day of treatment in EIN group was close to that of pre-treatment level. In EN group, cell percentage of CD4+ significantly decreased, while that of CD8+ significantly increased (P<0.05), and CD4+ was significantly higher [(56±8) %] in EIN group than that in EN group [(55±12) % , P <0.05]. In both groups, cell percentage of CD3+ was significantly higher than that in pre-treatment days (P<0.05), while there was no obvious change in CD4+/CD8+. Conclusions Arginine enriched enteral nutrition can effectively improve nutritional status and cellular immune function of burn patients.     

强化精氨酸肠内营养对烧伤患者营养状况和细胞免疫的影响

Objective To investigate the effects of arginine enriched enteral nutrition (EN) on nu-tritional status and cellular immunity of severely burned patients. Methods Randomized, single blind, parallel and positive control investigation was employed in the study. Thirty severely burned patients were di-vided into enteral immune nutrition (EIN) group and EN group. Sixteen patients in EIN group received en-teral nutrition enriched with arginine, while the other 14 patients in EN group received standard enteral nu-trition. Nutritional support was continued for 14 days. Gastrointestinal reaction of patients in 2 groups was observed. Fasting venous blood was drawn from patients of both groups before receiving nutrition treatment and on the morning of 7th, 14th day of treatment. Level of serum protein, hepatic function parameters, renal function parameters, fasting-blood glucose, and subpopulations of T lymphocytes in peripheral blood were determined. Results (1) Incidence of gastrointestinal side effect in EIN group (25.0%) was close to that of EN group (21.4% , P>0.05). (2) Compared with pre-treatment days, levels of prealbumin and transferrin in serum of patients in 2 groups on 7th and 14th post-treatment days were significantly increased (P<0.05 or P<0.01), but there was no significant difference between 2 groups. The level of total serum protein on 14th day of treatment of patients was significantly increased in both groups, and that of EIN group (66±7 g/L)was significantly higher compared with that in EN group (64 ± 11 g/L, P<0.05). The level of serum albumin (29±5, 32±5 g/L, respectively) of patients in EIN group on 7th and 14th day of treat-ment were significantly higher than that (26±4 g/L, P <0.05) in pre-treatment days, however there was no significant difference in EN group. (3) There was no significant difference in respect of hepatic function, renal function, and fasting-blood glucose between pre-treatment and post-treatment periods in both groups (P>0.05). (4) The ratio of CD4+ , CD8+ on 14th day of treatment in EIN group was close to that of pre-treatment level. In EN group, cell percentage of CD4+ significantly decreased, while that of CD8+ significantly increased (P<0.05), and CD4+ was significantly higher [(56±8) %] in EIN group than that in EN group [(55±12) % , P <0.05]. In both groups, cell percentage of CD3+ was significantly higher than that in pre-treatment days (P<0.05), while there was no obvious change in CD4+/CD8+. Conclusions Arginine enriched enteral nutrition can effectively improve nutritional status and cellular immune function of burn patients.     

强化精氨酸肠内营养对烧伤患者营养状况和细胞免疫的影响

Objective To investigate the effects of arginine enriched enteral nutrition (EN) on nu-tritional status and cellular immunity of severely burned patients. Methods Randomized, single blind, parallel and positive control investigation was employed in the study. Thirty severely burned patients were di-vided into enteral immune nutrition (EIN) group and EN group. Sixteen patients in EIN group received en-teral nutrition enriched with arginine, while the other 14 patients in EN group received standard enteral nu-trition. Nutritional support was continued for 14 days. Gastrointestinal reaction of patients in 2 groups was observed. Fasting venous blood was drawn from patients of both groups before receiving nutrition treatment and on the morning of 7th, 14th day of treatment. Level of serum protein, hepatic function parameters, renal function parameters, fasting-blood glucose, and subpopulations of T lymphocytes in peripheral blood were determined. Results (1) Incidence of gastrointestinal side effect in EIN group (25.0%) was close to that of EN group (21.4% , P>0.05). (2) Compared with pre-treatment days, levels of prealbumin and transferrin in serum of patients in 2 groups on 7th and 14th post-treatment days were significantly increased (P<0.05 or P<0.01), but there was no significant difference between 2 groups. The level of total serum protein on 14th day of treatment of patients was significantly increased in both groups, and that of EIN group (66±7 g/L)was significantly higher compared with that in EN group (64 ± 11 g/L, P<0.05). The level of serum albumin (29±5, 32±5 g/L, respectively) of patients in EIN group on 7th and 14th day of treat-ment were significantly higher than that (26±4 g/L, P <0.05) in pre-treatment days, however there was no significant difference in EN group. (3) There was no significant difference in respect of hepatic function, renal function, and fasting-blood glucose between pre-treatment and post-treatment periods in both groups (P>0.05). (4) The ratio of CD4+ , CD8+ on 14th day of treatment in EIN group was close to that of pre-treatment level. In EN group, cell percentage of CD4+ significantly decreased, while that of CD8+ significantly increased (P<0.05), and CD4+ was significantly higher [(56±8) %] in EIN group than that in EN group [(55±12) % , P <0.05]. In both groups, cell percentage of CD3+ was significantly higher than that in pre-treatment days (P<0.05), while there was no obvious change in CD4+/CD8+. Conclusions Arginine enriched enteral nutrition can effectively improve nutritional status and cellular immune function of burn patients.     

早期肠道营养对严重烧伤患者康复的影响

目的通过对早期肠道营养抑制肠内感染的分析探讨对严重烧伤患者康复的影响。方法22例严重烧伤患者随机分组为早期肠道营养组(EF)和延迟肠道营养组(DF)。烧伤后1、3、5d分别测每位患者的血清内毒素水平。结果严重烧伤患者的血清内毒素水平明显高于正常人群(P<0.01)。早期肠道营养组的血清内毒素水平明显低于延迟肠道营养组(P<0.01)。结论早期肠道营养可以减少肠源性感染,有利于营养支持,改善患者体质,增强机体抵抗力,促进损伤组织的修复,有利于烧伤患者的康复。